Skip to ContentSkip to Navigation
Over onsWaar vindt u onsdr. B.Z. (Behrooz) Alizadeh
University Medical Center Groningen

dr. B.Z. Alizadeh

Personal details

Title(s), first name, surname:                      Behrooz Z. Alizadeh,

Degrees:                                                   MD, MSc, DSc, PhD

Position:                                                   Chair, Unit of Digestive System Diseases,

                                                                Dept. of Epidemiology, UMCG Groningen, The Netherlands.


2016    University Teaching Qualification. UMCG certification commission, UMCG, Groningen, The Netherland.

2005    Doctor of Philosophy (PhD) in Genetic Epidemiology, EMC, Rotterdam, The Netherlands

2002    Doctor of Science (DSc) in Genetic Epidemiology, NIHES, The Netherlands.

2001    Master of Science (MSc) in Genetic Epidemiology, The Netherlands Institute of Health Science (NIHES).

1997   Doctor in Medicine (MD) Medical School, TUMS, Tehran, Iran.

Post graduate training

-Research fellow, NIHES, EMC, Rotterdam, the Netherlands (2000-2002)

-Research fellow, DDRC, Tehran University of Medical Sciences, Iran (1993-1997)

-Externship in Medicine, Tehran University of Medical Sciences, Iran (1990-1995)

-Courses in medicine and pathophysiology of medical diseases, Tehran University of Medical Sciences, Iran (1989-1990)

>20 Postgraduate courses followed

(1) Supervisionary curses; (2) Workshops in methodology and genetcie pidemiology; (3) Advanced methodological, statistical and Genetic courses: (4) Basic Courses:


-Chair Unit of Digestive System Diseases, Dept. of Epidemiology, UMC Groningen, The Netherlands.

-Staff & supervisor, Dept. Gastroenterology and Hepatology, UMCG Groningen, Groningen, the Netherlands.

-Principal Investigator & lecturer of GUIDE and SHARE institutes, UMCG, Groningen, theNetherlands.

-Staff member andmethodologist and statistics on clinical interdisciplinary medical education, (Learning ommunity)

-Principal Investigator & lecturer of 3GI community, GUIDE institute, UMCG, Groningen, theNetherlands. 

-Methodologist, Medical Ethical committee, UMCG, Groningen, The Netherlands.

-The Officer of Quality for Research Integration in Digitalized University-wide Registry of Patients and 

                  clinical processes.


Supervisor or (Co)-supervisor of > 30 PhD and Master Students.

LECTURing in Methods and Epidemiology, Genetic epidemiology, Epidemiology of psychosocial diseases, Clinical Epidemiology,The concept of researc                  

PUBLICATIONS (in reverse chronological order)


Journal Impact:


  * Impact factor > 8

2* Impact factor > 15

3* Impact factor > 25


Journal ranking:


  # Top 25%

2# Top 15%

3# Top 10%

4# Top 1%





  1. 3*,4#  Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism. Okbay A, Baselmans B, ….. Alizadeh B, …… , Bartels M,  Cesarini D.

Nature Gene. Revision March 2016.

  1. 3*,4# Genome-wide association study identifies 74 loci associated with educational attainment". Benjamin D, Cesarini D, Visscher P, … , Alizadeh  B, …., Chabris C, Derringer J, Kroh M, Rostapshova O.

Nature. March 2016. Accepted

  1. 3*,4# C-reactive protein and complex somatic and psychiatric outcomes; a large scale cross consortia Mendelian randomization study. Prins BP, ……<50 coauthors> ..Alizadeh BZ.

PLOS Medicine- Accepted, Jan. 2015.

  1. 3*,4# Large-scale genomic analyses link reproductive ageing to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA double strand break repair. Day FR, Ruth KS, …………… Alizadeh BZ , ……., Perry JRB, Murray A.

ScienceApril 2015, ConditionallyAccepted.

  1. 3*,4#  SNPs associated with education relate to brain function and disorders.

Okbay A, Beauchamp JP, …., Alizadeh BZ, ….Esko T, Koellinger PD, Cesarini D, Benjamin DJ.

Nature. Sept 2015. Accepted.




  1. 3*,4# Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Okbay A, Baselmans BM, De Neve JE, ……, Alizadeh BZ, ……. Koellinger PD, Benjamin DJ, Bartels M, Cesarini D.

Nat Genet. 2016. doi: 10.1038/ng.3552.

  1. 4# lodGWAS: a software package for genome-wide association anal-ysis of biomarkers with a limit of detection. Vaez A, van der Most PJ, Prins BP, Snieder H, van den Heuvel E, Alizadeh BZ, Nolte IM.

Bioinformatics. 2016  pii: btw021.




  1. Whole-exome sequencing is a powerful approach for establishing the etiological diagnosis in patients with intellectual disability and microcephaly. Rump P, Jazayeri O, van Dijk-Bos KK, Johansson LF, van Essen AJ, Verheij JB, Veenstra-Knol HE, Redeker EJ, Mannens MM, Swertz MA, Alizadeh BZ, van Ravenswaaij-Arts CM, Sinke RJ, Sikkema-Raddatz B.

