On the use of multicomponent reactions in high-throughput synthesis, and, the synthesis of some selectively modified carbohydrates

The research described in this thesis covers two major themes. Part I of the thesis emphasizes the potential of automated synthesis for facilitating and accelerating experimentation in organic and medicinal chemistry. Moreover, the first part of the thesis represents multicomponent reactions (MCRs) as a class of reactions highly amenable to automation.The focus of Part II is an important class of biomolecules, namely carbohydrates. Here, we discuss a synthetic strategy to selectively modify unprotected carbohydrates. This modification was subsequently used to explore the idea of developing a carbohydrate-based lipid probe for bioimaging purposes.

Dissertation: https://hdl.handle.net/11370/85474b1d-9498-45bd-a900-58045e04c98e