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About us Faculty of Science and Engineering Our Research GRIP Pharmaceutical Technology and Biopharmacy Output

Publications

In the list below, you find an overview of all publications of the department of Pharmaceutical Technology and Biopharmacy. Requests for electronic versions of publications may be submitted to respective corresponding authors.

2024

Nguyen, K. T. T., Zillen, D., Lasorsa, A., van der Wel, P. C. A., Frijlink, H. W., & Hinrichs, W. L. J. (2024). Combinations of arginine and pullulan reveal the selective effect of stabilization mechanisms on different lyophilized proteins. International Journal of Pharmaceutics, 654, Article 123938. https://doi.org/10.1016/j.ijpharm.2024.123938
Putri, K. S. S., Adhyatmika, A., Boorsma, C. E., Habibie, H., Ruigrok, M. J. R., Heukels, P., Timens, W., de Jager, M. H., Hinrichs, W. L. J., Olinga, P., & Melgert, B. N. (2024). Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis. Lung. Advance online publication. https://doi.org/10.1007/s00408-024-00691-5
Li, M., Larsen, F. T., van den Heuvel, M. C., Gier, K., Gorter, A. R., Oosterhuis, D., Bijzet, J., de Meijer, V. E., Ravnskjaer, K., Nagelkerke, A., & Olinga, P. (2024). Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions. Nutrients, 16(5), Article 626. https://doi.org/10.3390/nu16050626
van Leeuwen, L. L., Ruigrok, M. J. R., Kessler, B. M., Leuvenink, H. G. D., & Olinga, P. (2024). Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model. British Journal of Pharmacology, 181(3), 464-479. https://doi.org/10.1111/bph.16220
Glättli, S. C., Elzinga, F. A., van der Bijl, W., Leuvenink, H. G. D., Prins, J. R., van Goor, H., Gordijn, S. J., Olinga, P., Touw, D. J., & Mian, P. (2024). Variability in perfusion conditions and set-up parameters used in ex vivo human placenta models: A literature review. Placenta. Advance online publication. https://doi.org/10.1016/j.placenta.2024.03.007
Dontje, A. E. W. K., Schuiling-Veninga, C. C. M., van Hunsel, F. P. A. M., Ekhart, C., Demirci, F., & Woerdenbag, H. J. (2024). The Therapeutic Potential of Essential Oils in Managing Inflammatory Skin Conditions: A Scoping Review. Pharmaceuticals, 17(5), Article 571. https://doi.org/10.3390/ph17050571

2023

Otten, A. T., van der Meulen, H. H., Steenhuis, M., Loeff, F. C., Touw, D. J., Kosterink, J. G. W., Frijlink, H. W., Rispens, T., Dijkstra, G., Visschedijk, M. C., & Bourgonje, A. R. (2024). Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 30(3), 325–335. https://doi.org/10.1093/ibd/izad103
van der Kooij, R. S., Beukema, M., Huckriede, A. L. W., Zuidema, J., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2023). A Single Injection with Sustained-Release Microspheres and a Prime-Boost Injection of Bovine Serum Albumin Elicit the Same IgG Antibody Response in Mice. Pharmaceutics, 15(2), Article 676. https://doi.org/10.3390/pharmaceutics15020676
Frijlink, H., Lagarce, F., Touw, D., & Woerdenbag, H. (2023). Biopharmaceutics. In P. Le Brun, S. Crauste-Manciet, I. Krämer, J. Smith, & H. Woerdenbag (Eds.), Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition (pp. 67-91). Springer International Publishing AG. https://doi.org/10.1007/978-3-031-20298-8_5
Ahmed, A. A., Otten, A. T., Gareb, B., Huijmans, J. E., Eissens, A. C., Rehman, A., Dijkstra, G., Kosterink, J. G. W., Frijlink, H. W., & Schellekens, R. C. A. (2023). Capsules with Ileocolonic-Targeted Release of Vitamin B2, B3, and C (ColoVit) Intended for Optimization of Gut Health: Development and Validation of the Production Process. Pharmaceutics, 15(5), Article 1354. https://doi.org/10.3390/pharmaceutics15051354
Nugrahadi, P. P., Hinrichs, W. L. J., Frijlink, H. W., Schöneich, C., & Avanti, C. (2023). Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review. Pharmaceutics, 15(3), Article 15030935. https://doi.org/10.3390/pharmaceutics15030935
Heida, R., Akkerman, R., Silva, P. H. J., Lakerveld, A., Ortiz, D., Bigogno, C., Gasbarri, M., Van Kasteren, P. B., Stellacci, F., Frijlink, H. W., Huckriede, A., & Hinrichs, W. (2023). Development of an inhalable antiviral powder formulation against respiratory syncytial virus. Journal of Controlled Release, 357(5), 264-273. https://doi.org/10.1016/j.jconrel.2023.03.059
Otten, A. T., Peters, V., Barth, I., Stevens, C. L., Bourgonje, A. R., Frijlink, H. W., Harmsen, H. J. M., Rehman, A., Campmans-Kuijpers, M. J. E., & Dijkstra, G. (2023). Effects of ileocolonic delivered vitamin B2, B3 and C (ColoVit) or the Groningen anti-inflammatory diet on disease course and microbiome of patients with Crohn's disease (VITA-GrAID study): a protocol for a randomised and partially blinded trial. BMJ Open, 13(3), Article e069654. https://doi.org/10.1136/bmjopen-2022-069654
Heida, R., Frijlink, H. W., & Hinrichs, W. L. J. (2023). Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: Reasons to prioritize the pulmonary route of administration. mBio, 14(5), Article e0129523. https://doi.org/10.1128/mbio.01295-23
Mahri, S., Wilms, T., Hagedorm, P., Guichard, M. J., Vanvarenberg, K., Dumoulin, M., Frijlink, H., & Vanbever, R. (2023). Nebulization of PEGylated recombinant human deoxyribonuclease I using vibrating membrane nebulizers: A technical feasibility study. European Journal of Pharmaceutical Sciences, 189, Article 106522. https://doi.org/10.1016/j.ejps.2023.106522
Frijlink, H. W., Eissens, A. C., van Goor, H., Mulder, D. J., & Joles, J. A. (2023). Oral dosage forms of a therapeutically active acid-labile salt and methods and uses related thereto. (Patent No. WO2023140729).
Heida, R., Hagedoorn, P., Van Meel, M. C., Prins, R., Simonis, F., Akkerman, R., Frijlink, H. W., Huckriede, A., de Boer, A., & Hinrichs, W. (2023). Performance Testing of a Homemade Aerosol Generator for Pulmonary Administration of Dry Powder Formulations to Mice. Pharmaceutics, 15(7), Article 1847. https://doi.org/10.3390/pharmaceutics15071847
Nguyen, K. T. T., Zillen, D., van Heijningen, F. F. M., van Bommel, K. J. C., van Ee, R. J., Frijlink, H. W., & Hinrichs, W. L. J. (2023). Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings. Pharmaceutics, 15(9), Article 2193. https://doi.org/10.3390/pharmaceutics15092193
Lee, J., Beukema, M., Zaplatynska, O. A., O'Mahony, C., Hinrichs, W. L. J., Huckriede, A. L. W., Bouwstra, J. A., & van der Maaden, K. (2023). Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine. Biomaterials Science, 11(20), 6790–6800. https://doi.org/10.1039/d3bm00377a
Hinrichs, W., & van Gestel, R. (2023). Physical Chemistry. In P. Le Brun, S. Crauste-Manciet, I. Krämer, J. Smith, & H. Woerdenbag (Eds.), Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition (2nd ed., pp. 93-125). Springer. https://doi.org/10.1007/978-3-031-20298-8_6
Bendixen, S. M., Jakobsgaard, P. R., Hansen, D., Hejn, K. H., Terkelsen, M. K., Bjerre, F. A., Thulesen, A. P., Eriksen, N. G., Hallenborg, P., Geng, Y., Dam, T. V., Larsen, F. T., Wernberg, C. W., Vijayathurai, J., Scott, E. A. H., Marcher, A. B., Detlefsen, S., Grøntved, L., Dimke, H., ... Ravnskjaer, K. (2024). Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module. Journal of Hepatology, 80(3), 467-481. https://doi.org/10.1016/j.jhep.2023.11.001
Geng, Y., Arroyave-Ospina, J. C., Buist-Homan, M., Plantinga, J., Olinga, P., Reijngoud, D. J., Van Vilsteren, F. G. I., Blokzijl, H., Kamps, J. A. A. M., & Moshage, H. (2023). Differential effects of oleate on vascular endothelial and liver sinusoidal endothelial cells reveal its toxic features in vitro. Journal of Nutritional Biochemistry, 114, Article 109255. https://doi.org/10.1016/j.jnutbio.2022.109255
Li, R., Vedelaar, T. A., Sigaeva, A., Zhang, Y., Wu, K., Wang, H., Wu, X., Olinga, P., Wlodarzyk-Biegun, M. K., & Schirhagl, R. (2023). Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues. Analytical Chemistry, 95(35), 13046-13054. https://doi.org/10.1021/acs.analchem.3c01452
Geng, Y., Wang, J., Serna-Salas, S. A., Villanueva, A. H., Buist-Homan, M., Arrese, M., Olinga, P., Blokzijl, H., & Moshage, H. (2023). Hepatic stellate cells induce an inflammatory phenotype in Kupffer cells via the release of extracellular vesicles. Journal of Cellular Physiology, 238(10), 2293-2303. https://doi.org/10.1002/jcp.31086
Luangmonkong, T., Puphancharoensuk, P., Tongsongsang, V., Olinga, P., & Parichatikanond, W. (2023). Hepatoprotective Efficacy of Cycloastragenol Alleviated the Progression of Liver Fibrosis in Carbon-Tetrachloride-Treated Mice. Biomedicines, 11(1), Article 231. https://doi.org/10.3390/biomedicines11010231
Fridrichs, J., Hamel, B., Kelder, W., van den Hoed, E., van den Heuvel, M. C., Hulscher, J. B. F., & Olinga, P. (2023). Human precision-cut cystic duct and gallbladder slices: a novel method for studying cholangiopathies. Frontiers in Pediatrics, 11, Article 1058319. https://doi.org/10.3389/fped.2023.1058319
Moes, C. A., Gan, C. T., Venema, L. H., Hoffmann, R. F., Melgert, B. N., Kerstjens, H. A. M., Olinga, P., & Ruigrok, M. J. R. (2023). Modelling Acid-Induced Lung Damage in Precision-Cut Lung Slices: An Ex Vivo Animal Model. Transplantology, 4(4), 185-196. https://doi.org/10.3390/transplantology4040018
Elzinga, F. A., Khalili, B., Touw, D. J., Prins, J. R., Olinga, P., Leuvenink, H. G. D., van Goor, H., Gordijn, S. J., Nagelkerke, A., & Mian, P. (2023). Placenta-on-a-Chip as an In Vitro Approach to Evaluate the Physiological and Structural Characteristics of the Human Placental Barrier upon Drug Exposure: A Systematic Review. Journal of Clinical Medicine, 12(13), Article 4315. https://doi.org/10.3390/jcm12134315
Woerdenbag, H. J., Olinga, P., Kok, E. A., Brugman, D. A. P., van Ark, U. F., Ramcharan, A. S., Lebbink, P. W., Hoogwater, F. J. H., Knapen, D. G., de Groot, D. J. A., & Nijkamp, M. W. (2023). Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment. Cancers, 15(7), Article 2119. https://doi.org/10.3390/cancers15072119
de Jong, I. E. M., Bodewes, S. B., van Leeuwen, O. B., Oosterhuis, D., Lantinga, V. A., Thorne, A. M., Lascaris, B., van den Heuvel, M. C., Wells, R. G., Olinga, P., de Meijer, V. E., & Porte, R. J. (2023). Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion. Transplantation, 107(6), e161-e172. https://doi.org/10.1097/TP.0000000000004531
van Leeuwen, L. L., Ruigrok, M. J. R., Leuvenink, H. G. D., & Olinga, P. (2023). Slice of Life: Porcine Kidney Slices for Testing Antifibrotic Drugs in a Transplant Setting. Transplantology, 4(2), 59-70. https://doi.org/10.3390/transplantology4020007
Jensen, M. S., Merrild, C., Nørregaard, R., Olinga, P., & Mutsaers, H. A. M. (2023). Standardized Protocol for the Preparation of Precision-Cut Kidney Slices: A Translational Model of Renal Fibrosis. In T. D. Hewitson, N. D. Toussaint, & E. R. Smith (Eds.), Methods in Molecular Biology (pp. 123-134). (Methods in Molecular Biology; Vol. 2664). Humana Press. https://doi.org/10.1007/978-1-0716-3179-9_9
Luangmonkong, T., Parichatikanond, W., & Olinga, P. (2023). Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges. Biochemical Pharmacology, 215, Article 115740. https://doi.org/10.1016/j.bcp.2023.115740
Simon, E., Motyka, M., Prins, G. H., Li, M., Rust, W., Kauschke, S., Viollet, C., Olinga, P., & Oldenburger, A. (2023). Transcriptomic profiling of induced steatosis in human and mouse precision-cut liver slices. Scientific Data, 10(1), Article 304. https://doi.org/10.1038/s41597-023-02220-0
Tjeerdsma, A. M., van Hunsel, F. P. A. M., van de Koppel, S., Ekhart, C., Vitalone, A., & Woerdenbag, H. J. (2023). Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity. Pharmaceuticals, 16(8), Article 1137. https://doi.org/10.3390/ph16081137
Woerdenbag, H., Sznitowska, M., & Smeets, O. (2023). Basic Operations. In P. Le Brun, S. Crauste-Manciet, I. Krämer, J. Smith, & H. Woerdenbag (Eds.), Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition (2nd ed., pp. 705-730). Springer. https://doi.org/10.1007/978-3-031-20298-8_29
Brun, P. L., Crauste-Manciet, S., Krämer, I., Smith, J., & Woerdenbag, H. (2023). Introduction. In P. Le Brun, S. Crauste-Manciet, I. Krämer, J. Smith, & H. Woerdenbag (Eds.), Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition (pp. 1-5). Springer. https://doi.org/10.1007/978-3-031-20298-8_1
Le Brun, P., Crauste-Manciet, S., Krämer, I., Smith, J., & Woerdenbag, H. (Eds.) (2023). Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition. (2nd ed.) Springer. https://doi.org/10.1007/978-3-031-20298-8
Woerdenbag, H., Visser, J. C., Kauss, T., & Sznitowska, M. (2023). Rectal and Vaginal. In P. Le Brun , S. Crauste-Manciet, I. Krämer, J. Smith, & H. Woerdenbag (Eds.), Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Second Edition (2nd ed., pp. 405-437). Springer. https://doi.org/10.1007/978-3-031-20298-8_19
Bekhof, A. S. M. W., van Hunsel, F. P. A. M., van de Koppel, S., & Woerdenbag, H. J. (2023). Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum). Phytotherapy Research, 37(4), 1309-1318. https://doi.org/10.1002/ptr.7687

