Poelarends and coworkers publish in Nature Catalysis
The fungal natural product aspergillomarasmine A has been identified as a potent and selective inhibitor of metallo-β-lactamases and a promising codrug candidate to fight antibiotic resistant bacteria. Poelarends and co-workers now report the efficient asymmetric chemoenzymatic synthesis of aspergillomarasmine A as well as similar complex natural products. The synthetic route highlights a highly regio- and stereoselective carbon–nitrogen bond-forming step catalysed by ethylenediamine-N,N′-disuccinic acid lyase. This enzyme accepts a wide variety of amino acids with terminal amino groups for selective addition to fumarate, facilitating the production of valuable metal-chelating aminocarboxylic acids, which are being used in a broad range of domestic products and industrial and medical applications. The results were published online last week in the prominent scientific journal Nature Catalysis.
More information: Prof.dr. Gerrit J. Poelarends
Reference: Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor Aspergillomarasmine A and related aminocarboxylic acids , Nature Catalysis, 8 March 2018. Authors: Haigen Fu, Jielin Zhang, Mohammad Saifuddin, Gea Cruiming, Pieter G. Tepper, and Gerrit J. Poelarends.
| Last modified: | 15 March 2018 10.57 a.m. |
More news
-
24 September 2018
Being as green as you should be can cause great social inconvenience
Jan Willem Bolderdijk must be the ideal son-in-law. He is cheerful, athletic and articulate. He cares greatly about sustainability and is highly aware of the consequences of his choices. But he did book that trip to Thailand. Why is it so difficult...
-
21 September 2018
Heike Kamerlingh Onnes chair and Rudi Drent chair for Groningen professors
The Faculty of Science and Engineering has honoured two of her professors by appointing them to a named chair: Prof. Bart Van Wees on the Heike Kamerlingh Onnes chair and Prof. Theunis Piersma on the Rudi Drent chair in Global Flyway Ecology. Named...
-
11 September 2018
From Klokhuis question of the week to a Veni grant
Jorrig Vogels has always been fascinated by language. As a child, he even compared the different words for ingredients on any packaging he came across. Last summer, the language researcher managed to secure a much-coveted Veni grant. ‘There’s something...