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How to find us prof. dr. M.R. (Matthew) Groves

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers 

Publications

A synthetic peptide as an allosteric inhibitor of human arginase I and II

Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties

Repurposing the HCV NS3–4A protease drug boceprevir as COVID-19 therapeutics

Repurposing the HCV NS3–4A protease drug boceprevir as COVID-19 therapeutics

The Human Milk Oligosaccharides 3-FL, Lacto-N-Neotetraose, and LDFT Attenuate Tumor Necrosis Factor-alpha Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1

A novel mechanism of inhibition by phenylthiourea on PvdP, a tyrosinase synthesizing pyoverdine of Pseudomonas aeruginosa

Benchmark of Generic Shapes for Macrocycles

Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum

Making NSCLC Crystal Clear: How Kinase Structures Revolutionized Lung Cancer Treatment

Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application

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