2022

van der Kooij, R. S., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2022). An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 170, 24-42. https://doi.org/10.1016/j.ejpb.2021.11.007
Jansen, E. M., Frijlink, H. W., Hinrichs, W. L. J., & Ruigrok, M. J. R. (2022). Are inhaled mRNA vaccines safe and effective? A review of preclinical studies. Expert Opinion on Drug Delivery, 19(11), 1471-1485. https://doi.org/10.1080/17425247.2022.2131767
Heida, R., Born, P. A., Tapia-Calle, G., Frijlink, H. W., Salvati, A., Huckriede, A. L. W., & Hinrichs, W. L. J. (2022). Assessing the Immunomodulatory Effect of Size on the Uptake and Immunogenicity of Influenza- and Hepatitis B Subunit Vaccines In Vitro. Pharmaceuticals, 15(7), Article 887. https://doi.org/10.3390/ph15070887
Nguyen, K. T. T., Heijningen, F. F. M., Zillen, D., van Bommel, K. J. C., van Ee, R. J., Frijlink, H. W., & Hinrichs, W. L. J. (2022). Formulation of a 3D Printed Biopharmaceutical: The Development of an Alkaline Phosphatase Containing Tablet with Ileo-Colonic Release Profile to Treat Ulcerative Colitis. Pharmaceutics, 14(10), Article 2179. https://doi.org/10.3390/pharmaceutics14102179
Tian, Y., Lee, J., van der Maaden, K., Bhide, Y., de Vries-Idema, J. J., Akkerman, R., O'Mahony, C., Jiskoot, W., Frijlink, H. W., Huckriede, A. L. W., Hinrichs, W. L. J., Bouwstra, J. A., & Beukema, M. (2022). Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2022.01.033
Woerdenbag, H. J., Visser, J. C., Leferink Op Reinink, M. P. A. M., van Orsoy, R. R., Eissens, A. C., Hagedoorn, P., Dijkstra, H., Allersma, D. P., Ng, S. W., Smeets, O. S. N. M., & Frijlink, H. W. (2022). Performance of Tablet Splitters, Crushers, and Grinders in Relation to Personalised Medication with Tablets. Pharmaceutics, 14(2), Article 320. https://doi.org/10.3390/pharmaceutics14020320
Ruigrok, M. J. R., Roest, M. A. P., Frijlink, H. W., Olinga, P., Hinrichs, W. L. J., & Melgert, B. N. (2022). RANKL confers protection against cell death in precision-cut lung slices. Frontiers in Physiology, 13, Article 1029697. https://doi.org/10.3389/fphys.2022.1029697
de Reus, Y. A., Hagedoorn, P., Sturkenboom, M. G. G., Grasmeijer, F., Bolhuis, M. S., Sibum, I., Kerstjens, H. A. M., Frijlink, H. W., & Akkerman, O. W. (2022). Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers. PLoS ONE, 17(8), Article e0272034. https://doi.org/10.1371/journal.pone.0272034
Li, M., de Meijer, V., Olinga, P., Nagelkerke, A., & Geng, Y. (2022). Development of an ex vivo model for non-alcoholic fatty liver disease using precision-cut liver slices. Journal of Hepatology, 77, S711-S711.
Suriguga, S., Li, M., Luangmonkong, T., Boersema, M., de Jong, K. P., Oosterhuis, D., Gorter, A. R., Beljaars, L., & Olinga, P. (2022). Distinct responses between healthy and cirrhotic human livers upon lipopolysaccharide challenge: possible implications for acute-on-chronic liver failure. American journal of physiology. Gastrointestinal and liver physiology, 323(2), G114-G125. https://doi.org/10.1152/ajpgi.00243.2021
Luo, K., Geng, Y., de Meijer, V., Oosterhuis, D., & Olinga, P. (2022). Evaluation of the antifibrotic effects of naringenin, asiatic acid and icariin by using precision-cut liver slices of mouse and human. Journal of Hepatology, 77, S484-S484.
van Furth, L. A., Leuvenink, H. G. D., Seras, L., Graaf, I. A. M. D., Olinga, P., & Leeuwen, L. L. V. (2022). Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury. Transplantology, 3(2), 139–151. https://doi.org/10.3390/transplantology3020015
Biel, C., Martinec, O., Sibering, B., van Summeren, K., Wessels, A. M. A., Touw, D. J., de Jong, K. P., de Meijer, V. E., Faber, K. N., Klooster, J. P. T., de Graaf, I. A. M., & Olinga, P. (2022). Extending the viability of human precision-cut intestinal slice model for drug metabolism studies. Archives of toxicology. https://doi.org/10.1007/s00204-022-03295-1
Karsten, R. E. H., Krijnen, N. J. W., Maho, W., Permentier, H., Verpoorte, E., & Olinga, P. (2022). Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis. Archives of toxicology, 96(9), 2523-2543. https://doi.org/10.1007/s00204-022-03321-2
Adhyatmika, A., Putri, K. S. S., Gore, E., Mangnus, K. A., Reker-Smit, C., Schuppan, D., Beljaars, L., Olinga, P., & Melgert, B. N. (2022). Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ. Cellular physiology and biochemistry, 56(1), 28-38. https://doi.org/10.33594/000000492
van Leeuwen, L., Leuvenink, H. G. D., Olinga, P., & Ruigrok, M. (2022). Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants: Supplementing Perfusion Solutions With Anti-fibrotic Drugs. Frontiers in Medicine, 8, Article 806774. https://doi.org/10.3389/fmed.2021.806774
Puerta Cavanzo, N., Riesmeijer, S. A., Holt-Kedde, I. L., Werker, P. M. N., Piersma, B., Olinga, P., & Bank, R. A. (2022). Verteporfin ameliorates fibrotic aspects of Dupuytren's disease nodular fibroblasts irrespective the activation state of the cells. Scientific Reports, 12(1), Article 13940. https://doi.org/10.1038/s41598-022-18116-9
van Hunsel, F. P. A. M., van der Kooi, D., van de Koppel, S., Kroes, B. H., & Woerdenbag, H. J. (2022). Analysis of Reports on Adverse Drug Reactions Related to Herbal Medicinal Products and Herbal Supplements in the Netherlands Received by the National Pharmacovigilance Centre Lareb. Drug Safety, 45(6), 651-661. https://doi.org/10.1007/s40264-022-01180-5
Borgonje, P. E., Wibier, L., Noordman, P., Woerdenbag, H. J., & Gareb, B. (2022). The Development and Implementation of Airflow Visualization Studies ("Smoke" Studies) as a Training Tool in Aseptic Hospital Compounding Facilities. Pharmacy (Basel, Switzerland), 10(5), Article 101. https://doi.org/10.3390/pharmacy10050101

