PhD ceremony: Ms. E.C. de Haas, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Exploring predictors of chemotherapy efficacy and toxicity in testicular cancer
Promotor(s): prof. J.A. Gietema, prof. F.E. van Leeuwen, prof. D.Th. Sleijfer
Faculty: Medical Sciences
This thesis describes in testicular cancer patients treated with platinum-based chemotherapy that: 1) a common variation in the gene for bleomycin hydrolase, an enzyme inactivating the chemotherapeutic agent bleomycin, is associated with unfavourable disease outcome and reduced survival, 2) a common variant in the gene for Plasminogen Activator Inhibitor 1 is associated with unfavourable prognosis and reduced survival, 3) circulating cell skeleton component cytokeratin 18 seems to have no additional value for evaluation of disease response during chemotherapy, 4) circulating endothelial cells may predict chemotherapy-related vascular damage, and 5) the metabolic syndrome, a cluster of cardiovascular risk factors, occurs at earlier age after chemotherapy than in peers, may be the consequence of lower testosterone levels and contribute to the increased risk for cardiovascular disease through an association with atherosclerosis.
Guided by predictors, the ultimate goal is to develop an individual approach through adjustments in treatment strategy, tailored follow-up programs, preventive measures and early interventions.
Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...
De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...
The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.