Publications

van der Kooij, R. S., Beukema, M., Huckriede, A. L. W., Zuidema, J., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2023). A Single Injection with Sustained-Release Microspheres and a Prime-Boost Injection of Bovine Serum Albumin Elicit the Same IgG Antibody Response in Mice. Pharmaceutics, 15(2), [676]. https://doi.org/10.3390/pharmaceutics15020676

de Jong, I. E. M., Bodewes, S. B., van Leeuwen, O. B., Oosterhuis, D., Lantinga, V. A., Thorne, A. M., Lascaris, B., van den Heuvel, M. C., Wells, R. G., Olinga, P., de Meijer, V. E., & Porte, R. J. (2023). Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion. Transplantation. https://doi.org/10.1097/TP.0000000000004531

van der Kooij, R. S., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2022). An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 170, 24-42. https://doi.org/10.1016/j.ejpb.2021.11.007

Jansen, E. M., Frijlink, H. W., Hinrichs, W. L. J., & Ruigrok, M. J. R. (2022). Are inhaled mRNA vaccines safe and effective? A review of preclinical studies. Expert Opinion on Drug Delivery, 19(11), 1471-1485. https://doi.org/10.1080/17425247.2022.2131767

Heida, R., Born, P. A., Tapia-Calle, G., Frijlink, H. W., Salvati, A., Huckriede, A. L. W., & Hinrichs, W. L. J. (2022). Assessing the Immunomodulatory Effect of Size on the Uptake and Immunogenicity of Influenza- and Hepatitis B Subunit Vaccines In Vitro. Pharmaceuticals, 15(7), [887]. https://doi.org/10.3390/ph15070887

Tian, Y., Lee, J., van der Maaden, K., Bhide, Y., de Vries-Idema, J. J., Akkerman, R., O'Mahony, C., Jiskoot, W., Frijlink, H. W., Huckriede, A. L. W., Hinrichs, W. L. J., Bouwstra, J. A., & Beukema, M. (2022). Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2022.01.033

Woerdenbag, H. J., Visser, J. C., Leferink Op Reinink, M. P. A. M., van Orsoy, R. R., Eissens, A. C., Hagedoorn, P., Dijkstra, H., Allersma, D. P., Ng, S. W., Smeets, O. S. N. M., & Frijlink, H. W. (2022). Performance of Tablet Splitters, Crushers, and Grinders in Relation to Personalised Medication with Tablets. Pharmaceutics, 14(2), [320]. https://doi.org/10.3390/pharmaceutics14020320

Ruigrok, M. J. R., Roest, M. A. P., Frijlink, H. W., Olinga, P., Hinrichs, W. L. J., & Melgert, B. N. (2022). RANKL confers protection against cell death in precision-cut lung slices. Frontiers in Physiology, 13, [1029697]. https://doi.org/10.3389/fphys.2022.1029697

de Reus, Y. A., Hagedoorn, P., Sturkenboom, M. G. G., Grasmeijer, F., Bolhuis, M. S., Sibum, I., Kerstjens, H. A. M., Frijlink, H. W., & Akkerman, O. W. (2022). Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers. PLoS ONE, 17(8), [e0272034]. https://doi.org/10.1371/journal.pone.0272034

Li, M., de Meijer, V., Olinga, P., Nagelkerke, A., & Geng, Y. (2022). Development of an ex vivo model for non-alcoholic fatty liver disease using precision-cut liver slices. Journal of Hepatology, 77, S711-S711.

Suriguga, S., Li, M., Luangmonkong, T., Boersema, M., de Jong, K. P., Oosterhuis, D., Gorter, A. R., Beljaars, L., & Olinga, P. (2022). Distinct responses between healthy and cirrhotic human livers upon lipopolysaccharide challenge: possible implications for acute-on-chronic liver failure. American journal of physiology. Gastrointestinal and liver physiology, 323(2), G114-G125. https://doi.org/10.1152/ajpgi.00243.2021

Luo, K., Geng, Y., de Meijer, V., Oosterhuis, D., & Olinga, P. (2022). Evaluation of the antifibrotic effects of naringenin, asiatic acid and icariin by using precision-cut liver slices of mouse and human. Journal of Hepatology, 77, S484-S484.

van Furth, L. A., Leuvenink, H. G. D., Seras, L., Graaf, I. A. M. D., Olinga, P., & Leeuwen, L. L. V. (2022). Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury. Transplantology, 3(2), 139–151. https://doi.org/10.3390/transplantology3020015

Biel, C., Martinec, O., Sibering, B., van Summeren, K., Wessels, A. M. A., Touw, D. J., de Jong, K. P., de Meijer, V. E., Faber, K. N., Klooster, J. P. T., de Graaf, I. A. M., & Olinga, P. (2022). Extending the viability of human precision-cut intestinal slice model for drug metabolism studies. Archives of toxicology. https://doi.org/10.1007/s00204-022-03295-1

Karsten, R. E. H., Krijnen, N. J. W., Maho, W., Permentier, H., Verpoorte, E., & Olinga, P. (2022). Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis. Archives of toxicology, 96(9), 2523-2543. https://doi.org/10.1007/s00204-022-03321-2

Adhyatmika, A., Putri, K. S. S., Gore, E., Mangnus, K. A., Reker-Smit, C., Schuppan, D., Beljaars, L., Olinga, P., & Melgert, B. N. (2022). Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ. Cellular physiology and biochemistry, 56(1), 28-38. https://doi.org/10.33594/000000492

van Leeuwen, L., Leuvenink, H. G. D., Olinga, P., & Ruigrok, M. (2022). Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants: Supplementing Perfusion Solutions With Anti-fibrotic Drugs. Frontiers in Medicine, 8, [806774]. https://doi.org/10.3389/fmed.2021.806774

Puerta Cavanzo, N., Riesmeijer, S. A., Holt-Kedde, I. L., Werker, P. M. N., Piersma, B., Olinga, P., & Bank, R. A. (2022). Verteporfin ameliorates fibrotic aspects of Dupuytren's disease nodular fibroblasts irrespective the activation state of the cells. Scientific Reports, 12(1), [13940]. https://doi.org/10.1038/s41598-022-18116-9

van Hunsel, F. P. A. M., van der Kooi, D., van de Koppel, S., Kroes, B. H., & Woerdenbag, H. J. (2022). Analysis of Reports on Adverse Drug Reactions Related to Herbal Medicinal Products and Herbal Supplements in the Netherlands Received by the National Pharmacovigilance Centre Lareb. Drug Safety, 45(6), 651-661. https://doi.org/10.1007/s40264-022-01180-5

Borgonje, P. E., Wibier, L., Noordman, P., Woerdenbag, H. J., & Gareb, B. (2022). The Development and Implementation of Airflow Visualization Studies ("Smoke" Studies) as a Training Tool in Aseptic Hospital Compounding Facilities. Pharmacy (Basel, Switzerland), 10(5), [101]. https://doi.org/10.3390/pharmacy10050101

Heida, R., Hinrichs, W. L. J., & Frijlink, H. W. (2022). Inhaled vaccine delivery in the combat against respiratory viruses: A 2021 overview of recent developments and implications for COVID-19. Expert review of vaccines, 21(7), 957-974. https://doi.org/10.1080/14760584.2021.1903878

Larmené-Beld, K., Wijnsma, R., Kuiper, A., van Berkel, S., Robben, H., Taxis, K., & Frijlink, H. (2022). Science- and risk-based strategy to qualify prefillable autoclavable syringes as primary packaging material. European Journal of Hospital Pharmacy: Science and Practice, 29(5), 248-254. https://doi.org/10.1136/ejhpharm-2020-002333

Broesder, A., Bircan, S. Y., De Waard, A. B., Eissens, A. C., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Formulation and in vitro evaluation of pellets containing sulfasalazine and caffeine to verify ileo-colonic drug delivery. Pharmaceutics, 13(12), [1985]. https://doi.org/10.3390/pharmaceutics13121985

Ruigrok, M. J. R., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2021). Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions. Molecular Therapy - Methods & Clinical Development, 20, 483-496. https://doi.org/10.1016/j.omtm.2021.01.003

Broesder, A., Berends, J. M. E., Scheepers, S. M., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems. Pharmaceutics, 13(5). https://doi.org/10.3390/pharmaceutics13050731

Gareb, B., Beugeling, M., Posthumus, S., Otten, A. T., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2021). Infliximab formulation strategy for a stable ileo-colonic targeted oral dosage form intended for the topical treatment of inflammatory bowel disease. Journal of drug delivery science and technology, 64, [102552]. https://doi.org/10.1016/j.jddst.2021.102552

van der Kooij, R. S., Steendam, R., Zuidema, J., Frijlink, H. W., & Hinrichs, W. L. J. (2021). Microfluidic Production of Polymeric Core-Shell Microspheres for the Delayed Pulsatile Release of Bovine Serum Albumin as a Model Antigen. Pharmaceutics, 13(11), [1854]. https://doi.org/10.3390/pharmaceutics13111854

Zillen, D., Beugeling, M., Hinrichs, W. L. J., Frijlink, H. W., & Grasmeijer, F. (2021). Natural and bioinspired excipients for dry powder inhalation formulations. Current Opinion in Colloid and Interface Science, 56, [101497]. https://doi.org/10.1016/j.cocis.2021.101497

Ruigrok, M. J. R., El Amasi, K. E. M., Leeming, D. J., Sand, J. M. B., Frijlink, H. W., Hinrichs, W. L. J., & Olinga, P. (2021). Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis? Frontiers in Medicine, 8, [607962]. https://doi.org/10.3389/fmed.2021.607962

Sahal, G., Woerdenbag, H. J., Hinrichs, W. L. J., Visser, A., van der Mei, H. C., & Bilkay, I. S. (2021). Candida Biofilm Formation Assay on Essential Oil Coated Silicone Rubber. Bio-Protocol, 11(5), [3941]. https://doi.org/10.21769/BioProtoc.3941

Setyaningsih, D., Santoso, Y. A., Hartini, Y. S., Murti, Y. B., Hinrichs, W. L. J., & Patramurti, C. (2021). Isocratic high-performance liquid chromatography (HPLC) for simultaneous quantification of curcumin and piperine in a microparticle formulation containing Curcuma longa and Piper nigrum. Heliyon, 7(3), [e06541]. https://doi.org/10.1016/j.heliyon.2021.e06541

Chakraborty, P., Oosterhuis, D., Bonsignore, R., Casini, A., Olinga, P., & Scheffers, D-J. (2021). An organogold compound as potential antimicrobial agent against drug resistant bacteria: Initial mechanistic insights. ChemMedChem, 16(19), 3060-3070. https://doi.org/10.1002/cmdc.202100342

van Praagh, J. B., de Wit, J. G., Olinga, P., de Haan, J. J., Nagengast, W. B., Fehrmann, R. S. N., & Havenga, K. (2021). Colorectal anastomotic leak: Transcriptomic profile analysis. British Journal of Surgery, 108(3), 326-333. https://doi.org/10.1093/bjs/znaa066

Geng, Y., Buist-Homan, M., Olinga, P., Blokzijl, H., & Moshage, H. (2021). Conditioned medium of hepatic stellate cells induces a pro-inflammatory phenotype in kupffer cells via the release of extracellular vesicles. Hepatology, 74, 808A-809A.

