dr. J.K. Kruit
In the Netherlands, a dazzling number of 1 million people suffer from diabetes and this number is on the rise due to our aging and increasingly obese population. Most of these people have type 2 diabetes mellitus (T2DM), which is caused by a relative insufficient insulin secretion response of the pancreatic beta-cell to the increasing metabolic demand due to resistance caused by obesity, aging and/or genetic factors. Insufficient insulin secretion is an early and critical step in the pathogenesis of T2DM - the most common metabolic disease worldwide.
The reasons for beta-cell dysfunction in T2DM are, however, poorly understood. To develop strategies to improve beta-cell function in patients with diabetes, we aim to identify the molecular mechanisms behind the loss of beta-cell function in T2DM. We use transgenic mouse models and cell systems to perform in-depth analysis of systemic physiology, cellular biochemistry, intracellular signal transduction and transcriptional regulation.
|Last modified:||20 November 2016 09.24 a.m.|