dr. M.N. (Marjolijn) Lub-de Hooge

Hospital Pharmacist, associate professor

Research

Research interests

Dr. Marjolijn N. Lub-de Hooge

is a Hospital Pharmacist and associate professor at the department of Clinical Pharmacy and Pharmacology, and at the department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen. She obtained her PhD on pharmaceutical aspects and molecular imaging of new receptor targeted drugs.

Her research mainly focuses on molecular imaging to support and optimize treatment of cancer patients with novel (targeted and immuno) therapies. She is an expert in the development, evaluation and translation of new radiopharmaceuticals and optical tracers to the clinical setting. And she is also involved in the subsequent clinical application of these new tracers for drug development, and treatment optimization: visualization of presence of drug target (patient selection), drug biodistribution (pharmacokinetics, optimal dosing, target saturation) and tumor status during treatment (early predictive biomarker, pharmacodynamics).

 

 

Publications
  1. Customary concentrations appear to be fatal: The relationship between serum digoxin concentrations and therapeutic result in patients with heart failure

    Beukema, G., Lub-de Hooge, M. N. & Kosterink, J. G. W., 10-Oct-2003, In : Pharmaceutisch Weekblad. 138, 41, p. 1440-1441 2 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Imaging human pancreatic tumor xenografts with 89Zr-labeled anti-mesothelin antibody

    Ter Weele, E. J., Lub-De Hooge, M. N., Maslyar, D., Van Scheltinga, A. G. T. T., Kosterink, J. G. W., De Vries, E. G. E. & Williams, S. P., 15-Apr-2013, In : Cancer Research. 73, 8

    Research output: Contribution to journalArticleAcademicpeer-review

  3. 89Zr-bevacizumab PET as an early biomarker for response to everolimus treatment in an ovarian cancer xenograft model

    Van Scheltinga, A. G. T. T., Van Der Bilt, A. R. M., Timmer-Bosscha, H., Schröder, C. P., Pot, L., Kosterink, J. G. W., Van Der Zee, A. G. J., Lub-de Hooge, M. N., De Jong, S., De Vries, E. G. E. & Reyners, A. K. L., 15-Apr-2012, In : Cancer Research. 72, 8

    Research output: Contribution to journalArticleAcademicpeer-review

  4. [89Zr]trastuzumab for PET imaging of HER2-positive lesions in patients with metastatic breast cancer

    Dijkers, E. C. F., Munnink, T. H. O., De Vries, E. G. E., Brouwers, A. H., Jager, P. L., De Jong, J. R., Van Dongen, G. A. M. S., Schröder, C. P., Lub-De Hooge, M. N. & Kosterink, J. G. W., 20-Apr-2012, In : Pharmaceutisch Weekblad. 147, 16, p. 62-67 6 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Tumour uptake of 89Zr-alemtuzumab compared to 111In-IgG in human non-Hodgkin's B-cell lymphoma bearing mice

    Sturkenboom, M. G. G., Lub-De Hooge, M. N., Dierckx, R. A. J. O., Van Imhoff, G. W., Kluin-Nelemans, H. C. & Kosterink, J. G. W., 1-Oct-2010, p. 289. 1 p.

    Research output: Contribution to conferenceAbstractAcademic

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