dr. J.W.C. (Jan-Willem) Alffenaar

hospital pharmacist - clinical pharmacologist

dr. J.W.C. (Jan-Willem) Alffenaar
Telephone:
E-mail:
j.w.c.alffenaar umcg.nl

Research

Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

Publications
  1. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: first global report

    Borisov, S., Danila, E., Maryandyshev, A., Dalcolmo, M., Miliauskas, S., Kuksa, L., Manga, S., Skrahina, A., Diktanas, S., Codecasa, L. R., Aleksa, A., Bruchfeld, J., Koleva, A., Piubello, A., Udwadia, Z. F., Akkerman, O. W., Belilovski, E., Bernal, E., Boeree, M. J., Loidi, J. C., Cai, Q., Cebrian Gallardo, J. J., Dara, M., Davidavičienė, E., Forsman, L. D., De Los Rios Jefe, J., Denholm, J., Drakšienė, J., Duarte, R., Elamin, S. E., Salinas, N. E., Ferrarese, M., Filippov, A., Garcia, A., García-García, J-M., Gaudiesiute, I., Gavazova, B., Gayoso, R., Rosso, R. G., Gruslys, V., Gualano, G., Hoefsloot, W., Jonsson, J., Khimova, E., Kunst, H., Laniado-Laborín, R., Li, Y., Magis-Escurra, C., Manfrin, V., Marchese, V., Robles, E. M., Matteelli, A., Mazza-Stalder, J., Moschos, C., Munoz-Torrico, M., Hamdan, H. M., Nakčerienė, B., Nicod, L., Marcos, M. N., Palmero, D. J., Palmieri, F., Papavasileiou, A., Payen, M-C., Pontarelli, A., Quirós, S., Rendon, A., Saderi, L., Šmite, A., Solovic, I., Souleymane, M. B., Tadolini, M., van den Boom, M., Vescovo, M., Viggiani, P., Yedilbayev, A., Zablockis, R., Zhurkin, D., Zignol, M., Visca, D., Spanevello, A., Caminero, J. A., Alffenaar, J-W., Tiberi, S., Centis, R., D'Ambrosio, L., Pontali, E., Sotgiu, G. & Migliori, G. B., 2019, In : European Respiratory Journal.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Should we worry for bedaquiline exposure in the treatment of MDR- and XDR-TB?

    Global Tuberculosis Network Bedaquiline study group, Alffenaar, J-W. C., Akkerman, O. W., Tiberi, S., Sotgiu, G. & Migliori, G. B., 7-Nov-2019, In : European Respiratory Journal.

    Research output: Contribution to journalLetterAcademicpeer-review

View all (242) »

View graph of relations

ID: 200721