Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Cantilever systems for the next generation of biomechanical sensors

04 December 2012

PhD ceremony: Mr. M. Lazzarino, 9.00 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Cantilever systems for the next generation of biomechanical sensors

Promotor(s): prof. P. Rudolf

Faculty: Mathematics and Natural Sciences

In my thesis work I investigated alternative geometries of nanomechanical oscillators to be employed as biomolecular sensors. Simple mechanical oscillators, such as cantilevers and double clamped beams have been deeply investigated in the last decade and single molecule sensitivity was demonstrated. However, beside few marginal exceptions, the proof of principle demonstrations did not yet evolve into commercial devices. Alternative geometries can, in principle, improve the simple micromechanical systems studied so far, with more complex transfer functions suitable to operate also in demanding environments.

The thesis work was divided in two major sections.

In the first section twin cantilevers are discussed. Couples of cantilevers facing each other and separated by a nanometer gap may change their resonance response when one or more molecules are absorbed in the gap. Two different geometries have been fabricated and tested. One, with identical cantilevers, takes advantage of the shift in resonance frequency occurring upon molecular detection; the second with asymmetrical cantilevers, uses the shortest one to actuate the motion of the longer one through a molecular link.

In the second part the structure of the twin cantilevers is the starting point for creating a spatially confined chemical reaction in the gap between two cantilevers facing each other. This original process is extremely precise and represents an important milestone towards the future realization of complex micro- and nanomechanical systems for biomolecular detection.

Last modified:15 September 2017 3.41 p.m.
printView this page in: Nederlands

More news

  • 22 May 2019

    Noord-Nederland gaat down under tijdens Solar Challenge

    Studenten van de Hanzehogeschool Groningen, Rijksuniversiteit Groningen en Noorderpoort gaan met hun eigen gebouwde zonneauto voor de eerste keer meedoen aan de Bridgestone World Solar Challenge (BWSC) in Australië onder de naam Top Dutch Solar Racing...

  • 20 May 2019

    Forthcoming honorary doctor Titia de Lange: Splicing ropes and aging

    Titia de Lange has dedicated most of her working life to researching long telomeres – the ends of chromosomes. She was awarded an honorary doctorate in June for her ground-breaking research. De Lange’s first experiment as a PhD student, under the supervision...

  • 17 May 2019

    "Worms man" Dr. Jeroen Onrust wins Science Prize Campus Fryslân 2019

    Bioloog Jeroen Onrust mag zich de winnaar noemen van de Wetenschapsprijs Campus Fryslân 2019. Onrust onderzocht voor zijn promotieonderzoek bij Rijksuniversiteit Groningen/Campus Fryslân het belang van regenwormen op de vruchtbaarheid van agrarisch...