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Over ons Praktische zaken Waar vindt u ons M.R. (Matthew) Groves, Dr

M.R. (Matthew) Groves, Dr

Associate Professor
Research interests Publicaties Pers/media

Research interests

Applied Research Activities

Structure-based drug design in human diseases

Basic Research Activities

Structural, biochemical and molecular biology investigation of malarial pathways:

Carbon metabolism in P falciparum

Vitamin biosynthesis in P. falciparum

Method Developments

Crystal identification for structural biology

Biological imaging on free-electron lasers 

Publicaties

A protein-based self-assembled nanoparticle provides an improved malarial vaccine

Groves, M. R. & Chen, S., 28-feb.-2026, (E-pub ahead of print) In: Trends in parasitology. 2 blz.

Onderzoeksoutput: Article › › peer review

De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase

Peng, B., Wang, Z., Zhang, L., Groves, M. R. & Haslinger, K., 6-apr.-2026, (E-pub ahead of print) In: Microbial Cell Factories. 52 blz.

Onderzoeksoutput: Article › › peer review

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi

Chen, S., Cal, M., Mondile, Q., Oerlemans, R., Shashikant, M. M., Dömling, A. S. S., Bishop, Ö. T., Mäser, P. & Groves, M. R., 27-mrt.-2026, In: ChemMedChem. 21, 6, 9 blz., e202500817.

Onderzoeksoutput: Article › › peer review

1-Deoxy-D-xylulose 5-phosphate synthase: Structural perspectives on an essential enzyme in isoprenoid biosynthesis

Gawriljuk, V. O., Oerlemans, R., Reddem, E. R., Gierse, R. M., Hirsch, A. K. H. & Groves, M. R., sep.-2025, In: Journal of Structural Biology. 217, 3, 14 blz., 108236.

Onderzoeksoutput › peer review

Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design

Gawriljuk, V. O., Alhayek, A., Hirsch, A. K. H. & Groves, M. R., 2-feb.-2025, In: Biochemical and Biophysical Research Communications. 747, blz. 151246 6 blz.

Onderzoeksoutput: Article › › peer review

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

Sokolova, N., Osipyan, A., Zhang, L., Groves, M. R., Schmidt, S. & Haslinger, K., 27-dec.-2025, (E-pub ahead of print) In: The FEBS Journal. 19 blz.

Onderzoeksoutput: Article › › peer review

Exploring Aspartate Transcarbamoylase: A Promising Broad-Spectrum Target for Drug Development

Chen, S., Mondile, Q., Du, X., Wang, C., Mukim, M., Wrenger, C., Dömling, A. S. S., Tastan Bishop, Ö. & Groves, M. R., 1-apr.-2025, In: ChemBioChem. 26, 7, 11 blz., e202401009.

Onderzoeksoutput › peer review

New homocysteine consumption assay for high-throughput screening of human Cystathionine-β-synthase

Nakládal, D., Oerlemans, R., Molitorisová, M., Chomaničová, N., Zorkócy, G., Yoseif, C., van der Graaf, A. C., Stuchlík, S., Krenning, G., Groves, M. R., Heeres, A., Levarski, Z., Kyselovič, J., Henning, R. H. & Deelman, L. E., apr.-2025, In: SLAS discovery : advancing life sciences R & D. 32, 9 blz., 100234.

Onderzoeksoutput: Article › › peer review

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Gawriljuk, V. O., Godoy, A. S., Oerlemans, R., Welker, L. A. T., Hirsch, A. K. H. & Groves, M. R., dec.-2024, In: Nature Communications. 15, 1, 11 blz., 6642.

Onderzoeksoutput: Article › › peer review

Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids

Peng, B., Zhang, L., He, S., Oerlemans, R., Quax, W. J., Groves, M. R. & Haslinger, K., 10-jan.-2024, In: Journal of Agricultural and Food Chemistry. 72, 1, blz. 529–539 11 blz.

Onderzoeksoutput: Article › › peer review

Pers/media

Startup Protyon krijgt subsidie voor levensverlengende software

Groves, M.

06/07/2023

Pers / media: Expert Comment ›

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