Skip to ContentSkip to Navigation
About usFaculty of Science and EngineeringResearchGRIPNews and activities

Development and application of proteomics as aid for unraveling smoke-induced COPD

23 November 2015

Cigarette smoking is the main risk factor for for Chronic Obstructive Pulmonary Disease (COPD), yet only a subset of smokers develops COPD, therefore in order to obtain a deeper understanding of the first processes responsible of the disease, Lorenza Franciosi set up the acute smoking model in young susceptible and non-susceptible individuals, COPD patients and controls. Her data show that already at young age, subjects with a positive family history of COPD respond differently to cigarette smoke than those with a negative family history. Particularly SerpinB3 and Uteroglobin were found to be proteins that may play a role in the onset of COPD.

The scope of the thesis of Franciosi was to identify potential biomarkers for COPD via a proteomic approach.

In order to identify the first processes involved in the onset of COPD, she aimed to compare not only confirmed (older) COPD patients with healthy controls, but also younger subjects susceptible or non-susceptible to develop the disease, based on their family history.

After assessing the feasibility of our proteomic approach in the investigation in Epithelial Lining Fluid (ELF), Francioso firstly compared the differential proteomic profiles in COPD patients and healthy controls. The proteins that resulted as statistically significantly different between these groups were subsequently investigated via other approaches, namely immunohistochemistry and ELISA.

A comparative study of ELF from COPD patients and healthy controls using chemical stable isotope labeling (iTRAQ®-8Plex) showed that the levels of four proteins differed significantly between ELF from COPD patients and healthy controls. These proteins are directly involved in two of the key processes responsible for the onset and development COPD, namely inflammation and oxidative stress.


PhD ceremony: L. Franciosi
When: November 27, 2015
Start: 14:30
Promotor: prof. dr. R.P.H. (Rainer) Bischoff
Where: Academy building RUG
Faculty: Mathematics and Natural Sciences
Last modified:23 November 2015 11.57 a.m.
printView this page in: Nederlands

More news

  • 27 May 2019

    Heropening Universiteitsmuseum tijdens 81e lustrum RUG

    Het Universiteitsmuseum Groningen heropent op donderdag 6 juni met twee nieuwe tentoonstellingen: de speciaal voor het RUG-lustrum samengestelde tentoonstelling Ruimteschip Aarde en de spannende Dead Zoo. Daarnaast wordt het boek De rebelse held van...

  • 24 May 2019

    Four UG researchers win Vidi grants

    The Netherlands Organisation for Scientific Research (NWO) has awarded an EUR 800,000 Vidi grant each to 86 experienced researchers. Four of these conduct their research at just one faculty at the University of Groningen (UG): the Faculty of Science...

  • 24 May 2019

    First edition of Top HR Leadership Programme successfully completed

    The University of Groningen Business School (UGBS) and the In the LEAD centre of expertise at the University of Groningen are looking back on a successful first edition of the Top HR Leadership programme. On 21 May, eight top HR professionals with different...