Prof. Jevgenij A. Raskatov - From Alzheimer’s Amyloid β to Pauling-Corey Rippled β-Sheets
|When:||Mo 06-03-2023 16:00 - 17:00|
-sheet was hypothesized by Pauling and Corey in 1953, but remained an obscurity until relatively
recently. In 2017 we demonstrated that the addition of mirror-image peptide can be used to convert Amyloid β
into fibrils with unique morphology and reduced toxicity. Subsequent cross-disciplinary research combined
experiment and theory, identifying rippled β -sheet formation as the underlying mechanism, yielding the first
rippled β -sheet X-ray crystal structures in 2022.