Mutsaers, H. A. M., Nørregaard, R., & Olinga, P. (2021). Editorial: Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets. Frontiers in Medicine, 8, [793507]. https://doi.org/10.3389/fmed.2021.793507

Pasmans, K., Adriaens, M. E., Olinga, P., Langen, R., Rensen, S. S., Schaap, F. G., Olde Damink, S. W. M., Caiment, F., van Loon, L. J. C., Blaak, E. E., & Meex, R. C. R. (2021). Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk. Frontiers in endocrinology, 12, 733625. https://doi.org/10.3389/fendo.2021.733625

Li, M., Oosterhuis, D., De Meijer, V. E., Olinga, P., & Geng, Y. (2021). High saccharides, fatty acids and insulin promote a fibrogenic phenotype of healthy, but not nash, human precision-cut liver slices. Hepatology, 74, 1069A-1069A.

Geng, Y., Oosterhuis, D., De Meijer, V. E., & Olinga, P. (2021). Lipids inhibit the progression of fibrosis in human nash precision-cut liver slices and human hepatic stellate cells. Hepatology, 74, 1077A-1077A.

Jensen, C. G., Jensen, M. S., Tingskov, S. J., Olinga, P., Nørregaard, R., & Mutsaers, H. A. M. (2021). Local inhibition of indoleamine 2, 3-dioxygenase mitigates renal fibrosis. Biomedicines, 9(8), [856]. https://doi.org/10.3390/biomedicines9080856

Puerta Cavanzo, N., Bigaeva, E., Boersema, M., Olinga, P., & Bank, R. A. (2021). Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited. Frontiers in Medicine, 7, [615774]. https://doi.org/10.3389/fmed.2020.615774

Bartucci, R., van der Meer, A. Z., Boersma, Y. L., Olinga, P., & Salvati, A. (2021). Nanoparticle-induced inflammation and fibrosis in ex vivo murine precision-cut liver slices and effects of nanoparticle exposure conditions. Archives of toxicology, 95, 1267–1285. https://doi.org/10.1007/s00204-021-02992-7

Martinec, O., Biel, C., de Graaf, I. A. M., Huliciak, M., de Jong, K. P., Staud, F., Cecka, F., Olinga, P., Vokral, I., & Cerveny, L. (2021). Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices. Frontiers in Pharmacology, 12, [684156]. https://doi.org/10.3389/fphar.2021.684156

van Furth, L., Maassen, H., Venema, L., & Olinga, P. (2021). The effect of the ketogenic diet on mitochondrial function in porcine precision-cut kidney slices. Transplant International, 34(S1), 273-274.

Prins, G. H., Rios-Morales, M., Gerding, A., Reijngoud, D-J., Olinga, P., & Bakker, B. M. (2021). The Effects of Butyrate on Induced Metabolic-Associated Fatty Liver Disease in Precision-Cut Liver Slices. Nutrients, 13(12), [4203]. https://doi.org/10.3390/nu13124203

Henstra, C., van Praagh, J., Olinga, P., & Nagelkerke, A. (2021). The gastrointestinal microbiota in colorectal cancer cell migration and invasion. Clinical & experimental metastasis, 38, 495–510. https://doi.org/10.1007/s10585-021-10130-x

Majorova, D., Atkins, E., Martineau, H., Vokral, I., Oosterhuis, D., Olinga, P., Wren, B., Cuccui, J., & Werling, D. (2021). Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction. Frontiers in Veterinary Science, 8, [686088]. https://doi.org/10.3389/fvets.2021.686088

Herawati, F., Yulia, R., Arifin, B., Frasetyo, I., Setiasih, Woerdenbag, H. J., Avanti, C., & Andrajati, R. (2021). Educational Video Improves Knowledge about Outpatients' Usage of Antibiotics in Two Public Hospitals in Indonesia. Antibiotics , 10(5), [606]. https://doi.org/10.3390/antibiotics10050606

Zulzaga, Z., Myagmarsuren, E., Woerdenbag, H. J., & van Puijenbroek, E. P. (2021). Legislation and current developments in adverse drug reaction reporting in Mongolia: how far are we? Journal of Pharmaceutical Policy and Practice, 14(1), [15]. https://doi.org/10.1186/s40545-021-00298-8

Heida, R., Bhide, Y. C., Gasbarri, M., Kocabiyik, Ö., Stellacci, F., Huckriede, A. L. W., Hinrichs, W. L. J., & Frijlink, H. W. (2021). Advances in the development of entry inhibitors for sialic-acid-targeting viruses. Drug Discovery Today, 26(1), 122-137. https://doi.org/10.1016/j.drudis.2020.10.009

Akkerman-Nijland, A. M., Akkerman, O. W., Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., Rottier, B. L., Koppelman, G. H., & Touw, D. J. (2021). The pharmacokinetics of antibiotics in cystic fibrosis. Expert Opinion on Drug Metabolism & Toxicology, 17(1), 53-68. https://doi.org/10.1080/17425255.2021.1836157

Hagedoorn, P., Bawary, W., Frijlink, H. W., & Grasmeijer, F. (2020). A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers. Journal of Allergy and Clinical Immunology: In Practice, 8(3), 1124-1125.e4. https://doi.org/10.1016/j.jaip.2019.09.021

Sibum, I., Hagedoorn, P., Botterman, C. O., Frijlink, H. W., & Grasmeijer, F. (2020). Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops(R)High Dose Dry Powder Inhalation Device While Maintaining Dispersibility. Pharmaceutics, 12(7), 1-14. [645]. https://doi.org/10.3390/pharmaceutics12070645

Akkerman-Nijland, A. M., Grasmeijer, F., Kerstjens, H. A. M., Frijlink, H. W., van der Vaart, H., Vonk, J. M., Hagedoorn, P., Rottier, B. L., Koppelman, G. H., & Akkerman, O. W. (2020). Colistin dry powder inhalation with the Twincer (TM): An effective and more patient friendly alternative to nebulization. PLoS ONE, 15(9), [e0239658]. https://doi.org/10.1371/journal.pone.0239658

Hagedoorn, P., Grasmeijer, F., Bawari, W., Frijlink, H. W., & Grasmeijer, F. (2020). Comparing five antistatic valved holding chambers: How antistatic are they really? European Respiratory Journal, 56. https://doi.org/10.1183/13993003.congress-2020.3177

Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2020). De ontwikkeling van budesonidetabletten met nulde-orde-afgifte voor de behandeling van ileo-colonische inflammatoire darmziekten en vergelijking met huidige, commerciële preparaten. Pharmaceutisch Weekblad, 155(6), 29-36. https://www.npfo.nl/artikel/de-ontwikkeling-van-budesonidetabletten-met-nulde-orde-afgifte-voor-de-behandeling-van-ileo

Tian, Y., Bhide, Y. C., Woerdenbag, H. J., Huckriede, A. L. W., Frijlink, H. W., Hinrichs, W. L. J., & Visser, J. C. (2020). Development of an Orodispersible Film Containing Stabilized Influenza Vaccine. Pharmaceutics, 12(3), [245]. https://doi.org/10.3390/pharmaceutics12030245

Weerts, Z. Z. R. M., Masclee, A. A. M., Witteman, B. J. M., Clemens, C. H. M., Winkens, B., Brouwers, J. R. B. J., Frijlink, H. W., Muris, J. W. M., De Wit, N. J., Essers, B. A. B., Tack, J., Snijkers, J. T. W., Bours, A. M. H., de Ruiter-van der Ploeg, A. S., Jonkers, D. M. A. E., & Keszthelyi, D. (2020). Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome. Gastroenterology, 158(1), 123-136. [158]. https://doi.org/10.1053/j.gastro.2019.08.026

Akkerman-Nijland, A. M., Yousofi, M., Rottier, B. L., Van der Vaart, H., Burgerhof, J. G. M., Frijlink, H. W., Touw, D. J., Koppelman, G. H., & Akkerman, O. W. (2020). Eradication of Pseudomonas aeruginosa in cystic fibrosis patients with inhalation of dry powder tobramycin. Therapeutic advances in respiratory disease, 14, [1753466620905279]. https://doi.org/10.1177/1753466620905279

Pleguezuelos, O., Dille, J., de Groen, S., Oftung, F., Niesters, H. G. M., Islam, M. A., Naess, L. M., Hungnes, O., Aldarij, N., Idema, D. L., Perez, A. F., James, E., Frijlink, H. W., Stoloff, G., Groeneveld, P., & Hak, E. (2020). Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults. Annals of Internal Medicine, 172(7), 453-462. https://doi.org/10.7326/M19-0735

Nguyen, K. T. T., Frijlink, H. W., & Hinrichs, W. L. J. (2020). Inhomogeneous Distribution of Components in Solid Protein Pharmaceuticals: Origins, Consequences, Analysis, and Resolutions. Journal of Pharmaceutical Sciences, 109(1), 134-153. https://doi.org/10.1016/j.xphs.2019.10.010

Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2020). Optimisation of an isoniazid dry powder formulation for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 33(2), A2-A2.

Broesder, A., Woerdenbag, H. J., Prins, G. H., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2020). pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems. Drug Discovery Today, 25(8), 1362-1373. https://doi.org/10.1016/j.drudis.2020.06.011

Broesder, A., Kosta, A-M. M. A. C., Woerdenbag, H. J., Nguyen, D. N., Frijlink, H. W., & Hinrichs, W. L. J. (2020). pH-dependent ileocolonic drug delivery, part II: Preclinical evaluation of novel drugs and novel excipients. Drug Discovery Today, 25(8), 1374-1388. https://doi.org/10.1016/j.drudis.2020.06.012

Larmene-Beld, K. H. M., van Berkel, S., Wijnsma, R., Taxis, K., & Frijlink, H. W. (2020). Prefilled Cyclic Olefin Sterilized Syringes of Norepinephrine Injection Solution Do Not Need to Be Stabilized by Antioxidants. Aaps pharmscitech, 21(7), 247. [247]. https://doi.org/10.1208/s12249-020-01784-z

Hagedoorn, P., Bawary, W., Frijlink, H. W., & Grasmeijer, F. (2020). Relative lung dose from antistatic valved holding chambers Reply. Journal of Allergy and Clinical Immunology: In Practice, 8(3), 1166-1167. https://doi.org/10.1016/j.jaip.2019.11.023

Gareb, B., Otten, A. T., Frijlink, H. W., Dijkstra, G., & Kosterink, J. G. W. (2020). Review: Local Tumor Necrosis Factor-alpha Inhibition in Inflammatory Bowel Disease. Pharmaceutics, 12(6), 1-31. [539]. https://doi.org/10.3390/pharmaceutics12060539

