prof. dr. M. (Martina) Schmidt

Professor of Molecular Pharmacology


Postal address:
A Deusinglaan
Gebouw 3211, ruimte 0406
Phone: +31 50 363 3322Fax: +31 50 363 6908

Research interests

My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.


  1. Altered NOX expression does not seem to account for epidermal NLRP3 inflammasome activation in hidradenitis suppurativa

    Frings, V. G., Sennefelder, H., Presser, D., Goebeler, M. & Schmidt, M., Aug-2019, In : BRITISH JOURNAL OF DERMATOLOGY. 181, 2, p. 391-392 2 p.

    Research output: Contribution to journalLetterAcademicpeer-review

  2. cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs

    Aktories, K., Gierschik, P., zu Heringdorf, D. M., Schmidt, M., Schultz, G. & Wieland, T., Aug-2019, In : Naunyn-Schmiedebergs Archives of Pharmacology. 392, 8, p. 887-911 25 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  3. Second M-3 muscarinic receptor binding site contributes to bronchoprotection by tiotropium

    Kistemaker, L. E. M., Elzinga, C. R. S., Tautermann, C. S., Pieper, M. P., Seeliger, D., Alikhil, S., Schmidt, M., Meurs, H. & Gosens, R., Aug-2019, In : British Journal of Pharmacology. 176, 16, p. 2864-2876 13 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Function of cyclic AMP scaffolds in obstructive lung disease: Focus on epithelial-to-mesenchymal transition and oxidative stress

    Zuo, H., Cattani-Cavalieri, I., Valença, S. S., Musheshe, N. & Schmidt, M., Jul-2019, In : British Journal of Pharmacology. 176, 14, p. 2402-2415 14 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  5. Phosphodiesterases as therapeutic targets for respiratory diseases

    Zuo, H., Cattani-Cavalieri, I., Musheshe, N., Nikolaev, V. O. & Schmidt, M., 10-Feb-2019, In : Pharmacology & Therapeutics.

    Research output: Contribution to journalArticleAcademicpeer-review

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  1. Visiting professor

    Martina Schmidt (Recipient), 2014

    Prize: Honorary degreeAcademic

  2. Honorary LURN Lecture

    Martina Schmidt (Recipient), 13-Apr-2016

    Prize: National/international honourAcademic

  3. Fellowship of the British Pharmacological Society

    Martina Schmidt (Recipient), 2016

    Prize: National/international honourAcademic

View all (3) »

  1. Dutch Neuroscience Meeting 2019

    Ulrich Eisel (Chair), Martina Schmidt (Chair)

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  2. Research Network Healthy Aging

    Martina Schmidt (Keynote speaker)

    Activity: Talk or presentationProfessional

  3. British Journal of Pharmacology (Journal)

    Martina Schmidt (Editorial board member)
    2014 → …

    Activity: Publication peer-review and editorial workEditorial activityAcademic

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