BMC Med Genomics. 2016; 4;9:7.

  1. A comparison of indices for identifying the number of clusters in hierarchical clustering: A study on cognition in schizophrenia patients. Islam A, Alizadeh BZ, van den Heuvel ER, and GROUP Investigators.

Communications in Statistics.  2016 Jan.



  1. A bivariate Genome Wide Association Study (GWAS) of depressive symptoms and lipid levels has identified pleiotropic gene loci. Amare AT; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) depression working Group; Global Lipids Genetics Consortium, Nigatu YT, Hsu YH, Lahti J, Alizadeh BZ, Snieder H.

Int J Dev Neurosci. 2015 47:113-4.

  1. Systems medicine, personalized health and therapy. Siest G, Auffray C, Taniguchi N, Ingelman-Sundberg M, Murray H5, Visvikis-Siest S, Ansari M, Marc J, Jacobs P, Meyer U, Van Schaik RH, Müller MM, Wevers RA, Simmaco M, Kussmann M, Manolopoulos VG, Alizadeh BZ, Beastall G, Németh G.

Pharmacogenomics.  2015 16:1527-39.

  1. 3*, 4# Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Day FR, Ruth KS, Thompson DJ,….., Alizadeh BZ,….. Murabito JM, Perry JR, Murray A.

Nat Genet. 2015 47:1294-303

  1. 3*, 4# Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Liu JZ, van Sommeren S, ……………..  Alizadeh BZ, Parkes M, Thelma BK, Daly MJ, Kubo M , Anderson CA, Weersma RK.

Nat Genet; 2015 47:979-86.

  1. A bivariate Genome Wide Association Study (GWAS) of depressive symptoms and lipid levels has identified pleiotropic gene loci. Amare AT; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) depression working Group; Global Lipids Genetics Consortium, Nigatu YT, Hsu YH, Lahti J, Alizadeh BZ, Snieder H.

Int J Dev Neurosci. 2015;47:113-4.

  1. 3# An in silico Post-GWAS Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons. Vaez A, Jansen R, Prins BP, Hottenga JJ, de Geus EJC, Boomsma DI,Penninx BWJH, Nolte IM, Snieder H, Alizadeh BZ.

CIRCCVG 2015;8:487-97.

  1. 2*,4# Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study. Abbasi A, Deetman PE, Corpeleijn E, Gansevoort RT, Gans RO, Hillege HL, van der Harst P, Stolk RP, Navis G, Alizadeh BZ, Bakker SJ.

Diabetes. 2015 64:1459-69.



Co-author due to consortia publication:

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects. Peyrot WJ, Lee SH, Milaneschi Y …., Penninx BW; Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium Corporate Collaborator; Social Science Genetic Association Consortium Corporate Collaborator.

Mol Psychiatry 2015 Jun; 20:735-43.

Genetic studies of body mass index yield new insights for obesity biology. Locke AE, Kahali B, ……, Hirschhorn JN, Loos RJ, Speliotes EK.

Nature. 2015;12;518:197-206. (>2100 collaborators)

New genetic loci link adipose and insulin biology to body fat distribution. Shungin D, Winkler TW,..,Cupples LA, Morris AP, Lindgren CM, Mohlke KL.

Nature. 201512;518:187-96. (>2200 collaborators)

Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.

Dijkstra AE, Boezen HM, van den Berge M, Vonk JM, Hiemstra PS, Barr RG, Burkart KM, Manichaikul A, Pottinger TD, Silverman EK, Cho MH, Crapo JD, Beaty TH, Bakke P, Gulsvik A, Lomas DA, Bossé Y, Nickle DC, Paré PD, de Koning HJ, Lammers JW, Zanen P, Smolonska J, Wijmenga C, Brandsma CA, Groen HJ, Postma DS; LifeLines Cohort Study group.

Eur Respir J. 2015 Jan;45:60-75.



  1. 3*,4# Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, Day F, Elks CE, …. Alizadeh BZ, ……Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK.

Nature. 2014, 2;514:92-7.

  1. 3# Premorbid adjustment profiles in psychosis and the role of familial factors. Quee PJ, Meijer JH, Islam MA, Aleman A, Alizadeh BZ, Meijer CJ, van den Heuvel ER; GROUP Investigators.

J Abnorm Psychol. 2014;123:578-87.

  1. 4# QCGWAS: A flexible R package for automated quality control of genome-wide association results. van der Most PJ, Vaez A, Prins BP, Munoz ML, Snieder H, Alizadeh BZ, Nolte IM.

Bioinformatics. 2014 Jan 13.

  1. 3# Cognitive subtypes in non-affected siblings of schizophrenia patients: characteristics and profile congruency with affected family members. Quee PJ, Alizadeh BZ, Aleman A, van den Heuvel ER; GROUP Investigators.

Psychol Med. 2014;44:395-405.

