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How to find us prof. dr. K. (Kathrin) Thedieck

Research interests

Prof . Dr. Kathrin Thedieck joined  the University Medical Center Groningen (UMCG) and Oldenburg University  in 2013 in the frame of the European Medical School (EMS). In 2019, Kathrin Thedieck became full professor and institute head for Biochemistry at Innsbruck University in Austria. She continues to be affiliated and conducts research and teaching at all three institutions.

The Lab for Metabolic Signaling studies the control of metabolic homeostasis through kinase signaling networks converging on the metabolic master regulator mTOR (mammalian / mechanistic target of rapamycin) in health and disease.
We adopt biochemistry, cell biology, proteomics, metabolomics and systems modelling approaches.
mTOR is a central controller of metabolism and ageing. mTOR is dysregulated in most cancers as well as in metabolic, neurodegenerative and congenital disorders, and is therefore of major biomedical interest as a drug target and biomarker. The protein kinase mTOR is at the center of a complex signaling and metabolic network, and exists in two structurally and functionally distinct multiprotein complexes, mTOR complex 1 (mTORC1) and mTORC2. In response to growth factors, nutrients, energy and stress, mTORC1 enhances anabolic processes such as translation, and represses catabolic processes such as autophagy. mTORC2 is a central metabolic regulator as well which is for instance involved in lipid and glucose homeostasis.
mTOR controls virtually all metabolic processes at the cellular and organismal level. But how are specific metabolic responses to distinct metabolic inputs achieved? The complex wiring of signaling networks allows to link distinct metabolic stimuli with specific metabolic responses. Our lab aims to identify novel network components and to delineate their interconnection in relation to mTOR’s metabolic inputs and outputs. To this end, we analyze its interactome and ancillary signaling and metabolic networks by ultrahigh resolution mass spectrometry, including targeted, shotgun and fluxomic proteomic and metabolomic methods. To deal with mTOR network complexity, we adopt systems approaches to unravel novel regulatory connections. We functionally characterize novel regulators and effectors by means of biochemistry and cell biology in in vitro and in vivo models as well as in human samples.

Read further on the website of the Lab for Metabolic Signaling.

 

 

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Publications

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Breaking the interface: efficient extraction of magnetic beads from nanoliter-droplets for automated sequential immunoassays

The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner

Tomatidine, a novel antiviral compound towards dengue virus

Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate

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