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How to find us prof. dr. M.R. (Matthew) Groves

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers 

Publications

A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity

A synthetic peptide as an allosteric inhibitor of human arginase I and II

Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature

Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification

Correction to "Benchmark of Generic Shapes for Macrocycles"

Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties

Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers

Repurposing the HCV NS3–4A protease drug boceprevir as COVID-19 therapeutics

Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein

The Human Milk Oligosaccharides 3-FL, Lacto-N-Neotetraose, and LDFT Attenuate Tumor Necrosis Factor-alpha Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1

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