prof. dr. M. (Martina) Schmidt

Hoogleraar Moleculaire Farmacologie


Postal address:
A Deusinglaan
Gebouw 3211, ruimte 0406
Phone: +31 50 363 3322Fax: +31 50 363 6908

Research interests

My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.


  1. cAMP: From Long-Range Second Messenger to Nanodomain Signalling

    Musheshe, N., Schmidt, M. & Zaccolo, M. 27-Dec-2017 In : Trends in Pharmacological Sciences.

    Research output: Scientific - peer-reviewReview article

  2. Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2

    Barroso, M. V., Cattani-Cavalieri, I., de Brito-Gitirana, L., Fautrel, A., Lagente, V., Schmidt, M., Porto, L. C., Romana-Souza, B., Valença, S. S. & Lanzetti, M. 15-Oct-2017 In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5557-5568 12 p.

    Research output: Scientific - peer-reviewArticle

  3. The novel compound Sul-121 inhibits inflammation in experimental models of chronic obstructive pulmonary disease

    Schmidt, M., Han, B., Poppinga, W. J., Zuo, H., van der Graaf, K. & Meurs, H. Apr-2016 In : The FASEB Journal. 30, 1 Supplement, p. 1272.7 2 p.

    Research output: ScientificMeeting Abstract

  4. Epac1 links prostaglandin E-2 to beta-catenin transcriptional activity during epithelial-to-mesenchymal transition in A549 cells

    Jansen, S., De Jager, W., Yarwood, S. J., Lezoualc'h, F., Gosens, R. & Schmidt, M. Apr-2016 In : The FASEB Journal. 30, 1 Supplement, p. 714.5 2 p.

    Research output: ScientificMeeting Abstract

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  1. Visiting professor

    Martina Schmidt (Recipient), 2014

    Prize: Honorary degree

  2. Honorary LURN Lecture

    Martina Schmidt (Recipient), 13-Apr-2016

    Prize: National/international honour

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  1. Research Network Healthy Aging

    Schmidt, M. (Keynote speaker)

    Activity: Talk or presentationInvited talk

  2. British Journal of Pharmacology (Journal)

    Schmidt, M. (Editorial board member)
    2014 → …

    Activity: ScientificEditorial activity

  3. American Journal of Physiology (Journal)

    Schmidt, M. (Editorial board member)
    2012 → …

    Activity: ScientificEditorial activity

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