Skip to ContentSkip to Navigation
Research Medical Microbiology
University Medical Center Groningen

PhD ceremony Ms. N.V. Ayala Núñez: Dengue virus cell entry. Unraveling the role of antibodies, maturation status, and antiviral drugs

Dengue virus cell entry. Unraveling the role of antibodies, maturation status, and antiviral drugs
02 April 2014

PhD ceremony: Ms. N.V. Ayala Núñez, 12.45 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Dengue virus cell entry. Unraveling the role of antibodies, maturation status, and antiviral drugs

Promotor(s): prof.dr. J.M. Smit, prof.dr. J.C. Wilschut

Faculty: Medical Sciences

Summary:

Antibody-dependent enhancement (ADE) is thought to play a critical role in the exacerbation of dengue virus-induced disease during a heterologous re-infection. Pre-existing cross-reactive anti-dengue antibodies are generally believed to bind to the newly infecting DENV and target the antibody-virus complexes to Fc-receptor expressing cells, cells that are highly permissive to DENV infection. Intriguingly, instead of neutralizing viral infection, these cross-reactive antibodies have been shown to facilitate successful viral entry at sub-neutralizing antibody concentrations, thereby promoting viral infection and consequently disease. The mechanism by which antibodies influence viral infection is poorly understood. The work presented in this thesis provides a detailed insight into the internalisation route and endocytic trafficking of DENV in macrophages in the absence and presence of enhancing concentrations of antibody. Also, we analysed which antibodies stimulate the infectivity of immature DENV particles. Furthermore, given the clinical importance of ADE, we also aimed to identify anti-dengue compounds that interfere with DENV infection in the presence of antibodies.

Last modified:25 November 2015 4.47 p.m.
View this page in: Nederlands

More news

  • 16 April 2024

    UG signs Barcelona Declaration on Open Research Information

    In a significant stride toward advancing responsible research assessment and open science, the University of Groningen has officially signed the Barcelona Declaration on Open Research Information.

  • 02 April 2024

    Flying on wood dust

    Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...

  • 18 March 2024

    VentureLab North helps researchers to develop succesful startups

    It has happened to many researchers. While working, you suddenly ask yourself: would this not be incredibly useful for people outside of my own research discipline? There are many ways to share the results of your research. For example, think of a...