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Over ons Praktische zaken Waar vindt u ons dr. J.L. (Joost) Kluiver

Research interests

Over the last decade it has become clear that non-coding RNAs are important players in virtually all physiological processes. Deregulation of non-coding RNAs contributes to diseases including cancer.

In our studies we focus on understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. These include studies on MYC –regulated miRNAs and lncRNAs, miRNA-lncRNA interactions and the role of lncRNAs in epigenetics.

 

Keywords: B-cell lymphoma, non-coding RNAs, microRNA, lncRNAs

Publicaties

Detection of circulating tumor DNA in plasma of patients with primary CNS lymphoma by digital droplet PCR

Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis

A population-based study of transformed marginal zone lymphoma: identifying outcome-related characteristics

CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells

Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA

Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells

Long non-coding RNAs associated with transcriptomic signatures and treatment outcome in diffuse large B-cell lymphoma

Proliferation-promoting roles of linear and circular PVT1 are independent of their ability to bind miRNAs in B-cell lymphoma

Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature

The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells

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Pers/media

Receiving funding from Lymph&Co