The fungal natural product aspergillomarasmine A has been identified as a potent and selective inhibitor of metallo-β-lactamases and a promising codrug candidate to fight antibiotic resistant bacteria. Poelarends and co-workers now report the efficient asymmetric chemoenzymatic synthesis of aspergillomarasmine A as well as similar complex natural products. The synthetic route highlights a highly regio- and stereoselective carbon–nitrogen bond-forming step catalysed by ethylenediamine-N,N′-disuccinic acid lyase. This enzyme accepts a wide variety of amino acids with terminal amino groups for selective addition to fumarate, facilitating the production of valuable metal-chelating aminocarboxylic acids, which are being used in a broad range of domestic products and industrial and medical applications. The results were published online last week in the prominent scientific journal Nature Catalysis.
Prof.dr. Gerrit J. Poelarends
Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor Aspergillomarasmine A and related aminocarboxylic acids
, Nature Catalysis, 8 March 2018. Authors: Haigen Fu, Jielin Zhang, Mohammad Saifuddin, Gea Cruiming, Pieter G. Tepper, and Gerrit J. Poelarends.
Zito Ysenbaert is the first winner of the Gerrit Krol Award, the University of Groningen (UG) essay competition.
On Friday 14 June, the University of Groningen will be awarding honorary doctorates to Prof. Titia de Lange and Dr Philipp Blom. This academic ceremony is part of the 81st lustrum that takes place from 5 to 15 June 2019. During the ceremony, Prof. Elmer...
More than 200 researchers and their teams can begin to work on social and scientific issues in close collaboration with public and private parties. This close collaboration will take place in 17 research projects.