PhD ceremony: Mr. A.V.R. Madduri Venkata, 12.45 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Total syntheses of (-)-borrelidin and (-)-doliculide and the development of the catalytic asymmetric addition of Grignard reagents to ketones
Promotor(s): prof. A.J. Minnaard
Faculty: Mathematics and Natural Sciences
This thesis describes the application of copper-catalyzed asymmetric conjugate addition and ruthenium-catalyzed asymmetric hydrogenation in novel total syntheses of the macrocyclic polyketides Borrelidin and Doliculide. A second topic in the thesis comprizes the development of a novel asymmetric synthesis of chiral tertiary alcohols by copper-catalyzed addition of Grignard reagents to ketones. During the study of the latter reaction, asymmetric amplification was observed. A procedure for the copper-catalyzed conjugate addition reaction to 2-methyl cyclopentenone and 2-methyl cyclohexenone was developed as well. Finally, the already known procedure for iridium catalyzed epimerization of alcohols and amines, was extended to 1,2-amino alcohols and substrates containing multiple functional groups.
You can vote until October 5.
Dean Knoester leaves Groningen science faculty January 1, 2022
The grant of EUR 921,000 is for his project ‘Multi-scale assessment of liquid metal embrittlement at steel-zinc interfaces (MUSCLES).
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