An international group of over 100 researchers led by Professor Lude Franke of the UMCG has identified hundreds of ‘key genes’. These key genes provide insight into the development of diseases and offer leads for medicine development.
This large-scale study examined the effects of genetic factors in the blood of over 31,000 people. ‘We correlated genetic variants of which we know that they increase the risk of disease with gene expression patterns,’ says UMCG researcher Annique Claringbould. ‘We obtained the data from 37 existing cohorts around the world, including Lifelines. This huge group allows us to identify subtle patterns that would otherwise remain hidden.’
The researchers conducted several analyses to look at the direct and indirect influences on gene expression. They used polygenic risk scores to calculate each participant’s risk of developing any of 1,200 different diseases. ‘In a way, this score summarizes the genetic risk of a person, but it does not say much about how the disease develops. By linking the genetic score to gene expression patterns, we arrived at key genes that play an important role in the development of a disease,’ says Claringbould.
The candidate medicines that ultimately prove the most effective are Next to that, the data of this study, which has been made available online for everyone to use, offers many opportunities to researchers. By now, hundreds of publications have used the results of this study.
The study has been coordinated together with Urmo Võsa from the University of Tartu in Estonia. The results of this study have been published in the journal Nature Genetics on 2 September 2021.
A multidisciplinary team of researchers from 11 different countries are starting a project on speeding up the development of vaccines. Researchers from the University of Groningen (UG) and the University Medical Center Groningen (UMCG) will study...
Prof. Marian Joëls has been awarded the ALBA-FKNE Diversity Prize 2021 for her contribution to advancing gender equality in brain research. The prize highlights a scientist or group that has made outstanding contributions to promoting diversity in...
From 24 - 27 June, AIMED, COVER, and IFMSA Groningen hosted aiHackCovid, the online AI - COVID-19 hackathon. Talented students and staff from a variety of fields in AI, computer science, and epidemiology took on COVID-19 and found fascinating...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information