Kocabiyik, O., Cagno, V., Silva, P. J., Zhu, Y., Sedano, L., Bhide, Y., Mettier, J., Medaglia, C., Da Costa, B., Constant, S., Huang, S., Kaiser, L., Hinrichs, W. L. J., Huckeriede, A., Le Goffic, R., Tapparel, C., & Stellacci, F. (2021). Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo. Advanced science, 8(3), [2001012]. https://doi.org/10.1002/advs.202001012

Smith-Cortinez, N., Fagundes, R. R., Gomez, V., Kong, D., de Waart, D. R., Heegsma, J., Sydor, S., Olinga, P., de Meijer, V. E., Taylor, C. T., Bank, R., Paulusma, C. C., & Faber, K. N. (2021). Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition. The FASEB Journal, 35(2), [e21219]. https://doi.org/10.1096/fj.202001564RR

Mortensen, J. H., van Haaften, W. T., Karsdal, M. A., Bay-Jensen, A-C., Olinga, P., Grønbæk, H., Hvas, C. L., Manon-Jensen, T., Dijkstra, G., & Dige, A. (2021). The Citrullinated and MMP-degraded Vimentin Biomarker (VICM) Predicts Early Response to Anti-TNF alpha Treatment in Crohn's Disease. Journal of clinical gastroenterology, 55(1), 59-66. https://doi.org/10.1097/MCG.0000000000001341

Bartucci, R., Paramanandana, A., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Comparative study of nanoparticle uptake and impact in murine lung, liver and kidney tissue slices. Nanotoxicology, 14(6), 847-865. https://doi.org/10.1080/17435390.2020.1771785

Nomden, M., Beljaars, L., Verkade, H. J., Hulscher, J. B. F., & Olinga, P. (2020). Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature. Frontiers in Medicine, 7, [617261]. https://doi.org/10.3389/fmed.2020.617261

van Dijk, F., Hazelhoff, C. M., Post, E., Prins, G. G. H., Rombouts, K., Poelstra, K., Olinga, P., & Beljaars, L. (2020). Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis. Pharmaceutics, 12(3), [278]. https://doi.org/10.3390/pharmaceutics12030278

Bigaeva, E., Gore, E., Mutsaers, H. A. M., Oosterhuis, D., Kim, Y. O., Schuppan, D., Bank, R. A., Boersema, M., & Olinga, P. (2020). Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices. Biochimica et biophysica acta-Molecular basis of disease, 1866(1), [165582]. https://doi.org/10.1016/j.bbadis.2019.165582

Suriguga, S., Luangmonkong, T., Mutsaers, H. A. M., Groothuis, G. M. M., & Olinga, P. (2020). Host microbiota dictates the proinflammatory impact of LPS in the murine liver. Toxicology in Vitro, 67, [104920]. https://doi.org/10.1016/j.tiv.2020.104920

van Haaften, W. T., Blokzijl, T., Hofker, H. S., Olinga, P., Dijkstra, G., Bank, R. A., & Boersema, M. (2020). Intestinal stenosis in Crohn's disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets. Therapeutic advances in gastroenterology, 13. https://doi.org/10.1177/1756284820952578

Gore, E., Bigaeva, E., Oldenburger, A., Jansen, Y. J. M., Schuppan, D., Boersema, M., Rippmann, J. F., Broermann, A., & Olinga, P. (2020). Investigating fibrosis and inflammation in an ex vivo NASH murine model. American Journal of Physiology. Gastrointestinal and Liver Physiology, 318(2), G336-G351. https://doi.org/10.1152/ajpgi.00209.2019

Luangmonkong, T., & Olinga, P. (2020). Modified culture protocol for testing anti-fibrotic drugs using precision-cut liver slices. Pharmaceutical Sciences Asia, 47(3), 301-309. https://doi.org/10.29090/psa.2020.03.019.0137

Iswandana, R., Pham, B. T., Suriguga, S., Luangmonkong, T., van Wijk, L. A., Jansen, Y. J. M., Oosterhuis, D., Maria Mutsaers, H. A., & Olinga, P. (2020). Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs. Inflammatory Bowel Diseases, 26(5), 678-686. https://doi.org/10.1093/ibd/izz329

Adhyatmika, A., Beljaars, L., Putri, K. S. S., Habibie, H., Boorsma, C. E., Reker-Smit, C., Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post, E., Poelstra, K., Ravnskjaer, K., Olinga, P., & Melgert, B. N. (2020). Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver. Pharmaceutics, 12(5), [471]. https://doi.org/10.3390/pharmaceutics12050471

Prins, G. H., & Olinga, P. (2020). Potential implications of COVID-19 in non-alcoholic fatty liver disease. Liver International, 40(10), 2568. https://doi.org/10.1111/liv.14484

Bigaeva, E., Puerta Cavanzo, N., Stribos, E. G. D., de Jong, A. J., Biel, C., Mutsaers, H. A. M., Jensen, M. S., Nørregaard, R., Leliveld, A. M., de Jong, I. J., Hillebrands, J-L., van Goor, H., Boersema, M., Bank, R. A., & Olinga, P. (2020). Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis. Pharmaceutics, 12(5), [459]. https://doi.org/10.3390/pharmaceutics12050459

Habibie, H., Song, S., Putri, K., Boorsma, C., Cool, R., Wu, X., Gosens, R., Wang, Y., Quax, W., Olinga, P., Brandsma, C-A., Timens, W., Burgess, J., & Melgert, B. (2020). RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation. European Respiratory Journal, 56. https://doi.org/10.1183/13993003.congress-2020.5029

van Haaften, W. T., Mortensen, J. H., Dige, A. K., Gronbaek, H., Hvas, C. L., Bay-Jensen, A-C., Karsdal, M. A., Olinga, P., Manon-Jensen, T., & Dijkstra, G. (2020). Serological Biomarkers of Tissue Turnover Identify Responders to Anti-TNF Therapy in Crohn's Disease: A Pilot Study. Clinical and translational gastroenterology, 11(9), e00217. [00217]. https://doi.org/10.14309/ctg.0000000000000217

Biel, C., Bigaeva, E., Hesse, M., Bomers, J. J. M., van Summeren, K., Teunis, M. A. T., Vaessen, S., Ten Klooster, J. P., & Olinga, P. (2020). Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices. Toxicology in Vitro, 69, [104974]. https://doi.org/10.1016/j.tiv.2020.104974

Bartucci, R., Åberg, C., Melgert, B. N., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Time-Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision-Cut Liver Slices. Small, 16(21), [e1906523]. https://doi.org/10.1002/smll.201906523

Koster, A. S., Mantel-Teeuwisse, A. K., Woerdenbag, H. J., Mulder, W. M. C., Wilffert, B., Schalekamp, T., Buurma, H., Wilting, I., & Westein, M. P. D. (2020). Alignment of CanMEDS-Based Undergraduate and Postgraduate Pharmacy Curricula in The Netherlands. Pharmacy (Basel, Switzerland), 8(3), [117]. https://doi.org/10.3390/pharmacy8030117

Visser, J. C., Wibier, L., Kiefer, O., Orlu, M., Breitkreutz, J., Woerdenbag, H. J., & Taxis, K. (2020). A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films. Pharmaceutics, 12(2), [164]. https://doi.org/10.3390/pharmaceutics12020164

Mulder, S. M. E., Jipping, A-M., Silvester, N., van Hunsel, F. P. A. M., Kroes, B. H., & Woerdenbag, H. J. (2020). Gelijktijdig gebruik van zuclopentixol en ayurvedische producten: Veilig of niet? Nederlands Platform voor Farmaceutisch Onderzoek, (5), [a1732].

Woerdenbag, H., & Hak, E. (2020). Interview-based cross-sectional needs assessment to advance the implementation of an effective antibiotic stewardship program in Indonesian hospitals. Health Policy OPEN, 1, [100002]. https://doi.org/10.1016/j.hpopen.2019.100002

Visser, J. C., Wibier, L., Mekhaeil, M., Woerdenbag, H. J., & Taxis, K. (2020). Orodispersible films as a personalized dosage form for nursing home residents, an exploratory study. International Journal of Clinical Pharmacy, 42(2), 436–444. https://doi.org/10.1007/s11096-020-00990-w

Busscher, H. J., Woudstra, W., van Kooten, T. G., Jutte, P., Shi, L., Liu, J., Hinrichs, W. L. J., Frijlink, H. W., Shi, R., Liu, J., Parvizi, J., Kates, S., Rotello, V. M., Schaer, T. P., Williams, D., Grainger, D. W., & van der Mei, H. C. (2020). Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. Biomaterials, 232, [119737]. https://doi.org/10.1016/j.biomaterials.2019.119737

Yska, J. P., Wanders, J. T. M., Odigie, B., Apers, J. A., Emous, M., Totté, E. R. E., Boerma, E. C., Ubels, F. L., Woerdenbag, H. J., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2020). Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery. European Journal of Hospital Pharmacy: Science and Practice, 27(E1), e19–e24. https://doi.org/10.1136/ejhpharm-2018-001804

Boudewijn, I. M., Lan, A., Faiz, A., Cox, C. A., Brouwer, S., Schokker, S., Vroegop, S. J., Nawijn, M. C., Woodruff, P. G., Christenson, S. A., Hagedoorn, P., Frijlink, H. W., Choy, D. F., Brouwer, U., Wisman, M., Postma, D. S., Fingleton, J., Beasley, R., van den Berge, M., & Guryev, V. (2020). Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy, 75(1), 191-194. https://doi.org/10.1111/all.13952

Yska, J. P., Punter, R. J., Woerdenbag, H. J., Emous, M., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2019). A gastrointestinal simulation system for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass. European Journal of Hospital Pharmacy: Science and Practice, 26(3), 152-156. https://doi.org/10.1136/ejhpharm-2017-001360

Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., ten Hacken, N. H. T., Kerstjens, H. A. M., & van den Berge, M. (2019). Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma. BMC Pulmonary Medicine, 19(1), [23]. https://doi.org/10.1186/s12890-019-0783-0

Larmené-Beld, K. H. M., Frijlink, H. W., & Taxis, K. (2019). A systematic review and meta-analysis of microbial contamination of parenteral medication prepared in a clinical versus pharmacy environment. European Journal of Clinical Pharmacology, 75(5), 609-617. https://doi.org/10.1007/s00228-019-02631-2

Sibum, I., Hagedoorn, P., Frijlink, H. W., & Grasmeijer, F. (2019). Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation. Pharmaceutics, 11(5), [233]. https://doi.org/10.3390/pharmaceutics11050233

Janssen, R., Wouters, E. F. M., Janssens, W., Daamen, W. F., Hagedoorn, P., de Wit, H. A. J. M., Serre, J., Gayan-Ramirez, G., Franssen, F. M. E., Reynaert, N. L., von der Thusen, J. H., & Frijlink, H. W. (2019). Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale. International Journal of Chronic Obstructive Pulmonary Disease, 14, 2587-2602. https://doi.org/10.2147/COPD.S228411

Beugeling, M., Amssoms, K., Cox, F., De Clerck, B., Van Gulck, E., Verwoerd, J., Kraus, G., Roymans, D., Baert, L., Frijlink, H. W., & Hinrichs, W. (2019). Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study. Pharmaceutics, 11(10), [510]. https://doi.org/10.3390/pharmaceutics11100510