2021

Heida, R., Hinrichs, W. L. J., & Frijlink, H. W. (2022). Inhaled vaccine delivery in the combat against respiratory viruses: A 2021 overview of recent developments and implications for COVID-19. Expert review of vaccines, 21(7), 957-974. https://doi.org/10.1080/14760584.2021.1903878
Larmené-Beld, K., Wijnsma, R., Kuiper, A., van Berkel, S., Robben, H., Taxis, K., & Frijlink, H. (2022). Science- and risk-based strategy to qualify prefillable autoclavable syringes as primary packaging material. European Journal of Hospital Pharmacy: Science and Practice, 29(5), 248-254. https://doi.org/10.1136/ejhpharm-2020-002333
Broesder, A., Bircan, S. Y., De Waard, A. B., Eissens, A. C., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Formulation and in vitro evaluation of pellets containing sulfasalazine and caffeine to verify ileo-colonic drug delivery. Pharmaceutics, 13(12), Article 1985. https://doi.org/10.3390/pharmaceutics13121985
Ruigrok, M. J. R., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2021). Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions. Molecular Therapy - Methods & Clinical Development, 20, 483-496. https://doi.org/10.1016/j.omtm.2021.01.003
Broesder, A., Berends, J. M. E., Scheepers, S. M., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems. Pharmaceutics, 13(5). https://doi.org/10.3390/pharmaceutics13050731
Gareb, B., Beugeling, M., Posthumus, S., Otten, A. T., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2021). Infliximab formulation strategy for a stable ileo-colonic targeted oral dosage form intended for the topical treatment of inflammatory bowel disease. Journal of drug delivery science and technology, 64, Article 102552. https://doi.org/10.1016/j.jddst.2021.102552
van der Kooij, R. S., Steendam, R., Zuidema, J., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Microfluidic Production of Polymeric Core-Shell Microspheres for the Delayed Pulsatile Release of Bovine Serum Albumin as a Model Antigen. Pharmaceutics, 13(11), Article 1854. https://doi.org/10.3390/pharmaceutics13111854
Zillen, D., Beugeling, M., Hinrichs, W. L. J., Frijlink, H. W., & Grasmeijer, F. (2021). Natural and bioinspired excipients for dry powder inhalation formulations. Current Opinion in Colloid and Interface Science, 56, Article 101497. https://doi.org/10.1016/j.cocis.2021.101497
Ruigrok, M. J. R., El Amasi, K. E. M., Leeming, D. J., Sand, J. M. B., Frijlink, H. W., Hinrichs, W. L. J., & Olinga, P. (2021). Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis? Frontiers in Medicine, 8, Article 607962. https://doi.org/10.3389/fmed.2021.607962
Sahal, G., Woerdenbag, H. J., Hinrichs, W. L. J., Visser, A., van der Mei, H. C., & Bilkay, I. S. (2021). Candida Biofilm Formation Assay on Essential Oil Coated Silicone Rubber. Bio-Protocol, 11(5), Article 3941. https://doi.org/10.21769/BioProtoc.3941
Setyaningsih, D., Santoso, Y. A., Hartini, Y. S., Murti, Y. B., Hinrichs, W. L. J., & Patramurti, C. (2021). Isocratic high-performance liquid chromatography (HPLC) for simultaneous quantification of curcumin and piperine in a microparticle formulation containing Curcuma longa and Piper nigrum. Heliyon, 7(3), Article e06541. https://doi.org/10.1016/j.heliyon.2021.e06541
Chakraborty, P., Oosterhuis, D., Bonsignore, R., Casini, A., Olinga, P., & Scheffers, D.-J. (2021). An organogold compound as potential antimicrobial agent against drug resistant bacteria: Initial mechanistic insights. ChemMedChem, 16(19), 3060-3070. https://doi.org/10.1002/cmdc.202100342
van Praagh, J. B., de Wit, J. G., Olinga, P., de Haan, J. J., Nagengast, W. B., Fehrmann, R. S. N., & Havenga, K. (2021). Colorectal anastomotic leak: Transcriptomic profile analysis. British Journal of Surgery, 108(3), 326-333. https://doi.org/10.1093/bjs/znaa066
Geng, Y., Buist-Homan, M., Olinga, P., Blokzijl, H., & Moshage, H. (2021). Conditioned medium of hepatic stellate cells induces a pro-inflammatory phenotype in kupffer cells via the release of extracellular vesicles. Hepatology, 74, 808A-809A.
Mutsaers, H. A. M., Nørregaard, R., & Olinga, P. (2021). Editorial: Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets. Frontiers in Medicine, 8, Article 793507. https://doi.org/10.3389/fmed.2021.793507
Pasmans, K., Adriaens, M. E., Olinga, P., Langen, R., Rensen, S. S., Schaap, F. G., Olde Damink, S. W. M., Caiment, F., van Loon, L. J. C., Blaak, E. E., & Meex, R. C. R. (2021). Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk. Frontiers in endocrinology, 12, 733625. https://doi.org/10.3389/fendo.2021.733625
Li, M., Oosterhuis, D., De Meijer, V. E., Olinga, P., & Geng, Y. (2021). High saccharides, fatty acids and insulin promote a fibrogenic phenotype of healthy, but not nash, human precision-cut liver slices. Hepatology, 74, 1069A-1069A.
Geng, Y., Oosterhuis, D., De Meijer, V. E., & Olinga, P. (2021). Lipids inhibit the progression of fibrosis in human nash precision-cut liver slices and human hepatic stellate cells. Hepatology, 74, 1077A-1077A.
Jensen, C. G., Jensen, M. S., Tingskov, S. J., Olinga, P., Nørregaard, R., & Mutsaers, H. A. M. (2021). Local inhibition of indoleamine 2, 3-dioxygenase mitigates renal fibrosis. Biomedicines, 9(8), Article 856. https://doi.org/10.3390/biomedicines9080856
Puerta Cavanzo, N., Bigaeva, E., Boersema, M., Olinga, P., & Bank, R. A. (2021). Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited. Frontiers in Medicine, 7, Article 615774. https://doi.org/10.3389/fmed.2020.615774
Bartucci, R., van der Meer, A. Z., Boersma, Y. L., Olinga, P., & Salvati, A. (2021). Nanoparticle-induced inflammation and fibrosis in ex vivo murine precision-cut liver slices and effects of nanoparticle exposure conditions. Archives of toxicology, 95, 1267–1285. https://doi.org/10.1007/s00204-021-02992-7
Martinec, O., Biel, C., de Graaf, I. A. M., Huliciak, M., de Jong, K. P., Staud, F., Cecka, F., Olinga, P., Vokral, I., & Cerveny, L. (2021). Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices. Frontiers in Pharmacology, 12, Article 684156. https://doi.org/10.3389/fphar.2021.684156
van Furth, L., Maassen, H., Venema, L., & Olinga, P. (2021). The effect of the ketogenic diet on mitochondrial function in porcine precision-cut kidney slices. Transplant International, 34(S1), 273-274.
Prins, G. H., Rios-Morales, M., Gerding, A., Reijngoud, D.-J., Olinga, P., & Bakker, B. M. (2021). The Effects of Butyrate on Induced Metabolic-Associated Fatty Liver Disease in Precision-Cut Liver Slices. Nutrients, 13(12), Article 4203. https://doi.org/10.3390/nu13124203
Henstra, C., van Praagh, J., Olinga, P., & Nagelkerke, A. (2021). The gastrointestinal microbiota in colorectal cancer cell migration and invasion. Clinical & Experimental Metastasis, 38, 495–510. https://doi.org/10.1007/s10585-021-10130-x
Majorova, D., Atkins, E., Martineau, H., Vokral, I., Oosterhuis, D., Olinga, P., Wren, B., Cuccui, J., & Werling, D. (2021). Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction. Frontiers in Veterinary Science, 8, Article 686088. https://doi.org/10.3389/fvets.2021.686088
Herawati, F., Yulia, R., Arifin, B., Frasetyo, I., Setiasih, Woerdenbag, H. J., Avanti, C., & Andrajati, R. (2021). Educational Video Improves Knowledge about Outpatients' Usage of Antibiotics in Two Public Hospitals in Indonesia. Antibiotics , 10(5), Article 606. https://doi.org/10.3390/antibiotics10050606
Mulder, S. M. E., Jipping, A. M., Silvester, N., Van Hunsel, F. P. A. M., Kroes, B. H., & Woerdenbag, H. J. (2021). Gelijktijdig gebruik van zuclopentixol en ayurvedische producten: Veilig of niet? Pharmaceutisch Weekblad, 156(1-2), 31-36.
Zulzaga, Z., Myagmarsuren, E., Woerdenbag, H. J., & van Puijenbroek, E. P. (2021). Legislation and current developments in adverse drug reaction reporting in Mongolia: how far are we? Journal of Pharmaceutical Policy and Practice, 14(1), Article 15. https://doi.org/10.1186/s40545-021-00298-8

