PhD student Edwin Kroon from the group Drug Design (Groningen Research Institute of Pharmacy) has discovered an allosteric and potent PDK1 modifier using a combined computational and synthetic approach. PDK1 is an important kinase target with implications in cancer and diabetes. While pharmaceutical industry is mostly building on ATP competitive inhibitors, the Domling group investigates allosteric binding modes which promise to be more selective and devoid of side effects often seen in kinase drugs. The 3D structural elucidation of the small molecule inhibitor in PDK1 will form the starting point for new potent and selective anti cancer treatments.
The work is a collaboration between the Biondi biochemistry and crystallography group at the Universitatshospital Frankfurt and Camacho from the University of Pittsburgh and has been published in the high profile journal Angewandte Chemie: http://onlinelibrary.wiley.com/doi/10.1002/anie.201506310/abstract
Last week, Ben Feringa and Anouk Lubbe presented the first copy of their book Alledaagse Moleculen (Everyday Molecules) to minister Robbert Dijkgraaf. The richly illustrated book offers an accessible overview of 180 substances in our daily lives....
Dr Annette Scheepstra of the UG Arctic Centre, part of the Faculty of Arts, is about to conduct research into tourism in Antarctica and how tourists can become Antarctic ambassadors. She has been granted €1 million in funding by the Dutch Research...
The Royal Netherlands Academy of Arts and Sciences (KNAW) has appointed Professor Maria Loi and Professor Dirk Slotboom from the Faculty of Science and Engineering as members of the Academy.
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