Sibum, I., Hagedoorn, P., Kluitman, M. P. G., Kloezen, M., Frijlink, H. W., & Grasmeijer, F. (2019). Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine. Pharmaceutics, 12(1), [24]. https://doi.org/10.3390/pharmaceutics12010024

Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2019). Formulating Amikacin for dry powder inhalation. Journal of aerosol medicine and pulmonary drug delivery, 32(2), A7-A7. https://doi.org/10.1089/jamp.2019.ab01.abstracts

Luinstra, M., Isufi, V., de Jong, L., Rutgers, A. W. F., Hagedoorn, P., Puttenstein, J., van Laar, T., & Frijlink, H. W. (2019). Learning from Parkinson's patients: Usability of the Cyclops dry powder inhaler. International Journal of Pharmaceutics, 567, 118493. [118493]. https://doi.org/10.1016/j.ijpharm.2019.118493

Tian, Y., Orlu, M., Woerdenbag, H. J., Scarpa, M., Kiefer, O., Kottke, D., Sjoholm, E., Oblom, H., Sandler, N., Hinrichs, W. L. J., Frijlink, H. W., Breitkreutz, J., & Visser, J. C. (2019). Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery, 16(9), 981-993. https://doi.org/10.1080/17425247.2019.1652595

Luinstra, M., Rutgers, W., van Laar, T., Grasmeijer, F., Begeman, A., Isufi, V., Steenhuis, L., Hagedoorn, P., de Boer, A., & Frijlink, H. W. (2019). Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson's disease. Therapeutic advances in chronic disease, 10. https://doi.org/10.1177/2040622319857617

Tomar, J., Tonnis, W. F., Patil, H. P., de Boer, A. H., Hagedoorn, P., Vanbever, R., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination. Acta Pharmaceutica Sinica B, 9(6), 1231-1240. https://doi.org/10.1016/j.apsb.2019.05.003

Beugeling, M., De Zee, J., Woerdenbag, H. J., Frijlink, H. W., Wilschut, J. C., & Hinrichs, W. L. J. (2019). Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly. Expert review of vaccines, 18(9), 935-950. https://doi.org/10.1080/14760584.2019.1657013

van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., Steendam, R., Klose, M. H. M., Meier-Menches, S. M., Casini, A., Horvatovich, P. L., Sijbrandi, N. J., Frijlink, H. W., Hinrichs, W. L. J., Poelstra, K., Beljaars, L., & Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039

Ruigrok, M., Tomar, J., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2019). The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices. Scientific Reports, 9(1), [16239]. https://doi.org/10.1038/s41598-019-52813-2

Gareb, B., Posthumus, S., Beugeling, M., Koopmans, P., Touw, D. J., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2019). Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process. Pharmaceutics, 11(9), [428]. https://doi.org/10.3390/pharmaceutics11090428

Murti, Y. B., Hartini, Y. S., Hinrichs, W. L. J., Frijlink, H. W., & Setyaningsih, D. (2019). UV-Vis spectroscopy to enable determination of the dissolution behavior of solid dispersions containing curcumin and piperine. Journal of Young Pharmacists, 11(1), 26-30. https://doi.org/10.5530/jyp.2019.11.6

Sahal, G., Woerdenbag, H. J., Hinrichs, W. L. J., Visser, A., Tepper, P. G., Quax, W. J., van der Mei, H. C., & Bilkay, I. S. (2020). Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study. Journal of ethnopharmacology, 246, [112188]. https://doi.org/10.1016/j.jep.2019.112188

Tapia-Calle, G., Born, P. A., Koutsoumpli, G., Gonzalez-Rodriguez, M. I., Hinrichs, W. L. J., & Huckriede, A. L. W. (2019). A PBMC-Based System to Assess Human T Cell Responses to Influenza Vaccine Candidates In Vitro. Vaccines, 7(4), [181]. https://doi.org/10.3390/vaccines7040181

Bigaeva, E., Stribos, E. G. D., Mutsaers, H. A. M., Piersma, B., Leliveld, A. M., de Jong, I. J., Bank, R. A., Seelen, M. A., van Goor, H., Wollin, L., Olinga, P., & Boersema, M. (2020). Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis. American journal of physiology-Renal physiology, 318(1), F117-F134. https://doi.org/10.1152/ajprenal.00108.2019

Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T-H., & Norregaard, R. (2019). Activation of the prostaglandin E-2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica, 227(1), [e13291]. https://doi.org/10.1111/apha.13291

Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T-H., & Norregaard, R. (2019). Administration of a selective prostaglandin E-2 receptor agonist attenuates renal fibrosis in vitro and in vivo. FASEB Journal, 33.

Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J., & Olinga, P. (2019). A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. Nutrients, 11(3), [507]. https://doi.org/10.3390/nu11030507

Mutsaers, H. A. M., Jensen, M. S., Olinga, P., & Norregaard, R. (2019). Cyclooxygenase-2 Regulates the Renal Expression of Indoleamine 2,3-dioxygenase. FASEB Journal, 33.

Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019). Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro, 59, 312-321. https://doi.org/10.1016/j.tiv.2019.05.024

Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Olinga, P., & Gier, K. (2019). INDUCTION OF STEATOSIS IN HUMAN LIVER EX VIVO. Hepatology, 70, 1311A-1311A.

van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2019). Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage. Annals of Surgery, 269(5), 911-916. https://doi.org/10.1097/SLA.0000000000002651

Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., Quax, W. J., Olinga, P., Hirsch, A. K. H., & Dekker, F. J. (2019). Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. Journal of Medicinal Chemistry, 62(9), 4624-4637. https://doi.org/10.1021/acs.jmedchem.9b00212

de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E., & Porte, R. J. (2019). Peribiliary glands are key in regeneration of the biliary epithelium after severe ischemic bile duct injury during liver transplantation. Transplantation, 103(8), 3-3. https://doi.org/10.1097/01.tp.0000580472.17422.db

Gore, E., Bigaeva, E., Oldenburger, A., Ook, K. Y., Rippmann, J. F., Schuppan, D., Boersema, M., & Olinga, P. (2019). PI3K inhibition reduces murine and human liver fibrogenesis in precisioncut liver slices. Biochemical Pharmacology, 169, [113633]. https://doi.org/10.1016/j.bcp.2019.113633

Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Dekker, F. J., Olinga, P., & Gier, K. (2019). POLYUNSATURATED FATTY ACIDS AND 5-LIPOXYGENASE IN NON-ALCOHOLIC FATTY LIVER DISEASE. Hepatology, 70, 1311A-1311A.

Bartucci, R., Åberg, C., Boersma, Y. L., Olinga, P., & Salvati, A. (2019). Precision-cut liver slices as a promising ex vivo model for nanosafety studies. Toxicology Letters, 314(Supplement), S204-S205.

Bigaeva, E., Gore, E., Simon, E., Zwick, M., Oldenburger, A., de Jong, K. P., Hofker, H. S., Schlepütz, M., Nicklin, P., Boersema, M., Rippmann, J. F., & Olinga, P. (2019). Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices. Archives of toxicology, 93(12), 3549-3583. https://doi.org/10.1007/s00204-019-02611-6

Bartucci, R., Salvati, A., Olinga, P., & Boersma, Y. L. (2019). Vanin 1: Its Physiological Function and Role in Diseases. International Journal of Molecular Sciences, 20(16), [3891]. https://doi.org/10.3390/ijms20163891

Herawati, F., Yulia, R., Hak, E., Hartono, A. H., Michiels, T., Woerdenbag, H. J., & Avanti, C. (2019). A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia. Hospital Pharmacy Europe, 54(5), 323-329. https://doi.org/10.1177/0018578718792804

Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2019). Development of novel zero-order release budesonide tablets for the treatment of ileo-colonic inflammatory bowel disease and comparison with formulations currently used in clinical practice. International Journal of Pharmaceutics, 554, 366-375. https://doi.org/10.1016/j.ijpharm.2018.11.019

Grasmeijer, N., Tiraboschi, V., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle. European Journal of Pharmaceutical Sciences, 128, 152-157. https://doi.org/10.1016/j.ejps.2018.11.027

Tomar, J., Patil, H. P., Bracho, G., Tonnis, W. F., Frijlink, H. W., Petrovsky, N., Vanbever, R., Huckriede, A., & Hinrichs, W. L. J. (2018). Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. Journal of Controlled Release, 288, 199-211. https://doi.org/10.1016/j.jconrel.2018.09.006

Weerts, Z. Z. R. M., Keszthelyi, D., Vork, L., Aendekerk, N. C. P., Frijlink, H. W., Brouwers, J. R. B. J., Neef, C., Jonkers, D. M. A. E., & Masclee, A. A. M. (2018). A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers. Advances in therapy, 35(11), 1965-1978. https://doi.org/10.1007/s12325-018-0802-1

Sibum, I., Hagedoorn, P., de Boer, A. H., Frijlink, H. W., & Grasmeijer, F. (2018). Challenges for pulmonary delivery of high powder doses. International Journal of Pharmaceutics, 548(1), 325-336. https://doi.org/10.1016/j.ijpharm.2018.07.008

Akkerman, O. W., Grasmeijer, F., de Lange, W. C. M., Kerstjens, H. A. M., de Vries, G., Bolhuis, M. S., Alffenaar, J-W., Frijlink, H. W., Smith, G., Gajraj, R., de Zwaan, R., Hagedoorn, P., Dedicoat, M., van Soolingen, D., & van der Werf, T. S. (2018). Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis. European Respiratory Journal, 51(3), [1702490]. https://doi.org/10.1183/13993003.02490-2017

Kanojia, G., Raeven, R. H. M., van der Maas, L., Bindels, T. H. E., van Riet, E., Metz, B., Soema, P. C., Ten Have, R., Frijlink, H. W., Amorij, J-P., & Kersten, G. F. A. (2018). Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization. Journal of controlled release : official journal of the Controlled Release Society, 286, 167-178. https://doi.org/10.1016/j.jconrel.2018.07.035

Tuiten, A., van Rooij, K., Bloemers, J., Eisenegger, C., van Honk, J., Kessels, R., Kingsberg, S., Derogatis, L. R., de Leede, L., Gerritsen, J., Koppeschaar, H. P. F., Olivier, B., Everaerd, W., Frijlink, H. W., Höhle, D., de Lange, R. P. J., Böcker, K. B. E., & Pfaus, J. G. (2018). Efficacy and safety of on-demand use of 2 treatments designed for different etiologies of female sexual interest/arousal disorder: 3 Randomized Clinical Trials. Journal of Sexual Medicine, 15(2), 201-216. https://doi.org/10.1016/j.jsxm.2017.11.226

Kauppinen, A., Broekhuis, J., Grasmeijer, N., Tonnis, W., Ketolainen, J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle. European Journal of Pharmaceutics and Biopharmaceutics, 123, 50-58. https://doi.org/10.1016/j.ejpb.2017.11.009

Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2018). FORMULATING ISONIAZID FOR DRY POWDER INHALATION BY SPRAY DRYING. Journal of aerosol medicine and pulmonary drug delivery, 31(2), A2-A2.