  1. 2# Neglected role of hookah and opium in gastric carcinogenesis: a cohort study on risk factors and attributable fractions. Sadjadi A, Derakhshan MH, Yazdanbod A, Boreiri M, Parsaeian M, Babaei M, Alimohammadian M, Samadi F, Etemadi A, Pourfarzi F, Ahmadi E, Delavari A, Islami F, Farzadfar F, Sotoudeh M, Nikmanesh A, Alizadeh BZ, de Bock GH, Malekzadeh R.

Int J Cancer. 2014 1;134:181-8

  1. Pleiotropic genes for metabolic syndrome and inflammation. Kraja AT, Chasman DI….. Vaidya D, O'Donnell CJ, Benjamin EJ, Alizadeh BZ, Prokopenko I, Meigs JB, Borecki IB.

Mol Genet Metab. 2014;112:317-38


Co-author due to consortia publication:

GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. Eny KM, Lutgers HL, Maynard J, Klein BE, Lee KE, Atzmon G, Monnier VM, van Vliet-Ostaptchouk JV, Graaff R, van der Harst P, ….,  Lyons TJ, Howard K, Klein R, Crandall JP, Barzilai N, Milman S, Ben-Avraham D; LifeLines Cohort Study Group; DCCT/EDIC Research Group, Wolffenbuttel BH, Paterson AD. Diabetologia. 2014;57:1623-34.

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, Hwang SJ, Sijbrands E, Smith AV,…; LifeLines Cohort Study, …., van Duijn CM, Witteman JC, Chakravarti A, Rao DC. Am J Hum Genet. 2014 3;95:24-38.

Pesticides and other occupational exposures are associated with airway obstruction: the LifeLines cohort study. de Jong K, Boezen HM, Kromhout H, Vermeulen R, Postma DS, Vonk JM; LifeLines Cohort study. Occup Environ Med. 2014 ;71:88-96.

Susceptibility to chronic mucus hypersecretion, a genome wide association study. Dijkstra AE, Smolonska J, van den Berge M, Wijmenga C, Zanen P, Luinge MA, Platteel M, Lammers JW, ….., Vonk JM, Nawijn MC, Groen HJ, Timens W, Boezen HM, Postma DS; LifeLines Cohort study. PLoS One. 2014 8;9:e91621



  1. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A, Albrecht E, Alizadeh BZ, Amin N, …..,  van Duijn CM, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD.

Science. 201321;340:1467-71.

  1. * 3# Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, …..  Felix JF, Alizadeh BZ*, Cupples LA*, Perry JR*, Morris AP*.

Am J Hum Genet. 2013 5;91:744-53

  1. # Serum ghrelin; a new surrogate marker of gastric mucosal alterations in upper gastrointestinal carcinogenesis. Sadjadi A, Yazdanbod A, Lee YY, Boreiri M, Samadi F, Alizadeh BZ, Islami F, Fyfe V, Babaei M, Namazi MJ, Going JJ, Sotoudeh M, de Bock GH, Malekzadeh R, Derakhshan MH.

PLoS One. 2013 30;8:e74440.


Co-author due to consortia publication:

Mining the human phenome using allelic scores that index biological intermediates. Evans DM, Brion MJ, Paternoster L, Kemp JP, McMahon G, Munafò M, Whitfield JB, Medland SE, Montgomery GW; GIANT Consortium; CRP Consortium; TAG Consortium, Timpson NJ, St Pourcain B, Lawlor DA, Martin NG, Dehghan A, Hirschhorn J, Davey Smith G. PLoS Genet. 2013;9:e1003919.



  1. 3*, 4# Meta-analysis of genome-wide association studies of age at menopause: novel loci highlight DNA repair and immune pathways. Stolk L, …. Alizadeh BZ24 … Visser JA179, Lunetta KL180.

Nat. Genet. 2012 22;44:260-8.

  1. 2# Clinical response to antipsychotic drug treatment: Association study of polymorphisms in six candidate genes. Vehof J, Burger H, Wilffert B, Al Hadithy A, Alizadeh BZ, Snieder H; GROUP investigators.

Eur Neuropsychopharmacol. 2012 Feb 29.

  1. # The age-dependancy of genetic and environmental influences on serum cytokine levels; a twin study. Sas AA, Jamshidi Y, Zheng D, Wu T, Alizadeh BZ, Korf J, Spector TD, Snieder H.

Cytokine, 201260:108-13

  1. Association between age, IL-10, IFN╬│, stimulated C-peptide and disease progression 1 diabetes in children with newly diagnosed Type. Kaas A, Pfleger C, Kharagjitsingh AV, Schloot NC, Hansen L, Buschard K, Koeleman BP, Roep BO, Mortensen HB, Alizadeh BZ; on behalf of the Havidoere Study Group on Childhood Diabetes.

Diabet Med. 2012 29:734-741.

  1. Genetic correlates of early accelerated infant growth associated with juvenile-onset type 1 diabetes. Kharagjitsingh A, de Ridder M, Alizadeh B, Veeze H, Bruining G, Roep B, Koeleman BP.

Pediatr Diabetes. 2012 13:266-271.



