dr. R.S.N. (Rudolf) Fehrmann
MD/PhD
Research
Research units:
Research interests
My practical and theoretical background enables me to take an integrative omics approach to identify driver genetic alterations, genes and biological pathways that are relevant for the pathophysiological behaviour and treatment response of tumors and rapidly translate these findings to clinical practice.
In addition to my training as a medical doctor, I completed one full year of Mathematics and Computer Science, after which I continued to obtain my MSc degree in Cognitive Science and Engineering.
In parallel to my medical studies, I worked for several years as a bio-informatician at the Department of Genetics, UMCG. In 2010, I obtained my PhD on high dimensional data analysis for new insights into ovarian cancer phenotypes, after which I continued as an affiliated post-doc at the Departments of Genetics and Medical Oncology (UMCG).
I followed the residency program in Internal Medicine / Medical Oncology and now work as a medical oncologist (staff member) at the department of Medical Oncology at the UMCG. In addition, I am a principal investigator at the Cancer Research Center Groningen in the research programmes: ‘Guided Treatment in Optimal Selected Cancer Patients (GUTS)’ and ‘Damage and Repair in Cancer Development and Cancer (DARE)’.
Publications
Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)
DPOG & DCCG, 25-Apr-2019, In : BMC Cancer. 19, 15 p., 390.Research output: Contribution to journal › Article › Academic › peer-review
The transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells
Mattes, K., Geugien, M., Korthuis, P. M., Brouwers-Vos, A. Z., Fehrmann, R. S. N., Todorova, T. I., Steidl, U., Vellenga, E. & Schepers, H., 12-Apr-2019, In : Experimental Hematology. 19 p.Research output: Contribution to journal › Article › Academic › peer-review
A subset of cutaneous melanomas contains high expression of genes related to oxidative phosphorylation determined using consensus clustering
Wind, T. T., Jalving, M., De Haan, J., De Vries, E., Van Vugt, M., Reijngoud, D-J., Van Rijn, R., Blank, C. U., Hospers, G. A. & Fehrmann, R., 1-Jan-2017, In : Pigment cell & melanoma research. 30, 1, p. 151-152 2 p.Research output: Contribution to journal › Article › Academic
89Zr-labeled Bispecific T-cell Engager AMG 211 PET Shows AMG 211 Accumulation in CD3-rich Tissues and Clear, Heterogeneous Tumor Uptake
Moek, K. L., Waaijer, S. J. H., Kok, I. C., Suurs, F. V., Brouwers, A. H., Menke-van der Houven van Oordt, C. W., Wind, T. T., Gietema, J. A., Schröder, C. P., Mahesh, S. V. K., Jorritsma-Smit, A., Lub-de Hooge, M. N., Fehrmann, R. S. N., de Groot, D-J. & de Vries, E. G., 11-Feb-2019, In : Clinical Cancer Research.Research output: Contribution to journal › Article › Academic › peer-review
MAPK pathway activity plays a key role in programmed death ligand-1 expression of EGFR wild-type non-small cell lung adenocarcinoma cells
Stutvoet, T., Kol, A., de Vries, E., de Bruyn, M., Fehrmann, R., van Scheltinga, A. T. & de Jong, S., Nov-2018, p. E78-E79. 2 p.Research output: Contribution to conference › Poster › Academic
Datasets
Data to: Evidence Based Selection of Housekeeping Genes
de Jonge, H. (Creator), Fehrmann, R. (Creator), Bont, de, E. (Creator), Hofstra, R. M. W. (Creator), Gerbens, F. (Creator), Kamps, W. (Creator), Vries, de, E. G. E. (Creator), Zee, van der, A. (Creator), Meerman, te, G. (Creator), Elst, ter, A. (Creator), University of Groningen, 19-Sep-2007
https://figshare.com/articles/Evidence_Based_Selection_of_Housekeeping_Genes/151673
Dataset
Activities
European Research Council (ERC) (External organisation)
Rudolf Fehrmann (Reviewer)2018 → …Activity: Membership › Membership of committee › Academic
Dutch Cancer Society (KWF Kankerbestrijding) (External organisation)
Rudolf Fehrmann (Reviewer)2018Activity: Membership › Membership of committee › Academic
Dutch Society of Internal Medicine (NIV) (External organisation)
Rudolf Fehrmann (Member)2010 → …Activity: Membership › Membership of network › Professional
Prizes
Mandema-stipendium
Rudolf Fehrmann (Recipient), 2012
Prize: Fellowship awarded competitively › Academic
MD/PhD scholarship
Rudolf Fehrmann (Recipient), 2006
Prize: Fellowship awarded competitively › Academic
ID: 228591