dr. J.W.C. (Jan-Willem) Alffenaar

hospital pharmacist - clinical pharmacologist

dr. J.W.C. (Jan-Willem) Alffenaar
j.w.c.alffenaar umcg.nl


Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

  1. MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

    Migliori, G. B., Tiberi, S., Zumla, A., Petersen, E., Chakaya, J. M., Wejse, C., Torrico, M. M., Duarte, R., Alffenaar, J. W., Schaaf, H. S., Marais, B. J., Cirillo, D. M., Alagna, R., Rendon, A., Pontali, E., Piubello, A., Figueroa, J., Ferlazzo, G., Garcia-Basteiro, A., Centis, R., Visca, D., D'Ambrosio, L. & Sotgiu, G., Mar-2020, In : International Journal of Infectious Diseases. 92, p. S15-S25 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients

    Märtson, A-G., van der Elst, K. C. M., Veringa, A., Zijlstra, J. G., Beishuizen, A., van der Werf, T. S., Kosterink, J. G. W., Neely, M. & Alffenaar, J-W., Sep-2020, In : Antimicrobial Agents and Chemotherapy. 64, 9, 10 p., ARTN e00905-20.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Cross-validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Levofloxacin in Saliva

    Ghimire, S., Jongedijk, E. M., van den Elsen, S. H. J., Wessels, M. A., Touw, D. J. & Alffenaar, J-W. C., 15-Jun-2020, In : Journal of Applied Bioanalysis. 6, 2, p. 68-70 3 p.

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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