prof. dr. M. (Martina) Schmidt

Professor of Molecular Pharmacology


Postal address:
A Deusinglaan1
Gebouw 3211, ruimte 0406
9713 AV
Phone: +31 50 363 3322Fax: +31 50 363 6908

Research interests

My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.


  1. Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

    Baarsma, H. A., Han, B., Poppinga, W. J., Driessen, S., Elzinga, C. R. S., Halayko, A. J., Meurs, H., Maarsingh, H. & Schmidt, M., 2020, In : Frontiers in Cell and Developmental Biology. 8, p. 165

    Research output: Contribution to journalArticleAcademicpeer-review

  2. SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

    Krabbendam, I. E., Honrath, B., Dilberger, B., Iannetti, E. F., Branicky, R. S., Meyer, T., Evers, B., Dekker, F. J., Koopman, W. J. H., Beyrath, J., Bano, D., Schmidt, M., Bakker, B. M., Hekimi, S., Culmsee, C., Eckert, G. P. & Dolga, A. M., 23-Apr-2020, In : Cell death & disease. 11, 4, 18 p., 263.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Submicroscopic cAMP/PKA Compartmentalization: Ion flux at the Cardiomyocyte Plasmalemma

    Musheshe, N., Surdo, N. C., Schmidt, M. & Zaccolo, M., Apr-2019, In : FASEB Journal. 33, 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  4. A-kinase anchoring proteins define cAMP compartment in TGF-beta(1)/cigarette smoke induced lung EMT

    Schmidt, M., Zuo, H., Musheshe, N. & Nikolaev, V., 2019, In : FASEB Journal. 33, 2 p., 681.6.

    Research output: Contribution to journalMeeting AbstractAcademic

  5. Metabolic escape to glycolysis through SK channel activation inhibits ferroptosis and increases the life span of C. elegans in conditions of heat stress

    Dolga, A., Krabbendam, I., Honrath, B., Dilberger, B., Schmidt, M., Eckert, G. & Culmsee, C., Apr-2019, In : FASEB Journal. 33, 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

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  1. Improving memory retrieval in Alzheimer’s disease by Epac 2

    Martina Schmidt (Recipient), 1-Feb-2020

    Prize: National/international honourAcademic

  2. Onbezoldigd medewerker UMCG

    Martina Schmidt (Recipient), 30-Apr-2020

    Prize: National/international honourAcademic

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  1. Dynamics in signaling and the pharmacological toolboxAriëns, Schmiedeberg, and more …

    Martina Schmidt (Invited speaker)

    Activity: Participating in or organising an eventOrganising an eventAcademic

  2. Dutch Neuroscience Meeting 2019

    Ulrich Eisel (Chair), Martina Schmidt (Chair)

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  3. Research Network Healthy Aging

    Martina Schmidt (Keynote speaker)

    Activity: Talk or presentationProfessional

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