Tuiten, A., Michiels, F., Böcker, K. B., Höhle, D., van Honk, J., de Lange, R. P., van Rooij, K., Kessels, R., Bloemers, J., Gerritsen, J., Janssen, P., de Leede, L., Meyer, J-J., Everaerd, W., Frijlink, H. W., Koppeschaar, H. P., Olivier, B., & Pfaus, J. G. (2018). Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial. Women's health (London, England), 14. https://doi.org/10.1177/1745506518788970

Frijlink, H. W. (2018). Moeiteloos inhaleren. New scientist, (Special 'Engineering in Groningen'), 28-29.

Tian, Y., Visser, J. C., Klever, J. S., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Orodispersible films based on blends of trehalose and pullulan for protein delivery. European Journal of Pharmaceutics and Biopharmaceutics, 133, 104-111. https://doi.org/10.1016/j.ejpb.2018.09.016

Amssoms, K., Born, P. A., Beugeling, M., De Clerck, B., Van Gulck, E., Hinrichs, W. L. J., Frijlink, H. W., Grasmeijer, N., Kraus, G., Sutmuller, R., Simmen, K., & Baert, L. (2018). Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice. PLoS ONE, 13(8), e0202961. [0202961]. https://doi.org/10.1371/journal.pone.0202961

Tomar, J., Biel, C., de Haan, C. A. M., Rottier, P. J. M., Petrovsky, N., Frijlink, H. W., Huckriede, A., Hinrichs, W. L. J., & Peeters, B. (2018). Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. European Journal of Pharmaceutics and Biopharmaceutics, 133, 85-95. https://doi.org/10.1016/j.ejpb.2018.10.008

Luinstra, M., Rutgers, A. W. F., Vroegop, S. J., Begeman, A., Lexmond, A. J., Grasmeijer, F., Hagedoorn, P., de Boer, A. H., & Frijlink, H. W. (2018). PHARMACOKINETIC EVALUATION AND TOLERABILITY OF INHALED DRY POWDER LEVODOPA IN PARKINSON'S DISEASE PATIENTS. Journal of aerosol medicine and pulmonary drug delivery, 31(2), A9-A9.

Gafar, F., Boudewijn, I. M., Cox, C. A., Vonk, J. M., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Postma, D. S., & van den Berge, M. (2018). Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. Respiratory Research, 19(1), [256]. https://doi.org/10.1186/s12931-018-0961-2

Tian, Y., Visser, J. C., Frijlink, H. W., & Woerdenbag, H. (2018). Pullulan and trehalose based films for protein delivery in the oral cavity. Journal of Hepatology.

Bhide, Y., Tomar, J., Dong, W., de Vries-Idema, J., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2018). Pulmonary delivery of influenza vaccine formulations in cotton rats: Site of deposition plays a minor role in the protective efficacy against clinical isolate o H1N1pdm virus. Drug Delivery, 25(1), 533-545. https://doi.org/10.1080/10717544.2018.1435748

Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B., & van den Berge, M. (2018). Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. Pulmonary Pharmacology & Therapeutics, 49, 27-35. https://doi.org/10.1016/j.pupt.2018.01.004

Ruigrok, M. J. R., Xian, J-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. https://doi.org/10.1016/j.ejpb.2018.11.005

Kanojia, G., Ten Have, R., Brugmans, D., Soema, P. C., Frijlink, H. W., Amorij, J-P., & Kersten, G. (2018). The effect of formulation on spray dried Sabin inactivated polio vaccine. European Journal of Pharmaceutics and Biopharmaceutics, 129, 21-29. https://doi.org/10.1016/j.ejpb.2018.05.021

Beugeling, M., Grasmeijer, N., Born, P. A., van der Meulen, M., van der Kooij, R. S., Schwengle, K., Baert, L., Amssoms, K., Frijlink, H. W., & Hinrichs, W. L. J. (2018). The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts. International Journal of Pharmaceutics, 551(1-2), 195-202. https://doi.org/10.1016/j.ijpharm.2018.09.025

Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., Ten Hacken, N. H. T., Kerstjens, H. A. M., & Van den Berge, M. (2018). Unraveling adenosine and AMP induced dyspnea sensation in asthma. European Respiratory Journal, 52. https://doi.org/10.1183/13993003.congress-2018.PA3961

Visser, J. C., Ten Seldam, I. E. J., van der Linden, I. J., Hinrichs, W. L. J., Veenendaal, R. F. H., Dijkers, E. C. F., & Woerdenbag, H. J. (2018). Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations. International journal of pharmaceutical compounding, 22(3), 247-251. https://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4480

de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E., & Porte, R. J. (2019). Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury. Hepatology, 69(4), 1719-1734. https://doi.org/10.1002/hep.30365

Prins, G., Oosterhuis, D., Van Wijk, L. A., Shelton, L., & Olinga, P. (2018). Developing an Ex Vivo Non-Alcoholic Fatty Liver Disease Model Using Human Livers. Hepatology, 68, 1008A-1009A.

Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., de Jong, K. P., Mutsaers, H. A. M., & Olinga, P. (2018). In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β. Toxicology and Applied Pharmacology, 355, 127-137. https://doi.org/10.1016/j.taap.2018.07.001

Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., Mutsaers, H. A., & Olinga, P. (2018). Regional Differences in Intestinal Drug Metabolism. Drug Metabolism and Disposition, 46(11), 1879-1885. https://doi.org/10.1124/dmd.118.083428

Touw, D., Koc, S., Meints, J. W., Woerdenbag, H., Stoffers, S., & Pauline, K. (2018). Giftig gevolg van kauwen op blaadjes laurierkers. Pharmaceutisch Weekblad, 153(36), 18 - 19. https://www.pw.nl/achtergrond/2018/giftig-gevolg-van-kauwen-op-blaadjes-laurierkers

Lexmond, A. J., Boudewijn, I. M., Hagedoorn, P., Schokker, S., Cox, C. A., Vonk, J. M., ten Hacken, N. H. T., Frijlink, H. W., Vroegop, S. J., & van den Berge, M. (2018). Bronchial Provocation Testing Can Be Improved by Using Dry Powder Adenosine Instead of Nebulized Adenosine Monophosphate. American Journal of Respiratory and Critical Care Medicine, 197(3), 391-394. https://doi.org/10.1164/rccm.201704-0715LE

van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., Kim, Y. O., Frijlink, H. W., Schuppand, D., Poelstra, K., Hinrichs, W. L. J., & Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029

Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084

Patil, H. P., Herrera Rodriguez, J., de Vries-Idema, J., Meijerhof, T., Frijlink, H. W., Hinrichs, W. L. J., & Huckriede, A. (2017). Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation. Vaccines, 5(3). https://doi.org/10.3390/vaccines5030019

Lexmond, A. J., Boudewijn, I., Hagedoorn, P., Schokker, S., Cox, C., Vonk, J., Ten Hacken, N., Frijlink, H., de Boer, A., Vroegop, S., Postma, D., & van den Berge, M. (2017). An improved bronchial provocation test with dry powder adenosine instead of nebulised adenosine monophosphate (AMP). European Respiratory Journal, 50(Suppl. 61). https://doi.org/10.1183/1393003.congress-2017.PA4756

Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2017). Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 30(4), A2.

Kanojia, G., Have, R. T., Soema, P. C., Frijlink, H., Amorij, J-P., & Kersten, G. (2017). Developments in the formulation and delivery of spray dried vaccines. Human vaccines & immunotherapeutics, 13(10), 2364-2378. https://doi.org/10.1080/21645515.2017.1356952, https://doi.org/10.1080/21645515.2017.1359363

van Doorn, E., Liu, H., Ben-Yedidia, T., Hassin, S., Visontai, I., Norley, S., Frijlink, H. W., & Hak, E. (2017). Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine: Phase IIb study protocol. Medicine, 96(11), [e6339]. https://doi.org/10.1097/MD.0000000000006339

van Doorn, E., Pleguezuelos, O., Liu, H., Fernandez, A., Bannister, R., Stoloff, G., Oftung, F., Norley, S., Huckriede, A., Frijlink, H. W., & Hak, E. (2017). Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial. BMC Infectious Diseases, 17(1), [241]. https://doi.org/10.1186/s12879-017-2341-9

Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, E. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., ten Hacken, N. T. H., Kerstjens, H. A. M., Postma, D. S., & van den Berge, M. (2017). Extrafine compared to non-extrafine particle ICS in smokers and ex-smokers with asthma. European Respiratory Journal, 50. https://doi.org/10.1183/1393003.congress-2017.PA521

Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., Hagedoorn, P., Vonk, J. M., Farenhorst, M. P., Ten Hacken, N. H. T., Kerstjens, H. A. M., Postma, D. S., & van den Berge, M. (2017). Extrafine compared to non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. Respiratory Medicine, 130, 35-42. https://doi.org/10.1016/j.rmed.2017.07.005

Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2017). How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions. European Journal of Pharmaceutics and Biopharmaceutics, 114, 288-295. https://doi.org/10.1016/j.ejpb.2017.01.024

Mensink, M., Hinrichs, W., Frijlink, H. W., & van der Voort Maarschalk, K. (2017). Kleine, flexibele suikers meest geschikt voor stabilisatie eiwit. Pharmaceutisch Weekblad, 43. http://www.pw.nl/achtergrond/2017/kleine-flexibele-suikers-meest-geschikt-voor-stabilisatie-eiwit

Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., Post, E., Hillebrands, J. L., Frijlink, H. W., Poelstra, K., Beljaars, L., Olinga, P., & Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072

Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y

van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., Hinrichs, W., Schuppan, D., Poelstra, K., & Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.

Mensink, M. A., S ̌ib í k, J., Frijlink, H. W., Maarschalk, K. V. D. V., Hinrichs, W. L. J., & Zeitler, J. A. (2017). Thermal Gradient Mid- and Far-Infrared Spectroscopy as Tools for Characterization of Protein Carbohydrate Lyophilizates. Molecular pharmaceutics, 14(10), 3550-3557. https://doi.org/10.1021/acs.molpharmaceut.7b00568

Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., Poelstra, K., Frijlink, E., Hinrichs, W., & Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.

Caviglia, J. M., Yan, J., Jang, M-K., Gwak, G-Y., Affo, S., Yu, L., Olinga, P., Friedman, R. A., Chen, X., & Schwabe, R. F. (2018). MicroRNA-21 and Dicer are Dispensable for Hepatic Stellate Cell Activation and the Development of Liver Fibrosis. Hepatology, 67(6). https://doi.org/10.1002/hep.29627

Boorsma, C. E., van der Veen, T. A., Putri, K. S. S., de Almeida, A., Draijer, C., Mauad, T., Fejer, G., Brandsma, C-A., van den Berge, M., Bossé, Y., Sin, D., Hao, K., Reithmeier, A., Andersson, G., Olinga, P., Timens, W., Casini, A., & Melgert, B. N. (2017). A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Scientific Reports, 7(1), [12570]. https://doi.org/10.1038/s41598-017-12623-w

Mortensen, J. H., van Haaften, W. T., Olesen, M. L., Karsdal, M., Olinga, P., Dijkstra, G., & Bay-Jensen, A. -C. (2017). Early suppression of the serological macrophage activity biomarker VICM, and not suppression of CRP, predicts the response to infliximab in Crohn's disease patients. Journal of Crohn's and Colitis, 11, S423-S424.