2020

Heida, R., Bhide, Y. C., Gasbarri, M., Kocabiyik, Ö., Stellacci, F., Huckriede, A. L. W., Hinrichs, W. L. J., & Frijlink, H. W. (2021). Advances in the development of entry inhibitors for sialic-acid-targeting viruses. Drug Discovery Today, 26(1), 122-137. https://doi.org/10.1016/j.drudis.2020.10.009
Akkerman-Nijland, A. M., Akkerman, O. W., Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., Rottier, B. L., Koppelman, G. H., & Touw, D. J. (2021). The pharmacokinetics of antibiotics in cystic fibrosis. Expert Opinion on Drug Metabolism & Toxicology, 17(1), 53-68. https://doi.org/10.1080/17425255.2021.1836157
Hagedoorn, P., Bawary, W., Frijlink, H. W., & Grasmeijer, F. (2020). A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers. The Journal of Allergy and Clinical Immunology: In Practice, 8(3), 1124-1125.e4. https://doi.org/10.1016/j.jaip.2019.09.021
Sibum, I., Hagedoorn, P., Botterman, C. O., Frijlink, H. W., & Grasmeijer, F. (2020). Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops(R)High Dose Dry Powder Inhalation Device While Maintaining Dispersibility. Pharmaceutics, 12(7), 1-14. Article 645. https://doi.org/10.3390/pharmaceutics12070645
Akkerman-Nijland, A. M., Grasmeijer, F., Kerstjens, H. A. M., Frijlink, H. W., van der Vaart, H., Vonk, J. M., Hagedoorn, P., Rottier, B. L., Koppelman, G. H., & Akkerman, O. W. (2020). Colistin dry powder inhalation with the Twincer (TM): An effective and more patient friendly alternative to nebulization. PLoS ONE, 15(9), Article e0239658. https://doi.org/10.1371/journal.pone.0239658
Hagedoorn, P., Grasmeijer, F., Bawari, W., Frijlink, H. W., & Grasmeijer, F. (2020). Comparing five antistatic valved holding chambers: How antistatic are they really? European Respiratory Journal, 56. https://doi.org/10.1183/13993003.congress-2020.3177
Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2020). De ontwikkeling van budesonidetabletten met nulde-orde-afgifte voor de behandeling van ileo-colonische inflammatoire darmziekten en vergelijking met huidige, commerciële preparaten. Pharmaceutisch Weekblad, 155(6), 29-36. https://www.npfo.nl/artikel/de-ontwikkeling-van-budesonidetabletten-met-nulde-orde-afgifte-voor-de-behandeling-van-ileo
Tian, Y., Bhide, Y. C., Woerdenbag, H. J., Huckriede, A. L. W., Frijlink, H. W., Hinrichs, W. L. J., & Visser, J. C. (2020). Development of an Orodispersible Film Containing Stabilized Influenza Vaccine. Pharmaceutics, 12(3), Article 245. https://doi.org/10.3390/pharmaceutics12030245
Weerts, Z. Z. R. M., Masclee, A. A. M., Witteman, B. J. M., Clemens, C. H. M., Winkens, B., Brouwers, J. R. B. J., Frijlink, H. W., Muris, J. W. M., De Wit, N. J., Essers, B. A. B., Tack, J., Snijkers, J. T. W., Bours, A. M. H., de Ruiter-van der Ploeg, A. S., Jonkers, D. M. A. E., & Keszthelyi, D. (2020). Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome. Gastroenterology, 158(1), 123-136. Article 158. https://doi.org/10.1053/j.gastro.2019.08.026
Akkerman-Nijland, A. M., Yousofi, M., Rottier, B. L., Van der Vaart, H., Burgerhof, J. G. M., Frijlink, H. W., Touw, D. J., Koppelman, G. H., & Akkerman, O. W. (2020). Eradication of Pseudomonas aeruginosa in cystic fibrosis patients with inhalation of dry powder tobramycin. Therapeutic advances in respiratory disease, 14, Article 1753466620905279. https://doi.org/10.1177/1753466620905279
Pleguezuelos, O., Dille, J., de Groen, S., Oftung, F., Niesters, H. G. M., Islam, M. A., Naess, L. M., Hungnes, O., Aldarij, N., Idema, D. L., Perez, A. F., James, E., Frijlink, H. W., Stoloff, G., Groeneveld, P., & Hak, E. (2020). Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults. Annals of Internal Medicine, 172(7), 453-462. https://doi.org/10.7326/M19-0735
Nguyen, K. T. T., Frijlink, H. W., & Hinrichs, W. L. J. (2020). Inhomogeneous Distribution of Components in Solid Protein Pharmaceuticals: Origins, Consequences, Analysis, and Resolutions. Journal of Pharmaceutical Sciences, 109(1), 134-153. https://doi.org/10.1016/j.xphs.2019.10.010
Ruigrok, M., El-Amasi, K., Frijlink, H. W., Hinrichs, W., & Olinga, P. (2020). Knockdown of heat shock protein 47 (HSP47) and its effects on fibrogenesis. Poster session presented at Keystone Symposia on Fibrosis and Tissue Repair, Victoria, Canada.
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2020). Optimisation of an isoniazid dry powder formulation for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 33(2), A2-A2.
Broesder, A., Woerdenbag, H. J., Prins, G. H., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2020). pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems. Drug Discovery Today, 25(8), 1362-1373. https://doi.org/10.1016/j.drudis.2020.06.011
Broesder, A., Kosta, A.-M. M. A. C., Woerdenbag, H. J., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2020). pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients. Drug Discovery Today, 25(8), 1374-1388. https://doi.org/10.1016/j.drudis.2020.06.012
Larmene-Beld, K. H. M., van Berkel, S., Wijnsma, R., Taxis, K., & Frijlink, H. W. (2020). Prefilled Cyclic Olefin Sterilized Syringes of Norepinephrine Injection Solution Do Not Need to Be Stabilized by Antioxidants. Aaps pharmscitech, 21(7), 247. Article 247. https://doi.org/10.1208/s12249-020-01784-z
Hagedoorn, P., Bawary, W., Frijlink, H. W., & Grasmeijer, F. (2020). Relative lung dose from antistatic valved holding chambers Reply. The Journal of Allergy and Clinical Immunology: In Practice, 8(3), 1166-1167. https://doi.org/10.1016/j.jaip.2019.11.023
Gareb, B., Otten, A. T., Frijlink, H. W., Dijkstra, G., & Kosterink, J. G. W. (2020). Review: Local Tumor Necrosis Factor-alpha Inhibition in Inflammatory Bowel Disease. Pharmaceutics, 12(6), 1-31. Article 539. https://doi.org/10.3390/pharmaceutics12060539
Gerritsen, J., Bloemers, J., van Rooij, K., de Leede, L., van der Geest, R., Frijlink, H. W., Koppeschaar, H. P. F., Olivier, B., & Tuiten, A. (2020). The Effect of Food on the Pharmacokinetics of Buspirone After Single Administration of a Sublingual Testosterone and Oral Buspirone Combination Tablet in Healthy Female Subjects. Sexual medicine, 8(2), 186-194. https://doi.org/10.1016/j.esxm.2020.01.005
Kocabiyik, O., Cagno, V., Silva, P. J., Zhu, Y., Sedano, L., Bhide, Y., Mettier, J., Medaglia, C., Da Costa, B., Constant, S., Huang, S., Kaiser, L., Hinrichs, W. L. J., Huckeriede, A., Le Goffic, R., Tapparel, C., & Stellacci, F. (2021). Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo. Advanced science, 8(3), Article 2001012. https://doi.org/10.1002/advs.202001012
Smith-Cortinez, N., Fagundes, R. R., Gomez, V., Kong, D., de Waart, D. R., Heegsma, J., Sydor, S., Olinga, P., de Meijer, V. E., Taylor, C. T., Bank, R., Paulusma, C. C., & Faber, K. N. (2021). Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition. The FASEB Journal, 35(2), Article e21219. https://doi.org/10.1096/fj.202001564RR
Mortensen, J. H., van Haaften, W. T., Karsdal, M. A., Bay-Jensen, A.-C., Olinga, P., Grønbæk, H., Hvas, C. L., Manon-Jensen, T., Dijkstra, G., & Dige, A. (2021). The Citrullinated and MMP-degraded Vimentin Biomarker (VICM) Predicts Early Response to Anti-TNF alpha Treatment in Crohn's Disease. Journal of clinical gastroenterology, 55(1), 59-66. https://doi.org/10.1097/MCG.0000000000001341
Bartucci, R., Paramanandana, A., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Comparative study of nanoparticle uptake and impact in murine lung, liver and kidney tissue slices. Nanotoxicology, 14(6), 847-865. https://doi.org/10.1080/17435390.2020.1771785
Nomden, M., Beljaars, L., Verkade, H. J., Hulscher, J. B. F., & Olinga, P. (2020). Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature. Frontiers in Medicine, 7, Article 617261. https://doi.org/10.3389/fmed.2020.617261
van Dijk, F., Hazelhoff, C. M., Post, E., Prins, G. G. H., Rombouts, K., Poelstra, K., Olinga, P., & Beljaars, L. (2020). Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis. Pharmaceutics, 12(3), Article 278. https://doi.org/10.3390/pharmaceutics12030278
Bigaeva, E., Gore, E., Mutsaers, H. A. M., Oosterhuis, D., Kim, Y. O., Schuppan, D., Bank, R. A., Boersema, M., & Olinga, P. (2020). Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices. Biochimica et biophysica acta-Molecular basis of disease, 1866(1), Article 165582. https://doi.org/10.1016/j.bbadis.2019.165582
Suriguga, S., Luangmonkong, T., Mutsaers, H. A. M., Groothuis, G. M. M., & Olinga, P. (2020). Host microbiota dictates the proinflammatory impact of LPS in the murine liver. Toxicology in Vitro, 67, Article 104920. https://doi.org/10.1016/j.tiv.2020.104920
van Haaften, W. T., Blokzijl, T., Hofker, H. S., Olinga, P., Dijkstra, G., Bank, R. A., & Boersema, M. (2020). Intestinal stenosis in Crohn's disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets. Therapeutic advances in gastroenterology, 13. https://doi.org/10.1177/1756284820952578
Gore, E., Bigaeva, E., Oldenburger, A., Jansen, Y. J. M., Schuppan, D., Boersema, M., Rippmann, J. F., Broermann, A., & Olinga, P. (2020). Investigating fibrosis and inflammation in an ex vivo NASH murine model. American Journal of Physiology. Gastrointestinal and Liver Physiology, 318(2), G336-G351. https://doi.org/10.1152/ajpgi.00209.2019
Luangmonkong, T., & Olinga, P. (2020). Modified culture protocol for testing anti-fibrotic drugs using precision-cut liver slices. Pharmaceutical Sciences Asia, 47(3), 301-309. https://doi.org/10.29090/psa.2020.03.019.0137
Iswandana, R., Pham, B. T., Suriguga, S., Luangmonkong, T., van Wijk, L. A., Jansen, Y. J. M., Oosterhuis, D., Maria Mutsaers, H. A., & Olinga, P. (2020). Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs. Inflammatory Bowel Diseases, 26(5), 678-686. https://doi.org/10.1093/ibd/izz329
Adhyatmika, A., Beljaars, L., Putri, K. S. S., Habibie, H., Boorsma, C. E., Reker-Smit, C., Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post, E., Poelstra, K., Ravnskjaer, K., Olinga, P., & Melgert, B. N. (2020). Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver. Pharmaceutics, 12(5), Article 471. https://doi.org/10.3390/pharmaceutics12050471
Prins, G. H., & Olinga, P. (2020). Potential implications of COVID-19 in non-alcoholic fatty liver disease. Liver International, 40(10), 2568. https://doi.org/10.1111/liv.14484
Bigaeva, E., Puerta Cavanzo, N., Stribos, E. G. D., de Jong, A. J., Biel, C., Mutsaers, H. A. M., Jensen, M. S., Nørregaard, R., Leliveld, A. M., de Jong, I. J., Hillebrands, J.-L., van Goor, H., Boersema, M., Bank, R. A., & Olinga, P. (2020). Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis. Pharmaceutics, 12(5), Article 459. https://doi.org/10.3390/pharmaceutics12050459
Habibie, H., Song, S., Putri, K., Boorsma, C., Cool, R., Wu, X., Gosens, R., Wang, Y., Quax, W., Olinga, P., Brandsma, C.-A., Timens, W., Burgess, J., & Melgert, B. (2020). RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation. European Respiratory Journal, 56. https://doi.org/10.1183/13993003.congress-2020.5029
van Haaften, W. T., Mortensen, J. H., Dige, A. K., Gronbaek, H., Hvas, C. L., Bay-Jensen, A.-C., Karsdal, M. A., Olinga, P., Manon-Jensen, T., & Dijkstra, G. (2020). Serological Biomarkers of Tissue Turnover Identify Responders to Anti-TNF Therapy in Crohn's Disease: A Pilot Study. Clinical and translational gastroenterology, 11(9), e00217. Article 00217. https://doi.org/10.14309/ctg.0000000000000217
Biel, C., Bigaeva, E., Hesse, M., Bomers, J. J. M., van Summeren, K., Teunis, M. A. T., Vaessen, S., Ten Klooster, J. P., & Olinga, P. (2020). Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices. Toxicology in Vitro, 69, Article 104974. https://doi.org/10.1016/j.tiv.2020.104974
Bartucci, R., Åberg, C., Melgert, B. N., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Time-Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision-Cut Liver Slices. Small, 16(21), Article e1906523. https://doi.org/10.1002/smll.201906523
Koster, A. S., Mantel-Teeuwisse, A. K., Woerdenbag, H. J., Mulder, W. M. C., Wilffert, B., Schalekamp, T., Buurma, H., Wilting, I., & Westein, M. P. D. (2020). Alignment of CanMEDS-Based Undergraduate and Postgraduate Pharmacy Curricula in The Netherlands. Pharmacy (Basel, Switzerland), 8(3), Article 117. https://doi.org/10.3390/pharmacy8030117
Visser, J. C., Wibier, L., Kiefer, O., Orlu, M., Breitkreutz, J., Woerdenbag, H. J., & Taxis, K. (2020). A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films. Pharmaceutics, 12(2), Article 164. https://doi.org/10.3390/pharmaceutics12020164
Mulder, S. M. E., Jipping, A.-M., Silvester, N., van Hunsel, F. P. A. M., Kroes, B. H., & Woerdenbag, H. J. (2020). Gelijktijdig gebruik van zuclopentixol en ayurvedische producten: Veilig of niet? Nederlands Platform voor Farmaceutisch Onderzoek, (5), Article a1732.
Woerdenbag, H., & Hak, E. (2020). Interview-based cross-sectional needs assessment to advance the implementation of an effective antibiotic stewardship program in Indonesian hospitals. Health Policy OPEN, 1, Article 100002. https://doi.org/10.1016/j.hpopen.2019.100002
Visser, J. C., Wibier, L., Mekhaeil, M., Woerdenbag, H. J., & Taxis, K. (2020). Orodispersible films as a personalized dosage form for nursing home residents, an exploratory study. International Journal of Clinical Pharmacy, 42(2), 436–444. https://doi.org/10.1007/s11096-020-00990-w

