The potential use of N-octanoyl-dopamine (NOD) in organ transplantation

Transplantation of solid organs has become the treatment of choice for several end-stage organ diseases like end-stage heart disease and chronic kidney disease. As the mismatch between organ supply and demand of donor organs continues to grow, there is an unmet socio-economical and clinical demand for new strategies to increase the donor organ pool. This thesis identifies with N-octanoyl dopamine (NOD) a new class of molecules to enable the preservation of organs during the damaging environment of brain death and protecting grafts after transplantation from chronic graft loss. NOD is not only a potential therapeutic drug to improve transplant outcome but also to increase the number of organs that are up for transplantation.

Dissertation: http://irs.ub.rug.nl/ppn/387266283