dr. R.S.N. (Rudolf) Fehrmann

MD/PhD

Faculty of Medical Sciences

Telephone:

E-mail:

r.s.n.fehrmann umcg.nl

Homepage ORCID Research Portal

Research interests

My practical and theoretical background enables me to take an integrative omics approach to identify driver genetic alterations, genes and biological pathways that are relevant for the pathophysiological behaviour and treatment response of tumors and rapidly translate these findings to clinical practice.

In addition to my training as a medical doctor, I completed one full year of Mathematics and Computer Science, after which I continued to obtain my MSc degree in Cognitive Science and Engineering.

In parallel to my medical studies, I worked for several years as a bio-informatician at the Department of Genetics, UMCG. In 2010, I obtained my PhD on high dimensional data analysis for new insights into ovarian cancer phenotypes, after which I continued as an affiliated post-doc at the Departments of Genetics and Medical Oncology (UMCG).

I followed the residency program in Internal Medicine / Medical Oncology and now work as a medical oncologist (staff member) at the department of Medical Oncology at the UMCG. In addition, I am a principal investigator at the Cancer Research Center Groningen in the research programmes: ‘Guided Treatment in Optimal Selected Cancer Patients (GUTS)’ and ‘Damage and Repair in Cancer Development and Cancer (DARE)’.

Publications

Andere ontwikkelingen in het kankeronderzoek: Toepassing kunstmatige intelligentie in de oncologie

Fehrmann, R., 2-Feb-2023, Kanker: Over de laatste ontwikkelingen in het kankeronderzoek. Bio Wetenschap + Maatschappij, p. 131-134 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Professional

Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma

Bolte, L. A., Lee, K. A., Björk, J. R., Leeming, E. R., Campmans-Kuijpers, M. J. E., de Haan, J. J., Vila, A. V., Maltez-Thomas, A., Segata, N., Board, R., Harries, M., Lorigan, P., de Vries, E. G. E., Nathan, P., Fehrmann, R., Bataille, V., Spector, T. D., Hospers, G. A. P. & Weersma, R. K., 16-Feb-2023, In: JAMA oncology. 9, 5, p. 705-709 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

A Survival Tree of Advanced Melanoma Patients with Brain Metastases Treated with Immune Checkpoint Inhibitors

van Not, O. J., Wind, T. T., Ismail, R. K., Bhattacharya, A., Jalving, M., Blank, C. U., Aarts, M. J. B., van den Berkmortel, F. W. P. J., Boers-Sonderen, M. J., van den Eertwegh, A. J. M., de Groot, J. W. B., Haanen, J. B., Kapiteijn, E., Bloem, M., Piersma, D., van Rijn, R. S., Stevense-den Boer, M., van der Veldt, A. A. M., Vreugdenhil, G., Wouters, M. W. J. M., & 4 othersBlokx, W. A. M., Suijkerbuijk, K. P. M., Fehrmann, R. S. N. & Hospers, G. A. P., 26-May-2023, In: Cancers. 15, 11, 12 p., 2922.

Research output: Contribution to journal › Article › Academic › peer-review

Current state and prospects of artificial intelligence in allergy

van Breugel, M., Fehrmann, R. S. N., Bügel, M., Rezwan, F. I., Holloway, J. W., Nawijn, M. C., Fontanella, S., Custovic, A. & Koppelman, G. H., 16-Aug-2023, (E-pub ahead of print) In: Allergy. 21 p.

Research output: Contribution to journal › Review article › peer-review

Factors associated with long-term antibody response after COVID-19 vaccination in patients treated with systemic treatment for solid tumors

Oosting, S. F., van der Veldt, A. A. M., Fehrmann, R. S. N., Bhattacharya, A., van Binnendijk, R. S., GeurtsvanKessel, C. H., Dingemans, A-M. C., Smit, E. F., Hiltermann, T. J. N., den Hartog, G., Jalving, M., Westphal, T. T., de Wilt, F., Ernst, S. M., Boerma, A., van Zijl, L., Rimmelzwaan, G. F., Kvistborg, P., van Els, C. A. C. M., Rots, N. Y., & 3 othersvan Baarle, D., Haanen, J. B. A. G. & de Vries, E. G. E., Aug-2023, In: ESMO Open. 8, 4, 3 p., 101599.

Research output: Contribution to journal › Article › Academic › peer-review

FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

Stok, C., Tsaridou, S., van den Tempel, N., Everts, M., Wierenga, E., Bakker, F. J., Kok, Y., Alves, I. T., Jae, L. T., Raas, M. W. D., Huis In 't Veld, P. J., de Boer, H. R., Bhattacharya, A., Karanika, E., Warner, H., Chen, M., van de Kooij, B., Dessapt, J., ter Morsche, L., Perepelkina, P., & 6 othersFradet-Turcotte, A., Guryev, V., Tromer, E. C., Chan, K-L., Fehrmann, R. S. N. & van Vugt, M. A. T. M., 25-Jul-2023, In: Cell reports. 42, 7, 27 p., 112668.

Research output: Contribution to journal › Article › Academic › peer-review

One-year data on immunogenicity and breakthrough infections in patients with solid tumors vaccinated against COVID-19 during systemic cancer treatment

van der Veldt, A. A. M., Oosting, S. F., Fehrmann, R. S. N., GeurtsvanKessel, C. H., van Binnendijk, R. S., Dingemans, A. M. C., Smit, E. F., Hiltermann, T. J. N., Hartog, G. D., Jalving, M., Westphal, T. T., Bhattacharya, A., de Wilt, F., Ernst, S. M., Boerma, A., van Zijl, L., Rimmelzwaan, G. F., Kvistborg, P., van Els, C. A. C. M., Rots, N. Y., & 3 othersvan Baarle, D., Haanen, J. B. A. G. & de Vries, E. G. E., Feb-2023, In: ESMO Open. 8, 1, 2 p., 100785.

Research output: Contribution to journal › Letter › Academic › peer-review

Opportunities on the horizon for the management of early colon cancer

Knapen, D. G., de Haan, J. J., Fehrmann, R. S. N., de Vries, E. G. E. & de Groot, D. J. A., Mar-2023, In: Critical Reviews in Oncology/Hematology. 183, 8 p., 103918.

Research output: Contribution to journal › Review article › peer-review

Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

Visconti, A., Rossi, N., Deriš, H., Lee, K. A., Hanić, M., Trbojević-Akmačić, I., Thomas, A. M., Bolte, L. A., Björk, J. R., Hooiveld-Noeken, J. S., Board, R., Harland, M., Newton-Bishop, J., Harries, M., Sacco, J. J., Lorigan, P., Shaw, H. M., de Vries, E. G. E., Fehrmann, R. S. N., Weersma, R. K., & 7 othersSpector, T. D., Nathan, P., Hospers, G. A. P., Sasieni, P., Bataille, V., Lauc, G. & Falchi, M., Dec-2023, In: BMC Cancer. 23, 1, 12 p., 166.

Research output: Contribution to journal › Article › Academic › peer-review

An mRNA expression-based signature for oncogene-induced replication-stress

Guerrero Llobet, S., Bhattacharya, A., Everts, M., Kok, K., van der Vegt, B., Fehrmann, R. S. N. & van Vugt, M. A. T. M., 18-Feb-2022, In: ONCOGENE. 41, 8, p. 1216-1224 9 p.

Research output: Contribution to journal › Article › Academic › peer-review