dr. S.A. (Sarah) Pringle

Assistant Professor

dr. S.A. (Sarah) Pringle
E-mail:
s.a.pringle umcg.nl

Research

Research interests

Epithelial stem cells in disease contexts, with a primary basis on salivary gland stem cells. Disease contexts include the autoimmune disaease primary Sjögren's syndrome (pSS), radaition damage, medication-indcued xerostomia and check point inhibitor-indcued xerostomia. Development of iPS technology for generation of new salivary glands for patients with xerostomia. Cite-Seq analysis of salivary gland biopsies to elucidate potential early events in pSS. In vitro modelling of lymphoepithelial lesions in primary Sjögren's syndrome. Devlopment of senescence markers as surrogates for SG function in pSS. Development of in vitro cell culture models of vasculitis. Functionality of stem cells in other autoimmune idseases, for example Crohns and SLE. Development of mouse model of pSS, based on epithelial cell dysfunction.

Publications
  1. Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine

    Pringle, S., 2019, In : Inflammatory Bowel Diseases. izz295, p. izz295 doi.org/10.1093/ibd/izz295.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. IDENTIFICATION OF BIOMARKERS AND IMMUNE PATHWAYS FOR PERSONALIZED DRUG TARGETING IN PATIENTS WITH NEWLY DIAGNOSED PRIMARY SJOGREN'S SYNDROME

    Verstappen, G. M., Gao, L., Pringle, S. A., Terpstra, J. H., Liefers, S. C., van Nimwegen, J. F., Vissink, A., Patel, V., He, A., Truong, A., Hu, S., Dongre, A., Krishnakumar, A., Kirov, S., Carman, J., Bootsma, H. & Kroese, F. G. M., Jun-2019, In : Annals of the Rheumatic Diseases. 78, p. 397 1 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. Small-molecule inhibitors and the salivary gland epithelium in Sjogren's syndrome

    Pringle, S., Wang, X., Bootsma, H., Spijkervet, F. K. L., Vissink, A. & Kroese, F. G. M., 19-Jun-2019, In : Expert opinion on investigational drugs. p. 1-12 12 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

View all (19) »

Press / Media
  1. ReumaNederland 2018 Jaaroverzicht

    Sarah Pringle

    12/06/2019

    1 Media contribution

    Press/Media: Public Engagement ActivitiesAcademic

  2. Gammele speekselklieren en uitgeputte stamcellen

    Sarah Pringle

    06/11/2018

    1 Media contribution

    Press/Media: ResearchPopular

  3. Prematurely aged stem cells in pSS

    Sarah Pringle

    25/07/2018

    1 Media contribution

    Press/Media: ResearchPopular

View all (4) »

Activities
  1. Paola Serrano Martinez

    Sarah Pringle (Co-supervisor)
    20182020

    Activity: ExaminationSupervision of PhD studentsAcademic

  2. Yi Wu

    Sarah Pringle (Co-supervisor)
    20182022

    Activity: ExaminationSupervision of PhD studentsAcademic

  3. Xiaoyan Wang, PhD student

    Sarah Pringle (Supervisor)
    1-Nov-201631-Oct-2020

    Activity: ExaminationSupervision of PhD studentsAcademic

View all (16) »

Prizes
  1. Article 9 Laboratory Animal Science license (CDP Groningen).

    Sarah Pringle (Recipient), 2010

    Prize: Other distinctionAcademic

  2. eBROK (awarded 2017, valid until 03/04/2021).

    Sarah Pringle (Recipient), 2017

    Prize: Other distinctionAcademic

  3. University Teaching Qualification (UTQ) March 2018.

    Sarah Pringle (Recipient), Mar-2018

    Prize: Other distinctionAcademic

View all (15) »

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