  1. 3*, 4# Genome-wide association study of Pulse Pressure and Mean Arterial Pressure identifies seven novel loci. International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS). Wain L1, Verwoert GC, ………. Alizadeh BZ30, ……………, Tobin MD, Elliott P, van Duijn CM.

Nat. Genet. 2011 11;43:1005-11.

  1. 3*, 4#  Genome-wide association study identifies loci influencing plasma levels of liver enzymes. Chambers JC, Zhang W, Sehmi J. Li X, ….. Alizadeh BZ25…… Kathryn L, Järvelin MR, Elliot P, and Kooner JS.

Nat. Genet. 2011, 16;43:1131-8.

  1. *,4#Dehghan A, Dupuis J. ……., Alizadeh BZ20, …. Koenig W51, Ballantyne C26, Witteman JCM1, Benjamin EJ39, Perola MP6, Chasman DI24. Meta-analysis of genome-wide association studies in 81,059 subjects identifies 12 novel loci for C-reactive protein serum levels.

Circulation. 2011, 22;123:731-8.

  1. *, 3# Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. Gorlova O, Martin JE, Rueda B, Koeleman BPC., …., Alizadeh BZ9, …. Mayes MD, Martin J38.

PloS Genetic, 2011 7:e1002178.

  1. *, 3# Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia. Miedema KGE, Poele EMt, Tissing W, Postma DS, Koppelman GH, de Pagter AD, Alizadeh BZ, Boezen MH, de Bont ESJM.

Leukemia. 2011,25:995-1000.

  1. *, 3# Genetic variation in TLRs and CD14 genes as explanation between reverse association between childhood ALL and atopic disease. Miedema KGE, Tissing WJE, Poele EMT, Postma DS, Koppelman GH, Boezen MH, Alizadeh BZ, Kamps WA, de Bont ESJM.

Leukemia 2011;164:890-2.

  1. 3# COMT Val158Met polymorphism, verbalizing of emotion and activation of affective brain systems. Swart M, Bruggeman R, Larøi F, Alizadeh BZ, Kema I, Kortekaas R, Wiersma D, Aleman A.

Neuroimage. 2011;55:338-44.

  1. 2# Comment on "No major role for glutathione S-transferase gene polymorphisms in sensitization to para-phenylenediamine and other xenobiotics: a study of association and a meta-analysis: Reply from authors. Pot LM, Alizadeh BZ, Ahrenberg D, Coenraads P-J, Snieder H, Blömeke B.

BrJ Dermatol. 2011,164:890-2.

  1. 2# The PTPN22 Gene Influences Genetic Predisposition to Ulcerative Colitis and Crohn’s Disease. Diaz-Gallo LM, Espino-PaisánL, Fransen K,van Sommeren S, Gómez-García M,  Cardeña C, Rodrigo L, …..,  Ponsioen CY,  Wijmenga C, Roberts RL, Weersma RK, Merriman TR, Alizadeh BZ*, Martin J*.

Inflamm Bowel Dis. 2011, 17:2287-94.

  1. 2# Preliminary evidence of association of Protein-tyrosine Phosphatase Nonreceptor type substrate 1 (PTPNS1) with inflammatory bowel disease. Roberts RL, Hollis-Moffatt JE,  Gómez-GarcíaM, Fransen K, Ponsioen CY, Crusius JBA, Wijmenga C, Martín J, Weersma RK, Merriman TR, Barclay ML, Gearry RB, Alizadeh BZ.

Inflamm Bowel Dis. 2011;17:19-21.

  1. 2# Genetic Risk and Outcome in Psychosis (GROUP) investigators. Association of two DRD2 gene polymorphisms with acute and tardive antipsychotic-induced movement disorders in young Caucasian patients. Koning JP, Vehof J, Burger H, Wilffert B, Al Hadithy A, Alizadeh BZ, van Harten PN, Snieder H;

Psychopharmacology. 2011,219:727-36

  1. Evidence for the PTPN22 R620W polymorphism being the sole common risk variant for rheumatoid arthritis in the 1p13.2 region. Martín JE, Alizadeh BZ,………Koeleman BPC, Martín J

J Reumatol. 2011, 38;11:2290-6.

  1. Trend analysis of invasive prenatal diagnosis in the Netherlands 2000 to 2010. Lichtenbelt KD,Alizadeh BZ, Scheffer PG, Stoutenbeek P, Schielen P, Page-Christiaens GCM, Schuring-Blom GH.

Prenatal Diagnosis, 2011, 31:765-7.

  1. IGF1 promoter polymorphism and cranial growth in individuals born very preterm. Euser AM, Finken MJ, Kharagjitsingh AV, Alizadeh BZ, Roep BO, Meulenbelt I, Dekker FW, Wit JM.

Horm Res Paediatr. 2011;76:27-34.

  1. Genome-wide Linkage Analysis of Blood Pressure and Hemodynamic Parameters Under Mental and Physical Stress in Extended Omani Arab Pedigrees; The Oman Family Study. Hassan MO, Jaju D, Voruganti VS, Bayoumi RA, Albarwani S, Al-Yahyaee S, Aslani A, Snieder H, Lopez-Alvarenga JC, Al-Anqoudi ZM, Alizadeh BZ, Comuzzie AG.

