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How to find us dr. J.W.C. (Jan-Willem) Alffenaar

Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dri ed blood spot sampling and oral fluid as alternative for plasma and serum.

Publications

Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art

Levofloxacin pharmacokinetics in saliva as measured by a mobile microvolume UV spectrophotometer among people treated for rifampicin-resistant TB in Tanzania

Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort

Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs

Reply to Van Daele et al., "Fluconazole Underexposure in Critically Ill Patients: a Matter of Using the Right Targets?"

Saliva-based linezolid monitoring on a mobile UV spectrophotometer

Therapeutic Drug Monitoring in Non-Tuberculosis Mycobacteria Infections

Therapeutic drug monitoring in patients with tuberculosis and concurrent medical problems

A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva

Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients

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