dr. S.A. (Sarah) Pringle
Assistant Professor
Research
Research interests
Epithelial stem cells in disease contexts, with a primary basis on salivary gland stem cells. Disease contexts include the autoimmune disaease primary Sjögren's syndrome (pSS), radaition damage, medication-indcued xerostomia and check point inhibitor-indcued xerostomia. Development of iPS technology for generation of new salivary glands for patients with xerostomia. Cite-Seq analysis of salivary gland biopsies to elucidate potential early events in pSS. In vitro modelling of lymphoepithelial lesions in primary Sjögren's syndrome. Devlopment of senescence markers as surrogates for SG function in pSS. Development of in vitro cell culture models of vasculitis. Functionality of stem cells in other autoimmune idseases, for example Crohns and SLE. Development of mouse model of pSS, based on epithelial cell dysfunction.
Publications
Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine
Pringle, S., 2019, In : Inflammatory Bowel Diseases. izz295, p. izz295 doi.org/10.1093/ibd/izz295.Research output: Contribution to journal › Article › Academic › peer-review
Senescent progenitor cell depletion as a potential therapy for hyposalivation in primary Sjogren's syndrome?
Wang, X., Liefers, S., Vissink, A., Spijkervet, F. K. L., Bootsma, H., Coppes, R. P., Kroese, F. G. M. & Pringle, S., Oct-2019, In : European Journal of Immunology. 49, p. 769-770 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
IDENTIFICATION OF BIOMARKERS AND IMMUNE PATHWAYS FOR PERSONALIZED DRUG TARGETING IN PATIENTS WITH NEWLY DIAGNOSED PRIMARY SJOGREN'S SYNDROME
Verstappen, G. M., Gao, L., Pringle, S. A., Terpstra, J. H., Liefers, S. C., van Nimwegen, J. F., Vissink, A., Patel, V., He, A., Truong, A., Hu, S., Dongre, A., Krishnakumar, A., Kirov, S., Carman, J., Bootsma, H. & Kroese, F. G. M., Jun-2019, In : Annals of the Rheumatic Diseases. 78, p. 397 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
ABATACEPT TREATMENT OF PATIENTS WITH EARLY ACTIVE PRIMARY SJOGREN'S SYNDROME - A RANDOMIZED, DOUBLE-BLIND PLACEBO-CONTROLLED PHASE III-STUDY (ASAP-III)
van Nimwegen, J. F., van Zuiden, G. S., Arends, S., Mossel, E., Wijnsma, R. F., Stel, A. J., Delli, K., van der Vegt, B., Haacke, E. A., Olie, L., Los, L. I., Bulthuis-Kuiper, J., Verstappen, G. M., Pringle, S. A., Spijkervet, F. K. L., Kroese, F. G. M., Vissink, A. & Bootsma, H., Jun-2019, In : Annals of the Rheumatic Diseases. 78, p. 93-93 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Small-molecule inhibitors and the salivary gland epithelium in Sjogren's syndrome
Pringle, S., Wang, X., Bootsma, H., Spijkervet, F. K. L., Vissink, A. & Kroese, F. G. M., 19-Jun-2019, In : Expert opinion on investigational drugs. p. 1-12 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
Press / Media
ReumaNederland 2018 Jaaroverzicht
12/06/2019
1 Media contribution
Press/Media: Public Engagement Activities › Academic
Gammele speekselklieren en uitgeputte stamcellen
06/11/2018
1 Media contribution
Press/Media: Research › Popular
Activities
Paola Serrano Martinez
Sarah Pringle (Co-supervisor)2018 → 2020Activity: Examination › Supervision of PhD students › Academic
Yi Wu
Sarah Pringle (Co-supervisor)2018 → 2022Activity: Examination › Supervision of PhD students › Academic
Xiaoyan Wang, PhD student
Sarah Pringle (Supervisor)1-Nov-2016 → 31-Oct-2020Activity: Examination › Supervision of PhD students › Academic
Prizes
Article 9 Laboratory Animal Science license (CDP Groningen).
Sarah Pringle (Recipient), 2010
Prize: Other distinction › Academic
eBROK (awarded 2017, valid until 03/04/2021).
Sarah Pringle (Recipient), 2017
Prize: Other distinction › Academic
University Teaching Qualification (UTQ) March 2018.
Sarah Pringle (Recipient), Mar-2018
Prize: Other distinction › Academic
ID: 381362