prof. dr. M. (Martina) Schmidt
Professor of Molecular Pharmacology
Research
Research interests
My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.
Publications
Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice
Cattani Pinto Cavalieri, I., Da Maia Valença, H., Moraes, J. A., Brito-Gitirana, L., Romana-Souza, B., Schmidt, M. & Santos Valença, S., Dec-2020, In : Int. J. Mol. Sci. . 21(24), 24, p. 1-14 14 p., 9658.Research output: Contribution to journal › Article › Academic › peer-review
Metformin protects against diclofenac - induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via an alternative pathway involving epac
EPAC, Nov-2020, In : Hepatology. 72, p. 722A-722A 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity
Chatterjee, A., Eshwaran, R., Poschet, G., Lomada, S., Halawa, M., Wilhelm, K., Schmidt, M., Hammes, H-P., Wieland, T. & Feng, Y., 2020, In : Cells. 9, 10, 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Diesel Exhaust Particles-induced Dysfunctional Responses in Lung Epithelial Progenitors is mediated by oxidative stress
Wu, S., Bos, I. S. T., Kistemaker, L., Schmidt, M. & Gosens, R., 20-Jun-2020, In : ERJ Open Research. 6, Suppl. 5Research output: Contribution to journal › Meeting Abstract › Academic
Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High Glucose or Nucleoside Diphosphate Kinase B Deficiency
Chatterjee, A., Eshwaran, R., Huang, H., Zhao, D., Schmidt, M., Wieland, T. & Feng, Y., 2020, In : International Journal of Molecular Sciences. 21, 10, 3713.Research output: Contribution to journal › Article › Academic › peer-review
Prizes
Fellow of British Pharmacological Society, FBPhS
Schmidt, Martina (Recipient), 2016
Prize: National/international honour › Academic
Improving memory retrieval in Alzheimer’s disease by Epac 2
Schmidt, Martina (Recipient), 1-Feb-2020
Prize: National/international honour › Academic
Activities
EPHAR Executive Committee (External organisation)
Martina Schmidt (Member)
2020 → …Activity: Membership › Membership of committee › Academic
Organizing Committee FIGON Dutch Medicine Days (External organisation)
Martina Schmidt (Member)
2019 → …Activity: Membership › Membership of committee › Academic
Dagelijks Bestuur FIGON (External organisation)
Martina Schmidt (Member)
2019 → …Activity: Membership › Membership of committee › Academic
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