2019

Busscher, H. J., Woudstra, W., van Kooten, T. G., Jutte, P., Shi, L., Liu, J., Hinrichs, W. L. J., Frijlink, H. W., Shi, R., Liu, J., Parvizi, J., Kates, S., Rotello, V. M., Schaer, T. P., Williams, D., Grainger, D. W., & van der Mei, H. C. (2020). Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. Biomaterials, 232, Article 119737. https://doi.org/10.1016/j.biomaterials.2019.119737
Sibum, I., Hagedoorn, P., Kluitman, M. P. G., Kloezen, M., Frijlink, H. W., & Grasmeijer, F. (2020). Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine. Pharmaceutics, 12(1), Article 24. https://doi.org/10.3390/pharmaceutics12010024
Yska, J. P., Wanders, J. T. M., Odigie, B., Apers, J. A., Emous, M., Totté, E. R. E., Boerma, E. C., Ubels, F. L., Woerdenbag, H. J., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2020). Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery. European Journal of Hospital Pharmacy: Science and Practice, 27(E1), e19–e24. https://doi.org/10.1136/ejhpharm-2018-001804
Boudewijn, I. M., Lan, A., Faiz, A., Cox, C. A., Brouwer, S., Schokker, S., Vroegop, S. J., Nawijn, M. C., Woodruff, P. G., Christenson, S. A., Hagedoorn, P., Frijlink, H. W., Choy, D. F., Brouwer, U., Wisman, M., Postma, D. S., Fingleton, J., Beasley, R., van den Berge, M., & Guryev, V. (2020). Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy, 75(1), 191-194. https://doi.org/10.1111/all.13952
Yska, J. P., Punter, R. J., Woerdenbag, H. J., Emous, M., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2019). A gastrointestinal simulation system for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass. European Journal of Hospital Pharmacy: Science and Practice, 26(3), 152-156. https://doi.org/10.1136/ejhpharm-2017-001360
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., ten Hacken, N. H. T., Kerstjens, H. A. M., & van den Berge, M. (2019). Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma. BMC Pulmonary Medicine, 19(1), Article 23. https://doi.org/10.1186/s12890-019-0783-0
Larmené-Beld, K. H. M., Frijlink, H. W., & Taxis, K. (2019). A systematic review and meta-analysis of microbial contamination of parenteral medication prepared in a clinical versus pharmacy environment. European Journal of Clinical Pharmacology, 75(5), 609-617. https://doi.org/10.1007/s00228-019-02631-2
Sibum, I., Hagedoorn, P., Frijlink, H. W., & Grasmeijer, F. (2019). Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation. Pharmaceutics, 11(5), Article 233. https://doi.org/10.3390/pharmaceutics11050233
Janssen, R., Wouters, E. F. M., Janssens, W., Daamen, W. F., Hagedoorn, P., de Wit, H. A. J. M., Serre, J., Gayan-Ramirez, G., Franssen, F. M. E., Reynaert, N. L., von der Thusen, J. H., & Frijlink, H. W. (2019). Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale. International Journal of Chronic Obstructive Pulmonary Disease, 14, 2587-2602. https://doi.org/10.2147/COPD.S228411
Beugeling, M., Amssoms, K., Cox, F., De Clerck, B., Van Gulck, E., Verwoerd, J., Kraus, G., Roymans, D., Baert, L., Frijlink, H. W., & Hinrichs, W. (2019). Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study. Pharmaceutics, 11(10), Article 510. https://doi.org/10.3390/pharmaceutics11100510
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2019). Formulating Amikacin for dry powder inhalation. Journal of aerosol medicine and pulmonary drug delivery, 32(2), A7-A7. https://doi.org/10.1089/jamp.2019.ab01.abstracts
Luinstra, M., Isufi, V., de Jong, L., Rutgers, A. W. F., Hagedoorn, P., Puttenstein, J., van Laar, T., & Frijlink, H. W. (2019). Learning from Parkinson's patients: Usability of the Cyclops dry powder inhaler. International Journal of Pharmaceutics, 567, 118493. Article 118493. https://doi.org/10.1016/j.ijpharm.2019.118493
Tian, Y., Orlu, M., Woerdenbag, H. J., Scarpa, M., Kiefer, O., Kottke, D., Sjoholm, E., Oblom, H., Sandler, N., Hinrichs, W. L. J., Frijlink, H. W., Breitkreutz, J., & Visser, J. C. (2019). Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery, 16(9), 981-993. https://doi.org/10.1080/17425247.2019.1652595
Beugeling, M., Born, P., Amssoms, K., De Clerck, B., Van Gulck, E., Frijlink, H. W., Grasmeijer, N., Kraus, G., Baert, L., & Hinrichs, W. (2019). Ovalbumin-Containing Core-Shell Implants Suitable to Obtain a Delayed IgG1 Antibody Response in Mice. Poster session presented at AAPS PharmSci 360, San Antonio, United States.
Luinstra, M., Rutgers, W., van Laar, T., Grasmeijer, F., Begeman, A., Isufi, V., Steenhuis, L., Hagedoorn, P., de Boer, A., & Frijlink, H. W. (2019). Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson's disease. Therapeutic advances in chronic disease, 10. https://doi.org/10.1177/2040622319857617
Tian, Y., Visser, C., Woerdenbag, H., Frijlink, H. W., & Hinrichs, W. (2019). Printing biopharmaceuticals onto orodispersible films. Poster session presented at AAPS PharmSci 360, San Antonio, United States.
Tomar, J., Tonnis, W. F., Patil, H. P., de Boer, A. H., Hagedoorn, P., Vanbever, R., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination. Acta Pharmaceutica Sinica B, 9(6), 1231-1240. https://doi.org/10.1016/j.apsb.2019.05.003
Beugeling, M., De Zee, J., Woerdenbag, H. J., Frijlink, H. W., Wilschut, J. C., & Hinrichs, W. L. J. (2019). Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly. Expert review of vaccines, 18(9), 935-950. https://doi.org/10.1080/14760584.2019.1657013
van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., Steendam, R., Klose, M. H. M., Meier-Menches, S. M., Casini, A., Horvatovich, P. L., Sijbrandi, N. J., Frijlink, H. W., Hinrichs, W. L. J., Poelstra, K., Beljaars, L., & Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
Bloemers, J., Gerritsen, J., van Rooij, K., de Leede, L., van der Geest, R., Frijlink, H. W., Koppeschaar, H. P. F., Olivier, B., & Tuiten, A. (2019). The Effect of Food on the Pharmacokinetics of Sildenafil after Single Administration of a Sublingual Testosterone and Oral Sildenafil Combination Tablet in Healthy Female Subjects. Journal of Sexual Medicine, 16(9), 1433-1443. https://doi.org/10.1016/j.jsxm.2019.06.015
Ruigrok, M., Tomar, J., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2019). The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices. Scientific Reports, 9(1), Article 16239. https://doi.org/10.1038/s41598-019-52813-2
Beugeling, M., Grasmeijer, N., Born, P., van der Meulen, M., Kooij, van der, R., Schwengle, K., Baert, L., Amssoms, K., Frijlink, H. W., & Hinrichs, W. (2019). The Mechanism Behind the Biphasic Pulsatile Drug Release from Physically Mixed Poly(DL-Lactic(-Co-Glycolic) Acid)-Based Compacts. Poster session presented at AAPS PharmSci 360, San Antonio, United States.
Gareb, B., Posthumus, S., Beugeling, M., Koopmans, P., Touw, D. J., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2019). Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process. Pharmaceutics, 11(9), Article 428. https://doi.org/10.3390/pharmaceutics11090428
Murti, Y. B., Hartini, Y. S., Hinrichs, W. L. J., Frijlink, H. W., & Setyaningsih, D. (2019). UV-Vis spectroscopy to enable determination of the dissolution behavior of solid dispersions containing curcumin and piperine. Journal of Young Pharmacists, 11(1), 26-30. https://doi.org/10.5530/jyp.2019.11.6
Frijlink, H. W. (2019). Wisselen van medicijnen.
Sahal, G., Woerdenbag, H. J., Hinrichs, W. L. J., Visser, A., Tepper, P. G., Quax, W. J., van der Mei, H. C., & Bilkay, I. S. (2020). Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study. Journal of ethnopharmacology, 246, Article 112188. https://doi.org/10.1016/j.jep.2019.112188
Tapia-Calle, G., Born, P. A., Koutsoumpli, G., Gonzalez-Rodriguez, M. I., Hinrichs, W. L. J., & Huckriede, A. L. W. (2019). A PBMC-Based System to Assess Human T Cell Responses to Influenza Vaccine Candidates In Vitro. Vaccines, 7(4), Article 181. https://doi.org/10.3390/vaccines7040181
Bigaeva, E., Stribos, E. G. D., Mutsaers, H. A. M., Piersma, B., Leliveld, A. M., de Jong, I. J., Bank, R. A., Seelen, M. A., van Goor, H., Wollin, L., Olinga, P., & Boersema, M. (2020). Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis. American journal of physiology-Renal physiology, 318(1), F117-F134. https://doi.org/10.1152/ajprenal.00108.2019
Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T.-H., & Norregaard, R. (2019). Activation of the prostaglandin E-2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica, 227(1), Article e13291. https://doi.org/10.1111/apha.13291
Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T.-H., & Norregaard, R. (2019). Administration of a selective prostaglandin E-2 receptor agonist attenuates renal fibrosis in vitro and in vivo. FASEB Journal, 33.
Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J., & Olinga, P. (2019). A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. Nutrients, 11(3), Article 507. https://doi.org/10.3390/nu11030507
Mutsaers, H. A. M., Jensen, M. S., Olinga, P., & Norregaard, R. (2019). Cyclooxygenase-2 Regulates the Renal Expression of Indoleamine 2,3-dioxygenase. FASEB Journal, 33.
Karsten, R. E. H., Oosterhuis, D., van Wijk, L. A., & Olinga, P. (2019). Ex Vivo Model in Cholestasis Research. In M. Vinken (Ed.), Experimental Cholestasis Research (pp. 351-362). (Methods in Molecular Biology; Vol. 1981). Humana Press. https://doi.org/10.1007/978-1-4939-9420-5_23
Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019). Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro, 59, 312-321. https://doi.org/10.1016/j.tiv.2019.05.024
Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Olinga, P., & Gier, K. (2019). INDUCTION OF STEATOSIS IN HUMAN LIVER EX VIVO. Hepatology, 70, 1311A-1311A.
van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2019). Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage. Annals of Surgery, 269(5), 911-916. https://doi.org/10.1097/SLA.0000000000002651
Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., Quax, W. J., Olinga, P., Hirsch, A. K. H., & Dekker, F. J. (2019). Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. Journal of Medicinal Chemistry, 62(9), 4624-4637. https://doi.org/10.1021/acs.jmedchem.9b00212
de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E., & Porte, R. J. (2019). Peribiliary glands are key in regeneration of the biliary epithelium after severe ischemic bile duct injury during liver transplantation. Transplantation, 103(8), 3-3. https://doi.org/10.1097/01.tp.0000580472.17422.db
Gore, E., Bigaeva, E., Oldenburger, A., Ook, K. Y., Rippmann, J. F., Schuppan, D., Boersema, M., & Olinga, P. (2019). PI3K inhibition reduces murine and human liver fibrogenesis in precisioncut liver slices. Biochemical Pharmacology, 169, Article 113633. https://doi.org/10.1016/j.bcp.2019.113633
Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Dekker, F. J., Olinga, P., & Gier, K. (2019). POLYUNSATURATED FATTY ACIDS AND 5-LIPOXYGENASE IN NON-ALCOHOLIC FATTY LIVER DISEASE. Hepatology, 70, 1311A-1311A.
Bartucci, R., Åberg, C., Boersma, Y. L., Olinga, P., & Salvati, A. (2019). Precision-cut liver slices as a promising ex vivo model for nanosafety studies. Toxicology Letters, 314(Supplement), S204-S205.
Bigaeva, E., Gore, E., Simon, E., Zwick, M., Oldenburger, A., de Jong, K. P., Hofker, H. S., Schlepütz, M., Nicklin, P., Boersema, M., Rippmann, J. F., & Olinga, P. (2019). Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices. Archives of toxicology, 93(12), 3549-3583. https://doi.org/10.1007/s00204-019-02611-6
Bartucci, R., Salvati, A., Olinga, P., & Boersma, Y. L. (2019). Vanin 1: Its Physiological Function and Role in Diseases. International Journal of Molecular Sciences, 20(16), Article 3891. https://doi.org/10.3390/ijms20163891
Herawati, F., Yulia, R., Hak, E., Hartono, A. H., Michiels, T., Woerdenbag, H. J., & Avanti, C. (2019). A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia. Hospital Pharmacy Europe, 54(5), 323-329. https://doi.org/10.1177/0018578718792804

2018

Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2019). Development of novel zero-order release budesonide tablets for the treatment of ileo-colonic inflammatory bowel disease and comparison with formulations currently used in clinical practice. International Journal of Pharmaceutics, 554, 366-375. https://doi.org/10.1016/j.ijpharm.2018.11.019
Grasmeijer, N., Tiraboschi, V., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle. European Journal of Pharmaceutical Sciences, 128, 152-157. https://doi.org/10.1016/j.ejps.2018.11.027
Tomar, J., Patil, H. P., Bracho, G., Tonnis, W. F., Frijlink, H. W., Petrovsky, N., Vanbever, R., Huckriede, A., & Hinrichs, W. L. J. (2018). Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. Journal of Controlled Release, 288, 199-211. https://doi.org/10.1016/j.jconrel.2018.09.006
Weerts, Z. Z. R. M., Keszthelyi, D., Vork, L., Aendekerk, N. C. P., Frijlink, H. W., Brouwers, J. R. B. J., Neef, C., Jonkers, D. M. A. E., & Masclee, A. A. M. (2018). A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers. Advances in therapy, 35(11), 1965-1978. https://doi.org/10.1007/s12325-018-0802-1
Sibum, I., Hagedoorn, P., de Boer, A. H., Frijlink, H. W., & Grasmeijer, F. (2018). Challenges for pulmonary delivery of high powder doses. International Journal of Pharmaceutics, 548(1), 325-336. https://doi.org/10.1016/j.ijpharm.2018.07.008
Akkerman, O. W., Grasmeijer, F., de Lange, W. C. M., Kerstjens, H. A. M., de Vries, G., Bolhuis, M. S., Alffenaar, J.-W., Frijlink, H. W., Smith, G., Gajraj, R., de Zwaan, R., Hagedoorn, P., Dedicoat, M., van Soolingen, D., & van der Werf, T. S. (2018). Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis. European Respiratory Journal, 51(3), Article 1702490. https://doi.org/10.1183/13993003.02490-2017
Kanojia, G., Raeven, R. H. M., van der Maas, L., Bindels, T. H. E., van Riet, E., Metz, B., Soema, P. C., Ten Have, R., Frijlink, H. W., Amorij, J.-P., & Kersten, G. F. A. (2018). Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization. Journal of controlled release : official journal of the Controlled Release Society, 286, 167-178. https://doi.org/10.1016/j.jconrel.2018.07.035
Tuiten, A., van Rooij, K., Bloemers, J., Eisenegger, C., van Honk, J., Kessels, R., Kingsberg, S., Derogatis, L. R., de Leede, L., Gerritsen, J., Koppeschaar, H. P. F., Olivier, B., Everaerd, W., Frijlink, H. W., Höhle, D., de Lange, R. P. J., Böcker, K. B. E., & Pfaus, J. G. (2018). Efficacy and safety of on-demand use of 2 treatments designed for different etiologies of female sexual interest/arousal disorder: 3 Randomized Clinical Trials. Journal of Sexual Medicine, 15(2), 201-216. https://doi.org/10.1016/j.jsxm.2017.11.226
Kauppinen, A., Broekhuis, J., Grasmeijer, N., Tonnis, W., Ketolainen, J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle. European Journal of Pharmaceutics and Biopharmaceutics, 123, 50-58. https://doi.org/10.1016/j.ejpb.2017.11.009
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2018). FORMULATING ISONIAZID FOR DRY POWDER INHALATION BY SPRAY DRYING. Journal of aerosol medicine and pulmonary drug delivery, 31(2), A2-A2.
Broesder, A., Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., Frijlink, H. W., & Olinga, P. (2018). Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
Tuiten, A., Michiels, F., Böcker, K. B., Höhle, D., van Honk, J., de Lange, R. P., van Rooij, K., Kessels, R., Bloemers, J., Gerritsen, J., Janssen, P., de Leede, L., Meyer, J.-J., Everaerd, W., Frijlink, H. W., Koppeschaar, H. P., Olivier, B., & Pfaus, J. G. (2018). Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial. Women's health (London, England), 14. https://doi.org/10.1177/1745506518788970
Frijlink, H. W. (2018). Moeiteloos inhaleren. New scientist, (Special 'Engineering in Groningen'), 28-29.
Tian, Y., Visser, J. C., Klever, J. S., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Orodispersible films based on blends of trehalose and pullulan for protein delivery. European Journal of Pharmaceutics and Biopharmaceutics, 133, 104-111. https://doi.org/10.1016/j.ejpb.2018.09.016
Amssoms, K., Born, P. A., Beugeling, M., De Clerck, B., Van Gulck, E., Hinrichs, W. L. J., Frijlink, H. W., Grasmeijer, N., Kraus, G., Sutmuller, R., Simmen, K., & Baert, L. (2018). Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice. PLoS ONE, 13(8), e0202961. Article 0202961. https://doi.org/10.1371/journal.pone.0202961
Tomar, J., Biel, C., de Haan, C. A. M., Rottier, P. J. M., Petrovsky, N., Frijlink, H. W., Huckriede, A., Hinrichs, W. L. J., & Peeters, B. (2018). Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. European Journal of Pharmaceutics and Biopharmaceutics, 133, 85-95. https://doi.org/10.1016/j.ejpb.2018.10.008
Luinstra, M., Rutgers, A. W. F., Vroegop, S. J., Begeman, A., Lexmond, A. J., Grasmeijer, F., Hagedoorn, P., de Boer, A. H., & Frijlink, H. W. (2018). PHARMACOKINETIC EVALUATION AND TOLERABILITY OF INHALED DRY POWDER LEVODOPA IN PARKINSON'S DISEASE PATIENTS. Journal of aerosol medicine and pulmonary drug delivery, 31(2), A9-A9.
Gafar, F., Boudewijn, I. M., Cox, C. A., Vonk, J. M., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Postma, D. S., & van den Berge, M. (2018). Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. Respiratory Research, 19(1), Article 256. https://doi.org/10.1186/s12931-018-0961-2
Tian, Y., Visser, J. C., Frijlink, H. W., & Woerdenbag, H. (2018). Pullulan and trehalose based films for protein delivery in the oral cavity. Journal of Hepatology.
Bhide, Y., Tomar, J., Dong, W., de Vries-Idema, J., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2018). Pulmonary delivery of influenza vaccine formulations in cotton rats: Site of deposition plays a minor role in the protective efficacy against clinical isolate o H1N1pdm virus. Drug Delivery, 25(1), 533-545. https://doi.org/10.1080/10717544.2018.1435748
Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B., & van den Berge, M. (2018). Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. Pulmonary Pharmacology & Therapeutics, 49, 27-35. https://doi.org/10.1016/j.pupt.2018.01.004
Ruigrok, M. J. R., Xian, J.-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. https://doi.org/10.1016/j.ejpb.2018.11.005
Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, District of Columbia, United States.
Visser, J. C., Ten Seldam, I. E. J., van der Linden, I. J., Hinrichs, W. L. J., Veenendaal, R. F. H., Dijkers, E. C. F., & Woerdenbag, H. J. (2018). Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations. International journal of pharmaceutical compounding, 22(3), 247-251. https://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4480
Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
Beugeling, M., Grasmeijer, N., Born, P. A., van der Meulen, M., van der Kooij, R. S., Schwengle, K., Baert, L., Amssoms, K., Frijlink, H. W., & Hinrichs, W. L. J. (2018). The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts. International Journal of Pharmaceutics, 551(1-2), 195-202. https://doi.org/10.1016/j.ijpharm.2018.09.025
de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E., & Porte, R. J. (2019). Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury. Hepatology, 69(4), 1719-1734. https://doi.org/10.1002/hep.30365
Prins, G., Oosterhuis, D., Van Wijk, L. A., Shelton, L., & Olinga, P. (2018). Developing an Ex Vivo Non-Alcoholic Fatty Liver Disease Model Using Human Livers. Hepatology, 68, 1008A-1009A.
Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., de Jong, K. P., Mutsaers, H. A. M., & Olinga, P. (2018). In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β. Toxicology and Applied Pharmacology, 355, 127-137. https://doi.org/10.1016/j.taap.2018.07.001
Sharma, M., Patra, B., Hale, W., Karsten, R. E. H., Salentijn, G. I. J., Grajewski, M., Fuhrer, E., Zakhurdaeva, A., Mager, D., Korvink, J., Olinga, P., Verpoorte, E., & Utz, M. (2018). Micro magnetic resonance imaging of murine liver tissue slices on a microfluidic perfusion device. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1722-1724). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society .
Grajewski, M., Salentijn, G. I. J., Karsten, R. E. H., Olinga, P., & Verpoorte, E. (2018). Real-time monitoring of biliary transport in precision-cut liver slices. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1644-1646). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society .
Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., Mutsaers, H. A., & Olinga, P. (2018). Regional Differences in Intestinal Drug Metabolism. Drug Metabolism and Disposition, 46(11), 1879-1885. https://doi.org/10.1124/dmd.118.083428
Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018). Targeting Oxidative Stress for the Treatment of Liver Fibrosis. In B. Nilius, P. DeTombe, T. Gudermann, R. Jahn, & R. Lill (Eds.), Reviews of Physiology, Biochemistry and Pharmacology (pp. 71-102). (Reviews of Physiology Biochemistry and Pharmacology; Vol. 175). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/112_2018_10
Touw, D., Koc, S., Meints, J. W., Woerdenbag, H., Stoffers, S., & Pauline, K. (2018). Giftig gevolg van kauwen op blaadjes laurierkers. Pharmaceutisch Weekblad, 153(36), 18 - 19. https://www.pw.nl/achtergrond/2018/giftig-gevolg-van-kauwen-op-blaadjes-laurierkers

