prof. dr. M. (Michiel) Rienstra

prof. dr. M. (Michiel) Rienstra
+31 50 361 2355 ((secretariaat))
+31 50 361 2878 ((direct))


Research interests

Graduated in medicine at the University of Antwerp, Belgium in 2003. Obtained a PhD at the University of Groningen, The Netherlands in 2007 on Atrial Fibrillation, Underlying Disease and Prognosis. I completed my cardiology training at the University Medical Center Groningen in 2012, where continued working as clinical cardiologist and researcher. I was awarded with a NWO Rubicon grant in 2009 and went to Harvard Medical School, Massachusetts General Hospital and the Framingham Heart Study for a post-doc on population genetics and epidemiology in 2010-2011. In 2012 I was awarded with the NWO Veni grant for his project on genetics of atrial fibrillation. In 2015 I received the European Society of Cardiology academic grant for his project on a big data approach in atrial fibrillation. I am work package leader of 4 large national consortia; RACE V (hypercoagulability and AF progression), RED-CVD (early detection of cardiovascular disease in general practices), AI (catalyzing the application of artificial intelligence in CV disease), and MyDigiTwin (Big-data and Artificial Intelligence-based ecosystem to create a user’s personal “Digital Twin”). I am steering committee member of several investigator-initiated clinical studies (RACE 2 to 7, MARC 1-2, VIP-HF, DECISION). I am fellow of the European Society of Cardiology and the American Heart Association, and Scientific & Clinical Education Lifelong Learning Committee (SCILL) member of the AHA - Genomics and Precision Medicine council.


I combine clinical cardiology focusing on treatment of patients with arrhythmias, with clinical-oriented research. My research consists of conducting clinical studies to improve AF treatment, studying epidemiology of AF and its risk factors in PREVEND, Lifelines and Framingham Heart Study, uncovering the genetics of atrial fibrillation in part with the international AFGen onsortium, and applying novel bioinformatics tools to improve AF risk prediction.

  1. Nurse-led vs. usual-care for atrial fibrillation

    Wijtvliet, E. P. J. P., Tieleman, R. G., van Gelder, I. C., Pluymaekers, N. A. H. A., Rienstra, M., Folkeringa, R. J., Bronzwaer, P., Elvan, A., Elders, J., Tukkie, R., Luermans, J. G. L. M., Van Asselt, A. D. I. T., Van Kuijk, S. M. J., Tijssen, J. G. & Crijns, H. J. G. M., 23-Sep-2019, In : European Heart Journal. 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Atrial Fibrillation Genetics Update: Toward Clinical Implementation

    Kalsto, S. M., Siland, J. E., Rienstra, M. & Christophersen, I. E., 6-Sep-2019, In : Frontiers in cardiovascular medicine. 6, 16 p., 127.

    Research output: Contribution to journalReview articleAcademicpeer-review

  3. Residual confounding in observational studies: new data from the old DIG trial

    Boorsma, E. M., Rienstra, M., van Veldhuisen, D. J. & van der Meer, P., 7-Aug-2019, In : European Heart Journal.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation

    Mordi, I. R., Santema, B. T., Kloosterman, M., Choy, A-M., Rienstra, M., van Gelder, I., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Metra, M., Ng, L. L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F., Voors, A. A. & Lang, C. C., Jul-2019, In : Clinical Research in Cardiology. 108, 7, p. 797-805 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Heart rate in patients with atrial fibrillation and heart failure with preserved ejection fraction: a prognosticator like in sinus rhythm?

    Rienstra, M., Kotecha, D. & van Veldhuisen, D. J., Apr-2019, In : European Journal of Heart Failure. 21, 4, p. 480-481 2 p.

    Research output: Contribution to journalEditorialAcademicpeer-review

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Press / Media
  1. Dagblad van het Noorden interview; ‘Samen voor het hart‘

    Michiel Rienstra


    1 Media contribution

    Press/Media: Public Engagement ActivitiesPopular

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  1. Co-investigator HARMONY randomized trial (External organisation)

    Michiel Rienstra (Member)

    Activity: MembershipMembership of committeeAcademic

  2. Center - principal investigator MONITOR-HF trial (External organisation)

    Michiel Rienstra (Member)
    2019 → …

    Activity: MembershipMembership of committeeAcademic

  3. Steering committee of the APAF-CRT randomized trial (External organisation)

    Michiel Rienstra (Member)
    2019 → …

    Activity: MembershipMembership of committeeAcademic

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  1. ESC - Stroke Council award

    Michiel Rienstra (Recipient), 2019

    Prize: Fellowship awarded competitivelyAcademic

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