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Practical matters How to find us prof. dr. S. (Sijbren) Otto

Research interests

Our research is focused on Systems Chemistry and in particular on complex mixtures of synthetic molecules that can interconvert as well as interact noncovalently. Such mixtures constitute networks that can transmit molecular information. New properties can be expected to emerge from molecules acting in concert that are relevant to understanding how Nature evolved its complex molecular networks and, ultimately, to the origins of life. Furthermore, once we have learned how to design and control complex molecular systems, we should be able to design new functions complementary to those encountered in Nature, and eventually we should be able to synthesize life de-novo.

We are particularly interested in self-replicating molecules, foldamers (synthetic oliomeric molecules that adopt well-defined conformations), catalysis, molecular recognition of (among others) biomacromolecules with synthetic platforms, self-assembly of materials, including hydrogels.

The overarching aim of our work is the de-novo synthesis of life. We are pursuing the integration of our self-replicating systems with metabolism and compartmentalization and aim to operate the systems in a replication-destruction regime allowing them to undergo Darwinian evolution.


An Approach to the de Novo Synthesis of Life

An Optical Probe for Real-Time Monitoring of Self-Replicator Emergence and Distinguishing between Replicators

Out-of-equilibrium self-replication allows selection for dynamic kinetic stability in a system of competing replicators

Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library

Tailor-made functionalized self-assembled peptide (nano)fibers and hydrogels, and methods, uses and kits related thereto

Chemical Fueling Enables Molecular Complexification of Self-Replicators

Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators

Stoichiometry alone can steer supramolecular systems on complex free energy surfaces with high selectivity

Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries

Automated device for continuous stirring while sampling in liquid chromatography systems

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