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How to find us M.R. (Matthew) Groves, Prof Dr

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers 

Publications

Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature

Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

Feasibility of Follow-Up Studies and Reclassification in Spinocerebellar Ataxia Gene Variants of Unknown Significance

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase

Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein

A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity

A synthetic peptide as an allosteric inhibitor of human arginase I and II

Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification

Correction to "Benchmark of Generic Shapes for Macrocycles"

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