The unfolded protein response in glioblastoma stem cells: towards new targets for therapy
| PhD ceremony: | Ms N.M. (Natalia) Peñaranda Fajardo-Jimenez Zucchet |
| When: | May 11, 2020 |
| Start: | 16:15 |
| Supervisor: | prof. dr. F.A.E. (Frank ) Kruyt |
| Co-supervisor: | dr. J. Meijer |
| Where: | Academy building RUG / Student Information & Administration |
| Faculty: | Medical Sciences / UMCG |
The aim of this thesis was to investigate ER stress/ UPR signalling in GSCs and explore its potential as a target for therapy in GBM. The importance of the UPR in contributing to acute ER stress-induced cytotoxicity was examined, including effects on the self-renewal potential of GSCs and the underlying molecular mechanisms were elucidated. For this, previously in our lab generated and characterized patient-derived GSC-enriched GBM neurosphere models were employed. A novel noncanonical mechanism for PERK was identified that regulates differentiation and stemness in GSCs. We conclude that ER stress-inducing therapies and PERK modulation may provide promising therapeutic approaches in GBM.
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