Skip to ContentSkip to Navigation
About us Latest news News News articles

Vascular reactivity in cardiopulmonary bypass

06 April 2011

PhD ceremony: Ms. I. Samarska, 11.00 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Vascular reactivity in cardiopulmonary bypass

Promotor(s): prof. R.H. Henning, prof. M.M.R.F. Struys

Faculty: Medical Sciences

 

Cardiopulmonary bypass (CPB) is a widely used technique invaluable to cardiothoracic surgery, but it is also associated with organ dysfunction and increased incidence of postoperative clinical complications. These may occur in vital organs including the heart, kidneys, lungs, intestines and brain. Utilisation of CPB induces changes in vasoreactivity of macro- and microcirculatory beds, which may be a pivotal component in the development of organ dysfunction. The aim of this thesis was to study the pathophysiology of vasomotor function in a rat model of CPB. Key physiological components of the blood vessels did not fully normalise after a prolonged recovery period, suggesting a continuing pathological process. The researchers suggest that these findings are an important explanation for the ongoing complaints of patients after surgery with CPB. It was also found that the choice of anaesthesia largely impacts the vascular changes. Lastly, it was demonstrated that the negative effects of CPB were attenuated when patients were treated with drugs that modulate the Sphingosine 1 Phosphate receptor prior to surgery.

 

Last modified:13 March 2020 01.09 a.m.
View this page in: Nederlands

More news

  • 27 August 2024

    UMCG gaat onderzoeksfaciliteiten beschikbaar stellen voor geneesmiddelenontwikkeling

    Om de beschikbaarheid en effectiviteit van geneesmiddelen in Nederland te verbeteren gaat het UMCG het bedrijf G² Solutions opzetten. Dit bedrijf moet ervoor gaan zorgen dat belangrijke technologische ontwikkelingen op het gebied van DNA sequencing...

  • 17 July 2024

    Veni-grants for ten researchers

    The Dutch Research Council (NWO) has awarded a Veni grant of up to €320,000 each to ten researchers of the University of Groningen and the UMCG. The Veni grants are designed for outstanding researchers who have recently gained a PhD.

  • 16 July 2024

    Medicine still subjects to male bias

    Aranka Ballering studied the course of illness in people with common symptoms. One of the most striking findings to emerge from her research was that on average, women have a different – and less extensive – course of illness than men.