dr. S.A. (Sarah) Pringle
Assistant Professor
Research
Research interests
Epithelial stem cells in disease contexts, with a primary basis on salivary gland stem cells. Disease contexts include the autoimmune disaease primary Sjögren's syndrome (pSS), radaition damage, medication-indcued xerostomia and check point inhibitor-indcued xerostomia. Development of iPS technology for generation of new salivary glands for patients with xerostomia. Cite-Seq analysis of salivary gland biopsies to elucidate potential early events in pSS. In vitro modelling of lymphoepithelial lesions in primary Sjögren's syndrome. Devlopment of senescence markers as surrogates for SG function in pSS. Development of in vitro cell culture models of vasculitis. Functionality of stem cells in other autoimmune idseases, for example Crohns and SLE. Development of mouse model of pSS, based on epithelial cell dysfunction.
Publications
Lack of Conventional Acinar Cells in the Salivary Gland Following Anti PD-L1 and anti-PD-1 Immune Checkpoint Inhibitor Therapy
Pringle, S., van der Vegt, B., Wang, X., van Bakelen, N., Vissink, A., Kroese, F. & Bootsma, H., Oct-2020, In : Arthritis & Rheumatology. 72, 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
Novel approaches for rescuing function of the salivary gland epithelium in primary Sjogren's syndrome
Wang, X., Bootsma, H., de Koning, J., Kroese, F. G. M. & Pringle, S., 2020, In : Clinical and Experimental Rheumatology. 38, 4, p. S261-S270 10 p.Research output: Contribution to journal › Review article › Academic › peer-review
Novel approaches for rescuing function of the salivary gland epithelium in primary Sjögren's syndrome
Pringle, S., Wang, X., Bootsma, H., de Koning, J. & Kroese, F. G. M., 24-Oct-2020, In : Clinical and Experimental Rheumatology. 38 Suppl 126, 4, p. S261-S270 10 p.Research output: Contribution to journal › Review article › Academic › peer-review
Role of interaction between B cells and epithelial cells in pSS
Pringle, S., Verstappen, G. M., Bootsma, H. & Kroese, F. G. M., 2020, In : Annals of the Rheumatic Diseases. 2 p.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Role of interaction between B cells and epithelial cells in pSS: Correspondence
Pringle, S., Verstappen, G. & Bootsma, H., 16-Oct-2020, In : Annals of the Rheumatic Diseases. 2 p.Research output: Contribution to journal › Article › Academic › peer-review
Press / Media
ReumaNederland 2018 Jaaroverzicht
12/06/2019
1 Media contribution
Press/Media: Public Engagement Activities › Academic
Gammele speekselklieren en uitgeputte stamcellen
06/11/2018
1 Media contribution
Press/Media: Research › Popular
Activities
PhD Supervision of project Paola Serrano Martinez
Sarah Pringle (Co-supervisor)
2018 → …Activity: Examination › Supervision of PhD students › Academic
Role of microenvironment on the regenerative potential of salivary gland stem cells
Rob Coppes (Supervisor), Sarah Pringle (Co-supervisor) & Arjan Vissink (Co-supervisor)
2018 → 2022Activity: Examination › Supervision of PhD students › Academic
Xiaoyan Wang, PhD student
Sarah Pringle (Supervisor)
1-Nov-2016 → 31-Oct-2020Activity: Examination › Supervision of PhD students › Academic
Prizes
EULAR Abstract Award Basic Science
Verstappen, Gwenny (Recipient), Pringle, Sarah (Recipient), L Gao (Recipient), Liefers, Silvia (Recipient), Vegt, van der, Bert (Recipient), V Patel (Recipient), s Hu (Recipient), S Mukherjee (Recipient), Vissink, Arjan (Recipient), Bootsma, Hendrika (Recipient) & Kroese, Frans (Recipient), 3-Jun-2020
Prize › Academic
Article 9 Laboratory Animal Science license (CDP Groningen).
Pringle, Sarah (Recipient), 2010
Prize: Other distinction › Academic
eBROK (awarded 2017, valid until 03/04/2021).
Pringle, Sarah (Recipient), 2017
Prize: Other distinction › Academic
ID: 381362