prof. dr. O.C.M. (Ody) Sibon

Professor

Faculty of Medical Sciences

Telephone:

+31 50 361 6167 (OCM Sibon)

+31 50 361 6111 (Secretariat)

+31 50 361 6190 (fax)

E-mail:

o.c.m.sibon umcg.nl

ORCID Research Portal

Publications

Coenzyme A metabolism: a key driver of gut microbiota dynamics and metabolic profiles

Böttcher, J., Sibon, O. C. M. & El Aidy, S., 2025, In: FEMS Microbiology Reviews. 49, 18 p., fuaf051.

Research output: Contribution to journal › Review article › peer-review

Dysregulation of Glial Gap Junction Protein Innexin2 Mediates Seizures and Disrupted Sleep in a Drosophila Model for North Sea Progressive Myoclonus Epilepsy

Grzeschik, N. A., Lambrechts, R. A., van der Zwaag, M., Eggens-Meijer, E., Sibon, O. C. M. & Gorter, J. A., Nov-2025, In: Journal of Neuroscience Research. 103, 11, 17 p., e70087.

Research output: Contribution to journal › Article › Academic › peer-review

Opt1 imports CoA precursors as glutathione mixed disulphides

Wedman, J. J., de Vries, L., van Lingen, B., van der Zwaag, M., Gómez-Sánchez, R., Hardenberg, R., Huibers, W., Permentier, H., Strauss, E., Chang, M., Reggiori, F., de Kroon, A. I., Sibon, O. C. M. & Schepers, H., Sept-2025, In: The Journal of Biological Chemistry. 301, 9, 16 p., 110503.

Research output: Contribution to journal › Article › Academic › peer-review

Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder in patients and cell line models

Zhang, F., Dorn, T., Gnutti, B., Anikster, Y., Kuebler, S., Ahrens-Nicklas, R., Gosselin, R., Rahman, S., Durst, R., Zanuttigh, E., Güra, M. A., Poch, C. M., Meier, A. B., Laugwitz, K. L., Schüller, H. J., Messias, A. C., Sibon, O. C., Finazzi, D., Rippert, A. & Li, D., Truxal, K., Nandi, D., Lampert, B. C., Yeo, M., Gardham, A., Nissan, B., Horowitz Cederboim, S., Moretti, A. & Iuso, A., Dec-2025, In: Communications medicine. 5, 17 p., 323.

Research output: Contribution to journal › Article › Academic › peer-review

Conventional and novel anti-seizure medications reveal a particular role for GABAA in a North Sea progressive myoclonus Epilepsy Drosophila model

Polet, S. S., de Koning, T. J., Lambrechts, R. A., Tijssen, M. A. J., Sibon, O. C. M. & Gorter, J. A., Jul-2024, In: EPILEPSY RESEARCH. 203, 7 p., 107380.

Research output: Contribution to journal › Article › Academic › peer-review

Impaired coenzyme A homeostasis in cardiac dysfunction and benefits of boosting coenzyme A production with vitamin B5 and its derivatives in the management of heart failure

Wedman, J. J., Sibon, O. C. M., Mastantuono, E. & Iuso, A., 2024, In: Journal of Inherited Metabolic Disease. 47, 5, p. 885-894 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Coenzyme A precursors flow from mother to zygote and from microbiome to host

Yu, Y., van der Zwaag, M., Wedman, J. J., Permentier, H., Plomp, N., Jia, X., Kanon, B., Eggens-Meijer, E., Buist, G., Harmsen, H., Kok, J., Salles, J. F., Wertheim, B., Hayflick, S. J., Strauss, E., Grzeschik, N. A., Schepers, H. & Sibon, O. C. M., 21-Jul-2022, In: Molecular Cell. 82, 14, p. 2650-2665.e12 29 p.

Research output: Contribution to journal › Article › Academic › peer-review

PKAN pathogenesis and treatment

Hayflick, S. J., Jeong, S. Y. & Sibon, O. C. M., Nov-2022, In: Molecular Genetics and Metabolism. 137, 3, p. 283-291 9 p.

Research output: Contribution to journal › Review article › peer-review

Coenzyme A levels influence protein acetylation, CoAlation and 4'-phosphopantetheinylation: Expanding the impact of a metabolic nexus molecule

Yu, Y., Moretti, I. F., Grzeschik, N. A., Sibon, O. C. M. & Schepers, H., Apr-2021, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 4, 6 p., 118965.

Research output: Contribution to journal › Review article › peer-review

The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity

Mostert, K. J., Sharma, N., Van Der Zwaag, M., Staats, R., Koekemoer, L., Anand, R., Sibon, O. C. M. & Strauss, E., 19-Nov-2021, In: ACS chemical biology. 16, 11, p. 2401-2414 14 p.

Research output: Contribution to journal › Article › Academic › peer-review