dr. S.W.M. (Sophia) Bruggeman

Rosalind Franklin fellow (scientist, junior group leader)

dr. S.W.M. (Sophia) Bruggeman
s.w.m.bruggeman umcg.nl


Research interests

dr. S.W.M. Bruggeman
+31 503619554
E-mail: s.w.m.bruggeman@umcg.nl

Curriculum Vitae

Sophia Bruggeman (The Netherlands, 1979) studied Biology at the University of Nijmegen. As PhD student, she worked at the Netherlands Cancer Institute on the role of Polycomb group genes in brain development and cancer (2008, cum laude). She next moved to King's College London to work on the development of the chick and zebrafish forebrain on a KWF postdoctoral fellowship. This fellowship was completed at the European Research Institute for the Biology of Ageing (ERIBA/University Medical Center Groningen).

After awardance of a Rosalind Franklin fellowship (tenure track position) and a KWF Cancer Research career award, Sophia started her own research group at the department of Pediatric Oncology and Hematology/Pediatrics, UMCG (2014). In 2019, Sophia's research group moved to ERIBA, UMCG. Her research aims at understaning how normal neurodevelopmental processes influence pediatric brain cancer initiation and progression.

  1. Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study

    Hoff, F. W., van Dijk, A. D., Qiu, Y. H., Ruvolo, P. P., Gerbing, R. B., Leonti, A. R., Jenkins, G. N., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T., Meshinchi, S., De Bont, E., Bruggeman, S. W., Kornblau, S. M. & Horton, T. M., 21-Sep-2020, In : Blood. 36 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. The developmental stage of the medulloblastoma cell-of-origin is maintained in cancer and restricts hedgehog pathway usage and drug sensitivity

    Smit, M., Armandari, I., Bockaj, I., Martini, T., Zomerman, W., Siragna, Z., Meeuwsen-de Boer, T., Scherpen, F., Schoots, M., Ritsema, M., den Dunnen, W., Hoving, E., Paridaen, J., de Haan, G., Guryev, V. & Bruggeman, S., Apr-2019, In : Neuro-Oncology. 21, p. 104 1 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. RPPA-Profiling Identifies Patients with Low Phosphorylation Levels of HSF1 at Serine 326 As Potential Candidate for Bortezomib Treatment in Addition to Standard Therapy in Pediatric Acute Myeloid Leukemia

    Hoff, F. W., Hu, W., Qiu, Y., Gamis, A. S., Aplenc, R., Kolb, E. A., Alonzo, T. A., Qutub, A. A., de Bont, E. S., Bruggeman, S. W. M., Kornblau, S. M. & Horton, T. M., 29-Nov-2018, In : Blood. 132, Suppl.1, 3 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  4. Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

    Zomerman, W. W., Plasschaert, S. L. A., Conroy, S., Scherpen, F. J., Meeuwsen-de Boer, T. G. J., Lourens, H. J., Guerrero Llobet, S., Smit, M. J., Slagter-Menkema, L., Seitz, A., Gidding, C. E. M., Hulleman, E., Wesseling, P., Meijer, L., van Kempen, L. C., van den Berg, A., Warmerdam, D. O., Kruyt, F. A. E., Foijer, F., van Vugt, M. A. T. M., den Dunnen, W. F. A., Hoving, E. W., Guryev, V., de Bont, E. S. J. M. & Bruggeman, S. W. M., 20-Mar-2018, In : Cell reports. 22, 12, p. 3206-3216 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Revisiting the chromosome separation checkpoint

    Bockaj, I., Bruggeman, S. W. M. & Foijer, F., Jul-2017, In : BioEssays. 39, 7, 1 p., 1700084.

    Research output: Contribution to journalEditorialAcademicpeer-review

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  1. Princess Maxima Ctr Paediat Oncol

    Sophia Bruggeman (Visiting researcher)


    Activity: Visiting an external institutionVisiting an external academic institutionAcademic

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