P. (Patrick) Deelen

Faculty of Medical Sciences

Telephone:

E-mail:

p.deelen umcg.nl

Homepage ORCID Research Portal

Research interests

I am primarily interested in improving the diagnostic yield of genome sequencing of patients who have a rare disease. I do this by integrating population genetics and transcriptomics.

Publications

Improving the diagnostic yield of exome-sequencing by predicting gene-phenotype associations using large-scale gene expression analysis

Deelen, P. , van Dam, S., Herkert, J. C. , Karjalainen, J. M., Brugge, H. , Abbott, K. M. , van Diemen, C. C. , van der Zwaag, P. A. , Gerkes, E. H. , Zonneveld-Huijssoon, E. , Boer-Bergsma, J. J., Folkertsma, P. , Gillett, T. , van der Velde, K. J. , Kanninga, R., van den Akker, P. C. , Jan, S. Z., Hoorntje, E. T., Te Rijdt, W. P. , Vos, Y. J. , & 7 others Jongbloed, J. D. H. , van Ravenswaaij-Arts, C. M. A. , Sinke, R. , Sikkema-Raddatz, B. , Kerstjens-Frederikse, W. S. , Swertz, M. A. & Franke, L. , 28-Jun-2019 , In: Nature Communications. 10 , 1 , 13 p. , 2837.

Research output: Contribution to journal › Article › Academic › peer-review

Identification of context-dependent expression quantitative trait loci in whole blood

Pital-Zhernakova, D. , Deelen, P. , Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F. , Westra, H-J. , Bonder, M. J. , van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J., & 27 others Hottenga, J. J. , Stehouwer, C. D. A. , van der Kallen, C. J. H. , Schalkwijk, C. G. , Zhernakova, A. , Li, Y. , Tigchelaar, E. F. , de Klein, N. , Beekman, M. , Deelen, J. , van Heemst, D. , van den Berg, L. H. , Hofman, A. , Uitterlinden, A. G. , van Greevenbroek, M. M. J. , Veldink, J. H. , Boomsma, D. I. , van Duijn, C. M. , Wijmenga, C. , Slagboom, P. E. , Swertz, M. A. , Isaacs, A. , van Meurs, J. B. J. , Jansen, R. , Heijmans, B. T. , 't Hoen, P. A. C. & Franke, L. , Jan-2017 , In: Nature Genetics. 49 , 1 , p. 139-145 7 p.

Research output: Contribution to journal › Letter › Academic › peer-review

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

Deelen, P. , Zhernakova, D. V. , de Haan, M. , van der Sijde, M. , Bonder, M. J. , Karjalainen, J. , van der Velde, K. J. , Abbott, K. M. , Fu, J. , Wijmenga, C. , Sinke, R. J. , Swertz, M. A. & Franke, L. , 27-Mar-2015 , In: Genome medicine. 7 , 1 , 13 p. , 30.

Research output: Contribution to journal › Article › Academic › peer-review

A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative , 4-Aug-2022 , In: Nature. 608 , p. E1–E10 13 p.

Research output: Contribution to journal › Editorial › Academic › peer-review

Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project (Nature Genetics, (2022), 54, 2, (143-151), 10.1038/s41588-021-00992-y)

Lifelines Cohort Study, Lopera-Maya, E. A. , Kurilshikov, A. , van der Graaf, A. , Hu, S. , Andreu-Sánchez, S. , Chen, L. , Vila, A. V. , Gacesa, R. , Sinha, T. , Collij, V. , Klaassen, M. A. Y., Bolte, L. A. , Gois, M. F. B. , Neerincx, P. B. T. , Swertz, M. A. , Harmsen, H. J. M. , Wijmenga, C. , Fu, J. , Weersma, R. K. , & 2 others Zhernakova, A. & Sanna, S. , 1-Sept-2022 , In: Nature genetics. 54 , 9 , p. 1448 1 p.

Research output: Contribution to journal › Erratum

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (vol 53, pg 1636, 2021)

SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N. , Westra, H-J. , Bakker, O. B. , Deelen, P. , Shireby, G., Hannon, E., Moisse, M., Baird, D., Restuadi, R., Dolzhenko, E., & 34 others Dekker, A. M. , Gawor, K. , Westeneng, H-J. , Tazelaar, G. H. P. , van Eijk, K. R. , Kooyman, M. , Byrne, R. P. , Doherty, M. , Heverin, M. , Al Khleifat, A. , Iacoangeli, A. , Shatunov, A. , Ticozzi, N. , Cooper-Knock, J. , Smith, B. N. , Gromicho, M. , Chandran, S. , Pal, S. , Morrison, K. E. , Shaw, P. J. , Hardy, J. , Orrell, R. W. , Sendtner, M. , Meyer, T. , Basak, N. , van der Kooi, A. J. , Ratti, A. , Fogh, I. , Gellera, C. , Lauria, G. , Corti, S. , Kraft, J. , Franke, L. & Veldink, J. H. , Mar-2022 , In: Nature genetics. 54 , 3 , p. 361-361 1 p.

Research output: Contribution to journal › Erratum

Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

Lopera-Maya, E. A. , Kurilshikov, A. , van der Graaf, A. , Hu, S. , Lifelines Cohort Study, Andreu-Sánchez, S. , Chen, L. , Vila, A. V. , Gacesa, R. , Sinha, T. , Collij, V. , Klaassen, M. A. Y., Bolte, L. A. , Brandao Gois, M. F. , Neerincx, P. B. T. , Swertz, M. A. , Harmsen, H. J. M. , Wijmenga, C. , Fu, J. , Weersma, R. K. , & 2 others Zhernakova, A. & Sanna, S. , Feb-2022 , In: Nature genetics. 54 , p. 143-151 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Idéfix: identifying accidental sample mix-ups in biobanks using polygenic scores

Lifelines Cohort Study , Warmerdam, R. , Lanting, P. , Deelen, P. & Franke, L. , 15-Feb-2022 , In: Bioinformatics (Oxford, England). 38 , 4 , p. 1059–1066 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Impact of the COVID-19 pandemic on adults with moderate-to-severe atopic dermatitis in the Dutch general population

Lifelines Corona Research initiative, Zhang, J. , Loman, L. , Kamphuis, E. , Schuttelaar, M. L. A. , Boezen, H. M. , Mierau, J. , Franke, H. L. , Dekens, J. , Deelen, P. , Lanting, P. , Vonk, J. M. , Nolte, I. M. , Ori, A. P. S. , Claringbould, A. , Boulogne, F. , Dijkema, M. X. L., Wiersma, H. H. , Warmerdam, R. , Jankipersadsing, S. A. , & 1 others van Blokland, I. , Mar-2022 , In: JAAD international. 6 , p. 86-93 8 p.

Research output: Contribution to journal › Letter › Academic › peer-review

Increased genetic contribution to wellbeing during the COVID-19 pandemic

Lifelines Corona Research initiative , Warmerdam, C. A. R. , Wiersma, H. H. , Lanting, P. , Ani, A. , Dijkema, M. X. L. , Snieder, H. , Vonk, J. M. , Boezen, H. M. , Deelen, P. & Franke, L. H. , 19-May-2022 , In: PLoS genetics. 18 , 5 , 24 p. , e1010135.

Research output: Contribution to journal › Article › Academic › peer-review