dr. R.S.N. (Rudolf) Fehrmann

MD/PhD

Faculty of Medical Sciences

Telephone:

+31 50 361 2587

E-mail:

r.s.n.fehrmann umcg.nl

Homepage ORCID Research Portal

Research interests

My practical and theoretical background enables me to take an integrative omics approach to identify driver genetic alterations, genes and biological pathways that are relevant for the pathophysiological behaviour and treatment response of tumors and rapidly translate these findings to clinical practice.

In addition to my training as a medical doctor, I completed one full year of Mathematics and Computer Science, after which I continued to obtain my MSc degree in Cognitive Science and Engineering.

In parallel to my medical studies, I worked for several years as a bio-informatician at the Department of Genetics, UMCG. In 2010, I obtained my PhD on high dimensional data analysis for new insights into ovarian cancer phenotypes, after which I continued as an affiliated post-doc at the Departments of Genetics and Medical Oncology (UMCG).

I followed the residency program in Internal Medicine / Medical Oncology and now work as a medical oncologist (staff member) at the department of Medical Oncology at the UMCG. In addition, I am a principal investigator at the Cancer Research Center Groningen in the research programmes: ‘Guided Treatment in Optimal Selected Cancer Patients (GUTS)’ and ‘Damage and Repair in Cancer Development and Cancer (DARE)’.

Publications

Colorectal anastomotic leak: Transcriptomic profile analysis

van Praagh, J. B. , de Wit, J. G. , Olinga, P. , de Haan, J. J. , Nagengast, W. B. , Fehrmann, R. S. N. & Havenga, K. , Mar-2021 , In: British Journal of Surgery. 108 , 3 , p. 326-333 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

COVID-19 vaccination: the VOICE for patients with cancer

van der Veldt, A. A. M. , Oosting, S. F. , Dingemans, A-M. C. , Fehrmann, R. S. N. , GeurtsvanKessel, C. , Jalving, M. , Rimmelzwaan, G. F. , Kvistborg, P. , Blank, C. U. , Smit, E. F. , Lemmens, V. E. E. P. , Hiltermann, T. J. N. , Koopmans, M. P. G. , Huckriede, A. L. W. , Rots, N. Y. , van Els, C. A. C. M. , van Baarle, D. , Haanen, J. B. A. G. & de Vries, E. G. E. , 15-Feb-2021 , In: Nature Medicine. 2 p.

Research output: Contribution to journal › Letter › Academic › peer-review

Gallbladder Cancer: Current Insights in Genetic Alterations and Their Possible Therapeutic Implications

Kuipers, H. , de Bitter, T. J. J. , de Boer, M. T. , van der Post, R. S. , Nijkamp, M. W. , de Reuver, P. R. , Fehrmann, R. S. N. & Hoogwater, F. J. H. , 20-Oct-2021 , In: Cancers. 13 , 21 , 20 p. , 5257.

Research output: Contribution to journal › Review article › Academic › peer-review

Identification and Validation of Esophageal Squamous Cell Carcinoma Targets for Fluorescence Molecular Endoscopy

Zhao, X. , Huang, Q. , Koller, M. , Linssen, M. D. , Hooghiemstra, W. T. R. , de Jongh, S. J. , van Vugt, M. A. T. M. , Fehrmann, R. S. N. , Li, E. & Nagengast, W. B. , Sep-2021 , In: International Journal of Molecular Sciences. 22 , 17 , p. 1-16 16 p. , 9270.

Research output: Contribution to journal › Article › Academic › peer-review

Improving gene function predictions using independent transcriptional components

Urzúa-Traslaviña, C. G. , Leeuwenburgh, V. C. , Bhattacharya, A. , Loipfinger, S. , van Vugt, M. A. T. M. , de Vries, E. G. E. & Fehrmann, R. S. N. , 5-Mar-2021 , In: Nature Communications. 12 , 1 , 14 p. , 1464.

Research output: Contribution to journal › Article › Academic › peer-review

mRNA-1273 COVID-19 vaccination in patients receiving chemotherapy, immunotherapy, or chemoimmunotherapy for solid tumours: a prospective, multicentre, non-inferiority trial

Oosting, S. F. , van der Veldt, A. A. M., GeurtsvanKessel, C. H., Fehrmann, R. S. N. , van Binnendijk, R. S., Dingemans, A-M. C., Smit, E. F., Hiltermann, T. J. N. , den Hartog, G., Jalving, M. , Westphal, T. T., Bhattacharya, A. , van der Heiden, M. , Rimmelzwaan, G. F., Kvistborg, P., Blank, C. U., Koopmans, M. P. G., Huckriede, A. L. W. , van Els, C. A. C. M., Rots, N. Y.& 3 others , van Baarle, D. , Haanen, J. B. A. G. & de Vries, E. G. E. , 9-Nov-2021 , (E-pub ahead of print) In: Lancet Oncology. 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Robust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines

Leeuwenburgh, V. C. , Urzua-Traslavina, C. G. , Bhattacharya, A. , Walvoort, M. T. C. , Jalving, M. , de Jong, S. & Fehrmann, R. S. N. , 26-Sep-2021 , In: Cancer & Metabolism. 9 , 1 , 15 p. , 35.

Research output: Contribution to journal › Article › Academic › peer-review

Vaccination against SARS-CoV-2 in patients receiving chemotherapy, immunotherapy, or chemo-immunotherapy for solid tumors

Oosting, S. , Van der Veldt, A. A. M. , GeurtsvanKessel, C. H. , Fehrmann, R. S. N. , Van Binnendijk, R. S. , Dingemans, A-M. C. , Smit, E. F. F. , Hiltermann, T. J. N. , Den Hartog, G. , Jalving, M. , Westphal, T. , Battacharya, A. , van der Heiden, M. , Blank, C. U. , Koopmans, M. P. , van Els, C. A. , Rots, N. Y. , van Baarle, D. , Haanen, J. B. A. G. & de Vries, E. G. , Sep-2021 , In: Annals of Oncology. 32 , p. S1337-S1337 1 p.

Research output: Contribution to journal › Meeting Abstract › Academic

Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy

Boonstra, P. A. , Wind, T. T. , van Kruchten, M. , Schuuring, E. , Hospers, G. A. P. , van der Wekken, A. J. , de Groot, D-J. , Schröder, C. P. , Fehrmann, R. S. N. & Reyners, A. K. L. , 4-May-2020 , In: Cancer and metastasis reviews. 39 , 3 , p. 999-1013 15 p.

Research output: Contribution to journal › Review article › Academic › peer-review

Comparison of Carboplatin With 5-Fluorouracil vs. Cisplatin as Concomitant Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

Hanemaaijer, S. H. , Kok, I. C. , Fehrmann, R. S. N. , van der Vegt, B. , Gietema, J. A. , Plaat, B. E. C. , van Vugt, M. A. T. M. , Vergeer, M. R. , Leemans, C. R. , Langendijk, J. A. , Voortman, J. , Buter, J. & Oosting, S. F. , 5-Jun-2020 , In: Frontiers in Oncology. 10 , 9 p. , 761.

Research output: Contribution to journal › Article › Academic › peer-review