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Research interests

Steven Bergink received his master in molecular biology at the university of Groningen. He obtained his PhD at the ErasmusMC in Rotterdam in the group of Jan Hoeijmakers. He continued with a postdoc at the Max Planck Institute of Biochemistry (Munich, Germany) in the group of Stefan Jentsch. During both his PhD and postdoctoral period he focused on the regulation of DNA repair mechanisms by posttranslational modifications of the ubiquitin family.

           Currently he is a group leader at the medical faculty in Groningen. His current research at the Department of Cell biology aims to investigate the intertwinement of DNA repair, protein quality control and neurodegeneration.

Publications

DNAJB chaperones suppress destabilised protein aggregation via a region unique from that used to inhibit amyloidogenesis

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020

FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

Locked in a vicious cycle: the connection between genomic instability and a loss of protein homeostasis

Protein Quality Control Pathways at the Crossroad of Synucleinopathies

Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington's disease

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

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Press/media

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