prof. dr. M.J.H. (Martien) Kas

Professor of Behavioral Neuroscience

prof. dr. M.J.H. (Martien) Kas
Telephone:
+31 50 36 32381 (Direct contact)
Secretary:
+31 50 36 32340 (Alternative contact)
E-mail:

Research

Research units:

Research interests

The research of the group focuses on determinants of behavior, especially of behavioral strategies and of biological processes that are essential across species and that are affected in various neuropsychiatric disorders (e.g., social interaction and sensory information processing). By means of cross-species genetic analysis of neurobehavioral traits (of mice and men) we aim to identify genotype-phenotype relationships relevant to the development and treatment of autism spectrum disorders, Alzheimer's Disease, eating disorders, and schizophrenia. These studies will lead to our understanding of conserved gene function in regulating essential behavioral strategies and will ultimately improve therapeutic and preventive strategies to contribute to healthy aging.

 

Experimental strategy:

The identification of molecular genetic mechanisms of neurobehavioral traits is established by performing fine-grained analysis of behavior using both well-established testing paradigms, as well as novel automated behavioral phenotyping methods (e.g., automated home cage recordings in rodents and smartphone application monitoring of human behavior). Behavioral and EEG dynamics in developing genetic mouse models for human candidate genes of neuropsychiatric disorders are studied across different developmental stages and in relation to brain development. Ultimately, genotype-phenotype relationships are translated to relevant human patient populations.

 

Recent key publications:

1: Bruining H, Matsui A, Oguro-Ando A, Kahn RS, Van't Spijker HM, Akkermans G, Stiedl O, van Engeland H, Koopmans B, van Lith HA, Oppelaar H, Tieland L, Nonkes LJ, Yagi T, Kaneko R, Burbach JP, Yamamoto N, Kas MJ.  Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development. Biological Psychiatry,  2015, 78(7):485-95

2: Eskes P, Spruit M, Brinkkemper S, Vorstman J, Kas MJ. The sociability score: App-based social profiling from a healthcare perspective. Computers in Human Behavior, 2016, 59, 39-48

3: Schughart K, Libert C, and Kas MJ. Human disease: strength to strength for mouse models. Nature, 2012, 492, 41

4: Kas MJ, Kahn RS, Collier DA, Waddington JL, Ekelund J, Porteous DJ, Schughart K, Hovatta I. Translational neuroscience of schizophrenia: seeking a meeting of minds between mouse and man. Science Translational Medicine, 2011, 3(102):102mr3.

5: Laarakker MC, Reinders NR, Bruining H, Ophoff RA, Kas MJ. Sex-dependent novelty response in neurexin-1α mutant mice. PLoS One, 2012, 7(2):e31503.

Publications
  1. Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

    PGC-ED & ENIGMA Genetics Working Grp, Jul-2019, In : Molecular neurobiology. 56, 7, p. 5146-5156 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Reproducibility via coordinated standardization: A multi-center study in a Shank2 genetic rat model for Autism Spectrum Disorders

    Arroyo-Araujo, M., Graf, R., Maco, M., van Dam, E., Schenker, E., Drinkenburg, W., Koopmans, B., de Boer, S. F., Cullum-Doyle, M., Noldus, L. P. J. J., Loos, M., van Dommelen, W., Spooren, W., Biemans, B., Buhl, D. L. & Kas, M. J., 12-Aug-2019, In : Scientific Reports. 9, 1, 10 p., 11602.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

    Anorexia Nervosa Genetics Initiative & Kas, M. J. H., Aug-2019, In : Nature Genetics. 51, 8, p. 1207-+ 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. RFID-supported video tracking for automated analysis of social behaviour in groups of mice

    Peleh, T., Bai, X., Kas, M. J. H. & Hengerer, B., 1-Sep-2019, In : Journal of Neuroscience Methods. 325, 9 p., 108323.

    Research output: Contribution to journalReview articleAcademicpeer-review

  5. The reduction of astrocytes and brain volume loss in anorexia nervosa: The impact of starvation and refeeding in a rodent model

    Frintrop, L., Trinh, S., Liesbrock, J., Leunissen, C., Kempermann, J., Etdöger, S., Kas, M. J., Tolba, R., Heussen, N., Neulen, J., Konrad, K., Päfgen, V., Kiessling, F., Herpertz-Dahlmann, B., Beyer, C. & Seitz, J., 4-Jun-2019, In : Translational Psychiatry. 9, 1, 11 p., 159.

    Research output: Contribution to journalArticleAcademicpeer-review

View all (156) »

Press / Media
  1. PRISM project video series

    Martien Kas

    29/08/2019

    1 media contribution

    Press/Media: Public Engagement ActivitiesProfessional

  2. Anorexia not just a psychiatric problem, scientists find

    Martien Kas

    15/07/201916/07/2019

    2 items of media coverage

    Press/Media: ResearchAcademic

  3. AIMS-2-TRIALS Newsletter

    Martien Kas

    10/05/201925/06/2019

    2 media contributions

    Press/Media: Public Engagement ActivitiesProfessional

View all (26) »

Activities
  1. KNAW - Commissie Inventarisatie onderzoeksmethoden in de neurowetenschappen (External organisation)

    Martien Kas (Member)
    13-Feb-201827-Jun-2019

    Activity: MembershipMembership of committeeAcademic

  2. Dutch Neuroscience Meeting 2019

    Martien Kas (Invited speaker)
    20-Jun-2019

    Activity: Participating in or organising an eventParticipation in conferenceAcademic

  3. The biology of social withdrawal

    Martien Kas (Speaker)
    23-May-2019

    Activity: Talk or presentationAcademic

View all (35) »

Prizes
  1. Translational Neuroscience Prize 2019

    Martien Kas (Recipient), 20-Jun-2019

    PrizeAcademic

View all (1) »

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