Luangmonkong, T., Suriguga, S., Bigaeva, E., Boersema, M., Oosterhuis, D., de Jong, K. P., Schuppan, D., Mutsaers, H. A. M., & Olinga, P. (2017). Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. British Journal of Pharmacology, 174(18), 3107-3117. https://doi.org/10.1111/bph.13945

Pasricha, S-R., Lim, P. J., Duarte, T., Casu, C., Mleczko-Sanecka, K., Suciu, M., Areas, J., Da Silva, A. R., Frost, J., McHugh, K., Porto, G., Draper, S., Gooding, S., Olinga, P., Muckenthaler, M., Rivella, S., Hughes, J., Milne, T., Armitage, A., & Drakesmith, H. (2017). Hepcidin is an HDAC3 regulated gene and its expression is determined by promoter-associated histone acetylation. American Journal of Hematology, 92(8), E351-E351.

Pasricha, S-R., Lim, P. J., Duarte, T. L., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., Suciu, M., Da Silva, A. R., Al-Hourani, K., Arezes, J., McHugh, K., Gooding, S., Frost, J. N., Wray, K., Santos, A., Porto, G., Repapi, E., Gray, N., Draper, S. J., ... Drakesmith, H. (2017). Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature Communications, 8, [403]. https://doi.org/10.1038/s41467-017-00500-z

van Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay-Jensen, A. C., Dijkstra, G., & Olinga, P. (2017). Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease. Alimentary Pharmacology & Therapeutics, 46(1), 26-39. https://doi.org/10.1111/apt.14092

Stribos, E. G. D., Seelen, M. A., van Goor, H., Olinga, P., & Mutsaers, H. A. M. (2017). Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis. Frontiers in Physiology, 8, [1026]. https://doi.org/10.3389/fphys.2017.01026

Stribos, E. G. D., Nielsen, S. H., Brix, S., Karsdal, M. A., Seelen, M. A., van Goor, H., Bakker, S. J. L., Olinga, P., Mutsaers, H. A. M., & Genovese, F. (2017). Non-invasive quantification of collagen turnover in renal transplant recipients. PLoS ONE, 12(4), [e0175898]. https://doi.org/10.1371/journal.pone.0175898

Gore, E., Bigaeva, E., Boersema, M., Nicklin, P., Schuppan, D., & Olinga, P. (2017). PI3K/MTOR PATHWAY INHIBITION IN EX-VIVO LIVER MODEL. Gastroenterology, 152(5), S1105-S1105. https://doi.org/10.1016/S0016-5085(17)33723-X

van Haaften, W. T., Mortensen, J. H., Olesen, M. L., Karsdal, M. A., Olinga, P., Bay-Jensen, A. -C., & Dijkstra, G. (2017). Serological biomarkers of tissue turnover can early identify responders to infliximab in Crohn's disease. Journal of Crohn's and Colitis, 11, S57-S57.

Visser, J. C., Weggemans, O. A. F., Boosman, R. J., Loos, K. U., Frijlink, H. W., & Woerdenbag, H. J. (2017). Increased drug load and polymer compatibility of bilayered orodispersible films. European Journal of Pharmaceutical Sciences, 107, 183-190. https://doi.org/10.1016/j.ejps.2017.07.010

Alting, E. K., Riphagen, L. M., Schuiling-Veninga, C. C. M., Brouwers, J. R. B. J., & Woerdenbag, H. J. (2017). Is er een plaats voor voedingsmiddelen verrijkt met fytosterolen bij cardiovasculair risicomanagement? Kritische analyse van de bewijskracht voor cholesterol-verlaging. Pharmaceutisch Weekblad, 152(15), 20-32. https://www.knmp.nl/resolveuid/90b1976595c54359a3239a7fbc2e0a3b

Alting, E. K., Riphagen, LM., Schuiling-Veninga, C. C. M., Brouwers, J. R. B. J., & Woerdenbag, H. (2017). Is er een plaats voor voedingsmiddelen verrijkt met fytosterolen bij cardiovasculair risicomanagement? Kritische analyse van de bewijskracht voor cholesterolverlaging. Nederlands Platform voor Farmaceutisch Onderzoek, 2, 1-13. [A 1641].

Jacobs, M. S., Luinstra, M., Moes, J. R., Chan, T. C. Y., Minovic, I., Frijlink, H. W., & Woerdenbag, H. J. (2017). Ready-to-use parenteral amiodarone: A feasibility study towards a long-term stable product formulation. European Journal of Hospital Pharmacy: Science and Practice, 24(2), 110-114. https://doi.org/10.1136/ejhpharm-2015-000860

Jacobs, M. S., Hemminga, W. L., Woerdenbag, H. J., Bouma, M., & Moes, J. R. (2017). Zero-residual syringe als verpakkingsmateriaal voor bevacizumab als intravitreale injectie - Antwoord van de auteurs. Pharmaceutisch Weekblad, 152(3).

Visser, J., Eugresya, G., Hinrichs, W., Tjandrawinata, R., Avanti, C., Frijlink, H. W., & Woerdenbag, H. (2017). Development of orodispersible films with selected Indonesian medicinal plant extracts. Journal of Herbal Medicine, 7, 37-46. https://doi.org/10.1016/j.hermed.2016.10.002

de Boer, A., Hagedoorn, P., Hoppentocht, M., Buttini, F., Grasmeijer, F., & Frijlink, H. W. (2017). Dry powder inhalation: past, present and future. Expert Opinion on Drug Delivery, 14(4), 499-512. https://doi.org/10.1080/17425247.2016.1224846

Grasmeijer, N., Frijlink, H. W., & Hinrichs, W. L. J. (2016). An adaptable model for growth and/or shrinkage of droplets in the respiratory tract during inhalation of aqueous particles. Journal of Aerosol Science, 93, 21-34. https://doi.org/10.1016/j.jaerosci.2015.11.011

Setyaningsih, D., Murti, Y. B., Martono, S., Hinrichs, W. L. J., Hertiani, T., & Fudholi, A. (2016). A novel reversed phase high performance liquid chromatography method to accurately determine low concentrations of curcumin in rat plasma. International Journal of Pharmaceutical and Clinical Research, 8(5), Suppl. 377-386.

Maurer, J. M., Hofman, S., Schellekens, R. C. A., Tonnis, W. F., Dubois, A. O. T., Woerdenbag, H. J., Hinrichs, W. L. J., Kosterink, J. G. W., & Frijlink, H. W. (2016). Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study. International Journal of Pharmaceutics, 505(1-2), 175-186. https://doi.org/10.1016/j.ijpharm.2016.03.027

Tomar, J., Born, P. A., Frijlink, H. W., & Hinrichs, W. L. J. (2016). Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination. Expert review of vaccines, 15(11), 1431-1447. https://doi.org/10.1080/14760584.2016.1182869

Mensink, M. A., Nethercott, M. J., Hinrichs, W. L. J., Maarschalk, K. V. D. V., Frijlink, H. W., Munson, E. J., & Pikal, M. J. (2016). Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability. Aaps journal, 18(5), 1225-1232. https://doi.org/10.1208/s12248-016-9937-7

Grasmeijer, N., Frijlink, H. W., & Hinrichs, W. L. J. (2016). Model to predict inhomogeneous protein-sugar distribution in powders prepared by spray drying. Journal of Aerosol Science, 101, 22-33. https://doi.org/10.1016/j.jaerosci.2016.07.012

Ruigrok, M., Frijlink, H. W., & Hinrichs, W. (2016). Pulmonary administration of small interfering RNA: The route to go? Journal of Controlled Release, 235, 14-23. https://doi.org/10.1016/j.jconrel.2016.05.054

Vatakuti, S., Olinga, P., Pennings, J. L. A., & Groothuis, G. M. M. (2017). Validation of precision-cut liver slices to study drug-induced cholestasis: A transcriptomics approach. Archives of toxicology, 91(3), 1401-1412. https://doi.org/10.1007/s00204-016-1778-8

Visser, J. C., Woerdenbag, H. J., Hanff, L. M., & Frijlink, H. W. (2017). Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films. Aaps pharmscitech, 104(5), 1292-1300. https://doi.org/10.1208/s12249-016-0515-1

Jacobs, M. S., Hemminga, W., Woerdenbag, H., Bouma, M., & Moes, J. R. (2016). Kwalificatie van de zero-residual syringe (Zeringe) als verpakkingsmateriaal voor bevacizumab als intravitreale injectie. Pharmaceutisch Weekblad Wetenschappelijk Platform, 1-6.

Krampe, R., Visser, C., Frijlink, H. W., Breitkreutz, J., Woerdenbag, H. J., & Preis, M. (2016). Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes. Expert Opinion on Drug Delivery, 13(4), 493-506. https://doi.org/10.1517/17425247.2016.1118048

Patil, H. P., Murugappan, S., de Vries-Idema, J., Meijerhof, T., de Haan, A., Frijlink, H. W., Wilschut, J., Hinrichs, W. L. J., & Huckriede, A. (2015). Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration. European Journal of Pharmaceutics and Biopharmaceutics, 93, 231-241. https://doi.org/10.1016/j.ejpb.2015.04.004

Murugappan, S., Frijlink, H. W., Petrovsky, N., & Hinrichs, W. L. J. (2015). Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant. European Journal of Pharmaceutical Sciences, 66, 118-122. https://doi.org/10.1016/j.ejps.2014.10.008

Mensink, M. A., Van Bockstal, P-J., Pieters, S., De Meyer, L., Frijlink, H. W., van der Voort Maarschalk, K., Hinrichs, W. L. J., & De Beer, T. (2015). In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability. International Journal of Pharmaceutics, 792-800. https://doi.org/10.1016/j.ijpharm.2015.11.030

Mensink, M. A., Frijlink, H. W., Maarschalk, K. V. D. V., & Hinrichs, W. L. J. (2015). Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics. Carbohydrate Polymers, 130, 405-419. https://doi.org/10.1016/j.carbpol.2015.05.026

Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2015). Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydrate Polymers, 134, 418-428. https://doi.org/10.1016/j.carbpol.2015.08.022

Visser, C., Woerdenbag, H. J., Crediet, S., Gerrits, E., Lesschen, M. A., Hinrichs, W. L. J., Breitkreutz, J., & Frijlink, H. W. (2015). Orodispersible films in individualized pharmacotherapy: The development of a formulation for pharmacy preparations. International Journal of Pharmaceutics, 478(1), 155-163. https://doi.org/10.1016/j.ijpharm.2014.11.013

Stanković, M., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today, 20(7), 812-823. https://doi.org/10.1016/j.drudis.2015.01.012

Teekamp, N., Duque , L. F., Frijlink, H. W., Hinrichs, W. L., & Olinga, P. (2015). Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins. Expert Opinion on Drug Delivery, 12(8), 1311-1331. https://doi.org/10.1517/17425247.2015.1003807

Stanković, M., Hiemstra, C., de Waard, H., Zuidema, J., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants. International Journal of Pharmaceutics, 480(1-2), 73-83. https://doi.org/10.1016/j.ijpharm.2015.01.007

Visser, J. C., Dohmen, W. M. C., Hinrichs, W. L. J., Breitkreutz, J., Frijlink, H. W., & Woerdenbag, H. J. (2015). Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. International Journal of Pharmaceutics, 485(1-2), 70-76. https://doi.org/10.1016/j.ijpharm.2015.03.005

Tonnis, W. F., Mensink, M. A., de Jager, A., Maarschalk, K. V. D. V., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Size and molecular flexibility of sugars determine the storage stability of freeze-dried proteins. Molecular pharmaceutics, 12(3), 684-694. https://doi.org/10.1021/mp500423z

Beugeling, M., Ekoume, F., Woerdenbag, H. J., Luurtsema, G., Lub-de Hooge, M. N., Touw, D. J., Rubow, S. M., & Boersma, H. H. (2015). Assessment of microbiological monitoring for the evaluation of GMP-compliance at a department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen. European Journal of Nuclear Medicine and Molecular Imaging, 42(1), 486.

