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Research Chemical Biology Research

Emergent Functions

The emergence of an enzymatic function can reveal functional insights and allows engineering biological systems with enhanced properties. In the first example (a-b), we engineered an aHL nanopore to function as GroES, a protein that in complex with GroEL forms a two-stroke protein-folding nanomachine. In the second example (c-d), we engineered a biological nanopore to catalyse the selective transport of DNA across a biological membrane.



Ho CW, Van Meervelt V, Tsai KC, De Temmerman PJ, Mast J, and Maglia G. Engineering a nanopore with co-chaperonin function. Science Advances.11 Dec. Vol. 1, no. 11, e1500905 (2015) DOI: 10.1126/sciadv.1500905

Franceschini, L., Soskine, M, Biesemans, A, and Maglia, G. A nanopore machine promotes the vectorial transport of DNA across membranes. Nature Commun (2013). DOI: 10.1038/ncomms3415
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Maglia, G., Heron, A. J., Hwang, W. L., Holden, M. A., Mikhailova, E., Li, Q., Cheley, S., and Bayley, H. Droplet networks with incorporated protein diodes show collective properties. Nature Nanotechnol 4 (7), 437-440 (2009). DOI
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Last modified:12 December 2019 2.29 p.m.