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About us Practical matters How to find us G. (Giovanni) Maglia, Prof

G. (Giovanni) Maglia, Prof

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Faculty of Science and Engineering

Telephone:

+31 50 36 36138

E-mail:

giovanni.maglia rug.nl

Homepage ORCID Research Portal

Research interests

The main focus of our group is on the chemistry and biophysics of nanopores. We are engineering, modifying and redesigning these protein systems for applications in NanoBioTechnology and Single-Molecule Biophysics.

We are using biological nanopores in:

• Single-molecule enzymology

• Single-molecule sensing and DNA analysis

• Protein components for nanomachines

Research Group Webpage -Google pages

Research Group RUG Webpage

Publications

Engineered nanopores for exopeptidase protein sequencing

Bonini, A., Sauciuc, A. & Maglia, G., Jan-2024, In: Nature Methods. 21, p. 16-17 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Unravelled proteins form blobs during translocation across nanopores

Sauciuc, A., Whittaker, J., Tadema, M., Tych, K., Guskov, A. & Maglia, G., 25-Jan-2024, (Submitted) In: bioRxiv. 11 p.

Research output: Contribution to journal › Article › Academic

Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein

Volarić, J., van der Heide, N. J., Mutter, N. L., Samplonius, D. F., Helfrich, W., Maglia, G., Szymanski, W. & Feringa, B. L., 16-Feb-2024, In: ACS chemical biology. 19, 2, p. 451–461 11 p., 3c00640.

Research output: Contribution to journal › Article › Academic › peer-review

Evidence of Cytolysin A nanopore incorporation in mammalian cells assessed by a graphical user interface

Lucas, F. L. R., Finol-Urdaneta, R. K., Van Thillo, T., McArthur, J. R., van der Heide, N. J., Maglia, G., Dedecker, P., Strauss, O. & Wloka, C., Oct-2023, In: Nanoscale. 15, 23, p. 16914–16923 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Hydrophobically gated memristive nanopores for neuromorphic applications

Paulo, G., Sun, K., Di Muccio, G., Gubbiotti, A., Morozzo della Rocca, B., Geng, J., Maglia, G., Chinappi, M. & Giacomello, A., Dec-2023, In: Nature Communications. 14, 1, 9 p., 8390.

Research output: Contribution to journal › Article › Academic › peer-review

Protein Sizing with 15 nm Conical Biological Nanopore YaxAB

Straathof, S., Di Muccio, G., Yelleswarapu, M., Alzate Banguero, M., Wloka, C., van der Heide, N. J., Chinappi, M. & Maglia, G., 25-Jul-2023, In: Acs Nano. 17, 14, p. 13685–13699

Research output: Contribution to journal › Article › Academic › peer-review

Seeing the Invisibles: Detection of Peptide Enantiomers, Diastereomers, and Isobaric Ring Formation in Lanthipeptides Using Nanopores

Abraham Versloot, R. C., Arias-Orozco, P., Tadema, M. J., Rudolfus Lucas, F. L., Zhao, X., Marrink, S. J., Kuipers, O. P. & Maglia, G., 23-Aug-2023, In: Journal of the American Chemical Society. 145, 33, p. 18355-18365 11 p., 4076.

Research output: Contribution to journal › Article › Academic › peer-review

Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor

Zhang, X., Galenkamp, N. S., van der Heide, N. J., Moreno, J., Maglia, G. & Kjems, J., Jun-2023, In: Acs Nano. 17, 10, p. 9167-9177 11 p., 12733.

Research output: Contribution to journal › Article › Academic › peer-review

Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force

Sauciuc, A., Morozzo Della Rocca, B., Tadema, M. J., Chinappi, M. & Maglia, G., 18-Sept-2023, (E-pub ahead of print) In: Nature Biotechnology. 01954-x.

Research output: Contribution to journal › Article › Academic › peer-review

Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors

Kobauri, P., Galenkamp, N. S., Schulte, A. M., de Vries, J., Simeth, N. A., Maglia, G., Thallmair, S., Kolarski, D., Szymanski, W. & Feringa, B. L., 24-Mar-2022, In: Journal of Medicinal Chemistry. 65, 6, p. 4798-4817 20 p., 1c01962.

Research output: Contribution to journal › Article › Academic › peer-review

All (98) publications

Press/media

Current Approaches to Protein Sequencing

Giovanni Maglia

05/04/2024

Press/Media: Expert Comment › Popular

ERC Proof of Concept subsidie om monitoren van patiënten met hartfalen te verbeteren

Giovanni Maglia

18/01/2024

Press/Media: Public Engagement Activities › Popular

ERC Proof of Concept Grant to improve monitoring heart failure patients

Giovanni Maglia

18/01/2024

Press/Media: Public Engagement Activities › Popular

Breakthrough: Protein Triumphantly Transmitted Through Nanopore!

Giovanni Maglia

19/09/2023

Press/Media: Expert Comment › Popular

Protein Successfully Transported Through a Nanopore

Giovanni Maglia

19/09/2023

Press/Media: Expert Comment › Popular

Engineered Nanopore Translocates Full Length Proteins

Giovanni Maglia

19/09/2023

Press/Media: Expert Comment › Popular

The Final Piece Required for Easy Protein Sequencing

Giovanni Maglia

19/09/2023

Press/Media: Expert Comment › Popular

The missing link to make easy protein sequencing possible?

Giovanni Maglia

18/09/2023 → 19/09/2023

Press/Media: Expert Comment › Popular

Is There a Missing Link that Can Simplify Protein Sequencing?

Giovanni Maglia

18/09/2023

Press/Media: Expert Comment › Popular

Missing Link Discovered for Simplified Protein Sequencing

Giovanni Maglia

18/09/2023

Press/Media: Expert Comment › Popular

All (63) press/media

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