J.P. (John) LaCava

Telephone:

E-mail:

j.p.lacava umcg.nl

Research interests

For the latest information please consult the resources below.
Personal Website - http://www.macromolecule.fun
Twitter - https://twitter.com/macro_momo
ORCID - https://orcid.org/0000-0002-6307-7713

Others
http://copurification.org/
http://www.ncdir.org/

Publications

Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms

Sun, S., You, E., Hong, J., Hoyos, D., Del Priore, I., Tsanov, K. M., Mattagajasingh, O., Di Gioacchino, A., Marhon, S. A., Chacon-Barahona, J., Li, H., Jiang, H., Hozeifi, S., Rosas-Bringas, O., Xu, K. H., Song, Y., Lang, E. R., Rojas, A. S., Nieman, L. T. & Patel, B. K.& 12 others, Murali, R., Chanda, P., Karacay, A., Vabret, N., De Carvalho, D. D., Zenklusen, D., LaCava, J., Lowe, S. W., Ting, D. T., Iacobuzio-Donahue, C. A., Solovyov, A. & Greenbaum, B. D., 10-Dec-2024, In: Immunity. 57, 12, p. 2879-2894.e11 27 p.

Research output: Contribution to journal › Article › Academic › peer-review

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis

Olivier, J. F., Langlais, D., Jeyakumar, T., Polyak, M. J., Galarneau, L., Cayrol, R., Jiang, H., Molloy, K. R., Xu, G., Suzuki, H., LaCava, J., Gros, P. & Fodil, N., 10-Jan-2024, In: Communications biology. 7, 19 p., 77.

Research output: Contribution to journal › Article › Academic › peer-review

Multiparameter screen optimizes immunoprecipitation

Xie, S., Saba, L., Jiang, H., Bringas, O. R., Oghbaie, M., Stefano, L. D., Sherman, V. & LaCava, J., Apr-2024, In: Biotechniques. 76, 4, p. 145-152 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Structures, functions and adaptations of the human LINE-1 ORF2 protein

Baldwin, E. T., van Eeuwen, T., Hoyos, D., Zalevsky, A., Tchesnokov, E. P., Sánchez, R., Miller, B. D., Di Stefano, L. H., Ruiz, F. X., Hancock, M., Işik, E., Mendez-Dorantes, C., Walpole, T., Nichols, C., Wan, P., Riento, K., Halls-Kass, R., Augustin, M., Lammens, A. & Jestel, A.& 25 others, Upla, P., Xibinaku, K., Congreve, S., Hennink, M., Rogala, K. B., Schneider, A. M., Fairman, J. E., Christensen, S. M., Desrosiers, B., Bisacchi, G. S., Saunders, O. L., Hafeez, N., Miao, W., Kapeller, R., Zaller, D. M., Sali, A., Weichenrieder, O., Burns, K. H., Götte, M., Rout, M. P., Arnold, E., Greenbaum, B. D., Romero, D. L., LaCava, J. & Taylor, M. S., 1-Feb-2024, In: Nature. 626, p. 194–206 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes

Moadab, F., Sohrabi, S., Wang, X., Najjar, R., Wolters, J. C., Jiang, H., Miao, W., Romero, D., Zaller, D. M., Tran, M., Bays, A., Taylor, M. S., Kapeller, R., LaCava, J. & Mustelin, T., 27-Jun-2024, In: Mobile dna. 15, 14 p., 14.

Research output: Contribution to journal › Article › Academic › peer-review

Affinity-Based Interactome Analysis of Endogenous LINE-1 Macromolecules

Di Stefano, L. H., Saba, L. J., Oghbaie, M., Jiang, H., McKerrow, W., Benitez-Guijarro, M., Taylor, M. S. & LaCava, J., 2023, Methods in Molecular Biology. Humana Press, p. 215-256 42 p. (Methods in Molecular Biology; vol. 2607).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

Sun, S., Hong, J., You, E., Tsanov, K. M., Chacon-Barahona, J., Gioacchino, A. D., Hoyos, D., Li, H., Jiang, H., Ly, H., Marhon, S., Murali, R., Chanda, P., Karacay, A., Vabret, N., De Carvalho, D. D., LaCava, J., Lowe, S. W., Ting, D. T. & Iacobuzio-Donahue, C. A.& 2 others, Solovyov, A. & Greenbaum, B. D., 20-May-2023, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains

The Build-A-Genome Class, McCulloch, L. H., Sambasivam, V., Hughes, A. L., Annaluru, N., Ramalingam, S., Fanfani, V., Lobzaev, E., Mitchell, L. A., Cai, J., Jiang, H., LaCava, J., Taylor, M. S., Bishai, W. R., Stracquadanio, G., Steinmetz, L. M. & Bader, J. S., 8-Nov-2023, In: Cell Genomics. 3, 11, 15 p., 100419.

Research output: Contribution to journal › Article › Academic › peer-review

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus

Ukadike, K. C., Najjar, R., Ni, K., Laine, A., Wang, X., Bays, A., Taylor, M. S., LaCava, J. & Mustelin, T., 10-May-2023, In: Mobile dna. 14, 15 p., 5.

Research output: Contribution to journal › Article › Academic › peer-review