Re-engineering a tiny enzyme
Gerrit Poelarends was looking for an enzyme that would make a key step in the production of important pharmaceuticals greener and much more efficient. It led him to a tiny protein called 4-oxalocrotonate tautomerase. Over a period of five years, he managed to map the possibilities it offers and re-engineer it to perform the required step. The results were published in Nature Communications on 8 March.
Science linx has a commentary on the research
Reference: Jan-Ytzen van der Meer, Harshwardhan Poddar, Bert-Jan Baas, Yufeng Miao, Mehran Rahimi, Andreas Kunzendorf, Ronald van Merkerk, Pieter G. Tepper, Edzard M. Geertsema, Andy-Mark W.H. Thunnissen, Wim J. Quax and Gerrit J. Poelarends Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases, Nature Communications, 8 March, DOI 10.1038/NCOMMS10911.
| Last modified: | 17 June 2019 5.34 p.m. |
More news
-
21 September 2022
Board of the University proud of national coverage of Feringa’s ‘Everyday Molecules’
Last week, Ben Feringa and Anouk Lubbe presented the first copy of their book Alledaagse Moleculen (Everyday Molecules) to minister Robbert Dijkgraaf. The richly illustrated book offers an accessible overview of 180 substances in our daily lives....
-
04 July 2022
Research on how tourists become Antarctic ambassadors
Dr Annette Scheepstra of the UG Arctic Centre, part of the Faculty of Arts, is about to conduct research into tourism in Antarctica and how tourists can become Antarctic ambassadors. She has been granted €1 million in funding by the Dutch Research...
-
12 May 2022
KNAW appoints two UG professors as members
The Royal Netherlands Academy of Arts and Sciences (KNAW) has appointed Professor Maria Loi and Professor Dirk Slotboom from the Faculty of Science and Engineering as members of the Academy.