dr. S.A. (Sarah) Pringle
Assistant Professor
Research
Research interests
Epithelial stem cells in disease contexts, with a primary basis on salivary gland stem cells. Disease contexts include the autoimmune disaease primary Sjögren's syndrome (pSS), radaition damage, medication-indcued xerostomia and check point inhibitor-indcued xerostomia. Development of iPS technology for generation of new salivary glands for patients with xerostomia. Cite-Seq analysis of salivary gland biopsies to elucidate potential early events in pSS. In vitro modelling of lymphoepithelial lesions in primary Sjögren's syndrome. Devlopment of senescence markers as surrogates for SG function in pSS. Development of in vitro cell culture models of vasculitis. Functionality of stem cells in other autoimmune idseases, for example Crohns and SLE. Development of mouse model of pSS, based on epithelial cell dysfunction.
Publications
MACROPHAGES SKEWED BY GM-CSF PRODUCE YKL-40, INSTIGATING ANGIOGENESIS IN GIANT CELL ARTERITIS
Van Sleen, Y., Jiemy, W. F., Pringle, S. A., Abdulahad, W., Van der Geest, K., Sandovici, M., Heeringa, P., Brouwer, E. & Boots, A., Jun-2020, In : Annals of the Rheumatic Diseases. 79, p. 86-87 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
ABATACEPT TREATMENT FOR PATIENTS WITH EARLY ACTIVE PRIMARY SJOGREN'S SYNDROME: OPEN-LABEL EXTENSION PHASE OF A RANDOMIZED CONTROLLED PHASE III TRIAL
Arends, S., Van Nimwegen, J. F., Mossel, E., Van Zuiden, G. S., Delli, K., Stel, A. J., Van der Vegt, B., Haacke, E. A., Olie, L., Los, L., Verstappen, G. M., Pringle, S. A., Spijkervet, F. K. L., Kroese, F. G. M., Vissink, A. & Bootsma, H., Jun-2020, In : Annals of the Rheumatic Diseases. 79, p. 102-102 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
The transcriptome of paired minor and major salivary gland tissue in patients with primary Sjögren's syndrome: two of a kind?
Verstappen, G. M., Gao, L., Pringle, S. A., Liefers, S. C., Van der Vegt, B., Patel, V., Hu, S., Mukherjee, S., Vissink, A., Bootsma, H. & Kroese, F. G. M., Jun-2020, In : Annals of the Rheumatic Diseases. 79, p. 28-28 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response
Serrano Martinez, P., Cinat, D., van Luijk, P., Baanstra, M., de Haan, G., Pringle, S. & Coppes, R. P., 29-Jun-2020, In : Oral diseases. 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Lack of Conventional Acinar Cells in Parotid Salivary Gland of Patient Taking an Anti-PD-L1 Immune Checkpoint Inhibitor
Pringle, S., Vegt, van der, B., Wang, X., Bakelen, van, N., Hiltermann, J., Spijkervet, F. K. L., Vissink, A., Kroese, F. G. M. & Bootsma, H., 2020, In : Frontiers in Oncology. 10, 420.Research output: Contribution to journal › Article › Academic › peer-review
Press / Media
ReumaNederland 2018 Jaaroverzicht
12/06/2019
1 Media contribution
Press/Media: Public Engagement Activities › Academic
Gammele speekselklieren en uitgeputte stamcellen
06/11/2018
1 Media contribution
Press/Media: Research › Popular
Activities
PhD Supervision of project Paola Serrano Martinez
Sarah Pringle (Co-supervisor)2018 → …Activity: Examination › Supervision of PhD students › Academic
Role of microenvironment on the regenerative potential of salivary gland stem cells
Rob Coppes (Supervisor), Sarah Pringle (Co-supervisor), Arjan Vissink (Co-supervisor)2018 → 2022Activity: Examination › Supervision of PhD students › Academic
Xiaoyan Wang, PhD student
Sarah Pringle (Supervisor)1-Nov-2016 → 31-Oct-2020Activity: Examination › Supervision of PhD students › Academic
Prizes
Article 9 Laboratory Animal Science license (CDP Groningen).
Sarah Pringle (Recipient), 2010
Prize: Other distinction › Academic
eBROK (awarded 2017, valid until 03/04/2021).
Sarah Pringle (Recipient), 2017
Prize: Other distinction › Academic
University Teaching Qualification (UTQ) March 2018.
Sarah Pringle (Recipient), Mar-2018
Prize: Other distinction › Academic
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