Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Exploring predictors of chemotherapy efficacy and toxicity in testicular cancer

18 October 2010

PhD ceremony: Ms. E.C. de Haas, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Exploring predictors of chemotherapy efficacy and toxicity in testicular cancer

Promotor(s): prof. J.A. Gietema, prof. F.E. van Leeuwen, prof. D.Th. Sleijfer

Faculty: Medical Sciences


This thesis describes in testicular cancer patients treated with platinum-based chemotherapy that: 1) a common variation in the gene for bleomycin hydrolase, an enzyme inactivating the chemotherapeutic agent bleomycin, is associated with unfavourable disease outcome and reduced survival, 2) a common variant in the gene for Plasminogen Activator Inhibitor 1 is associated with unfavourable prognosis and reduced survival, 3) circulating cell skeleton component cytokeratin 18 seems to have no additional value for evaluation of disease response during chemotherapy, 4) circulating endothelial cells may predict chemotherapy-related vascular damage, and 5) the metabolic syndrome, a cluster of cardiovascular risk factors, occurs at earlier age after chemotherapy than in peers, may be the consequence of lower testosterone levels and contribute to the increased risk for cardiovascular disease through an association with atherosclerosis.

Guided by predictors, the ultimate goal is to develop an individual approach through adjustments in treatment strategy, tailored follow-up programs, preventive measures and early interventions.


Last modified:15 September 2017 3.39 p.m.
printView this page in: Nederlands

More news

  • 11 July 2019

    Major companies’ annual reports too vague about climate impact

    Many major Dutch companies publish extensive information about climate impact in their annual reports. However, very few companies provide concrete, detailed information about their own CO2 emissions, the impact of climate change on their business...

  • 08 July 2019

    Zeven RUG-projecten krijgen financiering via de NWA Ideeëngenerator

    De NWO heeft aan 37 out-of-the-box onderzoeksideeën financiering toegekend vanuit de Ideeëngenerator. Een belangrijk kenmerk van de projecten is een mogelijke maatschappelijke impact. Elk van de onderzoekers krijgt 50.000 euro beschikbaar om met samen...

  • 08 July 2019

    UG permanently closes Yantai project

    The University of Groningen (UG) has permanently closed the project aimed at creating a branch campus in Yantai. Discussions were held with China Agricultural University, the city of Yantai and the Province of Shandong.