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Nollen, Dr Ellen

Ellen Nollen
Ellen Nollen

Nollen, a medical geneticist, researches the genetic source of the development of neurodegenerative diseases like Parkinson’s, Alzheimer’s and Huntington’s within the framework of the Healthy Ageing programme. She has previously conducted research into this at Northwestern University in Chicago (US) and at the Hubrecht Laboratory, the Ronald Plasterk’s KNAW institute in Utrecht. Nollen discovered that the moag-4 gene regulates the aggregation and harmful effects of disease proteins during the process of cell ageing.

Ellen Nollen was the first female researcher to be awarded a Rosalind Franklin Fellowship at the UMCG. The University of Groningen and the UMCG set up the Rosalind Franklin Fellowships to attract talented female researchers. In 2011 she was awarded a EUR 1.5 million European ERC grant for her research. The ERC grants are intended to further reinforce outstanding research teams.

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2020

Koopman, M., Peter, Q., Seinstra, R. I., Perni, M., Vendruscolo, M., Dobson, C. M., ... Nollen, E. A. A. (2020). Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform. Nature protocols. https://doi.org/10.1038/s41596-020-0321-9

2019

Sorgdrager, F. J. H., Vermeiren, Y., Van Faassen, H. J. R., Van Der Ley, C. P., Nollen, E. A. A., Kema, I. P., & De Deyn, P. P. (2019). Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease. Journal of Neurochemistry, 151(5), 656-668. https://doi.org/10.1111/jnc.14843
Koopman, M., Seinstra, R. I., & Nollen, E. A. A. (2019). C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques. In T. Bartels (Ed.), Alpha-Synuclein (pp. 93-112). (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9124-2_9
Laine, R. F., Sinnige, T., Ma, K. Y., Haack, A. J., Poudel, C., Gaida, P., ... Kaminski, C. F. (2019). Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of alpha-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology, 14(7), 1628-1636. https://doi.org/10.1021/acschembio.9b00354
Koopman, M., Hetz, C., & Nollen, E. A. A. (2019). Saved by the Matrix: UPR Independent Survival under ER Stress. Cell, 179(6), 1246-1248. https://doi.org/10.1016/j.cell.2019.11.012
Janssens, G. E., Lin, X-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., ... Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044
Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019). Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nature Reviews Drug Discovery, 18(8), 379-401. https://doi.org/10.1038/s41573-019-0016-5
Sorgdrager, F. J. H., Naude, P. J. W., Kema, I. P., Nollen, E. A., & De Deyn, P. P. (2019). Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target. Frontiers in Immunology, 10, [2565]. https://doi.org/10.3389/fimmu.2019.02565

2018

Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., ... Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1
Perni, M., Casford, S., Aprile, F. A., Nollen, E. A., Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2018). Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of visualized experiments : JoVE, (141), [58643]. https://doi.org/10.3791/58643
Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., ... Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.
Sin, O., Mata-Cabana, A., Seinstra, R. I., & Nollen, E. A. A. (2018). Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Lysates. JMIR research protocols, 8(19), [3042]. https://doi.org/10.21769/BioProtoc.3042
Perni, M., Challa, P. K., Kirkegaard, J. B., Limbocker, R., Koopman, M., Hardenberg, M. C., ... Knowles, T. P. J. (2018). Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods, 306, 57-67. https://doi.org/10.1016/j.jneumeth.2018.02.005
Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466
Mata-Cabana, A., Sin, O., Seinstra, R. I., & Nollen, E. A. A. (2018). Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans. JMIR research protocols, 8(20), [3053]. https://doi.org/10.21769/BioProtoc.3053

2017

Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., ... Dobson, C. M. (2017). A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America, 114(6), E1009-E1017. https://doi.org/10.1073/pnas.1610586114
Stroo, E., Koopman, M., Nollen, E. A. A., & Mata-Cabana, A. (2017). Cellular Regulation of Amyloid Formation in Aging and Disease. Frontiers in Neuroscience, 11, [64]. https://doi.org/10.3389/fnins.2017.00064
Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., ... Dobson, C. M. (2017). Correction for Perni et al., A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017). Proceedings of the National Academy of Science of the United States of America, 114(12), E2543-E2543. https://doi.org/10.1073/pnas.1701964114
Nollen, E. A. A., & Michels, H. (2017). Cysteine dioxygenase inhibitors for prolonging the lifespan of a subject. (Patent No. EP3251664).
Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9
Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M. A., Aprile, F. A., ... Nollen, E. A. A. (2017). Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell, 65(6), 1096-1108. https://doi.org/10.1016/j.molcel.2017.02.022
Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., ... Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886

2016

Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., ... Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106
Habchi, J., Arosio, P., Perni, M., Costa, A. R., Yagi-Utsumi, M., Joshi, P., ... Vendruscolo, M. (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances, 2(2), [e1501244]. https://doi.org/10.1126/sciadv.1501244
Michels, H., Seinstra, R. I., Uitdehaag, J. C. M., Koopman, M., van Faassen, M., Martineau, C. N., ... Nollen, E. A. A. (2016). Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase. Scientific Reports, 6, [39199]. https://doi.org/10.1038/srep39199
Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., ... Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025

2015

Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., ... Sibon, O. C. M. (2015). Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis. Nature Chemical Biology, 11(10), 784-792.e3. https://doi.org/10.1038/NCHEMBIO.1906
Alvarenga Fernandes Sin, O., & Nollen, E. A. A. (2015). Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes. Cellular and molecular life sciences, 72(21), 4027-4047. https://doi.org/10.1007/s00018-015-1985-0