2017

Lexmond, A. J., Boudewijn, I. M., Hagedoorn, P., Schokker, S., Cox, C. A., Vonk, J. M., ten Hacken, N. H. T., Frijlink, H. W., Vroegop, S. J., & van den Berge, M. (2018). Bronchial Provocation Testing Can Be Improved by Using Dry Powder Adenosine Instead of Nebulized Adenosine Monophosphate. American Journal of Respiratory and Critical Care Medicine, 197(3), 391-394. https://doi.org/10.1164/rccm.201704-0715LE
van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., Kim, Y. O., Frijlink, H. W., Schuppand, D., Poelstra, K., Hinrichs, W. L. J., & Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084
Patil, H. P., Herrera Rodriguez, J., de Vries-Idema, J., Meijerhof, T., Frijlink, H. W., Hinrichs, W. L. J., & Huckriede, A. (2017). Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation. Vaccines, 5(3). https://doi.org/10.3390/vaccines5030019
Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2017). How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions. European Journal of Pharmaceutics and Biopharmaceutics, 114, 288-295. https://doi.org/10.1016/j.ejpb.2017.01.024
Mensink, M., Hinrichs, W., Frijlink, H. W., & van der Voort Maarschalk, K. (2017). Kleine, flexibele suikers meest geschikt voor stabilisatie eiwit. Pharmaceutisch Weekblad, 43. http://www.pw.nl/achtergrond/2017/kleine-flexibele-suikers-meest-geschikt-voor-stabilisatie-eiwit
Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., Post, E., Hillebrands, J. L., Frijlink, H. W., Poelstra, K., Beljaars, L., Olinga, P., & Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y
van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., Hinrichs, W., Schuppan, D., Poelstra, K., & Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
Mensink, M. A., S ̌ib í k, J., Frijlink, H. W., Maarschalk, K. V. D. V., Hinrichs, W. L. J., & Zeitler, J. A. (2017). Thermal Gradient Mid- and Far-Infrared Spectroscopy as Tools for Characterization of Protein Carbohydrate Lyophilizates. Molecular pharmaceutics, 14(10), 3550-3557. https://doi.org/10.1021/acs.molpharmaceut.7b00568
Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., Poelstra, K., Frijlink, E., Hinrichs, W., & Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.
Caviglia, J. M., Yan, J., Jang, M.-K., Gwak, G.-Y., Affo, S., Yu, L., Olinga, P., Friedman, R. A., Chen, X., & Schwabe, R. F. (2018). MicroRNA-21 and Dicer are Dispensable for Hepatic Stellate Cell Activation and the Development of Liver Fibrosis. Hepatology, 67(6). https://doi.org/10.1002/hep.29627
Boorsma, C. E., van der Veen, T. A., Putri, K. S. S., de Almeida, A., Draijer, C., Mauad, T., Fejer, G., Brandsma, C.-A., van den Berge, M., Bossé, Y., Sin, D., Hao, K., Reithmeier, A., Andersson, G., Olinga, P., Timens, W., Casini, A., & Melgert, B. N. (2017). A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Scientific Reports, 7(1), Article 12570. https://doi.org/10.1038/s41598-017-12623-w
Mortensen, J. H., van Haaften, W. T., Olesen, M. L., Karsdal, M., Olinga, P., Dijkstra, G., & Bay-Jensen, A. .-C. (2017). Early suppression of the serological macrophage activity biomarker VICM, and not suppression of CRP, predicts the response to infliximab in Crohn's disease patients. Journal of Crohn's and Colitis, 11, S423-S424.
Luangmonkong, T., Suriguga, S., Bigaeva, E., Boersema, M., Oosterhuis, D., de Jong, K. P., Schuppan, D., Mutsaers, H. A. M., & Olinga, P. (2017). Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. British Journal of Pharmacology, 174(18), 3107-3117. https://doi.org/10.1111/bph.13945
Pasricha, S.-R., Lim, P. J., Duarte, T., Casu, C., Mleczko-Sanecka, K., Suciu, M., Areas, J., Da Silva, A. R., Frost, J., McHugh, K., Porto, G., Draper, S., Gooding, S., Olinga, P., Muckenthaler, M., Rivella, S., Hughes, J., Milne, T., Armitage, A., & Drakesmith, H. (2017). Hepcidin is an HDAC3 regulated gene and its expression is determined by promoter-associated histone acetylation. American Journal of Hematology, 92(8), E351-E351.
Visser, J. C., Weggemans, O. A. F., Boosman, R. J., Loos, K. U., Frijlink, H. W., & Woerdenbag, H. J. (2017). Increased drug load and polymer compatibility of bilayered orodispersible films. European Journal of Pharmaceutical Sciences, 107, 183-190. https://doi.org/10.1016/j.ejps.2017.07.010
Alting, E. K., Riphagen, L. M., Schuiling-Veninga, C. C. M., Brouwers, J. R. B. J., & Woerdenbag, H. J. (2017). Is er een plaats voor voedingsmiddelen verrijkt met fytosterolen bij cardiovasculair risicomanagement? Kritische analyse van de bewijskracht voor cholesterol-verlaging. Pharmaceutisch Weekblad, 152(15), 20-32. https://www.knmp.nl/resolveuid/90b1976595c54359a3239a7fbc2e0a3b
Alting, E. K., Riphagen, LM., Schuiling-Veninga, C. C. M., Brouwers, J. R. B. J., & Woerdenbag, H. (2017). Is er een plaats voor voedingsmiddelen verrijkt met fytosterolen bij cardiovasculair risicomanagement? Kritische analyse van de bewijskracht voor cholesterolverlaging. Nederlands Platform voor Farmaceutisch Onderzoek, 2, 1-13. Article A 1641.
Jacobs, M. S., Luinstra, M., Moes, J. R., Chan, T. C. Y., Minovic, I., Frijlink, H. W., & Woerdenbag, H. J. (2017). Ready-to-use parenteral amiodarone: A feasibility study towards a long-term stable product formulation. European Journal of Hospital Pharmacy: Science and Practice, 24(2), 110-114. https://doi.org/10.1136/ejhpharm-2015-000860
Gerrits, E., Woerdenbag, H., Luurtsema, G., de Hooge, M., & Boersma, H. (2017). The added value of Good Manufacturing Practices (GMP) in the production of radiopharmaceuticals. In The added value of Good Manufacturing Practice (GMP) in the production of radiopharmaceuticals (pp. 59-67). Springer. https://doi.org/10.1007/978-3-319-33531-5_3
Woerdenbag, H. J., Bos, R., & Scheffer, J. J. C. (2017). Valerian: Quality assurance of the crude drug and its preparations. In P. Houghton (Ed.), Valerian: The Genus Valeriana (pp. 101-128). Routledge. https://doi.org/10.1201/9780203734483
Jacobs, M. S., Hemminga, W. L., Woerdenbag, H. J., Bouma, M., & Moes, J. R. (2017). Zero-residual syringe als verpakkingsmateriaal voor bevacizumab als intravitreale injectie - Antwoord van de auteurs. Pharmaceutisch Weekblad, 152(3).

