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Practical matters How to find us dr. P. (Peter) Meerlo

dr. P. (Peter) Meerlo

Assistant Professor Neurobiology

After studying biology at the University of Groningen, I did my PhD under supervision of Serge Daan and Jaap Koolhaas at the Department of Chronobiology and the Department of Behavioral Physiology. In 1997 I defended my PhD thesis on research concerning the influence of stress on circadian rhythmicity. I subsequently spent 3 years as a postdoctoral fellow and research associate at Northwestern University in Chicago, extending my research on stress, circadian rhythms and sleep. In 2001 I returned to the University of Groningen where I am now assistant professor at the Groningen Institute for Evolutionary Life Sciences (GELIFES). The main topics of my current research are: 1) the regulation and function of sleep with special emphasis on the role of sleep in neuronal plasticity and memory processes; and 2) the neurobiological and neuroendocrine consequences of chronically restricted or disrupted sleep with an emphasis on systems involved in cognitive function and emotional regulation. Part of this research is based on the hypothesis that chronically insufficient sleep may contribute to the development of cognitive disturbances and mood disorders such as depression. In 2005, I received a VIDI career development grant from the Netherlands Organization for Scientific Research to support my research on sleep and consequences of sleep loss. My work has resulted in many widely cited publications in, among others, the Journal of Sleep Research, Sleep, Sleep Medicine, and Sleep Medicine Reviews.  


Research interests

Biological clocks and circadian rhythms

The evolution and ecology of sleep

The regulation and function of sleep

The role of sleep in neuronal plasticity and memory processes

The neurobiological consequences of disrupted and restricted sleep

Effects of sleep loss on stress systems and stress sensitivity

Effects of stress on sleep and circadian rhythms

Individual differences and gender differences in stress and sleep

The relationship between sleep disturbance and depression

Psychiatric disorders: causes, mechanisms, and therapies


Selection of publications

Ota SM, Kong X, Hut RA, Suchecki S, Meerlo P. The impact of stress and stress hormones on endogenous clocks and circadian rhythms. Frontiers in Neuroendcocrinology 63: 100931, 2021.

Van Hasselt SJ, Hut RA, Allocca G, Vyssotski AL, Piersma T, Rattenborg NC, Meerlo P. Cloud cover amplifies the sleep-suppressing effect of artificial light at night in geese. Environmental Pollution 273: 116444, 2021.

Van Hasselt SJ, Mekenkamp GJ, Komdeur J, Vyssotski AL, Piersma T, Rattenborg NC, Meerlo P. Seasonal variation in sleep homeostasis in migratory geese: a rebound of NREM sleep following sleep deprivation in summer but not in winter. SLEEP 44: zsaa244, 2021.

Van Hasselt S, Rusche M, Vyssotski AL, Verhulst S, Rattenborg NC, Meerlo P. Sleep time in the European starling is strongly affected by night length and moon phase. Current Biology 30: 1664-1671, 2020.

Van Hasselt S, Rusche M, Vyssotski AL, Verhulst S, Rattenborg NC, Meerlo P. The European starling (Sturnus vulgaris) shows signs of NREM sleep homeostasis but has very little REM sleep and no REM sleep homeostasis. Sleep 43: zsz311, 2020.

Heckman PRA, Roig Kuhn F, Meerlo P, Havekes R. A brief period of sleep deprivation negatively impacts the acquisition, consolidation, and retrieval of object-location memories. Neurobiology of Learning and Memory 175: 107326, 2020.

Ota SM, Hut R, Riede S, Crosby P, Suchecki D, Meerlo P. Social stress and glucocorticoids alter PERIOD2 rhythmicity in the liver, but not in the suprachiasmatic nucleus. Hormones and Behavior 120: 104683, 2020. 

Raven F, Heckman PRA, Havekes R, Meerlo P. Sleep deprivation-induced impairment of memory consolidation is not mediated by glucocorticoid stress hormones. Journal of Sleep Research 29: e12972, 2020. 

Raven F, Meerlo P, Van der Zee EA, Abel T, Havekes R. A brief period of sleep deprivation causes spine loss in the dentate gyrus of mice. Neurobiology of Learning and Memory 160: 83-90, 2019.

Raven F, Van der Zee EA, Meerlo P, Havekes R. The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function. Sleep Medicine Reviews 39: 3-11, 2018.

Rattenborg NC, de la Iglesia HO, Kempenaers B, Lesku JA, Meerlo P, Scriba MF. Sleep research goes wild: new methods and approaches to investigate the ecology, evolution and functions of sleep. Philosophical Transactions Royal Society B 372: 20160251, 2017; doi: 10.1098/rstb.2016.0251.