2014

Alvarenga Fernandes Sin, O., Michels, H., & Nollen, E. A. A. (2014). Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochimica et biophysica acta-Molecular basis of disease, 1842(10), 1951-1959. https://doi.org/10.1016/j.bbadis.2014.01.015

2013

Holmberg, M., & Nollen, E. A. A. (2013). Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis. In D. M. Hatters, & A. J. Hannan (Eds.), Tandem Repeats in Genes, Proteins, and Disease (Vol. 1017, pp. 193-199). (Methods in Molecular Biology; Vol. 1017). Humana Press. https://doi.org/10.1007/978-1-62703-438-8_14
van der Goot, A. T., & Nollen, E. A. A. (2013). Tryptophan metabolism: entering the field of aging and age-related pathologies. TRENDS IN MOLECULAR MEDICINE, 19(6), 336-344. https://doi.org/10.1016/j.molmed.2013.02.007

2012

van der Goot, A. T., Zhu, W., Vazquez-Manrique, R. P., Seinstra, R. I., Dettmer, K., Michels, H., ... Nollen, E. A. A. (2012). Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. https://doi.org/10.1073/pnas.1203083109
Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., ... Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012

2011

Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., ... Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996
Siudeja, K., Srinivasan, B., Xu, L., Rana, A., de Jong, J., Nollen, E. A. A., ... Sibon, O. C. M. (2011). Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Molecular Medicine, 3(12), 755-766. https://doi.org/10.1002/emmm.201100180
Teuling, E., Bourgonje, A., Veenje, S., Thijssen, K., de Boer, J., van der Velde, J., ... Nollen, E. (2011). Modifiers of mutant huntingtin aggregation: Functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Currents, 3(RRN1255). https://doi.org/10.1371/currents.RRN1255

2010

van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., ... Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020
van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., ... Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell, 142(4), 601-12. https://doi.org/10.1016/j.cell.2010.07.020
van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S-T. D., Schierle, G. S. K., Kaminsk, C. F., ... Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066

2009

Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S-T., Fernandez-Montesinos, R., ... Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298
van Ham, T. J., Breitling, R., Swertz, M. A., & Nollen, E. A. A. (2009). Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Molecular Medicine, 1(8-9), 360-370. https://doi.org/10.1002/emmm.200900051

2008

van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., & Nollen, E. A. A. (2008). C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS genetics, 4(3), [1000027]. https://doi.org/10.1371/journal.pgen.1000027

2004

van Haaften, G., Vastenhouw, N. L., Nollen, E. A. A., Plasterk, R. H. A., & Tijsterman, M. (2004). Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proceedings of the National Academy of Sciences of the United States of America, 101(35), 12992-12996. https://doi.org/10.1073/pnas.0403131101
Nollen, E. A. A., Garcia, S. M., van Haaften, G., Kim, S., Chavez, A., Morimoto, R. I., & Plasterk, R. H. A. (2004). Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6403-6408. https://doi.org/10.1073/pnas.0307697101

2002

Nollen, E. A. A., & Morimoto, R. I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. Journal of Cell Science, 115(14), 2809-2816.
Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863

2001

Nollen, E. A., Salomons, F. A., Brunsting, J. F., van der Want, J. J. L., Sibon, O. C. M., & Kampinga, H. H. (2001). Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proceedings of the National Academy of Sciences of the United States of America, 98(21), 12038-12043. https://doi.org/10.1073/pnas.201112398
Nollen, E. A., Kabakov, A. E., Brunsting, J. F., Kanon, B., Höhfeld, J., & Kampinga, H. H. (2001). Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. The Journal of Biological Chemistry, 276(7), 4677-4682. https://doi.org/10.1074/jbc.M009745200

2000

Nollen, EAA., Brunsting, JF., Kampinga, HH., & Morimoto, RI. (2000). Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Molecular and Cellular Biology, 20(3), 1083-1088. https://doi.org/10.1128/MCB.20.3.1083-1088.2000
Nollen, E. A. (2000). HSP70 chaperone functions in stressed cells. s.n.

1999

van der Leij, FR., Roelofsen, H., Niezen-Koning, KE., Nollen, EAA., & Kuipers, JRG. (1999). Confocal laser scanning microscopy of human skin fibroblasts showing transient expression of a green fluorescent carnitine palmitoyltransferase 1 fusion protein. In PA. Quant, & S. Eaton (Eds.), CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS (pp. 111-115). (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY; Vol. 466). NEW YORK: Kluwer Academic/Plenum Publishers.
Nollen, EAA., Brunsting, JF., Roelofsen, H., Weber, LA., & Kampinga, HH. (1999). In vivo chaperone activity of heat shock protein 70 and thermotolerance. Molecular and Cellular Biology, 19(3), 2069-2079. https://doi.org/10.1128/MCB.19.3.2069

1997

Martens, D. E., Nollen, E. A., Hardeveld, M., Velden-de Groot, C. A., Gooijer, C. D., Beuvery, E. C., & Tramper, J. (1997). Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers. Cytotechnology, 23(1), 61-75. https://doi.org/10.1023/B:CYTO.0000010399.23373.65

1996

Martens, D. E., Nollen, E. A., Hardeveld, M., van der Velden-de Groot, C. A., de Gooijer, C. D., Beuvery, E. C., & Tramper, J. (1996). Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers. Cytotechnology, 21(1), 45-59. https://doi.org/10.1007/BF00364836

1994

Peters, S. A., Verver, J., Nollen, E. A., van Lent, J. W., Wellink, J., & van Kammen, A. (1994). The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication. The Journal of general virology, 75 ( Pt 11), 3167-76. https://doi.org/10.1099/0022-1317-75-11-3167
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