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Practical matters How to find us M.R. (Matthew) Groves, Prof Dr

M.R. (Matthew) Groves, Prof Dr

Associate Professor

Profielfoto van M.R. (Matthew) Groves, Prof Dr

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Faculty of Science and Engineering

Telephone:

+31 50 36 33305

E-mail:

m.r.groves rug.nl

ORCID Research Portal

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers

Publications

Structural characterization and extended substrate scope analysis of two Mg<sup>2+</sup>-dependent O-methyltransferases from bacteria

Sokolova, N. , Zhang, L. , Deravi, S. , Oerlemans, R. , Groves, M. R. & Haslinger, K. , 29-Jan-2023 , (Submitted) BioRxiv , 17 p.

Research output: Working paper › Preprint › Academic

Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature

Koopman, B. , Groen, H. J. M. , Schuuring, E. , Hiltermann, J. , Timens, W. , den Dunnen, W. F. A. , van den Berg, A. , ter Elst, A. , van Kruchten, M. , Kluiver, J. , Hiddinga, B. , Hijmering-Kappelle, L. , Groves, M. , Vilachá Madeira R Santos, J. , van Kempen, L. & van der Wekken, A. J. , Mar-2022 , In: Clinical lung cancer. 23 , 2 , p. e104-e115 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

Ulgheri, F. , Spanu, P. , Deligia, F. , Loriga, G. , Fuggetta, M. P. , de Haan, I. , Chandgudge, A. , Groves, M. & Domling, A. , 5-Feb-2022 , In: European Journal of Medicinal Chemistry. 229 , 114002.

Research output: Contribution to journal › Article › Academic › peer-review

Discovery of Small-Molecule Allosteric Inhibitors of PfATC as Antimalarials

Wang, C. , Zhang, B. , Krüger, A. , Du, X. , Visser, L. , Dömling, A. , Wrenger, C. & Groves, M. , 19-Oct-2022 , In: Journal of the American Chemical Society. 144 , 41 , p. 19070–19077 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Engineering a plant polyketide synthase for the biosynthesis of methylated flavonoids

Peng, B. , Zhang, L. , He, S. , Oerlemans, R. , Quax, W. J. , Groves, M. R. & Haslinger, K. , 2-Oct-2022 , (Submitted) BioRxiv , 27 p.

Research output: Working paper › Preprint › Academic

Feasibility of Follow-Up Studies and Reclassification in Spinocerebellar Ataxia Gene Variants of Unknown Significance

Ghorbani, F. , Alimohamed, M. Z. , Vilacha, J. F. , Van Dijk, K. K. , De Boer-Bergsma, J. , Fokkens, M. R. , Lemmink, H. , Sijmons, R. H. , Sikkema-Raddatz, B. , Groves, M. R. , Verschuuren-Bemelmans, C. C. , Verbeek, D. S. , Van Diemen, C. C. & Westers, H. , 25-Mar-2022 , In: Frontiers in Genetics. 13 , 13 p. , 782685.

Research output: Contribution to journal › Article › Academic › peer-review

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Gierse, R. M. , Oerlemans, R. , Reddem, E. R. , Gawriljuk, V. O. , Alhayek, A. , Baitinger, D. , Jakobi, H. , Laber, B. , Lange, G. , Hirsch, A. K. H. & Groves, M. R. , 25-Mar-2022 , In: Scientific Reports. 12 , 13 p. , 7221.

Research output: Contribution to journal › Article › Academic › peer-review

Multicomponent Macrocyclic IL-17a Modifier

Abdelraheem, E. , Lubberink, M. , Wang, W. , Li, J. , Reyes Romero, A. , Van Der Straat, R. , Du, X. , Groves, M. & Domling, A. , 8-Sept-2022 , In: ACS Medicinal Chemistry Letters. 13 , 9 , p. 1468–1471 4 p.

Research output: Contribution to journal › Article › Academic › peer-review

Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase

Wang, C. , Krüger, A. , Du, X. , Wrenger, C. & Groves, M. R. , 4-Mar-2022 , In: Frontiers in Cellular and Infection Microbiology. 12 , 9 p. , 841833.

Research output: Contribution to journal › Article › Academic › peer-review

Synthetic peptides blocking sars-cov-2 (covid-19), and compositions, methods and uses related thereto

Sadremomtaz, A. , Groves, M. R. , van Goor, H. , Doti, N. & Monti, A. , 1-Sept-2022 , Patent No. WO2022182241, 25-Feb-2022 , Priority date 26-Feb-2020

Research output: Patent

All (117) publications

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