prof. dr. M. (Martina) Schmidt
Professor of Molecular Pharmacology
Research
Research interests
My research focus on clustered signaling pathways of molecular partners in defined subcellular compartments (signalosomes) that enables cells to exert highly specialized tasks. Actually, our goal for the future is to unravel the organization of the recently discovered signaling components within functional units by biochemical, molecular, cell biological methods, genetic and omic’s. Research is embedded in the field of integrative pharmacology and translational medicine. We have directed our attention to chronic inflammatory disorders, as evidence exist for a role of our signaling components (Epac, PLD, AKAP, cofilin) in smooth muscle cells, neuronal cells, immune cells as well as cardiomyocytes. Many devastating diseases, e.g. cancer, type-II diabetes mellitus, Alzheimers’s dementia, cardiovascular and airway diseases (heart failure, cardiac arrhythmia, developmental defects, asthma and COPD), and infection diseases are associated with defective or derailed signaling processes, and research into the control of these processes clearly is of great public and social importance as well. My research group integrates in vivo, ex vivo translational pharmacology, molecular (cell) biology. Novel techniques like microfluidics, precision cut lung slices and others.
Publications
Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle
Baarsma, H. A., Han, B., Poppinga, W. J., Driessen, S., Elzinga, C. R. S., Halayko, A. J., Meurs, H., Maarsingh, H. & Schmidt, M., 2020, In : Frontiers in Cell and Developmental Biology. 8, p. 165Research output: Contribution to journal › Article › Academic › peer-review
SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans
Krabbendam, I. E., Honrath, B., Dilberger, B., Iannetti, E. F., Branicky, R. S., Meyer, T., Evers, B., Dekker, F. J., Koopman, W. J. H., Beyrath, J., Bano, D., Schmidt, M., Bakker, B. M., Hekimi, S., Culmsee, C., Eckert, G. P. & Dolga, A. M., 23-Apr-2020, In : Cell death & disease. 11, 4, 18 p., 263.Research output: Contribution to journal › Article › Academic › peer-review
Submicroscopic cAMP/PKA Compartmentalization: Ion flux at the Cardiomyocyte Plasmalemma
Musheshe, N., Surdo, N. C., Schmidt, M. & Zaccolo, M., Apr-2019, In : FASEB Journal. 33, 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
A-kinase anchoring proteins define cAMP compartment in TGF-beta(1)/cigarette smoke induced lung EMT
Schmidt, M., Zuo, H., Musheshe, N. & Nikolaev, V., 2019, In : FASEB Journal. 33, 2 p., 681.6.Research output: Contribution to journal › Meeting Abstract › Academic
Metabolic escape to glycolysis through SK channel activation inhibits ferroptosis and increases the life span of C. elegans in conditions of heat stress
Dolga, A., Krabbendam, I., Honrath, B., Dilberger, B., Schmidt, M., Eckert, G. & Culmsee, C., Apr-2019, In : FASEB Journal. 33, 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
Prizes
Improving memory retrieval in Alzheimer’s disease by Epac 2
Martina Schmidt (Recipient), 1-Feb-2020
Prize: National/international honour › Academic
Onbezoldigd medewerker UMCG
Martina Schmidt (Recipient), 30-Apr-2020
Prize: National/international honour › Academic
Avril McDonald Prize for excellent Master research
Martina Schmidt (Recipient), 31-Dec-2019
Prize › Academic
Activities
Dynamics in signaling and the pharmacological toolboxAriëns, Schmiedeberg, and more …
Martina Schmidt (Invited speaker)14-Dec-2018Activity: Participating in or organising an event › Organising an event › Academic
Dutch Neuroscience Meeting 2019
Ulrich Eisel (Chair), Martina Schmidt (Chair)20-Jun-2019Activity: Participating in or organising an event › Participation in conference › Academic
Research Network Healthy Aging
Martina Schmidt (Keynote speaker)8-Apr-2016 → 11-Apr-2016Activity: Talk or presentation › Professional
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