PhD ceremony: Ms. M.C.A. Wouters, 16.15 hrs, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Early events in Chikungunya and Dengue virus infections
Promotors: Prof.dr. H.W. Nijman, Prof.dr. C.A.H.H. Daemen, Prof.dr. C.J.M. Melief
Faculty: Medical Sciences / UMCG
Each year, approximately 1000 women in the Netherlands are diagnosed with ovarian cancer. The disease has an extremely poor prognosis and new treatment strategies are urgently needed. It is known that the immune system influences the survival of these patients and immunotherapy might therefore be a new effective form of treatment. Immunotherapy is a general term for strategies directed at inducing an immune reaction and/or improving the already existing immune response in order to support the body to eliminate the cancer.
In this thesis, we analysed the immune response against ovarian cancer in order to find new targets for immunotherapy. We found that a younger, less-differentiated subtype of T-cells is highly predictive for a better prognosis. Further, suppressive immune cell populations (subset of macrophages) present in the tumour environment correlated with worse prognosis. This suggests that for the treatment of ovarian cancer, combination strategies will be necessary that both stimulate the anti-tumour response and additionally inhibit the suppressive mechanisms. Finally, there is an urgent need for markers that could define patients that might benefit from such strategies. In this thesis, we provide evidence for the use of PD-L1 for selection of patients most likely to benefit from immunotherapy. In addition, we show that certain claudin proteins are overexpressed in ovarian cancer and might therefore provide an excellent target for therapy. Taken together, studies described in this thesis will further improve the development of immunotherapies and selection criteria for ovarian cancer patients most likely to benefit from these approaches.
Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...
Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...
Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether you want to accept
or reject other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information