dr. J.W.C. (Jan-Willem) Alffenaar

hospital pharmacist - clinical pharmacologist


Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

  1. Regimens to treat multidrug-resistant tuberculosis: past, present and future perspectives

    Global TB Network Clinical Trials, Pontali, E., Raviglione, M. C. & Migliori, G. B., 30-Jun-2019, In : European Respiratory Review. 28, 152, 7 p., 190035.

    Research output: Contribution to journalReview articleAcademicpeer-review

  2. Management of patients with multidrug-resistant tuberculosis

    Lange, C., Aarnoutse, R. E., Alffenaar, J. W. C., Bothamley, G., Brinkmann, F., Costa, J., Chesov, D., van Crevel, R., Dedicoat, M., Dominguez, J., Duarte, R., Grobbel, H. P., Guenther, G., Guglielmetti, L., Heyckendorf, J., Kay, A. W., Kirakosyan, O., Kirk, O., Koczulla, R. A., Kudriashov, G. G., Kuksa, L., van Leth, F., Magis-Escurra, C., Mandalakas, A. M., Molina-Moya, B., Peloquin, C. A., Reimann, M., Rumetshofer, R., Schaaf, H. S., Schon, T., Tiberi, S., Valda, J., Yablonskii, P. K. & Dheda, K., 1-Jun-2019, In : International Journal of Tuberculosis and Lung Disease. 23, 6, p. 645-662 18 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Therapeutic Drug Monitoring: The Need for Practical Guidance

    Alffenaar, J-W. C., Heysell, S. K. & Mpagama, S. G., 15-Mar-2019, In : Clinical Infectious Diseases. 68, 6, p. 1065-1066 2 p.

    Research output: Contribution to journalLetterAcademicpeer-review

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ID: 200721