Biomaterial surfaces differentially adhesive to microbes and mammalian cells

PhD ceremony: Ms. Y. Wang, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen

Dissertation: Biomaterial surfaces differentially adhesive to microbes and mammalian cells

Promotor(s): prof. H.J. Busscher, prof. M. Libera, prof. H.C. van der Mei

Faculty: Medical Sciences

Infection is the number one cause of failure of biomaterials implants and devices, despite decades of research into the development of anti‐adhesive coatings. The main aim of this thesis was to investigate up to what extent spatially modified, non‐adhesive PEG‐microgel patterns could favorably influence microbial adhesion, mammalian cell adhesion and spreading, and, ultimately, the outcome of the race for the surface to reduce the chance of occurrence of biomaterials‐associated‐infection.