Dissertations

In the table below, you find an overview of dissertations written by PhD students from the department of Pharmaceutical Technology and Biopharmacy. Click on the link to learn more about a particular dissertation.

Year	Author	Title
2026	Zillen, D.	Solid-state protein formulations: from mechanistic insights to application-driven strategies
2026	Fridrichs, J.	Exploring the use of precision-cut tissue slices to study biliary atresia
2025	Zielinski, P.	Harnessing melt electrowriting for tissue engineering: enhancing scaffold design and functionality
2025	Luo, K.	Investigating disease models and antifibrotic therapies ex vivo: a focus on liver fibrosis and metabolic dysfunction-associated steathohepatitis
2025	Henstra, C.	New horizons in colorectal cancer research: exploring microbial metabolites and tumour slices
2024	Chakraborty, P.	Bacterial membranes in life and death: determining the effects of antimicrobials and mutations on the membrane of Bacillus subtilis PhD
2024	Biel, C.	Precision-cut intestinal slices and intestinal fibrosis: towards better understanding of the human intestine ex vivo
2024	Karsten, R.	The Liver's (mal)funtions magnified
2024	Li, Mei	Unraveling MASLD: insights from ex vivo models
2022	Prins, G.H.	Metabolic-associated fatty liver disease: a major problem miniaturised
2021	Song, S.	MIF family proteins in lung diseases
2021	Puerta Cavanzo, N.	The potential of in vitro and ex vivo models to predict the efficacy of antifibrotic drugs
2020	Praagh, J. van	Elucidating the mechanisms of anastomotic leakage: a new point of view
2020	Luinstra, M.	Inhalable levodopa: from laboratory to the patient
2020	Bartucci, R.	Increasing the versatility of an ex vivo model in nanosafety studies and fibrosis
2019	Bigaeva, E.	Ex vivo fibrosis research: 5 mm closer to human studies
2019	Gore, E.	Integrating an ex vivo model into fibrosis research
2019	Iswandana, R.	Exploring the regional characteristics of intestinal drug metabolism and fibrogenesis
2019	Haaften, T. van	Biomarkers, models and mechanisms of intestinal fibrosis
2019	Putri, K.S.S.	Osteoprotegerin in organ fibrosis: biomarker, actor, and target of therapy?
2019	Ruigrok, M.J.R.	siRNA in precision-cut lung slices: knocking down fibrosis?
2019	Suriguga, S.	Pro- and anti-fibrotic agents in liver fibrosis: perspective from an ex vivo model of liver fibrosis
2018	Bhide, Y.	Towards improved and broadly protective influenza vaccines: focus on delivery systems, routes of administration and animal models
2018	Kanojia, G.	Drying made easy: spray drying a promising technology for the production of stable vaccine and therapeutic protein formulations
2018	Rios Ocampo, W.	Cellular stress response during hepatitis C virus infection: a balancing act between viral persistence and host cell survival
2018	Dijk, F. van	Delivery of biologicals: sustained release of cell-specific proteins in fibrosis
2018	Teekamp, N.	Protein delivery from polymeric matrices: from pre-formulation stabilization studies to site-specific delivery
2018	Tomar, J.	Paving the way for pulmonary influenza vaccines: exploring formulations, models and site of deposition
2017	Luangmonkong, T.	Exploring anti-fibrotic drugs: focusing on an ex vivo model of fibrosis
2017	Mensink, M.	Solid state stabilization of proteins by sugars: why size and flexibility matter
2017	Stribos, E.G.D.	Ex vivo studies of renal fibrosis: insights into mechanisms and treatment targets
2017	Visser, J.C.	Orodispersible films as pharmacy preparations: let’s get flexible
2016	Grasmeijer, N.	Improving protein stabilization by spray drying: formulation and process development
2016	Hoppentocht, M.	Dry powder inhalation of antibiotics: a promising approach for treatment of infectious diseases
2016	Pham, B.T.	Precision-cut tissue slices: a novel ex vivo model for fibrosis research
2016	Vatakuti, S.	Toxicogenomics of precision-cut liver slices for prediction of human liver toxicity
2014	Grasmeijer, F.	Adhesive mixtures for inhalation: the cohesion between formulation variables, inhalation variables and dispersion performance
2014	Lexmond, A.	Technology in practice: the importance of matching purpose, patient, and product in pulmonary aerosol delivery
