Skip to ContentSkip to Navigation
How to find us dr. J.W.C. (Jan-Willem) Alffenaar

Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dri ed blood spot sampling and oral fluid as alternative for plasma and serum.

Publications

Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art

A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva

Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients

Clinical and economic impact of medication non-adherence in drug-susceptible tuberculosis: a systematic review

Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations

Coronavirus Disease-19: An Interim Evidence Synthesis of the World Association for Infectious Diseases and Immunological Disorders (Waidid)

Cross-validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Levofloxacin in Saliva

Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid

Epidemic and pandemic viral infections: impact on tuberculosis and the lung

Evaluation of 10 years of parainfluenza virus, human metapneumovirus, and respiratory syncytial virus infections in lung transplant recipients

Read more