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Practical matters How to find us prof. dr. J.P. (John) LaCava

Research interests

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Affinity-Based Interactome Analysis of Endogenous LINE-1 Macromolecules

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus

Repeats Mimic Immunostimulatory Viral Features Across a Vast Evolutionary Landscape

Affinity Proteomic Analysis of the Human Exosome and Its Cofactor Complexes

Affinity proteomic dissection of the human nuclear cap-binding complex interactome

High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus

National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions

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Press/media Research Spotlight: John LaCava

Research Outreach, John LaCava