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About us Faculty of Science and Engineering Our Research GRIP Pharmaceutical Technology and Biopharmacy Output

2013

Requests for reprints can be addressed to:

Wouter Hinrichs


Avanti A, Saluja V, Streun van ELP, Frijlink HW, Hinrichs WLJ

Stability of lysozyme in aqueous extremolyte solutions during heat shock and accelerated thermal conditions

Plos One, 2014, 9, e86244


Jesus de MB, Radaic A, Hinrichs WLJ, Ferreira CV, de Paula E, Hoekstra D, Zuhorn IS

Inclusion of the helper lipid dioleoyl-phosphatidylethanolamine in solid lipid nanoparticles inhibits their transfection efficiency

Journal of Biomedical Nanotechnology, 2014, 10, 355-365


Murugappan S, Patil HP, Frijlink HW, Huckriede A, Hinrichs WLJ

Simplifying Influenza Vaccination during Pandemics: Sublingual Priming and Intramuscular Boosting of Immune Responses with Heterologous Whole Inactivated Influenza Vaccine

AAPS J, accepted for publication


Patil HP, Murugappan S, Veer ter W, Meijerhof T, Haan de A, Frijlink HW, Wilschut J, Hinrichs WLJ, Huckriede A

Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine

Journal of Controlled Release, 2014, 174, 51–62


Tonnis WF, Amorij JP, Kersten GF, Frijlink HW, Hinrichs WLJ

Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars

European Journal of Pharmaceutics Sciences, accepted for publication


Avanti C, Hinrichs WLJ, Casini A, Eissens AC, van Dam A, Kedrov A, Driessen AJM, Frijlink HW, Permentier HP

The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex

Journal of Pharmaceutical Sciences, 2013, 102, 1734-1741


Avanti C, Oktaviani NA, Hinrichs WLJ, Frijlink HW, Mulder FAA

Aspartate buffer and divalent metal ions affect the oxytocin in aqueous solution and protect it from degradation

International Journal of Pharmaceutics, 2013, 444, 139-145


Godoy P, Hewitt N J, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Bottger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley, S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring, CE, Gomez-Lechon MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Haussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhutter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen, P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J. Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stober R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Archives of Toxicology, 2013, 87, 1315-530


Grasmeijer F, Hagedoorn P, Frijlink HW, de Boer AH

The effect of mixing time on drug agglomeration and detachment for adhesive mixtures containing fine lactose carriers

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A7-A7


Grasmeijer F, Hagedoorn P, Frijlink HW, de Boer AH

The effect of mixing time on drug agglomeration and detachment for adhesive mixtures containing coarse lactose carriers

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A7-A7


Grasmeijer F, Hagedoorn P, Frijlink HW, de Boer AH

Carrier payload affects drug particle detachment from carriers in adhesive mixtures for inhalation

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A239-A239


Grasmeijer F, Hagedoorn P, Frijlink HW, de Boer AH

Drug Content Effects on the Dispersion Performance of Adhesive Mixtures for Inhalation

Plos One, 2013, 8, e71339


Grasmeijer F, Hagedoorn P, Frijlink HW, de Boer AH

Mixing Time Effects on the Dispersion Performance of Adhesive Mixtures for Inhalation

Plos One, 2013, 8, e 69263


Grasmeijer N, Stanković M, de Waard H, Frijlink HW, Hinrichs WLJ

Unravelling protein stabilization mechanisms: vitrification and water replacement in a glass transition temperature controlled system

Biochimica et Biophysica Acta - Proteins and Proteomics, 2013, 1834, 763-769


Grasmeijer N, de Waard H, Hinrichs WLJ, Frijlink HW

A user friendly model for spray drying to aid pharmaceutical product development

Plos One, 2013, 9, e74403


Hagedoorn P, Grasmeijer F, van den Noort M, Frijlink HW, de Boer AH

The effect of mixing time on dispersion performance of carrier based mixtures in relation to initial carrier payload

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A240-A240


Hoppentocht M, Hagedoorn, P, Frijlink HW, de Boer AH

Developments and strategies for inhaled antibiotic drugs in tuberculosis therapy: A critical evaluation

European Journal of Pharmaceutics and Biopharmaceutics, available online


Hoppentocht M, Hagedoorn P, Frijlink HW, de Boer AH

Formulation of dry powder tobramycin for the twincer (tm) high dose, disposable inhaler

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A237-A237


Ingvarsson PT, Schmidt ST, Christensen D, Larsen NB, Hinrichs WLJ, Andersen P, Rantanen J, Nielsen HM, Yang M, Fogeda C

Designing CAF-adjuvanted dry powder vaccines: Spray drying preserves the adjuvant activity of CAF01

