dr. J.W.C. (Jan-Willem) Alffenaar

hospital pharmacist - clinical pharmacologist


Research interests

During his routine TDM training he developed great interest into infectious diseases in critically ill patients. His research is focussed on the pharmacokinetics and pharmacodynamics of antimicrobial agents, in particular antifungal agents and anti-TB drugs. The aim is to optimize antimicrobial therapy based on PK/PD principles. The overall aim is to find a balance between efficacy and toxicity. Helpful tools are therapeutic drug monitoring, pharmacokinetic modeling, optimal sampling strategies. Also his more analytical oriented reasearch is focused on optimization of treatment by using alternative sampling strategies like dried blood spot sampling and oral fluid as alternative for plasma and serum.

  1. Official International Association for Therapeutic Drug Monitoring and Toxicology guideline: Development and Validation of Dried Blood Spot-based Methods for Therapeutic Drug Monitoring

    Capiau, S., Veenhof, H., Koster, R., Bergqvist, Y., Boettcher, M., Halmingh, O., Keevil, B., Koch, B., Linden, R., Pistos, C., Stolk, L., Touw, D., Stove, C. & Alffenaar, J-W., 1-Jun-2019, In : Therapeutic Drug Monitoring. 75 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Regimen design and pharmacokinetic-pharmacodynamic science: lessons learned

    Alffenaar, J-W. C., Tiberi, S. & Migliori, G. B., Jan-2019, In : Lancet Infectious Diseases. 19, 1, p. 3-4 3 p.

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

  3. Quality Assessment of Dried Blood Spots from Tuberculosis Patients from Four Countries

    Zuur, M. A., Veenhof, H., Aleksa, A., Boveneind-Vrubleuskaya, N. V. ., Darmawan, E., Hasnain, M. G., Heysell, S. K., Jongedijk, E. M., Koster, R. A., Magis-Escurra, C., Martinez, N., Molinas, G., Mondal, D., Mulyani, U. A., Perwitasari, D. A., Tsivunchyk, A., Touw, D. J. & Alffenaar, J-W. C., 4-Jun-2019, In : Therapeutic Drug Monitoring. 20 p.

    Research output: Contribution to journalArticleAcademicpeer-review

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