Twin Res Hum Genet. 2011 14:257-67.



  1. 3*,4# Genome-wide association study in systemic sclerosis identifies novel susceptibility loci. Radstake TRDJ*1, Gorlova O*, Rueda B*, Martin JE*, Alizadeh BZ, Palomino-Morales R, ………. Martin J*, Mayes MD*18.

Nat Genet. 2010;42:426-9.

  1. *, 4# Association of low-affinity Fc Gamma Receptor 3B (FCGR3B) copy number variation with rheumatoid arthritis in Caucasian populations. McKinney C, Fanciulli M, Merriman ME, Alizadeh BZ, Koeleman BPC, Dalbeth N, Harrison AA, Highton J, Jones PB, Stamp LK, Nissen M, Smith MD, Steer S, Barrera P, Coenen MJH, Franke B, Vyse T, Aitman T, Radstake T, Merriman TR.

Ann Rheum Dis. 2010;69:1711-6.

  1. *, 4# The association analysis of TRAF1/C5 region in multiple autoimmune diseases. KurreemanFAS, GoulielmosGN*, Alizadeh BZ*, Rueda B*, BevovaM, Radstake TR, Galanakis E,  OrtegoN, VerduynW, ZervouM, RoepBO, UrcelayE, BoumpasDT, KoelemanBPC, HuizingaTWJ, Toes REM, MartinJ.

Ann Rheum Dis. 2010;69:696-9

  1. *, 3# identification of oxidative stress related gene MSRA as rheumatoid arthritis susceptibility locus by genome-wide pathway analysis. Martín EJ, Alizadeh BZ,  González-GayMA, Balsa A, Pascual-Salcedo D, Fernández-Gutiérrez B, Raya E, Franke L, Van’t Slot R, Coenen MJH, van Riel P, Radstake TRDJ, Koeleman BPC, Martín J.

Arthritis Rheum. 2010;62:3183-90.

  1. 2# The association of FcgR2a and FcgR3a in inflammatory bowel diseases across three Caucasian populations. Weersma RK, Crusius BA, Koeleman BPC, Roberts RL, Morales RP, Wolfkamp S, Festen EAM, Robledo G, Meisneris S, Radstake TRDJ, Bodegraven AA, Wijmenga C, Merriman TR, Stokkers PCF, Salvador AP, Martín J, Alizadeh BZ#.

Inflamm Bowel Dis. 2010;16:2080-9.

  1. HFE gene mutations increase the risk of coronary heart disease in women. Pardo Silva MC, Njajou OT, Alizadeh BZ, Hofman A, Witteman JC, van Duijn CM, Janssens AC.

Eur J Epidemiol. 2010 25:643-9.

  1. Functional variants of Fc gamma receptor (FcgRIIa) or FcGRIIIa are not associated with SSc susceptibility or clinical phenotype. Results from the European EUSTAR based study. Alizadeh BZ*, Broen J*, Rueda B,Hesselstrand R, Herrick A, Worthington J, Denton C, Fonseca,Riemekasten G, Vonk MC, van den Hoogen, Matucci-Cerenic, Beretta L, Airo P, Coenen M, Martin J, Koeleman BPC, Radstake TRDJ.

J Rheumatol. 2010;37:1673-9.

  1. Association analysis of myosin IXB and Type 1 Diabetes. Persengiev S, Koeleman BPC, Downes K, van der SilkA, EerlighP, ValdigemG, BruiningJG, WijmengaC, ToddJA, RoepBO, Alizadeh BZ.

Hum Immunol. 2010 ;71:598-601.

  1. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. Wolters VMW, Alizadeh BZ, Weijerman ME, Zhernakova A, van Hoogstraten IMW, Mearin ML, Wapenaar MC,Wijmenga C, Marco WJ Schreurs.

Hum Immunol. 2010;71:392-6.

  1. Association of the CLCA1 p.S357N variant with meconium ileus in cystic fibrosis patients. van der Doef HPJ, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RHJ .

JPGN. 2010;50:347-9.



  1. *, 3# Genetics Sharing among IQ and Other Candidate Endophenotypes for Schizophrenia. Aukes AF, Alizadeh BZ, Sitskoorn MM, Kemner C, Ophoff RA, Kahn RA.

Biol. Psychiatry 2009 15; 65:527-34.

  1. 3# Association study of the CAPSL- IL7R locus with type 1 diabetes. Santiago JL, Alizadeh BZ, MartínezA, EspinoL, de la CalleH, Fernández-ArqueroM, FigueredoMA, de la ConchaEG, RoepBO, KoelemanBPC, UrcelayE.

Diabetologia, 2008;51:1653-8.

  1. 2# Evidence for Natural Killer cell mediated protection against metastasis formation in uveal melanoma patients. Maat W, Alizadeh BZ,* Verhoeven GHJ,* van der Slik AR,* Ly LV, Koeleman BPC, Verduijn W, Mulder A, Koning F, Jager M and van Bergen J.Inv. Opht. Vis. Sci. 2009;50:2888-95. *Shared second author.
  2. 3# Hemochromatosis Gene (HFE) Mutations, APOE and Alzheimer’s Disease: A Population-based Study. Alizadeh BZ, Njajou OT, Millán MR, Hofman A,Breteler MM,van Duijn CM.