2014	Westra, I.	Precision-cut liver slices: an ex vivo model for the early onset and end-stage of liver fibrosis
2014	Murugappan, S.	New strategies for simplifying influenza vaccination
2014	Nguyen, T.	Particle–particle interactions in dry powder blending: applying theoretical concepts to real-life particles
2014	Stankovic, M.	Innovative platform technologies for stabilization and controlled release of proteins from polymer depots
2014	Tonnis, W.	Powder to the people: the storage stability, handling, and administration advantages of powder formulations for pulmonary vaccination
2013	Willemsz, T.A.	Blending of agglomerates into powders: quantification and understanding of mixing mechanisms in dry blending
2012	Avanti, C.	Innovative strategies for stabilization of therapeutic peptides in aqueous formulations
2011	de Waard, H.	A novel bottom-up process to prepare drug nanocrystals: the art of the soluble
2011	Schellekens, R.C.A.	Translational research into oral colon-specific drug delivery: from laboratory to clinic
2011	Srinarong, P.	Improved dissolution behavior of lipophilic drugs by solid dispersions: a matter of composition
2010	Laksmana, F.L.	Functional encapsulation of small particles: quantification and control of the morphology of the coating layers
2010	Saluja, V.	Novel perspectives for influenza vaccine formulation and administration: L. lactis cell wall derived adjuvant, stable dry powder vaccines and mucosal vaccine delivery
2009	Westerman, E.M.	Studies on antibiotic aerosols for inhalation in cystic fibrosis
2009	Zijlstra, G.S.	Dry powder inhalation of biopharmaceuticals: from formulation to proof-of-concept
2008	Amorij, J-P.	The development of stable influenza vaccine powder formulations for new needle-free dosage forms
2008	Wu, Y.S.	Looking into tablets: characterization of pore structure in tablets using image analysis
2007	de Jonge, J.M.	Reconstituted viral envelopes as delivery vehicles for nucleic acids
2007	de Vegt, O.M.	Jet milling from a particle perspective: predicting particle fracture based on mechanical material properties
2007	Weda, M.	Equivalence testing of inhaled drugs: the predictive value of cascade impactor results for the detection of differences in efficiency and safety of medicines for the treatment of asthma and COPD
2006	Dickhoff, B.H.J.	Adhesive mixtures for powder inhalation: the effect of carrier (surface and bulk) properties, carrier payload and mixing conditions on the performance of adhesive mixtures for inhalation
2006	van Drooge, D.J.	Combining the incompatible: inulin glass dispersions for fast dissolution, stabilization and formulation of lipophilic drugs
2005	Bouwman, A.M.	Form, formation and deformation: the influence of material properties and process conditions on the shape of granules produced by high shear granulation
2005	de Boer, A.H.	Optimisation of dry powder inhalation: the application of air classifier and laser diffraction technology for the generation and characterisation of aerosols from adhesive mixtures
2005	Steendam, R.	Amylodextrin and poly(DL-lactide) oral controlled release matrix tablets: concepts for understanding their release mechanisms
2004	Eriksson, H.J.C.	Analytical techniques and formulation strategies for the therapeutic protein alkaline phosphatase
2003	van Veen, B.	Compaction of powder blends : effect of pores, particles and percolation on tablet strength
2002	van Sorge, A.A.	Reflections on flurbiprofen eyedrops
2001	de Koning, J.P.	Dry powder inhalation: technical and physiological aspects, prescribing and use
2001	Le Brun, P.P.H.	Optimization of antibiotic inhalation therapy in cystic fibrosis: studies on nebulized tobramycin
2001	Ramaker, J.S.	Fundamentals of the high-shear pelletisation process
2000	Hartman Kok, P.J.A.	Development and description of controlled release formulations for use in powder detergents
2000	Schaafsma, S.H.	Down-scaling of a fluidised bed agglomeration process
2000	Wientjes, K.J.C.	Development of a glucose sensor for diabetic patients

Last modified:02 June 2026 09.57 a.m.

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