prof. dr. M. (Martina) Schmidt
Professor of Molecular Pharmacology
Research
1
Gebouw 3211, ruimte 0406
Groningen
Research interests
My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.
Publications
Altered NOX expression does not seem to account for epidermal NLRP3 inflammasome activation in hidradenitis suppurativa
Frings, V. G., Sennefelder, H., Presser, D., Goebeler, M. & Schmidt, M., Aug-2019, In : BRITISH JOURNAL OF DERMATOLOGY. 181, 2, p. 391-392 2 p.Research output: Contribution to journal › Letter › Academic › peer-review
cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs
Aktories, K., Gierschik, P., zu Heringdorf, D. M., Schmidt, M., Schultz, G. & Wieland, T., Aug-2019, In : Naunyn-Schmiedebergs Archives of Pharmacology. 392, 8, p. 887-911 25 p.Research output: Contribution to journal › Review article › Academic › peer-review
Second M-3 muscarinic receptor binding site contributes to bronchoprotection by tiotropium
Kistemaker, L. E. M., Elzinga, C. R. S., Tautermann, C. S., Pieper, M. P., Seeliger, D., Alikhil, S., Schmidt, M., Meurs, H. & Gosens, R., Aug-2019, In : British Journal of Pharmacology. 176, 16, p. 2864-2876 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Function of cyclic AMP scaffolds in obstructive lung disease: Focus on epithelial-to-mesenchymal transition and oxidative stress
Zuo, H., Cattani-Cavalieri, I., Valença, S. S., Musheshe, N. & Schmidt, M., Jul-2019, In : British Journal of Pharmacology. 176, 14, p. 2402-2415 14 p.Research output: Contribution to journal › Review article › Academic › peer-review
Phosphodiesterases as therapeutic targets for respiratory diseases
Zuo, H., Cattani-Cavalieri, I., Musheshe, N., Nikolaev, V. O. & Schmidt, M., 10-Feb-2019, In : Pharmacology & Therapeutics.Research output: Contribution to journal › Article › Academic › peer-review
Prizes
Honorary LURN Lecture
Martina Schmidt (Recipient), 13-Apr-2016
Prize: National/international honour › Academic
Fellowship of the British Pharmacological Society
Martina Schmidt (Recipient), 2016
Prize: National/international honour › Academic
Activities
Dutch Neuroscience Meeting 2019
Ulrich Eisel (Chair), Martina Schmidt (Chair)20-Jun-2019Activity: Participating in or organising an event › Participation in conference › Academic
Research Network Healthy Aging
Martina Schmidt (Keynote speaker)8-Apr-2016 → 11-Apr-2016Activity: Talk or presentation › Professional
British Journal of Pharmacology (Journal)
Martina Schmidt (Editorial board member)2014 → …Activity: Publication peer-review and editorial work › Editorial activity › Academic
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