dr. J.W.C. (Jan-Willem) Alffenaar

hospital pharmacist - clinical pharmacologist


Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

  1. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study

    members of the International Study Group on new anti-tuberculosis drugs and adverse events monitoring, 3-Apr-2019, In : International Journal of Infectious Diseases. 83, p. 72-76 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Optimal Sampling Strategies for Therapeutic Drug Monitoring of First-Line Tuberculosis Drugs in Patients with Tuberculosis

    Saktiawati, A. M. I., Harkema, M., Setyawan, A., Subronto, Y. W., Sumardi, N. V., Stienstra, Y., Aarnoutse, R. E., Magis-Escurra, C., Kosterink, J. G. W., van der Werf, T. S., Alffenaar, J-W. C. & Sturkenboom, M. G. G., 10-May-2019, In : Clinical Pharmacokinetics. 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Limited sampling strategies using linear regression and the Bayesian approach for therapeutic drug monitoring of moxifloxacin in tuberculosis patients

    van den Elsen, S. H. J., Sturkenboom, M. G. G., Akkerman, O. W., Manika, K., Kioumis, I. P., van der Werf, T. S., Johnson, J. L., Peloquin, C., Touw, D. J. & Alffenaar, J-W. C., 22-Apr-2019, In : Antimicrobial Agents and Chemotherapy. 38 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Anidulafungin pharmacokinetics in critically ill patients

    Van Wanrooy, M. J. P., Rodgers, M. G. G., Uges, D. R. A., Arends, J. P., Zijlstra, J. G., Van Der Werf, T. S., Kosterink, J. G. W. & Alffenaar, J. W. C., 1-Apr-2012, p. 445-446. 2 p.

    Research output: Contribution to conferencePosterAcademic

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