prof. dr. L.H. (Lude) Franke
Full Professor Functional Genomics

Research
Publications
Associations of autozygosity with a broad range of human phenotypes
Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M., Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I-T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H-H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O'connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E-S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31-Oct-2019, In : Nature Communications. 10, 1, 17 p., 4957.Research output: Contribution to journal › Article › Academic › peer-review
Integration of similar to 10,000 metabolite features with genotype data and immune phenotypes reveals genetic determinants and common regulatory modules
Chu, X., Jaeger, M., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., Withoff, S., Netea-Maier, R. T., Koenen, H. J. P. M., Joosten, I., Xavier, R. J., Franke, L., Joosten, L. A. B., Sanna, S., Kumar, V., Wijmenga, C., Netea, M. G. & Li, Y., Jul-2019, In : European Journal of Human Genetics. 27, p. 787-787 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Allele specific expression identifies rare variants as cause for extreme allelic imbalance
BIOS Consortium, Jul-2019, In : European Journal of Human Genetics. 27, p. 601 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Improving diagnostic yield of exome-sequencing through prioritization of genes with predicted HPO assignments
Deelen, P., van Dam, S., Karjalainen, J. M., Brugge, H., Folkertsma, P., van Diemen, C. C., Kerstjens-Frederikse, W. S., Herkert, J. C., Gillett, T., Swertz, M. A. & Franke, L., Jul-2019, In : European Journal of Human Genetics. 27, p. 537-537 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults
BIOS Consortium, van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B. & Boomsma, D., 15-Oct-2019, In : Biological Psychiatry. 86, 8, p. 599-607 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Datasets
Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
Onderwater, G. L. J. (Creator), Ligthart, L. (Creator), Bot, M. (Creator), Demirkan, A. (Creator), Yang-Fu, J. (Creator), van der Kallen, C. J. H. (Creator), Vijfhuizen, L. S. (Creator), Pool, R. (Creator), Liu, J. (Creator), Vanmolkot, F. H. M. (Creator), Beekman, M. (Creator), Wen, K. (Creator), Amin, N. (Creator), Thesing, C. S. (Creator), Pijpers, J. A. (Creator), Kies, D. A. (Creator), Zielman, R. (Creator), Boer, de, I. (Creator), van Greevenbroek, M. M. J. (Creator), Arts, I. C. W. (Creator), Milaneschi, Y. (Creator), Schram, M. T. (Creator), Dagnelie, P. C. (Creator), Ikram, M. A. (Creator), Ferrari, M. D. (Creator), Goeman, J. (Creator), Slagboom, P. E. (Creator), Stehouwer, C. D. A. (Creator), Boomsma, D. (Creator), Duijn, C. M. V. (Creator), Penninx, B. W. (Creator), 't Hoen, P. A. C. (Creator), Terwindt, G. M. (Creator), van den Maagdenberg, A. M. J. M. (Creator), Dryad Digital Repository, 3-Apr-2019
DOI: https://doi.org/10.5061/dryad.p698mn7, http://(bbmri.researchlumc.nl/ atlas
Dataset
Data from: Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians
Pierce, B. L. (Creator), Tong, L. (Creator), Chen, L. S. (Creator), Rahaman, R. (Creator), Argos, M. (Creator), Jasmine, F. (Creator), Roy, S. (Creator), Paul-Brutus, R. (Creator), Westra, H. J. (Creator), Franke, L. (Creator), Esko, T. (Creator), Zaman, R. (Creator), Islam, T. (Creator), Rahman, M. (Creator), Baron, J. A. (Creator), Kibriya, M. G. (Creator), Ahsan, H. (Creator), University of Groningen, 12-Dec-2014
DOI: https://doi.org/10.5061/dryad.tp097
Dataset
Activities
Ongoing collaboration: bioinformatics analysis of genomic instability
Marcel A. T. M. van Vlugt (Other), Lude Franke (Other), Rudolf Fehrmann (Other)2015 → …Activity: Other › Academic
Prizes
Highly Cited Researcher
Serena Sanna (Recipient), Cisca Wijmenga (Recipient) & Lude Franke (Recipient), 2018
Prize: National/international honour › Academic
ID: 303672