prof. dr. M.R. (Matthew) Groves

Associate Professor

prof. dr. M.R. (Matthew) Groves


Postal address:
A Deusinglaan1
Gebouw 3211, ruimte 0474
9713 AV
Phone: +31 50 363 3305Fax: +31 50 363 6908

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers 

  1. TEAD-YAP interaction inhibitors and MDM2 binders from DNA-encoded indole-focused Ugi-peptidomimetics

    Kunig, V. B. K., Potowski, M., Akbarzadeh, M., Klika Škopić, M., Dos Santos Smith, D., Arendt, L., Dormuth, I., Adihou, H., Andlovic, B., Karatas, H., Shaabani, S., Zarganes-Tzitzikas, T., Neochoritis, C. G., Zhang, R., Groves, M., Guéret, S. M., Ottmann, C., Rahnenführer, J., Fried, R., Dömling, A. & Brunschweiger, A., 14-Jun-2020, In : Angewandte Chemie (International ed. in English).

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application

    Sadremomtaz, A., Ali, A. M., Jouyandeh, F., Balalaie, S., Navari, R., Broussy, S., Mansouri, K., Groves, M. R. & Asghari, S. M., 5-Jun-2020, In : Signal transduction and targeted therapy. 5, 1, 4 p., 76.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. The aroma of TEMED as an activation and stabilizing signal for the antibacterial enzyme HEWL

    Seraj, Z., Ahmadian, S., Groves, M. R. & Seyedarabi, A., 19-May-2020, In : PLoS ONE. 15, 5, 17 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Molecular target validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2

    Bosch, S., Lunev, S., Batista, F. A., Linzke, M., Kronenberger, T., Dömling, A., Groves, M. R. & Wrenger, C., 2020, In : ACS Infectious Diseases.

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Pharmacy Day 2018

    Anna Salvati (Organiser), Amalia Dolga (Organiser), Matthew Groves (Organiser), Klaus Mathwig (Organiser), Peter Horvatovich (Organiser), Wim J. Quax (Organiser), Anne Lexmond (Organiser), Gillian Dempsey (Organiser)

    Activity: Participating in or organising an eventOrganising an eventAcademic

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