Grønli G, Meerlo P, Pedersen TT, Pallesen S, Skrede S, Marti AR, Wisor JP, Murison R, Henriksen TEG, Rempe MJ, Mrdalj J. A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Journal of Biological Rhythms 32: 48-62, 2017.

Zhang SL, Bai L, Goel  N, Bailey A, Jang CJ, Bushman FD, Meerlo P, Dinges DF, Sehgal A. Human and rat gut microbiome composition is maintained following sleep restriction. PNAS 114: E1564-E1571, 2017.

Kamphuis J, Baichel S, Lancel M, De Boer SF, Koolhaas JM, Meerlo P. Sleep restriction in rats leads to changes in operant behavior indicative of reduced prefrontal cortex function. Journal of Sleep Research 26: 5-13, 2017.

Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, RadwaƄska K, Meerlo P­­, Houslay MD, Baillie GS, Abel T. Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. eLIFE 5: e13424, 2016.

Meerlo P, Havekes R, Steiger A. Sleep disruption as a causal factor in the development of depression. Current Topics in Behavioral Neuroscience 25: 459-481, 2015.

Sanford LD, Suchecki D, Meerlo P. Sleep, stress and arousal. Current Topics in Behavioral Neuroscience 25: 379-410, 2015.

Mueller A, Meerlo P, McGinty D, Mistlberger R. Sleep and adult neurogenesis: implications for cognition and mood. Current Topics in Behavioral Neuroscience 25: 151-181, 2015.

Havekes R, Meerlo P, Abel T. Animal studies on the role of sleep in memory: from behavioral performance to molecular mechanisms. Current Topics in Behavioral Neuroscience 25: 183-206, 2015.

Kreutzmann JC, Havekes R, Abel T, Meerlo P. Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function. Neuroscience 309: 173-190, 2015.

Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A. Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. PNAS 112: 2569-2574, 2015.

Havekes R, Bruinenberg VM, Tudor JC, Ferri SL, Baumann A, Meerlo P, Abel T. Transiently increasing cAMP levels selectively in hippocampal excitatory neurons during sleep deprivation prevents memory deficits caused by sleep loss. Journal of Neuroscience 34: 15715-21, 2014.

Coolen A, Plassman K, Barf P, Fuchs E, Meerlo P. Telemetric study of sleep architecture and sleep homeostasis in the day-active tree shrew Tupaia belangeri. Sleep 35: 879-888, 2012.

Kamphuis J, Meerlo P, Koolhaas JM, Lancel M. Poor sleep as a potential causal factor in aggression and violence. Sleep Medicine 13: 327-334, 2012.

Koolhaas JM, Bartolumucci A, Buwalda B, de Boer SF, Flügge G, Korte SM, Meerlo P, Murison R, Olivier B, Palanza P, Richter-Levin G, Sgiofo A,  Steimer T, Stiedl O, Van Dijk G, Wöhr M, Fuchs E. Stress revisited: a critical review of the stress concept. Neuroscience and Biobehavioral Reviews 35: 1291-1301, 2011.

Hagewoud R, Bultsma L, Koolhaas JM, Meerlo P. Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioral, endocrine and neuronal responses. Journal of Sleep Research 20: 259-266, 2011.

Hagewoud R, Havekes R, Tiba P, Novati A, Hogenelst K, Weinreder P, Van der Zee EA, Meerlo P. Coping with sleep deprivation: shifts in regional brain activity and learning strategy. Sleep 33: 1465-1473, 2010.

Hagewoud R, Havekes R, Novati A, Keijser JN, Van der Zee EA, Meerlo P. Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation. Journal of Sleep Research 19: 280-288, 2010.

Lucassen PJ , Meerlo P, Naylor AS, Van Dam AM, Dayer AG, Fuchs E, Oomen CA, Czeh B. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: implications for depression and antidepressant action. European Neuropsychopharmacology 20: 1-17, 2010.

Meerlo P, Mistlberger R, Jacobs BL, Heller C, McGinty D. New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Medicine Reviews 13: 187-194, 2009.

Novati A, Roman V, Cetin T, Hagewoud R, Den Boer JA, Luiten PGM, Meerlo P. Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats. Sleep 31: 1579-1585, 2008.

Meerlo P, Sgoifo A, Suchecki D. Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity. Sleep Medicine Reviews 12: 197-210, 2008.

Last modified:25 June 2022 2.39 p.m.