There is an increasing interest for dried protein formulations in pharmacy. They may offer several advantages over aqueous formulations, such as ease of storage, longer shelf life, and use for solid dosage forms. However, the mechanisms underlying stabilization in the solid state are not yet fully understood.
Proteins in their solid state can be stabilized by incorporating them into a matrix of sugar molecules. The sugar is believed to act as a replacement for water or to keep the protein vitrified. Although usually only one of the mechanisms is considered, in the study of Niels Grasmeijer both were found to play a role. The importance of either mechanism depends on the storage temperature and ambient humidity, which should therefore be taken into account when developing dry stabilized protein formulations.
Furthermore, the drying technique should also be considered during the development. For example, because spray drying can be stressful to the protein, the process conditions can largely affect the quality of the product. Therefore, also the drying process should be tailored to the specific protein to be formulated. Therefore, a mathematical model was developed to predict optimal process conditions.
It is believed that more detailed models can further help with the formulation and process development by understanding better what happens at a more microscopic level. For protein formulations, predicting the behavior of drying droplets showed and quantified the separation of the stabilizing sugar and the protein on a molecular level inside the droplet. With this knowledge a better approach can be chosen to obtain optimal protein stability.
Leonardo Arriagada Beltran conducted his PhD research on the interface of computer-generated art and the constantly evolving field of Artificial Intelligence (AI). He will defend his Phd thesis on 21 September. His research offers valuable insights...
Harish Vedantham and Casper van der Kooi have been nominated by New Scientist for Wetenschapstalent 2023 (Science Talent 2023). This election is meant to give young scientists and their research a stage.
No less than five promising PhD graduates from the University of Groningen will be able to conduct research at top institutes abroad for two years thanks to the Rubicon programme organized by the Netherlands Organisation for Scientific Research...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether you want to accept
or reject other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information