prof. dr. M. (Martina) Schmidt
Professor of Molecular Pharmacology
Research
Research interests
My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.
Publications
A-kinase anchoring proteins diminish lung EMT induced by TGF-ß1/cigarette smoke
Schmidt, M., Veen, van der, M., Zuo, H. & O. Nikolaev, V., 21-Nov-2019, In : European Respiratory Journal. 54, suppl 63, PA3852.Research output: Contribution to journal › Meeting Abstract › Academic
Cigarette smoke and diesel particles repress functional responses in lung epithelial progenitors
Schmidt, M., Wu, S., Bos, I. S. T., Kistemaker, L. & Gosens, R., 2019, In : European Respiratory Journal. 54, (suppl 63) PA2437, p. PA2437Research output: Contribution to journal › Meeting Abstract › Academic
SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells
Krabbendam, I. E., Honrath, B., Bothof, L., Silva-Pavez, E., Huerta, H., Peñaranda Fajardo, N. M., Dekker, F., Schmidt, M., Culmsee, C., César Cárdenas, J., Kruyt, F. & Dolga, A. M., 15-Nov-2019, In : Biochemical Pharmacology. 13 p., 113714.Research output: Contribution to journal › Article › Academic › peer-review
Cigarette Smoke exposure Alters Phosphodiesterases in Human Structural Lung Cells
Zuo, H., Faiz, A., van den Berge, M., Mudiyanselage, S. N. H. R., Borghuis, T., Timens, W., Nikolaev, V. O., Burgess, J. K. & Schmidt, M., 30-Oct-2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 16 p.Research output: Contribution to journal › Article › Academic › peer-review
ELEVATED cAMP PROTECTS AGAINST DICLOFENAC-INDUCED TOXICITY IN PRIMARY RAT HEPATOCYTES, A PROTECTIVE EFFECT MEDIATED BY EPACS.
Mora, F. A., Buist-Homan, M., Schmidt, M. & Moshage, H., Oct-2019, In : Hepatology. 70, p. 1220A-1221A 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
Prizes
Honorary LURN Lecture
Martina Schmidt (Recipient), 13-Apr-2016
Prize: National/international honour › Academic
Fellowship of the British Pharmacological Society
Martina Schmidt (Recipient), 2016
Prize: National/international honour › Academic
Activities
Dutch Neuroscience Meeting 2019
Ulrich Eisel (Chair), Martina Schmidt (Chair)20-Jun-2019Activity: Participating in or organising an event › Participation in conference › Academic
Research Network Healthy Aging
Martina Schmidt (Keynote speaker)8-Apr-2016 → 11-Apr-2016Activity: Talk or presentation › Professional
British Journal of Pharmacology (Journal)
Martina Schmidt (Editorial board member)2014 → …Activity: Publication peer-review and editorial work › Editorial activity › Academic
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