dr. S.W.M. (Sophia) Bruggeman

Rosalind Franklin fellow (scientist, junior group leader)

Faculteit Medische Wetenschappen/UMCG

Telefoon:

050 361 6493

E-mail:

s.w.m.bruggeman umcg.nl

ORCID Research Portal

Research interests

Faculty of Medical Sciences	Telephone:	+31 503619554
E-mail: s.w.m.bruggeman@umcg.nl

Curriculum Vitae

Sophia Bruggeman (The Netherlands, 1979) studied Biology at the University of Nijmegen. As PhD student, she worked at the Netherlands Cancer Institute on the role of Polycomb group genes in brain development and cancer (2008, cum laude). She next moved to King's College London to work on the development of the chick and zebrafish forebrain on a KWF postdoctoral fellowship. This fellowship was completed at the European Research Institute for the Biology of Ageing (ERIBA/University Medical Center Groningen).

After awardance of a Rosalind Franklin fellowship (tenure track position) and a KWF Cancer Research career award, Sophia started her own research group at the department of Pediatric Oncology and Hematology/Pediatrics, UMCG (2014). In 2019, Sophia's research group moved to ERIBA, UMCG. Her research aims at understaning how normal neurodevelopmental processes influence pediatric brain cancer initiation and progression.

Publicaties

Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum

Bockaj, I., Martini, T. E., Smit, M. J., Armandari, I., Bakker, B., Wardenaar, R., Meeuwsen-de Boer, T. G. J., Bakker, P. L., Spierings, D. C. J., Hoving, E. W., Guryev, V., Foijer, F. & Bruggeman, S. W. M., 30-aug.-2022, In: International Journal of Molecular Sciences. 23, 17, 15 blz., 9852.

Onderzoeksoutput › › peer review

The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

Smit, M. J., Martini, T. E. I., Armandari, I., Bočkaj, I., Zomerman, W. W., de Camargo Magalhães, E. S., Siragna, Z., Meeuwsen, T. G. J., Scherpen, F. J. G., Schoots, M. H., Ritsema, M., den Dunnen, W. F. A., Hoving, E. W., Paridaen, J. T. M. L., de Haan, G., Guryev, V. & Bruggeman, S. W. M., jun.-2022, In: Journal of Cell Science. 135, 11, 14 blz., jeb258608.

Onderzoeksoutput › › peer review

CREB signaling activity correlates with differentiation and survival in medulloblastoma

Armandari, I., Zomerman, W. W., Plasschaert, S. L. A., Smit, M. J., Martini, T. E., Magalhaes, E. S. D. C., Hogeling, S. M., Rozema-Huizinga, G. C., Lourens, H. J., Meeuwsen-de Boer, T. G. J., Scherpen, F. J. G., de Bont, E. S. J. M. & Bruggeman, S. W. M., 9-aug.-2021, In: Scientific Reports. 11, 1, 12 blz., 16077.

Onderzoeksoutput › › peer review

Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study

Hoff, F. W., van Dijk, A. D., Qiu, Y. H., Ruvolo, P. P., Gerbing, R. B., Leonti, A. R., Jenkins, G. N., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T., Meshinchi, S., De Bont, E., Bruggeman, S. W., Kornblau, S. M. & Horton, T. M., 25-feb.-2021, In: Blood. 137, 8, blz. 1050-1060 11 blz.

Onderzoeksoutput › › peer review

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

Bočkaj, I., Martini, T. E. I., de Camargo Magalhães, E. S., Bakker, P. L., Meeuwsen-de Boer, T. G. J., Armandari, I., Meuleman, S. L., Mondria, M. T., Stok, C., Kok, Y. P., Bakker, B., Wardenaar, R., Seiler, J., Broekhuis, M. J. C., van den Bos, H., Spierings, D. C. J., Ringnalda, F. C. A., Clevers, H., Schüller, U., van Vugt, M. A. T. M., & 2 anderenFoijer, F. & Bruggeman, S. W. M., nov.-2021, In: PLoS genetics. 17, 11, 28 blz., 1009868.

Onderzoeksoutput › › peer review

Loss of H3K27 Methylation Identifies Poor Outcome in Adult-Onset Acute Myeloid Leukemia

van Dijk, A. D., Hoff, F. W., Qiu, Y., de Bont, E. S., Bruggeman, S. W. M., Horton, T. M. & Kornblau, S. M., 5-nov.-2020, In: Blood. 136, 3 blz.

Onderzoeksoutput ›

Loss of H3K27 Methylation Identifies Poor Outcomes in Adult-Onset Acute Lymphoblastic and Myeloid Leukemia

van Dijk, A., Hoff, F., Qiu, Y., Jabbour, E., de Bont, E., Bruggeman, S., Horton, T. & Kornblau, S., sep.-2020, In: Clinical lymphoma myeloma & leukemia. 20, blz. S205-S206 2 blz.

Onderzoeksoutput ›

Prognostic Significance of FOXO3 in Pediatric Acute Myeloid Leukemia (AML) Patients Treated with Bortezomib Addition to Standard Therapy: Results from a Children's Oncology Group Phase 3 Clinical Trial

van Dijk, A. D., Ruvolo, P. P., Hoff, F. W., Qiu, Y., Gamis, A. S., Aplenc, R., Kolb, A. E., Alonzo, T. A., Gerbing, R. B., de Bont, E. S., Bruggeman, S. W. M., Horton, T. M. & Kornblau, S. M., 13-nov.-2019, In: Blood. 134, 4 blz.

Onderzoeksoutput ›

The developmental stage of the medulloblastoma cell-of-origin is maintained in cancer and restricts hedgehog pathway usage and drug sensitivity

Smit, M., Armandari, I., Bockaj, I., Martini, T., Zomerman, W., Siragna, Z., Meeuwsen-de Boer, T., Scherpen, F., Schoots, M., Ritsema, M., den Dunnen, W., Hoving, E., Paridaen, J., de Haan, G., Guryev, V. & Bruggeman, S., apr.-2019, In: Neuro-Oncology. 21, blz. 104 1 blz.

Onderzoeksoutput ›

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

Zomerman, W. W., Plasschaert, S. L. A., Conroy, S., Scherpen, F. J., Meeuwsen-de Boer, T. G. J., Lourens, H. J., Guerrero Llobet, S., Smit, M. J., Slagter-Menkema, L., Seitz, A., Gidding, C. E. M., Hulleman, E., Wesseling, P., Meijer, L., van Kempen, L. C., van den Berg, A., Warmerdam, D. O., Kruyt, F. A. E., Foijer, F., van Vugt, M. A. T. M., & 5 anderenden Dunnen, W. F. A., Hoving, E. W., Guryev, V., de Bont, E. S. J. M. & Bruggeman, S. W. M., 20-mrt.-2018, In: Cell reports. 22, 12, blz. 3206-3216 11 blz.

Onderzoeksoutput › › peer review

Lees meer

Alle (25) publicaties

Bekijk volledig onderzoeksprofiel