prof. dr. M.J.H. (Martien) Kas

Professor of Behavioral Neuroscience

prof. dr. M.J.H. (Martien) Kas
Telephone:
+31 50 36 32381 (Direct contact)
Secretary:
+31 50 36 32340 (Alternative contact)
E-mail:
m.j.h.kas rug.nl

Research

Research units:

Research interests

The research of the group focuses on determinants of behavior, especially of behavioral strategies and of biological processes that are essential across species and that are affected in various neuropsychiatric disorders (e.g., social interaction and sensory information processing). By means of cross-species genetic analysis of neurobehavioral traits (of mice and men) we aim to identify genotype-phenotype relationships relevant to the development and treatment of autism spectrum disorders, Alzheimer's Disease, eating disorders, and schizophrenia. These studies will lead to our understanding of conserved gene function in regulating essential behavioral strategies and will ultimately improve therapeutic and preventive strategies to contribute to healthy aging.

 

Experimental strategy:

The identification of molecular genetic mechanisms of neurobehavioral traits is established by performing fine-grained analysis of behavior using both well-established testing paradigms, as well as novel automated behavioral phenotyping methods (e.g., automated home cage recordings in rodents and smartphone application monitoring of human behavior). Behavioral and EEG dynamics in developing genetic mouse models for human candidate genes of neuropsychiatric disorders are studied across different developmental stages and in relation to brain development. Ultimately, genotype-phenotype relationships are translated to relevant human patient populations.

 

Recent key publications:

1: Bruining H, Matsui A, Oguro-Ando A, Kahn RS, Van't Spijker HM, Akkermans G, Stiedl O, van Engeland H, Koopmans B, van Lith HA, Oppelaar H, Tieland L, Nonkes LJ, Yagi T, Kaneko R, Burbach JP, Yamamoto N, Kas MJ.  Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development. Biological Psychiatry,  2015, 78(7):485-95

2: Jongs N, Jagesar R, van Haren NEM, Penninx BWJH, Reus L, Visser PJ, van der Wee NJA, Koning IM, Arango C, Sommer IEC, Eijkemans MJC, Vorstman JA, Kas MJ.  A framework for assessing neuropsychiatric phenotypes by using smartphone-based location data.  Translational Psychiatry 2020 Jul 1;10(1):211.

3: Schughart K, Libert C, and Kas MJ. Human disease: strength to strength for mouse models. Nature, 2012, 492, 41

4: Kas MJ, Kahn RS, Collier DA, Waddington JL, Ekelund J, Porteous DJ, Schughart K, Hovatta I. Translational neuroscience of schizophrenia: seeking a meeting of minds between mouse and man. Science Translational Medicine, 2011, 3(102):102mr3.

5: Laarakker MC, Reinders NR, Bruining H, Ophoff RA, Kas MJ. Sex-dependent novelty response in neurexin-1α mutant mice. PLoS One, 2012, 7(2):e31503.

Publications
  1. How the COVID-19 pandemic highlights the necessity of animal research

    Genzel, L., Adan, R., Berns, A., van den Beucken, J., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., Dam, A-M. V., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., Fentener van Vlissingen, J. M., la Fleur, S., Fouchier, R., Fitzsimons, C. P., Frieling, W., Haagmans, B., Heesters, B. A., Henckens, M., Herfst, S., Hol, E., van den Hove, D., de Jonge, M. I., Jonkers, J., Joosten, L. A. B., Kalsbeek, A., Kamermans, M., Kampinga, H. H., Kas, M. J., Keijer, J., Kersten, S., Kiliaan, A. J., Kooij, T. W. A., Kooijman, S., Koopman, W. J. H., Korosi, A., Krugers, H. J., Kuiken, T., Kushner, S. A., Langermans, J. A. M., Lesscher, H., Lucassen, P. J., Lutgens, E., Netea, M. G., Noldus, L. P. J. J., van der Meer, J. W. M., Meye, F. J., Mul, J. D., van Oers, K., Olivier, J. D. A., Pasterkamp, R. J., Philippens, I. H. C. H. M., Prickaerts, J., Pullox, B. J. A., Rensen, P. C. N., van Rheenen, J., van Rij, R. P., Ritsma, L., Rockx, B. H. G., Roozendaal, B., van Schothorst, E. M., Stittelaar, K., Stockhofe, N., Swaab, D. F., de Swart, R. L., Vanderschuren, L. J. M. J., de Vries, T., de Vrij, F., van Wezel, R., Wierenga, C. J., Wiesmann, M., Willuhn, I., de Zeeuw, C. I. & Homberg, J. R., 21-Sep-2020, In : Current Biology. 30, 18, p. R1014-R1018 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Reply to 'It is time for an empirically informed paradigm shift in animal research'

    Würbel, H., Voelkl, B., Altman, N. S., Forsman, A., Forstmeier, W., Gurevitch, J., Jaric, I., Karp, N. A., Kas, M. J., Schielzeth, H. & Van de Casteele, T., 21-Aug-2020, In : Nature reviews neuroscience. 2 p.

    Research output: Contribution to journalLetterAcademicpeer-review

  3. Patient-Perspective: need for care after a first psychosis

    Heijden-Hobus, I., Van der Heijden-Hobus, I., Rosema, B-S., Vorstman, J., Kas, M., Begemann, M., Kikkert, M. & Sommer, I., Apr-2020, In : Schizophrenia Bulletin. 46, p. S148-S149 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  4. Social withdrawal: An initially adaptive behavior that becomes maladaptive when expressed excessively

    Ike, K. G. O., de Boer, S. F., Buwalda, B. & Kas, M. J. H., Sep-2020, In : Neuroscience and Biobehavioral Reviews. 116, p. 251-267 17 p.

    Research output: Contribution to journalReview articleAcademicpeer-review

  5. A framework for assessing neuropsychiatric phenotypes by using smartphone-based location data

    Jongs, N., Jagesar, R., van Haren, N. E. M., Penninx, B. W. J. H., Reus, L., Visser, P. J., van der Wee, N. J. A., Koning, I. M., Arango, C., Sommer, I. E. C., Eijkemans, M. J. C., Vorstman, J. A. & Kas, M. J., 1-Jul-2020, In : Translational Psychiatry. 10, 1, 10 p., 211.

    Research output: Contribution to journalArticleAcademicpeer-review

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Press / Media
  1. PRISM project video series

    Martien Kas

    29/08/2019

    1 Media contribution

    Press/Media: Public Engagement ActivitiesProfessional

  2. Anorexia not just a psychiatric problem, scientists find

    Martien Kas

    15/07/201916/07/2019

    2 items of Media coverage

    Press/Media: ResearchAcademic

View all (27) »

Prizes
  1. Translational Neuroscience Prize 2019

    Kas, Martien (Recipient), 20-Jun-2019

    PrizeAcademic

View all (1) »

Activities
  1. 33rd ECNP congress

    Martien Kas (Chair)

    13-Sep-2020

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  2. Lessons learned from digital technologies

    Martien Kas (Invited speaker)

    13-Sep-2020

    Activity: Talk or presentationAcademic

  3. Linking neuropsychiatry to quantitative biology

    Martien Kas (Invited speaker)

    11-Jul-2020

    Activity: Talk or presentationAcademic

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