Neurobiol. Aging2009, 30:330-2.

  1. Does the genetic and familial background of males undertaking ICSI affect the outcome? Maiburg M, Alizadeh BZ, KastropP, LockM, LansS., Giltay J.

J. of Assisted Reproduction & Genetics 2009;26:297-303.

  1. Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach. Palomino-Morales RJ, Oliver J, Gómez-García M, López-Nevot MA, Rodrigo L, Nieto A, Alizadeh BZ, Martín J.

Genes and Immunity 2009;10:356-64.



  1. *, 3# Finding Phenotypes Suitable for Molecular Genetic Studies of Schizophrenia: a Segregation Analysis. Aukes AF, Alizadeh BZ, Selten JP, Sinke RJ, Sitskoorn MM, Kahn RS.

Biol. Psychiatry 2008 64:128-36.

  1. *, 3# Association analysis of STAT4 gene with rheumatoid arthritis in three European populations. Orozco G, Alizadeh BZ, Delgado-Vera AM, González-Gay MA, Balsa A, Pascual-Salcedo D, Fernández-Gutierrez B, González-Escribano MF, Petersson IF, van Riel PLCM, Barrera P, Radstake TRDG, Wijmenga C, Koeleman BPC, Alarcón-Riquelme M, Martín J.

Arthritis Rheum 2008 58:1968-73.

  1. # Huurman VAL, Hilbrands R., Pinkse GGM, Gillard P, Duinkerken G, van de Linde P, van der Meer-Prins EM, Versteeg-van der Voort Maarschalk MF, Verbeeck K, Alizadeh BZ, Mathieu C, Gorus FK, Roelen DL, Claas FHJ, Keymeulen B, Pipeleers DG and Roep BO. Cellular islet autoimmunity as a critical obstacle in clinical islet transplantation.

PLosOne 2008, 18;3:e2435.

  1. Genetic polymorphisms in susceptibility to type 1 diabetes: A Review. Alizadeh BZ, Koeleman BPC

Clinica Chimica Acta 2008 387:9-17.

  1. Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. Pfleger C, Kaas A, Hansen L, Alizadeh BZ, Hougaard P, Holl R, Kolb H; Roep BO, Mortensen HB, Schloot NC. Clinical Immunology 2008;128:57-65.



  1. *, 4# Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis. Alizadeh BZ#. Valdigem G, Coenen MJH, Zhernakova A, Franke B, Monsuur A, van Riel PLCM, Barrera P, Radstake TRDJ, Roep BO,Wijmenga C and Koeleman BPC.

Hum Mol Genet. 2007 16:2552-9.

  1. *, 4# The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and osteoarthritis. Alizadeh BZ, Njajou OT, Hazes JM, Hofman A, Slagboom PE, Pols HA, van Duijn CM.

Ann Rheum Dis. 2007 66:1436-42.

  1. *, 4# Novel association in 4q27 region in rheumatoid arthritis and confirmation in type 1 diabetes points to its importance as general autoimmune risk locus. Zhernakova A, Alizadeh BZ, van der Steege G, van Riel PLM, Bevova M, Franke L, van HeelDA, van Leeuwen M, Radstake TRJD, Roep BO, Koeleman BPC, Wijmenga C.

Am J Hum Genet 2007 81:1284-8.

  1. MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: An association and meta-analysis. Alizadeh BZ, Eerligh P, van der Slik AR, Shastry A, Zhernakova A, Valdigem G, Bruining JG, Sanjeevi CB, Wijmenga C, Roep BO, Koeleman BP.

Mol Immunol. 2007; 44:2806-12.

  1. MYO9B gene polymorphisms are associated with autoimmune disease in Spanish population. Sánchez E, Alizadeh BZ, Valdigem G, Ortego-Centeno Norberto, Jiménez-Alonso J, de Ramón E, García A, López-Nevot MA, Koeleman BPC, Martín J.

Hum Immunol. 2007 68:610-5.

  1. Modelling KIR-HLA genotype disparities in type 1 diabetes. van der Slik AR, Alizadeh BZ, Koeleman BP, Roep BO, Giphart MJ.

Tissue Antigens2007; 69:101-5.

  1. Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission. Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T

Diabet Med. 2007;24:512-20.



  1. # Linkage analysis localizes a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25. Geremek M, Zietkiewicz E, Diehl SR, Alizadeh BZ, Wijmenga C, Witt M

J Med Gene 2006 43:1-3.

  1. Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes. Alizadeh BZ, Hanifi-Moghaddam P, Eerligh P, van der Slik AR, Kolb H, Kharagjitsingh AV, Pereira Arias AM, Ronkainen M, Knip M, Bonfanti R, Bonifacio E, Devendra D, Wilkin T, Giphart MJ, Koeleman BP, Nolsoe R, Mandrup Poulsen T, Schloot NC, Roep BO; DIABMARKER Study Group.

