Prof. Patrick Onck from the Zernike Institute for Advanced Materials (ZIAM) is a partner in an ENW-GROOT project funded by NWO. The consortium receives EUR 2.7 million for the project ‘Guardians of Protein Disorder’. Prof. Onck collaborates in this consortium with four partners from ERIBA, UMCG and TU Delft. Prof. Veenhoff from ERIBA (European Institute for the Biology of Ageing) coordinates the consortium. Onck receives EUR 580,000 for his part in the project.
Intrinsically disordered proteins are proteins that lack a stable structure. They fulfil essential functions in cells, but are also involved in protein-aggregation diseases such as Parkinson’s disease and ALS. Intrinsically disordered proteins can exist in different phases, such as a liquid droplet, a gel or a more rigid form, an aggregate. The goal of this research project is to reveal what protection mechanisms ensure that intrinsically disordered proteins exist in the right phase state to perform their biological function and to prevent disease. By studying how these transitions are guarded, the researchers think they will contribute to a better understanding of neurodegenerative diseases.
Prof. Onck’s research group will carry out coarse-grained molecular dynamics simulations to reveal the underlying physical mechanisms that are responsible for the different phase state transitions.
Different from previous years but still surprising, fun, healthy, and for the whole family: join Groningen’s take on this year’s national weekend of science, organized by the University of Groningen (UG) and Hanze University of Applied Sciences...
Northern Netherlands Top Dutch Solar Racing team joins forces to prepare for solar race in Morocco.
Proverbs. Without thinking about it, we make use of them daily. But our society is constantly changing. Are these ancient wisdoms any use to us still? Young researchers from various disciplines, among whom are many members of the Young Academy...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information