2016

Visser, J., Eugresya, G., Hinrichs, W., Tjandrawinata, R., Avanti, C., Frijlink, H. W., & Woerdenbag, H. (2017). Development of orodispersible films with selected Indonesian medicinal plant extracts. Journal of Herbal Medicine, 7, 37-46. https://doi.org/10.1016/j.hermed.2016.10.002
Grasmeijer, N., Frijlink, H. W., & Hinrichs, W. L. J. (2016). An adaptable model for growth and/or shrinkage of droplets in the respiratory tract during inhalation of aqueous particles. Journal of Aerosol Science, 93, 21-34. https://doi.org/10.1016/j.jaerosci.2015.11.011
Setyaningsih, D., Murti, Y. B., Martono, S., Hinrichs, W. L. J., Hertiani, T., & Fudholi, A. (2016). A novel reversed phase high performance liquid chromatography method to accurately determine low concentrations of curcumin in rat plasma. International Journal of Pharmaceutical and Clinical Research, 8(5), Suppl. 377-386.
Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Steendam, R., Zuidema, J., Poelstra, K., Frijlink, H. W., & Olinga, P. (2016). Biodegradable microspheres for the sustained release of PDGF-receptor directed pPB-HSA targeted to the fibrotic kidney. Abstract from FIGON Dutch Medicine Days, Ede, Netherlands.
Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., Frijlink, H. W., & Olinga, P. (2016). Biodegradable microspheres for the sustained release of PDGF-receptor directed PPB-HSA targeted to the fibrotic kidney. Poster session presented at Congress on Innovation in Drug Delivery, Antibes, France.
Teekamp, N., van Dijk, F., Beljaars, E., Post, E., Hinrichs, W., Poelstra, K., & Olinga, P. (2016). Biodegradable microspheres for the sustained release of ppB-HSA to target PDGFβ-receptors in fibrotic tissues. Poster session presented at 14th European Symposium on Controlled Drug Delivery (ESCDD), Egmond aan Zee, Netherlands.
Frijlink, H. W., Grasmeijer, N., Hinrichs, W. L. J., Amssoms, K. I. E., & Baert, L. E. C. (2016). Compacted Solid Dosage Form. (Patent No. WO2016020308). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2016020308A1&KC=A1&FT=D&ND=3&date=20160211&DB=&locale=en_EP
Maurer, J. M., Hofman, S., Schellekens, R. C. A., Tonnis, W. F., Dubois, A. O. T., Woerdenbag, H. J., Hinrichs, W. L. J., Kosterink, J. G. W., & Frijlink, H. W. (2016). Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study. International Journal of Pharmaceutics, 505(1-2), 175-186. https://doi.org/10.1016/j.ijpharm.2016.03.027
Tomar, J., Born, P. A., Frijlink, H. W., & Hinrichs, W. L. J. (2016). Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination. Expert review of vaccines, 15(11), 1431-1447. https://doi.org/10.1080/14760584.2016.1182869
Mensink, M. A., Nethercott, M. J., Hinrichs, W. L. J., Maarschalk, K. V. D. V., Frijlink, H. W., Munson, E. J., & Pikal, M. J. (2016). Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability. Aaps journal, 18(5), 1225-1232. https://doi.org/10.1208/s12248-016-9937-7
Grasmeijer, N., Frijlink, H. W., & Hinrichs, W. L. J. (2016). Model to predict inhomogeneous protein-sugar distribution in powders prepared by spray drying. Journal of Aerosol Science, 101, 22-33. https://doi.org/10.1016/j.jaerosci.2016.07.012
Ruigrok, M., Frijlink, H. W., & Hinrichs, W. (2016). Pulmonary administration of small interfering RNA: The route to go? Journal of Controlled Release, 235, 14-23. https://doi.org/10.1016/j.jconrel.2016.05.054
Visser, J. C., Woerdenbag, H. J., Hanff, L. M., & Frijlink, H. W. (2017). Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films. Aaps pharmscitech, 104(5), 1292-1300. https://doi.org/10.1208/s12249-016-0515-1
Cremers, T., Flik, G., Frijlink, H. W., & Woerdenbag, H. J. (2016). Body Sculpting. (Patent No. WO2016060564). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2016060564A1&KC=A1&FT=D&ND=3&date=20160421&DB=&locale=en_EP
Jacobs, M. S., Hemminga, W., Woerdenbag, H., Bouma, M., & Moes, J. R. (2016). Kwalificatie van de zero-residual syringe (Zeringe) als verpakkingsmateriaal voor bevacizumab als intravitreale injectie. Pharmaceutisch Weekblad Wetenschappelijk Platform, 1-6.
Krampe, R., Visser, C., Frijlink, H. W., Breitkreutz, J., Woerdenbag, H. J., & Preis, M. (2016). Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes. Expert Opinion on Drug Delivery, 13(4), 493-506. https://doi.org/10.1517/17425247.2016.1118048

2015

Patil, H. P., Murugappan, S., de Vries-Idema, J., Meijerhof, T., de Haan, A., Frijlink, H. W., Wilschut, J., Hinrichs, W. L. J., & Huckriede, A. (2015). Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration. European Journal of Pharmaceutics and Biopharmaceutics, 93, 231-241. https://doi.org/10.1016/j.ejpb.2015.04.004
Murugappan, S., Frijlink, H. W., Petrovsky, N., & Hinrichs, W. L. J. (2015). Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant. European Journal of Pharmaceutical Sciences, 66, 118-122. https://doi.org/10.1016/j.ejps.2014.10.008
Mensink, M. A., Van Bockstal, P.-J., Pieters, S., De Meyer, L., Frijlink, H. W., van der Voort Maarschalk, K., Hinrichs, W. L. J., & De Beer, T. (2015). In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability. International Journal of Pharmaceutics, 792-800. https://doi.org/10.1016/j.ijpharm.2015.11.030
Mensink, M. A., Frijlink, H. W., Maarschalk, K. V. D. V., & Hinrichs, W. L. J. (2015). Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics. Carbohydrate Polymers, 130, 405-419. https://doi.org/10.1016/j.carbpol.2015.05.026
Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2015). Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydrate Polymers, 134, 418-428. https://doi.org/10.1016/j.carbpol.2015.08.022
Visser, C., Woerdenbag, H. J., Crediet, S., Gerrits, E., Lesschen, M. A., Hinrichs, W. L. J., Breitkreutz, J., & Frijlink, H. W. (2015). Orodispersible films in individualized pharmacotherapy: The development of a formulation for pharmacy preparations. International Journal of Pharmaceutics, 478(1), 155-163. https://doi.org/10.1016/j.ijpharm.2014.11.013
Hinrichs, W., & Dreijer - van der Glas, S. (2015). Physical Chemistry. In Practical Pharmaceutics, an international guideline for the preparation care and use of medicinal products (pp. 357-382). Springer. https://doi.org/10.1007/978-3-319-15814-3_18
Stanković, M., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today, 20(7), 812-823. https://doi.org/10.1016/j.drudis.2015.01.012
Teekamp, N., Duque , L. F., Frijlink, H. W., Hinrichs, W. L., & Olinga, P. (2015). Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins. Expert Opinion on Drug Delivery, 12(8), 1311-1331. https://doi.org/10.1517/17425247.2015.1003807
Stanković, M., Hiemstra, C., de Waard, H., Zuidema, J., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants. International Journal of Pharmaceutics, 480(1-2), 73-83. https://doi.org/10.1016/j.ijpharm.2015.01.007
Teekamp, N., Olinga, P., Hinrichs, W., & Frijlink, H. W. (2015). Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Hydrophilicity of Polymers and Sugar Glass Pre-stabilization. Poster session presented at Biopharmacy Day 2015, Leuven, Belgium.
Teekamp, N., Olinga, P., Frijlink, H. W., & Hinrichs, W. (2015). Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Hydrophilicity of Polymers and Sugar Glass Pre-stabilization. Poster session presented at AAPS Annual Meeting and Exposition, Orlando, United States. http://abstracts.aaps.org/Verify/AAPS2015/PosterSubmissions/R6255.pdf
Tonnis, W. F., Huckriede, A. L. W., Hinrichs, W. L. J., & Frijlink, H. W. (2015). Pulmonary administration of subunit vaccines. In C. Foged, T. Rades, Y. Perrie, & S. Hook (Eds.), Subunit Vaccine Delivery (pp. 307-329). (Advances in Delivery Science and Technology). Springer. https://doi.org/10.1007/978-1-4939-1417-3_16
Visser, J. C., Dohmen, W. M. C., Hinrichs, W. L. J., Breitkreutz, J., Frijlink, H. W., & Woerdenbag, H. J. (2015). Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. International Journal of Pharmaceutics, 485(1-2), 70-76. https://doi.org/10.1016/j.ijpharm.2015.03.005
Tonnis, W. F., Mensink, M. A., de Jager, A., Maarschalk, K. V. D. V., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Size and molecular flexibility of sugars determine the storage stability of freeze-dried proteins. Molecular pharmaceutics, 12(3), 684-694. https://doi.org/10.1021/mp500423z
Beugeling, M., Ekoume, F., Woerdenbag, H. J., Luurtsema, G., Lub-de Hooge, M. N., Touw, D. J., Rubow, S. M., & Boersma, H. H. (2015). Assessment of microbiological monitoring for the evaluation of GMP-compliance at a department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen. European Journal of Nuclear Medicine and Molecular Imaging, 42(1), 486.
Woerdenbag, H., Sznitowska, M., & Bouwman-Boer, Y. (2015). Basic Operations. In Practical Pharmaceutics, An international guideline for the preparation care and use of medicinal products (pp. 651-676). Springer. https://doi.org/10.1007/978-3-319-15814-3_29
Frijlink, H. W., Touw, D., & Woerdenbag, H. (2015). Biopharmaceutics. In Practical Pharmaceutics, An international guideline for the preparation care and use of medicinal products (pp. 323-346). Springer. https://doi.org/10.1007/978-3-319-15814-3_16
Maurer, J. M., Schellekens, R. C. A., van Rieke, H. M., Wanke, C., Iordanov, V., Stellaard, F., Wutzke, K. D., Dijkstra, G., van der Zee, M., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2015). Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets. PLoS ONE, 10(7), Article e0129076. https://doi.org/10.1371/journal.pone.0129076
Haas, S., Woerdenbag, H., & Sznitowska, M. (2015). Rectal and Vaginal. In Practical Pharmaceutics, An international guideline for the preparation care and use of medicinal products (pp. 189-227). Article 11 Springer. https://doi.org/10.1007/978-3-319-15814-3_11
de Roo, F. M., Hilgerink, K., Kosterink, J. G. W., Luurtsema, G., Woerdenbag, H. J., & Boersma, H. H. (2015). Tracer application in cardiovascular imaging: A triple jump. In R. Slart, R. Tio, P. Elsinga, & M. Schwaiger (Eds.), Autonomic Innervation of the Heart: Role of Molecular Imaging (pp. 137-159). Springer. https://doi.org/10.1007/978-3-662-45074-1_7

2014

Tonnis, W. F., Bagerman, M., Weij, M., Sjollema, J., Frijlink, H. W., Hinrichs, W. L. J., & de Boer, A. H. (2014). A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals. European Journal of Pharmaceutics and Biopharmaceutics, 88(3), 1056-1063. https://doi.org/10.1016/j.ejpb.2014.10.011
Patil, H. P., Murugappan, S., Ter Veer, W., Meijerhof, T., De Haan, A., Frijlink, H. W., Wilschut, J., Hinrichs, W. L. J., & Huckriede, A. (2014). Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine. Journal of controlled release : official journal of the Controlled Release Society, 174(1), 51-62. https://doi.org/10.1016/j.jconrel.2013.11.013
Tonnis, W. F., Amorij, J.-P., Vreeman, M. A., Frijlink, H. W., Kersten, G. F., & Hinrichs, W. L. J. (2014). Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars. European Journal Pharmaceutical Sciences, 55(1), 36-45. https://doi.org/10.1016/j.ejps.2014.01.005
de Jesus, M. B., Radaic, A., Hinrichs, W. L. J., Ferreira, C. V., de Paula, E., Hoekstra, D., & Zuhorn, I. S. (2014). Inclusion of the helper lipid dioleoyl-phosphatidylethanolamine in solid lipid nanoparticles inhibits their transfection efficiency. Journal of biomedical nanotechnology, 10(2), 1-11. https://doi.org/10.1166/jbn.2014.1804
Rosas, J. G., de Waard, H., De Beer, T., Vervaet, C., Remon, J. P., Hinrichs, W. L. J., Frijlink, H. W., & Blanco, M. (2014). NIR spectroscopy for the in-line monitoring of a multicomponent formulation during the entire freeze-drying process. Journal of Pharmaceutical and Biomedical Analysis, 97, 39-46. https://doi.org/10.1016/j.jpba.2014.04.010
Yska, J. P., Punter, R. J., Woerdenbag, H. J., Apers, J. A., Emous, M., Totte, E., Frijlink, H. W., Wilffert, B., & van Roon, E. N. (2014). A GASTROINTESTINAL SIMULATION SYSTEM (GISS) FOR DISSOLUTION OF DRUGS BEFORE AND AFTER ROUX-EN-Y GASTRIC BYPASS: FIRST RESULTS. British Journal of Clinical Pharmacology, 78(4), 774-774. https://doi.org/10.1111/bcp.12400
Elfahmi, Woerdenbag, H. J., & Kayser, O. (2014). Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. Journal of Herbal Medicine, 4(2), 51-73. https://doi.org/10.1016/j.hermed.2014.01.002
Gechev, T. S., Hille, J., Woerdenbag, H. J., Benina, M., Mehterov, N., Toneva, V., Fernie, A. R., & Mueller-Roeber, B. (2014). Natural products from resurrection plants: Potential for medical applications. Biotechnology Advances, 32(6), 1091-1101. https://doi.org/10.1016/j.biotechadv.2014.03.005

2013

Maurer, J. M., Schellekens, R. C. A., Van Rieke, H. M., Stellaard, F., Wutzke, K. D., Buurman, D. J., Dijkstra, G., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2013). ColoPulse tablets perform comparably in healthy volunteers and Crohn's patients and show no influence of food and time of food intake on bioavailability. Journal of controlled release : official journal of the Controlled Release Society, 172(3), 618-624. https://doi.org/10.1016/j.jconrel.2013.09.021
Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2013). Erratum: Applications of stable isotopes in clinical pharmacology (vol 72, pg 879, 2011). British Journal of Clinical Pharmacology, 75(4), 1171. https://doi.org/10.1111/bcp.12107
Woerdenbag, H., Visser, C., & Frijlink, H. (2013). Pharmacy preparations, customized quality in Dutch clinical care. 19-22. Pharma Indochina VIII. ASEAN Pharmacy - Integration for development, Hanoi, Viet Nam.
Woerdenbag, H., & Brouwers, J. R. B. J. (2013). Traditionele geneeskunde in Vietnam. Nederlands Tijdschrift voor Fytotherapie, 1, 9-13.