Clin Exp Immunol. 2006;145:480-4.

  1. Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) Study. Njajou OT, Alizadeh BZ, Aulchenko Y, Zillikens MC, Pols HA, Oostra BA, Swinkels DW, van Duijn CM.

Hum Hered 2006; 61:222-8.

  1. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Zhernakova A, Alizadeh BZ, Eerligh P, Hanifi-Moghaddam Schloot NC, Diosdado B, Wijmenga C, Roep BO, Koeleman BP.

Genes Immun 2006; 7:544-9.

  1. Is there an influence of X-chromosomal imprinting on the phenotype in Klinefelter syndrome? A clinical and molecular genetic study of 61 cases. Stemkens D, Roza T, Verrij L, Swaab H, van Werkhoven MK, Alizadeh BZ, Sinke RJ, Giltay JC.

Clin Genet. 2006; 70:43-8.



  1. 3*, 4# Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Monsuur AJ, Bakker PI, Alizadeh BZ, Zhernakova A, Bevova MR, Strengman E, Franke L, Slot RV, Belzen MJ, Lavrijsen IC, Diosdado B, Daly MJ, Mulder CJ, Mearin ML, Meijer JW, Meijer GA, Oort EV, Wapenaar MC, Koeleman BP, Wijmenga C:

Nat Genet 2005, 37:1341-44.

  1. *, 3# The Gene Encoding for Alpha Domain of Collagen IX Proteoglycan (COL9A1) and Hip Osteoarthritis, a Population-based Study. Alizadeh BZ, Njajou OT, Bijkerk C, Meulenbelt I, De Wildt SC, Hofman A, Pols HAP, Slagboom PE, van Duijn CM.

Arthritis Rheum 2005; 52:1437-42.


  1. 3#. Is genetic testing for hemochromatosis worthwhile? Njajou OT, Alizadeh BZ, Van Duijn CM

Eur J Epidemiol 2004;19:101-109.

  1. Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease. Croes EA, Alizadeh BZ, Bertoli-Avella AM, Rademaker T, Vergeer-Drop J, Dermaut B, Houwing-Duistermaat JJ, Wientjens DP, Hofman A, Van Broeckhoven C, Van Duijn CM.

Eur J Hum Genet 2004;12:389-94.

  1. Genetic and serological markers to identify phenotypic subgroups in a Dutch Crohn's disease population. Linskens RK, Mallant-Hent RC, Murillo LS, von Blomberg BM, Alizadeh BZ, Pena AS.

Dig Liver Dis 2004;36:29-34.

  1. Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran. Malekzadeh R, Sotoudeh M, Derakhshan MH, Mikaeli J, Yazdanbod A, Merat S, Yoonessi A, Tavangar M, Abedi BA, Sotoudehmanesh R, Pourshams A, Asgari AA, Doulatshahi S, Alizadeh BZ, Arshi S, Madjidpoor A, Mir Moomen S, Fleischer DE.

J Clin Pathol 2004;57:37-42.

  1. Does bilirubin protect against hemochromatosis gene (HFE) related mortality? Alizadeh BZ, Njajou OT, Houwing-Duistermaat JJ, De Jong G, Vergeer JM, Hofman A, Pols HAP, and van Duijn CM.

Am J Med GenePart A, 2004, 15; 129:39-43.

  1. Association of FAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease. Wu J, Alizadeh BZ, Veen TV, Meijer JW, Mulder CJ, Pena AS.

W J Gastroenterol 2004;10:717-20.



  1. 3# Genetic screening for common mutations: lessons from hereditary hemochromatosis. Njajou OT, Alizadeh BZ, Van Duijn CM.

EurJ Epidemiol 2003;18:3-4.

  1. Genotype-phenotype correlations: how many disorders constitute inflammatory bowel disease?  Gasche C, Alizadeh BZ, Pena AS.

Eur J Gastroenterol Hepatol 2003;15:599-606.

  1. 2# IL-1B promoter polymorphism and Epstein-Barr virus in Dutch patients with gastric carcinoma. Zur Hausen A, Crusius JB, Murillo LS, Alizadeh BZ, Morre SA, Meijer CJ, van den Brule AJ, Pena AS.

Int J Cancer 2003;10:866-7.



  1. *, 3# The role of hemochromatosis C282Y and H63D gene mutations in type 2 diabetes: findings from the Rotterdam Study and meta-analysis. Njajou OT, Alizadeh BZ, Vaessen N, Vergeer JM, Houwing-Duistermaat JJ, Hofman A, Pols HAP, Van Duijn CM.

Diabetes Care 2002, 25:2112-3.

  1. CARD15 gene and the classification of Crohn's disease. Murillo L, Crusius JB, van Bodegraven AA, Alizadeh BZ, and Pena AS.

Immunogenetics 2002;54:59-61.

  1. Interleukin-1 beta and interleukin-1 beta receptor antagonist gene polymorphisms in ankylosing spondylitis. Van der Paardt M, Crusius JB, Garcia-Gonzalez MA, Baudoin P, Kostense PJ, Alizadeh BZ, Dijkmans BA, Pena AS, van der Horst-Bruinsma IE.

