prof. dr. M.R. (Matthew) Groves

Associate Professor

prof. dr. M.R. (Matthew) Groves


Postal address:
A Deusinglaan1
Gebouw 3211, ruimte 0474
9713 AV
Phone: +31 50 363 3305Fax: +31 50 363 6908

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers 

  1. TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics

    Kunig, V. B. K., Potowski, M., Akbarzadeh, M., Klika Škopić, M., Dos Santos Smith, D., Arendt, L., Dormuth, I., Adihou, H., Andlovic, B., Karatas, H., Shaabani, S., Zarganes-Tzitzikas, T., Neochoritis, C. G., Zhang, R., Groves, M., Guéret, S. M., Ottmann, C., Rahnenführer, J., Fried, R., Dömling, A. & Brunschweiger, A., 14-Jun-2020, In : Angewandte Chemie (International ed. in English). 6 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application

    Sadremomtaz, A., Ali, A. M., Jouyandeh, F., Balalaie, S., Navari, R., Broussy, S., Mansouri, K., Groves, M. R. & Asghari, S. M., 5-Jun-2020, In : Signal transduction and targeted therapy. 5, 1, 4 p., 76.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. The aroma of TEMED as an activation and stabilizing signal for the antibacterial enzyme HEWL

    Seraj, Z., Ahmadian, S., Groves, M. R. & Seyedarabi, A., 19-May-2020, In : PLoS ONE. 15, 5, 17 p., e0232953.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Molecular target validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2

    Bosch, S., Lunev, S., Batista, F. A., Linzke, M., Kronenberger, T., Dömling, A., Groves, M. R. & Wrenger, C., 2020, In : ACS Infectious Diseases. 6, 5, p. 986-999 14 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Pharmacy Day 2018

    Anna Salvati (Organiser), Amalia Dolga (Organiser), Matthew Groves (Organiser), Klaus Mathwig (Organiser), Peter Horvatovich (Organiser), Wim J. Quax (Organiser), Anne Lexmond (Organiser) & Gillian Dempsey (Organiser)


    Activity: Participating in or organising an eventOrganising an eventAcademic

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