PhD ceremony: Ms. J.C. Wolters, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Profiling of ABC transporters
Promotor(s): prof. B. Poolman
Faculty: Mathematics and Natural Sciences
This thesis describes a new method to enrich ATP-binding proteins, and more specifically ATP-binding cassette (ABC) transporters from complex mixtures in the cell. ABC transporters, amongst others, transport nutrients and regulate a variety of processes, like the regulation of the cell volume. The importance of the ABC transporters is shown in diseases like cystic fibrosis and drug resistance, which are caused by mutations and/or folding defects in the proteins. Next to the development of a method for the enrichment of these proteins, more detailed analyses have been performed on the osmoregulatory ABC transporter OpuA from the bacterium Lactococcus lactis. OpuA protects microorganisms from high salt concentrations (high osmolarity) in the environment. The crystal structure of the substrate-binding domain has been determined, which has yielded important information on how the receptor domain recognizes the ligand glycine betaine. Moreover, a number biophysical techniques, like electron microscopy and mass spectrometry, have been used to obtain structural information on the entire OpuA complex, which so far has been refractory to structure determination by crystallography.
The timing, route, and destination for godwit migration is learned rather than innate. Researchers at the University of Groningen discovered this in a daring experiment, which has been published in the latest issue of the journal Current Biology.
The grant is worth EUR 500,000, of which Avraamidou and Sburlea receive around EUR 100,000.
George Azzopardi and Guru Swaroop Bennabhaktula from the Faculty of Science and Engineering have won the Ben Feringa Impact Award 2023 for their project ‘4NSEEK; Forensic Against Sexual Exploitation of Children’. In the ‘students’ category, Nine van...
The UG website uses functional and anonymous analytics cookies. Please answer the question of whether or not you want to accept other cookies (such as tracking cookies).
If no choice is made, only basic cookies will be stored. More information