prof. dr. M. (Martina) Schmidt
Professor of Molecular Pharmacology
Research
Research interests
My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.
Publications
Diesel Exhaust Particles-induced Dysfunctional Responses in Lung Epithelial Progenitors is mediated by oxidative stress
Wu, S., Bos, I. S. T., Kistemaker, L., Schmidt, M. & Gosens, R., 20-Jun-2020, In : ERJ Open Research. 6, Suppl. 5Research output: Contribution to journal › Meeting Abstract › Academic
Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency
Chatterjee, A., Eshwaran, R., Huang, H., Zhao, D., Schmidt, M., Wieland, T. & Feng, Y., 2020, In : International Journal of Molecular Sciences. 21, 10Research output: Contribution to journal › Article › Academic › peer-review
Nanodomains in cardiopulmonary disorders and the impact of air pollution
Cattani-Cavalieri, I., Valença, S. D. S. & Schmidt, M., 29-Jun-2020, In : Biochemical Society Transactions. 48, 3, p. 799-811Research output: Contribution to journal › Article › Academic › peer-review
Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases
Schmidt, M., Cattani-Cavalieri, I., Nuñez, F. J. & Ostrom, R. S., Apr-2020, In : Current Opinion in Pharmacology. 51, p. 34-42 9 p.Research output: Contribution to journal › Review article › Academic › peer-review
Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle
Baarsma, H. A., Han, B., Poppinga, W. J., Driessen, S., Elzinga, C. R. S., Halayko, A. J., Meurs, H., Maarsingh, H. & Schmidt, M., 9-Apr-2020, In : Frontiers in Cell and Developmental Biology. 8, p. 165 13 p., 165.Research output: Contribution to journal › Article › Academic › peer-review
Prizes
Improving memory retrieval in Alzheimer’s disease by Epac 2
Martina Schmidt (Recipient), 1-Feb-2020
Prize: National/international honour › Academic
Onbezoldigd medewerker UMCG
Martina Schmidt (Recipient), 30-Apr-2020
Prize: National/international honour › Academic
Avril McDonald Prize for excellent Master research
Martina Schmidt (Recipient), 31-Dec-2019
Prize › Academic
Activities
Dynamics in signaling and the pharmacological toolboxAriëns, Schmiedeberg, and more …
Martina Schmidt (Invited speaker)14-Dec-2018Activity: Participating in or organising an event › Organising an event › Academic
Dutch Neuroscience Meeting 2019
Ulrich Eisel (Chair), Martina Schmidt (Chair)20-Jun-2019Activity: Participating in or organising an event › Participation in conference › Academic
Research Network Healthy Aging
Martina Schmidt (Keynote speaker)8-Apr-2016 → 11-Apr-2016Activity: Talk or presentation › Professional
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