Rheumatology 2002;41:1419-23.


  1. A randomized controlled comparison of three quadruple therapy regimens in a population with low H.pylori eradication rates. Sotoudehmanesh R, MalekzadehR, Massarrat S, Fazel A, Alizadeh BZ, Eshraghian MR.

J Gastroenterol & Hepatol 2001;16:264-68.

  1. Clarithromycin vs. furazolidone in quadruple therapy regimens for the treatment of Helicobacter pylori in a population with a high Metronidazole resistance rate. Fakheri H, MalekzadehR, Merat Sh, Khatibian M, Fazel A, Alizadeh BZ, Massarrat S.

Aliment Pharmacol & Ther 2001;15:411–16.

  1. Furazolidone versus metronidazole in quadruple therapy for eradication of Helico­bacter pylori in duodenal ulcer disease. Malekzadeh R, Ansari R, Vahedi H, Siavoshi F, Alizadeh BZ, Eshraghian MR, Vakili A, Saghari M & Massarrat S.

Aliment Pharmacol & Ther 2000;14: 299-303.

  1. Prevalence of Helicobacter pylori in two Iranian Provinces with high and low incidence of gastric carcinoma. Mikaeli J, Malekzadeh R, Alizadeh BZ, Nasseri Moghaddam S, Valizadeh S, Khoncheh R, Massarrat S.

Arch Iran Med 2000;3:6-9

Publications in Iranian Academic Journals (prior to 1999)

  •  “Graded pneumatic dilatation without fluoroscopy in treatment of achalasia”. Mikaeli J, Malekzadeh R, Khatibian M, Vahedi H, Ansari R, Soleimani H and Alizadeh BZ. Medical Journal of the Islamic Republic of Iran (Abstract published in:

Gastrointest Endo 1997;45:201.

  • A comparative study of paracentesis of massive ascites in cirrhotic patients with and without using IV Albumin. Ansari R, Malekzadeh R, Mikaeli J, Tabib M, Khatibian M and Alizadeh BZ. Journal of Faculty of Medicine (journal of Tehran University of Medical Sciences) 1998;6:11-6 (Abstract published in: Gastroenterol 1999;116:L0025.


Abstracts of scientific work in international journals not yet mentioned

  • Helicobacter pylori recurrence after successful eradication, one year follow up in Iran. Zahedi MJ, Malekzadeh R, Amini M, Khatibian M, Soleimani MH, Vahedi H, Alizadeh BZ, Saghari M, Siavoshi F.

Digestion 1998, 59:Exhb 3233.

  • Prospective controlled trial of interferon alpha (INE) in Iranian patients with chronic hepatitis. Yousefi-Rad M, Malekzadeh R, Khatibian M, Alavian SM, Rezvan R, Kamalian N, Alizadeh BZ.

Gastroenterol 1997;112:A1420.

  • Six months reinfection rate in helicobacter pylori positive acid peptic disease in Iranian patients after eradication. Malekzadeh R, Amini M, Mikaeli J, Vakili A, Siavoshi F, Kashifard M, Alizadeh BZ.

Gastroenterol 1997;112:A207.


Papers published only in Iranian scientific journals

The etiology of chronic hepatitis in Iran, a multi center cross sectional study. Alizadeh BZ, Taheri H, Malekzadeh R, Ansari R, Khatibian M, Ebraheemi Daryanee N. Govaresh (official journal of Iranian Society of Gastroenterology & Hepatology) 1999;13&14:13-23.

Effect Furazolidone vs Metronidazole in helicobacter pylori eradication. Malekzadeh R, Ansari R, Vahedi H, Siavoshi F, Alizadeh BZ, Eshraghian R, Vakeli A, Saghari M. Govaresh (official journal of Iranian Society of Gastroenterology & Hepatology) 1999; 13&14:8-11.

Total pepsin activity and gastrin in sera as markers of eradication of helicobacter pylori. Khoshkholgh M, Saberi Firoozi M, Farahi M, Siavoshi F, Khatibian M, Vahedi H, Mikaeli J, Ansari R, Alizadeh BZ, Malekzadeh R, Massarrat S. Iranian Journal of Medical Science, 1994;19:106-08 (In English)

Comparing replacement of metronidazole rather than prolongation of treatment duration in quadruple therapy for Hp eradication. Sotudehmanesh R, Malekzadeh R, Massarrat S, Alizadeh BZ, Eshraghian M. Govaresh (official Journal of Iranian Society of Gastroenterology & Hepatology), 1999;3:142-5.

Result of triple therapy in eradication of Helicobacter pylori and duodenal ulcer healing. Mikaeli J, Malekzadeh R, Ansari R, Khatibian M, Alizadeh BZ, Daneshvar C, Siavoshi F. Scientific Journal of Medical Council of Iran1998; 16;4:265-70.


Last modified:22 April 2016 03.32 a.m.


Hanzeplein 1
9713 GZ Groningen