Researchers Gea Holtman and Marjolein Berger of the Department of General Practice and Elderly care medicine have received a ZonMw grant of € 500,000. With this grant they will investigate whether a rapid test for a protein that is released in the intestines when there is an inflammation (calprotectin), helps the general practitioner to distinguish between functional abdominal symptoms and Inflammatory Bowel Disease (IBD) in children.
Chronic abdominal pain and diarrhea are common in children in general practice. The symptoms are often functional. This means that they are not caused by an abnormality in the organs, such as IBD (Crohn's disease or ulcerative colitis). The GP can not easily distinguish between functional symptoms and IBD, because the symptoms are similar. As a result, many children are referred to the hospital for further diagnostics; that is stressful for the children and their parents.
In this study, the patient delivers their faeces to the general practitioner. This stool is mixed with a buffer and this can be placed in a test device. The result is then known within 15 minutes. Children with IBD have a higher value of calprotectin in their faeces than children with functional abdominal symptoms, who have no inflammation in the intestine.
In this study, half of the general practitioners will use the rapid test and the other half will not. This study will evaluate whether the rapid test will reduce the referral rate of children with chronic abdominal pain or diarrhea, without missing a child with IBD. A total of 154 general practices are participating in the study to recruit around 400 children. The study takes four years and starts in January 2019.
De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...
Out of the 25 entries for the Dutch Huibregtsen Prize, the jury has nominated six scientific research projects. UG professor Pauline Westerman and Cisca Wijmenga, Rector Magnificus of the UG as of 1 September 2019, are two of the six nominees for the...
More than 200 researchers and their teams can begin to work on social and scientific issues in close collaboration with public and private parties. This close collaboration will take place in 17 research projects.