Skip to ContentSkip to Navigation
About usNews and EventsNews articles

ABC transporters and cholesterol metabolism in acute myeloid leukemia

16 February 2011

PhD ceremony: Ms. S.D.P.W.M. de Jonge-Peeters, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: ABC transporters and cholesterol metabolism in acute myeloid leukemia

Promotor(s): prof. E. Vellenga, prof. E.G.E. de Vries, prof. F. Kuiper

Faculty: Medical Sciences

 

Acute myeloid leukemia (AML) is a malignant disease of hematopoietic bone marrow stem cells. Knowledge about the defence mechanisms of bone marrow stem cells against chemotherapy may provide important new targets to improve antileukemic treatment.In this thesis ATP binding Cassette (ABC) transporter expression and function in different hematopoietic cell fractions were studied. Result show that some ABC transporters, which are known to be involved in cholesterol metabolism, are highly expressed in the primitive cell fraction of hematopoietic cells. Subsequently, in vitro studies showed that, for a subgroup of AML patients, malignant cells became more sensitive to standard chemotherapeutic treatment when used with commonly used cholesterol lowering drugs (statins).

 

Last modified:15 September 2017 3.41 p.m.
printView this page in: Nederlands

More news

  • 20 May 2019

    Forthcoming honorary doctor Titia de Lange: Splicing ropes and aging

    Titia de Lange has dedicated most of her working life to researching long telomeres – the ends of chromosomes. She was awarded an honorary doctorate in June for her ground-breaking research. De Lange’s first experiment as a PhD student, under the supervision...

  • 15 May 2019

    Academy Medal for Trudy Dehue

    Trudy Dehue, scientific sociologist, author and emeritus professor of the University of Groningen, will receive the Academy Medal from the Royal Netherlands Academy of Arts and Sciences (KNAW). The Academy Medal is awarded every other year to individuals...

  • 15 May 2019

    Van Rijn advice hits UG hard

    The advice from the Van Rijn committee concerning the funding of higher education has heavy consequences for the UG as a broad-based classical university. The proposed redistribution of funds in favour of technical sciences is at the expense of degree...