Journal of Controlled Release, 2013, 167, 256–264


Lexmond AJ, Hagedoorn, P, Frijlink HW, de Boer AH

Challenging the Two-Minute Tidal Breathing Challenge Test

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, 380-386


Lexmond AJ, Hagedoorn, P, Frijlink HW, Ten Hacken NH, Steckel H, de Boer AH

Dry powder formulation in the twincer (tm) for bronchial challenge testing

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A241-A241


Lexmond AJ, Hagedoorn, P, Frijlink HW, de Boer AH

Challenges in bronchial challenge testing

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A17-A18


Lexmond AJ, Kruizinga TJ, Hagedoorn, P, Frijlink HW, Rottier BL, de Boer AH

Investigation of the applicability of dry powder inhalation in school children

Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013, 26, A56-A56


Lexmond A J, Hagedoorn P, van der Wiel E, Ten Hacken NH, Frijlink HW, de Boer AH

Adenosine dry powder inhalation for bronchial challenge testing, part 1: Inhaler and formulation development and in vitro performance testing

European Journal of Pharmaceutics and Biopharmaceutics, available online


Maurer JM, Schellekens R C, van Rieke, HM, Stellaard, F, Wutzke, KD, Buurman, DJ, Dijkstra G, Woerdenbag HJ, Frijlink, HW, Kosterink, JG

ColoPulse tablets perform comparably in healthy volunteers and Crohn's patients and show no influence of food and time of food intake on bioavailability

Journal of Controlled Release, 2013, 172, 618-624


Murugappan S, Patil HP, Kanojia G, Veer ter W, Mijerhof T, Frijlink HW, Huckriede A, Hinrichs WLJ

Physical and immunogenic stability of spray freeze dried influenza vaccine powder for pulmonary delivery: comparison of inulin, dextran or a mixture of dextran and trehalose as protectants

European Journal of Pharmaceutics and Biopharmaceutics, 2013, 85, 716-725


Olinga P, Schuppan D

Precision-cut liver slices: a tool to model the liver ex vivo

Journal of hepatology, 2013, 58, 1252-1253


Pham BT, Oosterhuis D, Rieder F, Olinga P

Mouse Strain Differences in the Early Onset of Intestinal Fibrosis Using Ex Vivo Precision-Cut Intestinal Slices

Gastroenterology, 2013, 144, S672-672


Pham BT, Westra I, Oosterhuis D, de Graaf I, Olinga P

Rat and human intestinal slices as a model for intestinal fibrosis in Inflammatory Bowel Disease

Gastroenterology, 2013, 144, S672-672


Siissalo S, de Waard H, de Jager MH, Hayeshi R, Frijlink HW, Hinrichs WLJ, Dinter-Heidorn H, van Dam A, Proost JH, Groothuis GMM, de Graaf IAM

Nanoparticle formulation of a poorly soluble CB-1 antagonist improves absorption by rat and human intestine

Drug Metabolism and Disposition, 2013, 41, 1557-1565, 2013


Stanković M, de Waard H, Steendam R, Hiemstra C, Zuidema J, Frijlink HW, Hinrichs WLJ

Low temperature extruded implants based on novel hydrophilic multiblock copolymer for long-term protein delivery

European Journal of Pharmaceutics and Sciences, 2013, 49, 578–587


Tonnis WF, Lexmond AJ, Frijlink HW, de Boer AH, Hinrichs WLJ

Devices and formulations for pulmonary vaccination

Expert Opinion on Drug Delivery, 2013, 10, 1383-1397


Tonnis WF, Lexmond AJ, Frijlink HW, de Boer AH, Hinrichs WLJ

Rebuttal from the authors

Expert Opinion on Drug Delivery, 2013, 10, 1594-1595


Wahjudi M, Murugappan S, van Merkerk R, Eissens AC, Visser MR, Hinrichs WLJ, Quax WJ

Development of a dry, stable and inhalable PvdQ powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections

European Journal of Pharmaceutics and Sciences, 2013, 48, 637-643


Werkhoven van MB, Damman J, van Dijk MC, Daha, MR, de Jong IJ, Leliveld A, Krikke C, Leuvenink HG, van Goor H, van Son W J, Olinga P, Hillebrands JL, Seelen MA

Complement mediated renal inflammation induced by donor brain death: role of renal C5a-C5aR interaction

American journal of transplantation, 2013, 13, 875-882


Westra IM, Pham BT, Groothuis GM, Olinga P

Evaluation of fibrosis in precision-cut tissue slices

Xenobiotica, 2013, 43, 98-112


Willemsz TA, Nguyen TT, Hooijmaijers R, Frijlink HW, Vromans H ,van der Voort Maarschalk K

Quantitative Characterization of Agglomerate Abrasion in a Tumbling Blender

by Using the Stokes Number Approach

AAPS PharmSciTech, 2013, 14, 183-188

Laatst gewijzigd:24 januari 2014 09:42