Maurer, J. M., Schellekens, R. C. A., van Rieke, H. M., Wanke, C., Iordanov, V., Stellaard, F., Wutzke, K. D., Dijkstra, G., van der Zee, M., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2015). Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets. PLoS ONE, 10(7), [e0129076]. https://doi.org/10.1371/journal.pone.0129076

Tonnis, W. F., Bagerman, M., Weij, M., Sjollema, J., Frijlink, H. W., Hinrichs, W. L. J., & de Boer, A. H. (2014). A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals. European Journal of Pharmaceutics and Biopharmaceutics, 88(3), 1056-1063. https://doi.org/10.1016/j.ejpb.2014.10.011

Patil, H. P., Murugappan, S., Ter Veer, W., Meijerhof, T., De Haan, A., Frijlink, H. W., Wilschut, J., Hinrichs, W. L. J., & Huckriede, A. (2014). Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine. Journal of controlled release : official journal of the Controlled Release Society, 174(1), 51-62. https://doi.org/10.1016/j.jconrel.2013.11.013

Tonnis, W. F., Amorij, J-P., Vreeman, M. A., Frijlink, H. W., Kersten, G. F., & Hinrichs, W. L. J. (2014). Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars. European Journal Pharmaceutical Sciences, 55(1), 36-45. https://doi.org/10.1016/j.ejps.2014.01.005

de Jesus, M. B., Radaic, A., Hinrichs, W. L. J., Ferreira, C. V., de Paula, E., Hoekstra, D., & Zuhorn, I. S. (2014). Inclusion of the helper lipid dioleoyl-phosphatidylethanolamine in solid lipid nanoparticles inhibits their transfection efficiency. Journal of biomedical nanotechnology, 10(2), 1-11. https://doi.org/10.1166/jbn.2014.1804

Rosas, J. G., de Waard, H., De Beer, T., Vervaet, C., Remon, J. P., Hinrichs, W. L. J., Frijlink, H. W., & Blanco, M. (2014). NIR spectroscopy for the in-line monitoring of a multicomponent formulation during the entire freeze-drying process. Journal of Pharmaceutical and Biomedical Analysis, 97, 39-46. https://doi.org/10.1016/j.jpba.2014.04.010

Peeters, B., Tonnis, W. F., Murugappan, S., Rottier, P., Koch, G., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2014). Pulmonary immunization of chickens using non-adjuvanted spray-freeze dried whole inactivated virus vaccine completely protects against highly pathogenic H5N1 avian influenza virus. Vaccine, 32(48), 6445-6450. https://doi.org/10.1016/j.vaccine.2014.09.048

Murugappan, S., Patil, H. P., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2014). Simplifying influenza vaccination during pandemics: sublingual priming and intramuscular boosting of immune responses with heterologous whole inactivated influenza vaccine. Aaps journal, 16(2), 342-349. https://doi.org/10.1208/s12248-014-9565-z

Avanti, C., Saluja, V., Van Streun, E. L. P., Frijlink, H. W., & Hinrichs, W. L. J. (2014). Stability of lysozyme in aqueous extremolyte solutions during heat shock and accelerated thermal conditions. PLoS ONE, 9(1), [e86244]. https://doi.org/10.1371/journal.pone.0086244

Stankovic, M., Tomar, J., Hiemstra, C., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2014). Tailored protein release from biodegradable poly(ε-caprolactone-PEG)- b-poly(ε-caprolactone) multiblock-copolymer implants. European Journal of Pharmaceutics and Biopharmaceutics, 87(2), 329-337. https://doi.org/10.1016/j.ejpb.2014.02.012

Yska, J. P., Punter, R. J., Woerdenbag, H. J., Apers, J. A., Emous, M., Totte, E., Frijlink, H. W., Wilffert, B., & van Roon, E. N. (2014). A GASTROINTESTINAL SIMULATION SYSTEM (GISS) FOR DISSOLUTION OF DRUGS BEFORE AND AFTER ROUX-EN-Y GASTRIC BYPASS: FIRST RESULTS. British Journal of Clinical Pharmacology, 78(4), 774-774. https://doi.org/10.1111/bcp.12400

Elfahmi, Woerdenbag, H. J., & Kayser, O. (2014). Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. Journal of Herbal Medicine, 4(2), 51-73. https://doi.org/10.1016/j.hermed.2014.01.002

Gechev, T. S., Hille, J., Woerdenbag, H. J., Benina, M., Mehterov, N., Toneva, V., Fernie, A. R., & Mueller-Roeber, B. (2014). Natural products from resurrection plants: Potential for medical applications. Biotechnology Advances, 32(6), 1091-1101. https://doi.org/10.1016/j.biotechadv.2014.03.005

Avanti, C., Oktaviani, N. A., Hinrichs, W. L. J., Frijlink, H. W., & Mulder, F. A. A. (2013). Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation. International Journal of Pharmaceutics, 444(1-2), 139-145. https://doi.org/10.1016/j.ijpharm.2013.01.051

Grasmeijer, N., de Waard, H., Hinrichs, W. L. J., & Frijlink, H. W. (2013). A user-friendly model for spray drying to aid pharmaceutical product development. PLoS ONE, 8(9), [e74403]. https://doi.org/10.1371/journal.pone.0074403

Ingvarsson, P. T., Schmidt, S. T., Christensen, D., Larsen, N. B., Hinrichs, W. L. J., Andersen, P., Rantanen, J., Nielsen, H. M., Yang, M., & Foged, C. (2013). Designing CAF-adjuvanted dry powder vaccines: Spray drying preserves the adjuvant activity of CAF01. Journal of Controlled Release, 167(3), 256-264. https://doi.org/10.1016/j.jconrel.2013.01.031

Wahjudi, M., Murugappan, S., van Merkerk, R., Eissens, A. C., Visser, M. R., Hinrichs, W. L. J., & Quax, W. J. (2013). Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections. European Journal of Pharmaceutical Sciences, 48(4-5), 637-643. https://doi.org/10.1016/j.ejps.2012.12.015

Tonnis, W. F., Lexmond, A. J., Frijlink, H. W., De Boer, A. H., & Hinrichs, W. L. J. (2013). Devices and formulations for pulmonary vaccination. Expert Opinion on Drug Delivery, 10(10), 1383-1397. https://doi.org/10.1517/17425247.2013.810622

Stankovic, M., de Waard, H., Steendam, R., Hiemstra, C., Zuidema, J., Frijlink, H. W., & Hinrichs, W. L. J. (2013). Low temperature extruded implants based on novel hydrophilic multiblock copolymer for long-term protein delivery. European Journal of Pharmaceutical Sciences, 49(4), 578-587. https://doi.org/10.1016/j.ejps.2013.05.011

Maurer, J. M., Schellekens, R. C. A., Van Rieke, H. M., Stellaard, F., Wutzke, K. D., Buurman, D. J., Dijkstra, G., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2013). ColoPulse tablets perform comparably in healthy volunteers and Crohn's patients and show no influence of food and time of food intake on bioavailability. Journal of controlled release : official journal of the Controlled Release Society, 172(3), 618-624. https://doi.org/10.1016/j.jconrel.2013.09.021

Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2013). Erratum: Applications of stable isotopes in clinical pharmacology (vol 72, pg 879, 2011). British Journal of Clinical Pharmacology, 75(4), 1171. https://doi.org/10.1111/bcp.12107

Woerdenbag, H., & Brouwers, J. R. B. J. (2013). Traditionele geneeskunde in Vietnam. Nederlands Tijdschrift voor Fytotherapie, 1, 9-13.

Maurer, M. J. M., Schellekens, R. C. A., Wutzke, K. D., Dijkstra, G., Woerdenbag, H. J., Frijlink, H. W., Kosterink, J. G. W., & Stellaard, F. (2012). A non-invasive, low-cost study design to determine the release profile of colon drug delivery systems: A feasibility study. Pharmaceutical Research, 29(8), 2070-2078. https://doi.org/10.1007/s11095-012-0735-3

Tu, H. A., Vu, H. D., Rozenbaum, M. H., Woerdenbag, H. J., & Postma, M. J. (2012). A review of the literature on the economics of vaccination against TB. Expert review of vaccines, 11(3), 303-317. https://doi.org/10.1586/ERV.11.197

Tu, H. A. T., de Vries, R., Woerdenbag, H. J., Li, S. C., Le, H. H., van Hulst, M., & Postma, M. J. (2012). Cost-Effectiveness Analysis of Hepatitis B Immunization in Vietnam: Application of Cost-Effectiveness Affordability Curves in Health Care Decision Making. Value in Health Regional Issues, 1(1), 7-14. https://doi.org/10.1016/j.vhri.2012.03.007

Tu, H. A., de Vries, R., Woerdenbag, H., Li, SC., Le, H., Phan, TL., van Hulst, M., & Postma, M. (2012). Cost-effectiveness of hepatitis B immunization in Vietnam: application of affordability curves in decision making. Value in Health, (Regional issue) (1), 7-14.

Tu, H. A. T., Woerdenbag, H. J., Riewpaiboon, A., Kane, S., Le, D. M., Postma, M. J., & Li, S. C. (2012). Cost of Illness of Chronic Hepatitis B Infection in Vietnam. Value in Health Regional Issues, 1(1), 23-28. https://doi.org/10.1016/j.vhri.2012.03.008

Tu, H., Riewpaiboon , A., Woerdenbag, H., Le, H., Le, MD., Phan, TL., Postma, M., & Li, SC. (2012). Cost-of-illness of chronic hepatitis B in Vietnam. Value in Health, 1( (Regional Issue) ), 23-28.

