prof. dr. M. (Martina) Schmidt

Professor of Molecular Pharmacology


Postal address:
A Deusinglaan1
Gebouw 3211, ruimte 0406
9713 AV
Phone: +31 50 363 3322Fax: +31 50 363 6908

Research interests

My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.


  1. Diesel Exhaust Particles-induced Dysfunctional Responses in Lung Epithelial Progenitors is mediated by oxidative stress

    Wu, S., Bos, I. S. T., Kistemaker, L., Schmidt, M. & Gosens, R., 20-Jun-2020, In : ERJ Open Research. 6, Suppl. 5

    Research output: Contribution to journalMeeting AbstractAcademic

  2. Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency

    Chatterjee, A., Eshwaran, R., Huang, H., Zhao, D., Schmidt, M., Wieland, T. & Feng, Y., 2020, In : International Journal of Molecular Sciences. 21, 10

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Nanodomains in cardiopulmonary disorders and the impact of air pollution

    Cattani-Cavalieri, I., Valença, S. D. S. & Schmidt, M., 29-Jun-2020, In : Biochemical Society Transactions. 48, 3, p. 799-811

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases

    Schmidt, M., Cattani-Cavalieri, I., Nuñez, F. J. & Ostrom, R. S., Apr-2020, In : Current Opinion in Pharmacology. 51, p. 34-42 9 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  5. Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

    Baarsma, H. A., Han, B., Poppinga, W. J., Driessen, S., Elzinga, C. R. S., Halayko, A. J., Meurs, H., Maarsingh, H. & Schmidt, M., 9-Apr-2020, In : Frontiers in Cell and Developmental Biology. 8, p. 165 13 p., 165.

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Improving memory retrieval in Alzheimer’s disease by Epac 2

    Martina Schmidt (Recipient), 1-Feb-2020

    Prize: National/international honourAcademic

  2. Onbezoldigd medewerker UMCG

    Martina Schmidt (Recipient), 30-Apr-2020

    Prize: National/international honourAcademic

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  1. Dynamics in signaling and the pharmacological toolboxAriëns, Schmiedeberg, and more …

    Martina Schmidt (Invited speaker)

    Activity: Participating in or organising an eventOrganising an eventAcademic

  2. Dutch Neuroscience Meeting 2019

    Ulrich Eisel (Chair), Martina Schmidt (Chair)

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  3. Research Network Healthy Aging

    Martina Schmidt (Keynote speaker)

    Activity: Talk or presentationProfessional

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