prof. dr. M.J.H. (Martien) Kas

Professor of Behavioral Neuroscience

prof. dr. M.J.H. (Martien) Kas
+31 50 36 32381 (Direct contact)
+31 50 36 32340 (Alternative contact)


Research units:

Research interests

The research of the group focuses on determinants of behavior, especially of behavioral strategies and of biological processes that are essential across species and that are affected in various neuropsychiatric disorders (e.g., social interaction and sensory information processing). By means of cross-species genetic analysis of neurobehavioral traits (of mice and men) we aim to identify genotype-phenotype relationships relevant to the development and treatment of autism spectrum disorders, Alzheimer's Disease, eating disorders, and schizophrenia. These studies will lead to our understanding of conserved gene function in regulating essential behavioral strategies and will ultimately improve therapeutic and preventive strategies to contribute to healthy aging.


Experimental strategy:

The identification of molecular genetic mechanisms of neurobehavioral traits is established by performing fine-grained analysis of behavior using both well-established testing paradigms, as well as novel automated behavioral phenotyping methods (e.g., automated home cage recordings in rodents and smartphone application monitoring of human behavior). Behavioral and EEG dynamics in developing genetic mouse models for human candidate genes of neuropsychiatric disorders are studied across different developmental stages and in relation to brain development. Ultimately, genotype-phenotype relationships are translated to relevant human patient populations.


Recent key publications:

1: Bruining H, Matsui A, Oguro-Ando A, Kahn RS, Van't Spijker HM, Akkermans G, Stiedl O, van Engeland H, Koopmans B, van Lith HA, Oppelaar H, Tieland L, Nonkes LJ, Yagi T, Kaneko R, Burbach JP, Yamamoto N, Kas MJ.  Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development. Biological Psychiatry,  2015, 78(7):485-95

2: Eskes P, Spruit M, Brinkkemper S, Vorstman J, Kas MJ. The sociability score: App-based social profiling from a healthcare perspective. Computers in Human Behavior, 2016, 59, 39-48

3: Schughart K, Libert C, and Kas MJ. Human disease: strength to strength for mouse models. Nature, 2012, 492, 41

4: Kas MJ, Kahn RS, Collier DA, Waddington JL, Ekelund J, Porteous DJ, Schughart K, Hovatta I. Translational neuroscience of schizophrenia: seeking a meeting of minds between mouse and man. Science Translational Medicine, 2011, 3(102):102mr3.

5: Laarakker MC, Reinders NR, Bruining H, Ophoff RA, Kas MJ. Sex-dependent novelty response in neurexin-1α mutant mice. PLoS One, 2012, 7(2):e31503.

  1. Preliminary fMRI results exploring brain activity in a spatial navigation task in schizophrenia, Alzheimer's Disease, and healthy controls

    PRISM Consortium, Dec-2019, In : European Neuropsychopharmacology. 29, Suppl. 6, p. S132-S133 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  2. Preliminary fMRI results exploring processing of monetary and social rewards in schizophrenia, Alzheimer's disease, and healthy controls

    Raslescu, A., Malik, A., Clark, J. R., Bilderbeck, A., Hayen, A., Dawson, G. R., Penninx, B. W. J. H., Arango, C., Van der Wee, N., van Rossum, I. W., Kas, M., Marston, H. & Sommer, B., Dec-2019, In : European Neuropsychopharmacology. 29, Suppl. 6, p. S340-S341 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  3. Preliminary results from a comparison of facial emotion recognition in schizophrenia and Alzheimer's Disease, and relationship with social withdrawal

    PRISM Consortium, Dec-2019, In : European Neuropsychopharmacology. 29, p. S67-S68 2 p.

    Research output: Contribution to journalMeeting AbstractAcademic

  4. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Psychiat Genomics Consortium, 23andMe Res Team, Psychosis Endopheno-types Int Cons & Wellcome Trust Case-Control Consor, 12-Dec-2019, In : Cell. 179, 7, p. 1469-1482.e11 25 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Quantitative neurosymptomatics; linking quantitative biology to Neuropsychiatry

    Kas, M. (Guest ed.), Serretti, A. (Guest ed.) & Marston, H. (Guest ed.), 6-Mar-2019, In : Neuroscience and Biobehavioral Reviews. 97, p. 1-152 152 p.

    Research output: Contribution to journalSpecial issue editingAcademic

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Press / Media
  1. PRISM project video series

    Martien Kas


    1 Media contribution

    Press/Media: Public Engagement ActivitiesProfessional

  2. Anorexia not just a psychiatric problem, scientists find

    Martien Kas


    2 items of Media coverage

    Press/Media: ResearchAcademic

  3. AIMS-2-TRIALS Newsletter

    Martien Kas


    2 Media contributions

    Press/Media: Public Engagement ActivitiesProfessional

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  1. Translational Neuroscience Prize 2019

    Martien Kas (Recipient), 20-Jun-2019


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  1. Invited Speaker at the EURON advanced workshop: Drugs and the Brain

    Martien Kas (Invited speaker)

    Activity: Talk or presentationAcademic

  2. European College of Neuropsychopharmacology (ECNP) (External organisation)

    Martien Kas (Chair)

    Activity: MembershipMembership of networkAcademic

  3. KNAW - Commissie Inventarisatie onderzoeksmethoden in de neurowetenschappen (External organisation)

    Martien Kas (Member)

    Activity: MembershipMembership of committeeAcademic

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