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Over ons Praktische zaken Waar vindt u ons dr. S.A. (Sarah) Pringle

Research interests

The salivary glands (SGs) are innocuous organs, organs which we perhaps do not spend so much time thinking about. Their lack of function however, confers a dramatic decrease in quality of life. Speaking, eating and sleeping become challenging, and dental problems rife.  

My research focuses mainly on unravelling the reasons underpinning loss of SG function in the autoimmune condition Sjogren’s Disease (SjD), but also in relation to medication and immune checkpoint inhibitor use, and radiation. We leverage organoid technology using SG biopsies from patients experiencing lack of SG function to understand these phenomenon, in combination with transcriptomics approaches and histological analysis, to probe mechanisms driving these pathogeneses. A large focus of my work is the development of a SG-stem cell-based therapy for the rescue of SG function in SjD patients, wit the overarching goal to provide durable relief from dry mouth complaints.

Other current interests and projects include in vitro modelling of lymphoepithelial lesions in SjD, development of senescence markers as surrogates for SG function in SjD, development of in vitro cell culture models of vasculitis, and examination of functionality of stem cells in other autoimmune diseases, for example Crohns and SLE.

Publicaties

Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation

Away from definition and back to the clinic – as response to Kumar et al, ‘Evidence is not sufficient to declare the tubal gland conglomerates as salivary.’

Immunohistological profiling confirms salivary gland-like nature of the tubarial glands and suggests closest resemblance to the palatal salivary glands

Indication of activated senescence pathways in the temporal arteries of patients with giant cell arteritis

The diagnostic power of salivary electrolytes for Sjögren's disease: a systematic literature review and meta-analysis

Why do drug treatments fail in Sjögren's disease?: Considerations for treatment, trial design and interpretation of clinical efficacy

A 3D-organoid drug screening method for the elimination of radiation- induced senescent cells

A Roadmap for the Human Oral and Craniofacial Cell Atlas

Lymphoepithelial lesions in the salivary glands of primary Sjögren’s syndrome patients: The perfect storm?

Pathophysiology of Sjögren's-like syndrome induced by cancer immunotherapies: similarities and differences with classical Sjögren's syndrome

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Pers/media

Mond biedt schat aan informatie over gezondheid en ziekten, ook reuma

ReumaNederland steunt ontwikkeling stamceltherapie bij ziekte Sjögren

ReumaNederland 2018 Jaaroverzicht

Gammele speekselklieren en uitgeputte stamcellen

Prematurely aged stem cells in pSS

@SjogrensUMCG Twitter handle

International Society for Stem Cell Research Travel Grant

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