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How to find us prof. dr. M.N. (Marjolijn) Lub-de Hooge

Research interests

Prof. Dr. Marjolijn N. Lub-de Hooge

is a Hospital Pharmacist and professor at the department of Clinical Pharmacy and Pharmacology, and at the department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen. She obtained her PhD on pharmaceutical aspects and molecular imaging of new receptor targeted drugs.

Her research mainly focuses on molecular imaging to support drug development and to optimize treatment of cancer patients with novel (targeted and immuno) therapies. She is an expert in the development, evaluation and translation of new radiopharmaceuticals and optical tracers to the clinical setting. And she is also involved in the subsequent clinical application of these new tracers for drug development, and treatment optimization: visualization of presence of drug target (patient selection), drug biodistribution (pharmacokinetics, optimal dosing, target saturation) and tumor status during treatment (early predictive biomarker, pharmacodynamics).

 

 

Publications

Zr-89-pembrolizumab imaging as a non-invasive approach to assess clinical response to PD-1 blockade in cancer

Basic aspects of good manufacturing practice for PET-rediopharmaceuticals

First-in-human study of the biodistribution and pharmacokinetics of 89Zr-CX-072, a novel immunopet tracer based on an anti–PD-L1 probody

Mesothelin/CD3 half-life extended bispecific T-cell engager molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues

Modelling Tools to Characterize Acetaminophen Pharmacokinetics in the Pregnant Population

Molecular Imaging of the Receptor HER2 and the Ligand VEGF as Role Models for the Use of ImmunoPET in Drug Development

(89)ZED88082A PET imaging to visualize CD8(+) T cells in patients with cancer treated with immune checkpoint inhibitor.

Development and evaluation of interleukin-2 derived radiotracers for PET imaging of T-cells in mice

Moleculaire beeldvorming met 89Zr-immunoPET in translationele studies op het gebied van immuuntherapie

Molecular imaging biomarkers for immune checkpoint inhibitor therapy

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