prof. dr. M. (Martina) Schmidt

Professor of Molecular Pharmacology

Research

Postal address:
A Deusinglaan1
Gebouw 3211, ruimte 0406
9713 AV
Groningen
Netherlands
Phone: +31 50 363 3322Fax: +31 50 363 6908

Research interests

My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.

 

Publications
  1. Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice

    Cattani Pinto Cavalieri, I., Da Maia Valença, H., Moraes, J. A., Brito-Gitirana, L., Romana-Souza, B., Schmidt, M. & Santos Valença, S., Dec-2020, In : Int. J. Mol. Sci. . 21(24), 24, p. 1-14 14 p., 9658.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Metformin protects against diclofenac - induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via an alternative pathway involving epac

    EPAC, Nov-2020, In : Hepatology. 72, p. 722A-722A 1 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

    Chatterjee, A., Eshwaran, R., Poschet, G., Lomada, S., Halawa, M., Wilhelm, K., Schmidt, M., Hammes, H-P., Wieland, T. & Feng, Y., 2020, In : Cells. 9, 10, 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Diesel Exhaust Particles-induced Dysfunctional Responses in Lung Epithelial Progenitors is mediated by oxidative stress

    Wu, S., Bos, I. S. T., Kistemaker, L., Schmidt, M. & Gosens, R., 20-Jun-2020, In : ERJ Open Research. 6, Suppl. 5

    Research output: Contribution to journalMeeting AbstractAcademic

  5. Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency

    Chatterjee, A., Eshwaran, R., Huang, H., Zhao, D., Schmidt, M., Wieland, T. & Feng, Y., 2020, In : International Journal of Molecular Sciences. 21, 10, 3713.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (138) »

Prizes
  1. Teacher Award Bachelor Pharmacy 2019-2020

    Schmidt, Martina (Recipient), May-2020

    PrizeAcademic

  2. Fellow of British Pharmacological Society, FBPhS

    Schmidt, Martina (Recipient), 2016

    Prize: National/international honourAcademic

  3. Improving memory retrieval in Alzheimer’s disease by Epac 2

    Schmidt, Martina (Recipient), 1-Feb-2020

    Prize: National/international honourAcademic

View all (9) »

Activities
  1. EPHAR Executive Committee (External organisation)

    Martina Schmidt (Member)

    2020 → …

    Activity: MembershipMembership of committeeAcademic

  2. Organizing Committee FIGON Dutch Medicine Days (External organisation)

    Martina Schmidt (Member)

    2019 → …

    Activity: MembershipMembership of committeeAcademic

  3. Dagelijks Bestuur FIGON (External organisation)

    Martina Schmidt (Member)

    2019 → …

    Activity: MembershipMembership of committeeAcademic

View all (12) »

ID: 272274