Skip to ContentSkip to Navigation
Research Zernike (ZIAM) News Seminars

Prof. Jevgenij A. Raskatov - From Alzheimer’s Amyloid β to Pauling-Corey Rippled β-Sheets

When:Mo 06-03-2023 16:00 - 17:00
Where:5114.0004, Nb4

The “rippled” β -sheet was hypothesized by Pauling and Corey in 1953, but remained an obscurity until relatively
recently. In 2017 we demonstrated that the addition of mirror-image peptide can be used to convert Amyloid
into fibrils with unique morphology and reduced toxicity. Subsequent cross-disciplinary research combined
experiment and theory, identifying rippled
β -sheet formation as the underlying mechanism, yielding the first
β -sheet X-ray crystal structures in 2022.