Tu, H-A. T., Rozenbaum, M. H., Coyte, P. C., Li, S. C., Woerdenbag, H. J., & Postma, M. J. (2012). Health economics of rotavirus immunization in Vietnam: Potentials for favorable cost-effectiveness in developing countries. Vaccine, 30(8), 1521-1528. https://doi.org/10.1016/j.vaccine.2011.11.052

Hendrawati, O., Hille, J., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2012). In vitro regeneration of wild chervil (Anthriscus sylvestris L.). In vitro cellular & developmental biology-Plant, 48(3), 355-361. https://doi.org/10.1007/s11627-011-9410-3

Woerdenbag, H. J., Nguyen, T. M., Vu, D. V., Tran, H., Nguyen, D. T., Tran, T. V., De Smet, P. A., & Brouwers, J. R. (2012). Vietnamese traditional medicine from a pharmacist's perspective. Expert Review of Clinical Pharmacology, 5(4), 459-477. https://doi.org/10.1586/ecp.12.34

Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2011). Applications of stable isotopes in clinical pharmacology. British Journal of Clinical Pharmacology, 72(6), 879-897. https://doi.org/10.1111/j.1365-2125.2011.04071.x

Tu, H. A. T., Woerdenbag, H. J., Kane, S., Rozenbaum, M. H., Li, S. C., & Postma, M. J. (2011). Economic evaluations of rotavirus immunization for developing countries: a review of the literature. Expert review of vaccines, 10(7), 1037-1051. https://doi.org/10.1586/ERV.11.65

Woerdenbag, H. J., Dillingh, J. H., Wanders, J. T. M., Boer, E. J., Frijlink, H. W., Kosterink, J. G. W., & Schellekens, R. C. A. (2011). Elastomeer-infuuspompen getest voor de praktijk. Pharmaceutisch Weekblad, 146(15), 58-64.

Hendrawati, O., Woerdenbag, H. J., Michiels, P. J. A., Aantjes, H. G., van Dam, A., & Kayser, O. (2011). Identification of lignans and related compounds in Anthriscus sylvestris by LC-ESI-MS/MS and LC-SPE-NMR. Phytochemistry, 72(17), 2172-2179. https://doi.org/10.1016/j.phytochem.2011.08.009

Hendrawati, O., Woerdenbag, H. J., Hille, J., Quax, W. J., & Kayser, O. (2011). Seasonal Variations in the Deoxypodophyllotoxin Content and Yield of Anthriscus sylvestris L. (Hoffm.) Grown in the Field and under Controlled Conditions. Journal of Agricultural and Food Chemistry, 59(15), 8132-8139. https://doi.org/10.1021/jf200177q

Staniek, A., Muntendam, R., Woerdenbag, H. J., & Kayser, O. (2010). Essential oil constituents derived from different organs of a relictual conifer Wollemia nobilis. Biochemical Systematics and Ecology, 38(2), 131-135. https://doi.org/10.1016/j.bse.2009.12.022

Schellekens, R. C. A., Baltink, J. H., Woesthuis, E. M., Stellaard, F., Kosterink, J. G. W., Woerdenbag, H. J., & Frijlink, H. W. (2010). Film coated tablets (ColoPulse technology) for targeted delivery in the lower intestinal tract: influence of the core composition on release characteristics. Pharmaceutical development and technology, 17(1), 40-47. https://doi.org/10.3109/10837450.2010.513986

Hendrawati, O., Woerdenbag, H. J., Hille, J., & Kayser, O. (2010). Metabolic engineering strategies for the optimization of medicinal and aromatic plants: realities and expectations. Zeitschrift für Arznei- & Gewurzpflanzen, 15(3), 111-126.

Schellekens, R. C. A., Stellaard, F., Olsder, G. G., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2010). Oral ileocolonic drug delivery by the colopulse-system: A bioavailability study in healthy volunteers. Journal of controlled release : official journal of the Controlled Release Society, 146(3), 334-340. https://doi.org/10.1016/j.jconrel.2010.05.028

Ruslan Wirasutisna, K., Batterman, S., Koulman, A., Kayser, O., Woerdenbag, H. J., & Quax, W. J. (2010). Reduced Coniferin and Enhanced 6-Methoxypodophyllotoxin Production in Linum flavum Cell Cultures. Pharmacognosy Journal, 2(17), 74-80. https://doi.org/10.1016/S0975-3575(10)80015-X

Tu, H. A. T., Bos, J. H. J., Woerdenbag, H. J., Visser, S. T., Wilschut, J. C., van Assen, S., de Jong-van den Berg, L. T. W., & Postma, M. J. (2010). Results of a retrospective database analysis of drug utilization and costs for treatment of chronic hepatitis B virus infection in the northern Netherlands between 2000 and 2006. Clinical Therapeutics, 32(1), 133-144. https://doi.org/10.1016/j.clinthera.2010.01.015

Staniek, A., Woerdenbag, H. J., & Kayser, O. (2010). Screening the endophytic flora of Wollemia nobilis for alternative paclitaxel sources. Journal of plant interactions, 5(3), 189-195. https://doi.org/10.1080/17429141003714721

Aslan, S., Kartal, M., Kurucu, S., Kuiper, J. M., Kruizinga, W. H., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Composition of the Essential Oil From Roots and Rhizomes of Valeriana phu L. Growing Wild in Turkey. Journal of Essential Oil Research, 21(5), 437-440.

Tu, H. A. T., Woerdenbag, H. J., Kane, S., Riewpaiboon, A., van Hulst, M., & Postma, M. J. (2009). Economic evaluations of hepatitis B vaccination for developing countries. Expert review of vaccines, 8(7), 907-920. https://doi.org/10.1586/ERV.09.53

Azizi, M., Davareenejad, G., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Essential Oil Content and Constituents of Black Zira (Bunium persicum [Boiss.] B. Fedtsch.) from Iran During Field Cultivation (Domestication). Journal of Essential Oil Research, 21(1), 78-82.

Azizi, M., Davareenejad, G., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Essential Oil Content and Constituents of Black Zira (Bunium persicum [Boiss.] B. Fedtsch.) From Iran During Field Cultivation (Domestication) (vol 21, pg 78, 2009). Journal of Essential Oil Research, 21(3), 193-194.

Maurer, J. M., Kouwen, S., Woerdenbag, H. J., Brouwers, J. R. B. J., Kosterink, J. G. W., & Schellekens, R. C. A. (2009). Pharmacotherapeutic rationale of pharmacy drug compounding: Evaluation and applicability of the guideline from the Laboratory of Dutch Pharmacists (LNA). Pharmaceutisch Weekblad, 144(51-52), 217-222.

Ozbay, O., Aslan, S., Kartal, M., Kurucu, S., Bos, R., Woerdenbag, H. J., & Kayser, O. (2009). Preliminary Examination of the Composition of the Essential Oil From the Roots and Rhizomes of Valeriana alpestris Stev. Growing in Turkey. Journal of Essential Oil Research, 21(6), 555-557.

Schellekens, R. C. A., Olsder, G. G., Langenberg, S. M. C. H., Boer, T., Woerdenbag, H. J., Frijlink, H. W., Kosterink, J. G. W., & Stellaard, F. (2009). Proof-of-concept study on the suitability of 13C-urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms. British Journal of Pharmacology, 158(2), 532-540. https://doi.org/10.1111/j.1476-5381.2009.00302.x

Staniek, A., Woerdenbag, H. J., & Kayser, O. (2009). Taxomyces andreanae: A Presumed Paclitaxel Producer Demystified? Planta Medica, 75(15), 1561-1566. https://doi.org/10.1055/s-0029-1186181

Julsing, M. K., Fichera, M. A., Malz, F., Ebbelaar, M., Bos, R., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2008). Bioconversion of Mono- and Sesquiterpenoids by Recombinant Human Cytochrome P450 Monooxygenases. Pharmaceutical biology, 46(10-11), 710-718. https://doi.org/10.1080/13880200802215487

Staniek, A., Woerdenbag, H. J., & Kayser, O. (2008). Endophytes: Exploiting biodiversity for the improvement of natural product-based drug discovery. Journal of plant interactions, 3(2), 75-93. https://doi.org/10.1080/17429140801886293

Julsing, M. K., Vasilev, N. P., Schneidman-Duhovny, D., Muntendarn, R., Woerdenbag, H. J., Quax, W. J., Wolfson, H. J., Ionkova, I., & Kayser, O. (2008). Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. European Journal of Medicinal Chemistry, 43(6), 1171-1179. https://doi.org/10.1016/j.ejmech.2007.09.005

Bos, R., Woerdenbag, H. J., Kayser, O., Quax, W. J., Ruslan, K., & Elfahmi (2007). Essential oil constituents of Piper cubeba L. fils. from Indonesia. Journal of Essential Oil Research, 19(1), 14-17. https://doi.org/10.1080/10412905.2007.9699217

Julsing, M. K., Rijpkema, M., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2007). Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis. Applied Microbiology and Biotechnology, 75(6), 1377-1384. https://doi.org/10.1007/s00253-007-0953-5

Bos, R., Windono, T., Woerdenbag, H. J., Boersma, Y. L., Koulman, A., & Kayser, O. (2007). HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia. Phytochemical Analysis, 18(2), 118-122. https://doi.org/10.1002/pca.959

Elfahmi, Ruslan, K., Batterman, S., Bos, R., Kayser, O., Woerdenbag, H. J., & Quax, W. J. (2007). Lignan profile of Piper cubeba, an Indonesian medicinal plant. Biochemical Systematics and Ecology, 35(7), 397-402. https://doi.org/10.1016/j.bse.2007.01.003

Vasilev, N. P., Julsing, M. K., Koulman, A., Clarkson, C., Woerdenbag, H. J., Ionkova, I., Bos, R., Jaroszewski, J. W., Kayser, O., & Quax, W. J. (2006). Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E-coli using human cytochrome P450 3A4. Journal of Biotechnology, 126(3), 383-393. https://doi.org/10.1016/j.jbiotec.2006.04.025

Julsing, M. K., Koulman, A., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2006). Combinatorial biosynthesis of medicinal plant secondary metabolites. Biomolecular Engineering, 23(6), 265-279. https://doi.org/10.1016/j.bioeng.2006.08.001

Elfahmi, Batterman, S., Koulman, A., Hackl, T., Bos, R., Kayser, O., Woerdenbag, H. J., & Quax, W. J. (2006). Lignans from cell suspension cultures of Phyllanthus niruri, an Indonesian medicinal plant. Journal of Natural Products, 69(1), 55-58. https://doi.org/10.1021/np050288b

Bos, R., Stojanova, A. S., Woerdenbag, H. J., Koulman, A., & Quax, W. (2005). Volatile components of the aerial parts of Artemisia pontica L. grown in Bulgaria. Flavour and Fragrance Journal, 20(2), 145-148. https://doi.org/10.1002/ffj.1399

Woerdenbag, HJ., Windono, T., Bos, R., Riswan, S., & Quax, WJ. (2004). Composition of the essential oils of Kaempferia rotunda L. and Kaempferia angustifolia Roscoe rhizomes from Indonesia. Flavour and Fragrance Journal, 19(2), 145-148. https://doi.org/10.1002/ffj.1284