The European Commission awarded dr. Bart Crielaard a prestigious Marie Skłodowska-Curie Individual Fellowship for his proposal “Aptamer nanostructures dual-targeted to the HER receptor family for cancer therapy (ADHERE)”.
In cancer immunotherapy, antibodies that target specific antigens expressed by cancer cells are used for the treatment of several forms of cancer. There is, however, evidence that targeting multiple receptors at the same time is beneficial for improving treatment efficacy and reducing drug resistance. Aptamers are short single-stranded oligonucleotides that can bind a target molecule in a similar fashion as antibodies, and they may represent, due to their physicochemical properties and modular design capacity, a superior alternative strategy for targeted cancer therapy.
In ADHERE, which is funded for period of 2 years, Dr. Crielaard will design and study aptamer nanostructures with bispecific (against two different receptors) and multivalent (up to 4 binding ligands on a single nanostructure) targeting properties for cancer therapy.
This project is part of the reintegration panel of the Marie Curie Action, which is aimed at researchers that have recently returned from a research position outside Europe to enable them to integrate into a long-term research position in Europe.
The research group of Dr. Crielaard at Zernike Institute for Advanced Materials works on the design and evaluation of nano- and biomaterials that can be used for clinical applications, such as nanoparticles for therapeutics and diagnostics.
For more information regarding the Marie Skłodowska-Curie Individual Fellowship, please consult the website of the European Commission.
Proverbs. Without thinking about it, we make use of them daily. But our society is constantly changing. Are these ancient wisdoms any use to us still? Young researchers from various disciplines, among whom are many members of the Young Academy...
Vera Heininga is the Open Science coordinator and future programme leader of the upcoming Open Science programme of the University of Groningen. Together with her colleagues, she created the Open Science Community Groningen (OSCG). She explains...
Four and a half years ago, he received the Nobel Prize. During the award ceremony in Stockholm, Ben Feringa made a resolution: I will put science on the map. His mission is being given a new boost with the establishment of the Ben Feringa Fund,...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information