2012

Maurer, M. J. M., Schellekens, R. C. A., Wutzke, K. D., Dijkstra, G., Woerdenbag, H. J., Frijlink, H. W., Kosterink, J. G. W., & Stellaard, F. (2012). A non-invasive, low-cost study design to determine the release profile of colon drug delivery systems: A feasibility study. Pharmaceutical Research, 29(8), 2070-2078. https://doi.org/10.1007/s11095-012-0735-3
Tu, H. A., Vu, H. D., Rozenbaum, M. H., Woerdenbag, H. J., & Postma, M. J. (2012). A review of the literature on the economics of vaccination against TB. Expert review of vaccines, 11(3), 303-317. https://doi.org/10.1586/ERV.11.197
Tu, H. A. T., de Vries, R., Woerdenbag, H. J., Li, S. C., Le, H. H., van Hulst, M., & Postma, M. J. (2012). Cost-Effectiveness Analysis of Hepatitis B Immunization in Vietnam: Application of Cost-Effectiveness Affordability Curves in Health Care Decision Making. Value in Health Regional Issues, 1(1), 7-14. https://doi.org/10.1016/j.vhri.2012.03.007
Tu, H. A., de Vries, R., Woerdenbag, H., Li, SC., Le, H., Phan, TL., van Hulst, M., & Postma, M. (2012). Cost-effectiveness of hepatitis B immunization in Vietnam: application of affordability curves in decision making. Value in Health, (Regional issue) (1), 7-14.
Tu, H. A. T., Woerdenbag, H. J., Riewpaiboon, A., Kane, S., Le, D. M., Postma, M. J., & Li, S. C. (2012). Cost of Illness of Chronic Hepatitis B Infection in Vietnam. Value in Health Regional Issues, 1(1), 23-28. https://doi.org/10.1016/j.vhri.2012.03.008
Tu, H., Riewpaiboon , A., Woerdenbag, H., Le, H., Le, MD., Phan, TL., Postma, M., & Li, SC. (2012). Cost-of-illness of chronic hepatitis B in Vietnam. Value in Health, 1( (Regional Issue) ), 23-28.
Bakker, P., Woerdenbag, H., Gooskens, V., Naafs, B., Kaaij, R. V. D., & Wieringa, N. (2012). Dermatological preparations for the tropics. A formulary of dermatological preparations and background information on choices, production and dispensing. s.n.
Tu, H.-A. T., Rozenbaum, M. H., Coyte, P. C., Li, S. C., Woerdenbag, H. J., & Postma, M. J. (2012). Health economics of rotavirus immunization in Vietnam: Potentials for favorable cost-effectiveness in developing countries. Vaccine, 30(8), 1521-1528. https://doi.org/10.1016/j.vaccine.2011.11.052
Hendrawati, O., Hille, J., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2012). In vitro regeneration of wild chervil (Anthriscus sylvestris L.). In vitro cellular & developmental biology-Plant, 48(3), 355-361. https://doi.org/10.1007/s11627-011-9410-3
Hendrawati, O., Woerdenbag, H. J., Hille, J., & Kayser, O. (2012). Metabolic Engineering of Medicinal Plants and Microorganisms for the Production of Natural Products. In O. Kayser, & H. Warzecha (Eds.), Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications, Second Edition (pp. 491-526). s.n..
Woerdenbag, H. J., Nguyen, T. M., Vu, D. V., Tran, H., Nguyen, D. T., Tran, T. V., De Smet, P. A., & Brouwers, J. R. (2012). Vietnamese traditional medicine from a pharmacist's perspective. Expert Review of Clinical Pharmacology, 5(4), 459-477. https://doi.org/10.1586/ecp.12.34

2011

Hendrawati, O., Hille, J., Woerdenbag, H. J., Warzecha, H., Dekker, F. J., Quax, W. J., & Kayser, O. (2011). Agrobacterium mediated transformation of Anthriscus sylvestris with human cytochrome P450 3A4 followed by regeneration. In Studies on Anthriscus sylvestris L. (HOFFM.): Metabolic engineering of combinatorial biosynthesis of podophyllotoxin (pp. 93-106)
Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2011). Applications of stable isotopes in clinical pharmacology. British Journal of Clinical Pharmacology, 72(6), 879-897. https://doi.org/10.1111/j.1365-2125.2011.04071.x
Tu, H. A. T., Woerdenbag, H. J., Kane, S., Rozenbaum, M. H., Li, S. C., & Postma, M. J. (2011). Economic evaluations of rotavirus immunization for developing countries: a review of the literature. Expert review of vaccines, 10(7), 1037-1051. https://doi.org/10.1586/ERV.11.65
Woerdenbag, H. J., Dillingh, J. H., Wanders, J. T. M., Boer, E. J., Frijlink, H. W., Kosterink, J. G. W., & Schellekens, R. C. A. (2011). Elastomeer-infuuspompen getest voor de praktijk. Pharmaceutisch Weekblad, 146(15), 58-64.
Hendrawati, O., Woerdenbag, H. J., Michiels, P. J. A., Aantjes, H. G., van Dam, A., & Kayser, O. (2011). Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR. Phytochemistry, 72(17), 2172-2179. https://doi.org/10.1016/j.phytochem.2011.08.009
Hendrawati, O., Woerdenbag, H. J., Hille, J., Quax, W. J., & Kayser, O. (2011). Seasonal Variations in the Deoxypodophyllotoxin Content and Yield of Anthriscus sylvestris L. (Hoffm.) Grown in the Field and under Controlled Conditions. Journal of Agricultural and Food Chemistry, 59(15), 8132-8139. https://doi.org/10.1021/jf200177q

2010

Staniek, A., Muntendam, R., Woerdenbag, H. J., & Kayser, O. (2010). Essential oil constituents derived from different organs of a relictual conifer Wollemia nobilis. Biochemical Systematics and Ecology, 38(2), 131-135. https://doi.org/10.1016/j.bse.2009.12.022
Schellekens, R. C. A., Baltink, J. H., Woesthuis, E. M., Stellaard, F., Kosterink, J. G. W., Woerdenbag, H. J., & Frijlink, H. W. (2010). Film coated tablets (ColoPulse technology) for targeted delivery in the lower intestinal tract: influence of the core composition on release characteristics. Pharmaceutical development and technology, 17(1), 40-47. https://doi.org/10.3109/10837450.2010.513986
Hendrawati, O., Woerdenbag, H. J., Hille, J., & Kayser, O. (2010). Metabolic engineering strategies for the optimization of medicinal and aromatic plants: realities and expectations. Zeitschrift für Arznei- & Gewurzpflanzen, 15(3), 111-126.
Schellekens, R. C. A., Stellaard, F., Olsder, G. G., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2010). Oral ileocolonic drug delivery by the colopulse-system: A bioavailability study in healthy volunteers. Journal of controlled release : official journal of the Controlled Release Society, 146(3), 334-340. https://doi.org/10.1016/j.jconrel.2010.05.028
Ruslan Wirasutisna, K., Batterman, S., Koulman, A., Kayser, O., Woerdenbag, H. J., & Quax, W. J. (2010). Reduced Coniferin and Enhanced 6-Methoxypodophyllotoxin Production in Linum flavum Cell Cultures. Pharmacognosy Journal, 2(17), 74-80. https://doi.org/10.1016/S0975-3575(10)80015-X
Tu, H. A. T., Bos, J. H. J., Woerdenbag, H. J., Visser, S. T., Wilschut, J. C., van Assen, S., de Jong-van den Berg, L. T. W., & Postma, M. J. (2010). Results of a retrospective database analysis of drug utilization and costs for treatment of chronic hepatitis B virus infection in the northern Netherlands between 2000 and 2006. Clinical Therapeutics, 32(1), 133-144. https://doi.org/10.1016/j.clinthera.2010.01.015
Staniek, A., Woerdenbag, H. J., & Kayser, O. (2010). Screening the endophytic flora of Wollemia nobilis for alternative paclitaxel sources. Journal of plant interactions, 5(3), 189-195. https://doi.org/10.1080/17429141003714721

2009

Aslan, S., Kartal, M., Kurucu, S., Kuiper, J. M., Kruizinga, W. H., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Composition of the Essential Oil From Roots and Rhizomes of Valeriana phu L. Growing Wild in Turkey. Journal of Essential Oil Research, 21(5), 437-440.
Tu, H. A. T., Woerdenbag, H. J., Kane, S., Riewpaiboon, A., van Hulst, M., & Postma, M. J. (2009). Economic evaluations of hepatitis B vaccination for developing countries. Expert review of vaccines, 8(7), 907-920. https://doi.org/10.1586/ERV.09.53
Azizi, M., Davareenejad, G., Woerdenbag, H. J., & Kayser, O. (2009). Essential oil content and constituents of black zira [bunium persicum [boiss.] b. fedtsch.) from iran during field cultivation (domestication). Journal of Essential Oil Research, 21(3), 193-194. https://doi.org/10.1080/10412905.2009.9700145
Azizi, M., Davareenejad, G., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Essential Oil Content and Constituents of Black Zira (Bunium persicum [Boiss.] B. Fedtsch.) from Iran During Field Cultivation (Domestication). Journal of Essential Oil Research, 21(1), 78-82.
Maurer, J. M., Kouwen, S., Woerdenbag, H. J., Brouwers, J. R. B. J., Kosterink, J. G. W., & Schellekens, R. C. A. (2009). Pharmacotherapeutic rationale of pharmacy drug compounding: Evaluation and applicability of the guideline from the Laboratory of Dutch Pharmacists (LNA). Pharmaceutisch Weekblad, 144(51-52), 217-222.
Ozbay, O., Aslan, S., Kartal, M., Kurucu, S., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Preliminary Examination of the Composition of the Essential Oil From the Roots and Rhizomes of Valeriana alpestris Stev. Growing in Turkey. Journal of Essential Oil Research, 21(6), 555-557.
Schellekens, R. C. A., Olsder, G. G., Langenberg, S. M. C. H., Boer, T., Woerdenbag, H. J., Frijlink, H. W., Kosterink, J. G. W., & Stellaard, F. (2009). Proof-of-concept study on the suitability of 13C-urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms. British Journal of Pharmacology, 158(2), 532-540. https://doi.org/10.1111/j.1476-5381.2009.00302.x
Staniek, A., Woerdenbag, H. J., & Kayser, O. (2009). Taxomyces andreanae: A Presumed Paclitaxel Producer Demystified? Planta Medica, 75(15), 1561-1566. https://doi.org/10.1055/s-0029-1186181

2008

Julsing, M. K., Fichera, M. A., Malz, F., Ebbelaar, M., Bos, R., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2008). Bioconversion of Mono- and Sesquiterpenoids by Recombinant Human Cytochrome P450 Monooxygenases. Pharmaceutical biology, 46(10-11), 710-718. https://doi.org/10.1080/13880200802215487
Staniek, A., Woerdenbag, H. J., & Kayser, O. (2008). Endophytes: Exploiting biodiversity for the improvement of natural product-based drug discovery. Journal of plant interactions, 3(2), 75-93. https://doi.org/10.1080/17429140801886293
Elfahmi, K. R., Bos, R., Kayser, O., Woerdenbag, H. J., & Quax, W. J. (2008). Jamu: The Indonesian traditional herbal medicine. In Phytochemical and biosynthetic studies of lignans: With a focus on Indonesian medicinal plants (pp. 13)
Last modified:09 June 2023 8.36 p.m.