dr. M.N. (Machteld) Hylkema

Associate Professor

dr. M.N. (Machteld) Hylkema
E-mail:
m.n.hylkema umcg.nl

Research

Research interests

Machteld Hylkema (1965) is an immunologist with a broad interest in the pathogenesis of asthma and COPD. She obtained a master in Biology at the University of Leiden in 1991 and completed her PhD at the University of Amsterdam in 1995. In the same year she moved to Groningen for a post-doc position at the department of Cell Biology and Histology, University of Groningen. In 1998 she continued to work as a post-doc at the StanfordUniversity. Palo Alto, USA. After her return to Groningen she started as a post-doc at the department of Pathology from the UMCG and was appointed as assistant professor in 2001. In 2011 she was appointed as associate professor.

 

She developed several mouse models for asthma and COPD but is involved in clinical studies as well. During the last 10 years, she has investigated the effects of maternal smoking during pregnancy on lung development and susceptibility to develop asthma and/or chronic obstructive pulmonary disease (COPD). In the offspring, alterations in lung development are being linked with gene-specific epigenetic profiles in the lung. As development of chronic mucus hypersecretion is one of the phenotypes in offspring following prenatal smoke exposure, epigenetic mechanisms related to epithelial cell fate are investigated, in vitro and in vivo. Epigenetic mutations that underlie aberrant epithelial mucus-secreting cell differentiation are targets for Epigenetic Editing to selectively silence or re-express specific gene expression to prevent this phenotype.

Publications
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells

    Wu, D-D., Xu, Y-M., Chen, D-J., Liang, Z-L., Chen, X-L., Hylkema, M. N., Rots, M. G., Li, S-Q. & Lau, A. T. Y., 10-Oct-2020, In : Cell biology and toxicology. 17 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Elevated expression of AhR and NLRP3 link polycyclic aromatic hydrocarbon exposure to cytokine storm in preschool children

    Cheng, Z., Huo, X., Dai, Y., Lu, X., Hylkema, M. N. & Xu, X., Jun-2020, In : Environment international. 139, 10 p., 105720.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (123) »

Press / Media
  1. Patientenparticipatie binnen GRIAC onderzoek

    Machteld Hylkema

    01/11/2018

    1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

  2. Opinie: Groningen een rookvrije stad?

    Machteld Hylkema

    09/10/2018

    1 Media contribution

    Press/Media: Expert CommentPopular

  3. Groningen rookvrij: op naar een compleet rookvrije stad?

    Machteld Hylkema

    09/10/2018

    1 Media contribution

    Press/Media: Expert CommentAcademic

View all (3) »

Activities
  1. Epigenetics and CRISPR/Cas9 Symposium

    Machteld Hylkema (Invited speaker)

    5-Nov-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  2. Effect of prenatal smoke exposure on nicotine metabolism- consequences for nicotine addiction and smoking behavior

    Machteld Hylkema (Invited speaker)

    18-Nov-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

View all (12) »

ID: 91080